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276, 306, 323, 353, 380, 407, 424, 471, 488, 518, 535, 565, 592, 619, 935, 955, 982, 999, 1031, 1036, 1073, 1093, 1102, 1119, 2137], 'Li': [118, 287, 1033, 2730, 2748, 3163, 3404, 3607, 4359], 'ZhouFeng': [120], 'Zhou': [121, 3157, 3303, 3307], 'From': [122, 921, 1059], 'Medical': [124, 162, 763, 779, 862, 923, 1020, 1038, 1061, 1099, 2139, 3422, 3777], 'Science': [125, 867, 924, 1025, 1039, 1062, 2140], 'Research': [126, 649, 904, 925, 1040, 1063, 2141, 3423], 'Center,': [127, 926, 1041, 1064, 2142], 'Zhongnan': [128, 842, 927, 1042, 1065, 2143], 'Hospital': [129, 185, 232, 279, 326, 427, 491, 538, 669, 691, 737, 759, 789, 809, 812, 827, 843, 928, 1002, 1016, 1043, 1066, 1122, 2144], 'Wuhan': [131, 158, 167, 187, 214, 234, 261, 281, 308, 328, 355, 382, 409, 429, 473, 493, 520, 540, 567, 594, 621, 807, 814, 829, 845, 930, 957, 984, 1004, 1045, 1068, 1095, 1104, 1124, 2146], 'University,': [132, 159, 168, 188, 215, 235, 262, 282, 309, 329, 356, 383, 410, 430, 445, 474, 494, 521, 541, 568, 595, 622, 634, 676, 694, 815, 830, 846, 931, 958, 985, 1005, 1046, 1069, 1096, 1105, 1125, 2147], 'China': [133, 160, 169, 189, 216, 236, 263, 283, 310, 330, 357, 384, 411, 431, 447, 475, 495, 522, 542, 569, 596, 623, 678, 696, 710, 727, 745, 765, 781, 795, 816, 831, 847, 871, 932, 959, 986, 1006, 1028, 1070, 1097, 1106, 1126], '(F.Z.,': [134, 142, 164, 173, 198, 220, 245, 267, 292, 314, 339, 366, 393, 415, 457, 479, 504, 526, 551, 578, 605, 933, 941, 968, 990, 1071, 1079, 1101, 1110], 'P.Z.,': [135, 154, 210, 257, 304, 351, 378, 405, 469, 516, 563, 590, 617, 934, 953, 980, 1072, 1091], 'Li)': [137, 936, 1074], 'Institute': [138, 194, 241, 288, 335, 362, 389, 453, 500, 547, 574, 601, 791, 937, 964, 1075], 'Model': [140, 196, 243, 290, 337, 364, 391, 455, 502, 549, 576, 603, 939, 966, 1077], 'Animal': [141, 197, 244, 291, 338, 365, 392, 456, 503, 550, 577, 604, 940, 967, 1078], 'Y.-M.L.,': [143, 174, 199, 221, 246, 268, 293, 315, 340, 367, 394, 416, 458, 480, 505, 527, 552, 579, 606, 942, 969, 991, 1080, 1111], 'F.L.,': [146, 202, 249, 296, 343, 370, 397, 461, 508, 555, 582, 609, 945, 972, 1083], 'H.Y.,': [147, 203, 250, 297, 344, 371, 398, 462, 509, 556, 583, 610, 946, 973, 1084], 'J.-J.Q.,': [148, 178, 204, 225, 251, 272, 298, 319, 345, 372, 399, 420, 463, 484, 510, 531, 557, 584, 611, 947, 974, 995, 1085, 1115], 'X.-J.Z.,': [149, 179, 205, 226, 252, 273, 299, 320, 346, 373, 400, 421, 464, 485, 511, 532, 558, 585, 612, 948, 975, 996, 1086, 1116], 'B.W.,': [150, 180, 206, 227, 253, 274, 300, 321, 347, 374, 401, 422, 465, 486, 512, 533, 559, 586, 613, 949, 976, 997, 1087, 1117], 'M.X.,': [151, 207, 254, 301, 348, 375, 402, 466, 513, 560, 587, 614, 950, 977, 1088], 'D.X.,': [152, 208, 255, 302, 349, 376, 403, 467, 514, 561, 588, 615, 951, 978, 1089], 'C.Y.,': [153, 209, 256, 303, 350, 377, 404, 468, 515, 562, 589, 616, 952, 979, 1090], 'Z.-G.S.,': [155, 181, 211, 228, 258, 275, 305, 322, 352, 379, 406, 423, 470, 487, 517, 534, 564, 591, 618, 954, 981, 998, 1092, 1118], 'Li),': [157, 166, 183, 213, 230, 260, 277, 307, 324, 354, 381, 408, 425, 472, 489, 519, 536, 566, 593, 620, 956, 983, 1000, 1094, 1103, 1120], 'Basic': [161, 1098], 'School': [163, 908, 1100], 'Department': [170, 217, 264, 311, 412, 436, 476, 523, 628, 663, 684, 703, 716, 751, 771, 804, 836, 882, 987, 1011, 1107], 'Cardiology': [172, 219, 266, 313, 414, 478, 525, 989, 1109], 'J.X.,': [175, 222, 269, 316, 417, 481, 528, 992, 1112], 'Renmin': [184, 231, 278, 325, 426, 490, 537, 826, 1001, 1121], ',': [190, 237, 284, 331, 358, 385, 432, 449, 496, 543, 570, 597, 624, 638, 659, 680, 699, 712, 729, 747, 767, 800, 818, 832, 849, 873, 893, 917, 960, 1007], 'LiuYe-Mao': [192], 'Liu': [193, 878, 2228, 2269, 2732, 2744, 2746, 3080, 3165, 3315, 3333, 3341, 3345, 4364], 'XieJing': [239], 'Xie': [240, 2226, 3323], 'LiHaomiao': [286], 'LeiFang': [333], 'Lei': [334, 2222, 3305], 'YangHuilin': [360], 'Yang': [361, 600, 770, 2762, 2767, 3331, 3371, 3602], 'QinJuan-Juan': [387], 'Qin': 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1925, 2115, 2364, 2371, 2574, 2669, 3415, 3462, 3820, 3948, 4156, 4266], 'Clinic': [644], 'Pharmacology,': [645, 2549, 3053, 3525], 'William': [647], 'Harvey': [648], 'Institute,': [650, 889], 'Queen': [651], 'Mary': [652], 'University': [653, 740, 784, 798, 865, 885, 911, 1023], 'London,': [655], 'United': [656], 'Kingdom': [657], '(Q.X.)': [658], 'LuZhigang': [661], 'Lu': [662, 683, 3355, 3359], 'Neurology,': [665], 'First': [667, 689, 775], "People's": [668, 788], 'Jingmen': [671], 'affiliated': [672], 'Hubei': [674, 725, 739, 762, 1244], 'Minzu': [675], 'Jingmen,': [677], '(Z.L.)': [679], 'LuHaofeng': [682], 'Hepatobiliary': [686, 705, 718, 753, 838], 'Surgery,': [687, 706, 721, 756, 841, 858, 1014], 'Affiliated': [690, 736, 760], 'Changjiang': [693], 'Jingzhou,': [695], '(Haofeng': [697], 'Lu)': [698], 'XiaXigang': [701], 'Jingzhou': [707], '(X.X.)': [711], 'WangDaihong': [714], 'Wang': [715, 896, 2522, 2750, 3067, 3317, 3357, 3363, 3399, 3671, 3673, 3676, 4355], 'Pancreatic': [720, 755, 840], 'Xianning': [722], 'Province,': [726, 1245], '(D.W.)': [728], 'LiaoXiaofeng': [731], 'Liao': [732, 3365], 'Xiangyang': [733], 'Arts': [742], 'Science,': [744, 780, 4093, 4310], '(X.L.)': [746], 'PengGang': [749], 'Suizhou': [757], 'central': [758, 1336], 'College,': [764, 863, 1021], '(G.P.)': [766], 'YangJun': [769], 'College': [776, 4386], 'Clinical': [778, 3052, 3114, 3294, 3524, 3578, 3615, 3884, 4309], 'Three': [782, 796], 'Gorges': [783, 797], '&': [785, 810, 3051], 'Yichang': [786], 'Cardiovascular': [793, 903, 1013, 2794, 3624, 3707, 4243], 'Diseases,': [794, 3580], '(J.Y.)': [799], 'HuangXiaodong': [802], 'Huang': [803, 2232, 2528, 3389], 'Gastroenterology,': [806], 'Tongren': [811], '(X.H.)': [817], 'ZhangBing-Hong': [820], 'Departments': [822, 897], 'Neonatology': [824], '(B.-H.Z.),': [825], 'YuanYufeng': [834], 'Yuan': [835, 3393], '(Y.Y)': [848], 'WeiXiang': [851], 'Wei': [852, 3385], 'Division': [853, 879], 'Cardiothoracic': [855], 'Vascular': [857], 'Tongji': [859, 861, 1019], 'Huazhong': [864, 1022], 'Technology,': [869, 1027], 'Wuhan,': [870, 1018, 1050, 2151], '(X.W.)': [872], 'LiuPeter': [876], 'Ottawa': [887], 'Heart': [888, 2642, 2721, 3148, 4498], 'ON,': [890], 'Canada': [891], '(P.P.L.)': [892], 'WangYibin': [895], 'Anesthesiology,': [899], 'Physiology': [900], 'Laboratories,': [905], 'David': [906], 'Geffen': [907], 'California,': [913], 'Los': [914], 'Angeles': [915], '(Y.W.)': [916], 'ZhangPeng': [919], 'SheZhi-Gang': [962], 'She': [963, 3395], 'XiaJiahong': [1009], 'Union': [1015], '(J.X.).': [1029], 'LiHongliang': [1032], 'Correspondence': [1034, 2457], '169': [1047, 2148], 'Donghu': [1048, 2149], 'Rd,': [1049, 2150], '430072,': [1051, 2152], 'China.': [1052, 2153], 'Email': [1053, 2154], 'E-mail': [1054], 'Address:': [1055], '[email': [1056], 'protected]': [1057], 'https://orcid.org/0000-0002-9821-0297': [1058], 'Originally': [1127, 4502], 'published3': [1128], '2020https://doi.org/10.1161/HYPERTENSIONAHA.120.15622Hypertension.': [1130], '2020;76:e15–e17Other': [1131], 'version(s)': [1132], 'this': [1134, 1143, 1221, 1225, 1369, 1417, 2062, 2101], 'articleYou': [1135], 'are': [1136, 1371, 1730, 2098, 2360, 2369, 2379, 2384, 2392, 2399, 2419], 'viewing': [1137], 'most': [1139], 'recent': [1140, 1186], 'version': [1141], 'article.': [1144], 'Previous': [1145, 2467], 'versions:': [1146], 'June': [1147], '4,': [1148], '2020:': [1149], 'Ahead': [1150], 'Print': [1152], 'Treating': [1153], 'coronavirus': [1154, 1406, 1935, 2129], 'disease': [1155, 1407, 1568, 1678, 1689, 1708, 1996, 2014], '2019': [1156, 1250, 1408, 3568, 3889], '(COVID-19)': [1157, 3569], 'using': [1158, 1561], '(angiotensin-converting': [1160, 1392], 'enzyme)': [1161, 1393], 'inhibitors': [1162, 1206, 1394, 1480, 1727, 1771, 1791, 1837, 1858, 1896, 1908, 2037, 2203, 2246, 2947, 3185, 3724, 3766, 4473], 'angiotensin': [1164, 1396, 2179, 2243, 2330, 2941, 3085, 3187, 4299], 'receptor': [1166, 1398, 2250, 2331, 2942, 3089, 3188], 'blockers': [1167, 1399, 1574, 2164, 2251, 2332, 2943, 3038, 3090, 3189, 4034], '(ARBs)': [1168, 1400], 'is': [1169, 1201, 2173], 'a': [1170, 1316, 1320, 1599, 1876, 1980, 2041, 2074, 2106, 2362, 2462, 2632, 2673, 2712, 2953, 3732, 4272, 4478], 'clinical': [1171, 2113, 3099, 3503, 4088], 'dilemma': [1172], 'due': [1173, 1276], 'perceived': [1176], 'risk': [1177, 1623, 1655, 1778, 1821, 1850, 1982, 2045, 3093, 3408, 3413, 3650], 'exacerbating': [1179], 'by': [1181, 1319, 1334, 1344, 1358, 1815, 1930, 2084, 2324], 'elevating': [1182], 'ACE2': [1183, 3456], 'expression.1': [1184], 'Despite': [1185, 2087], 'studies': [1187, 2093], 'showing': [1188, 1422, 1448, 1472, 1503], 'no': [1189, 1898, 2174, 2407], 'harm': [1190], 'continue': [1192], 'inhibitors/ARBs': [1194, 1272, 1293, 1430, 1433, 1453, 1456, 1463, 1546, 1559, 1582, 1594, 1617, 1643, 1650, 1715, 1720, 1976, 2021, 2026, 2120], 'in': [1195, 1224, 1281, 1315, 1416, 1451, 1508, 1647, 1721, 1734, 1743, 1756, 1855, 1947, 1950, 2027, 2204, 2289, 2333, 2356, 2395, 2402, 2428, 2537, 2542, 2666, 2780, 2787, 2837, 2851, 3041, 3101, 3139, 3287, 3418, 3455, 3464, 3505, 3623, 3695, 3706, 3728, 3826, 3859, 3886, 3917, 4109, 4271, 4298, 4342, 4455, 4474], 'setting': [1197, 1723, 2029], 'COVID-19,2,3': [1199], 'it': [1200], 'still': [1202, 2099], 'unknown': [1203], 'whether': [1204], 'ARBs': [1208, 1482, 1729, 1773, 1806, 1842, 1872, 1941], 'have': [1209, 2040], 'equivalent': [1210], 'impacts': [1211], 'mortality': [1214, 1627, 1659, 1781, 1825, 1879, 1904, 1949, 2049, 2253, 2323, 2949, 3040, 3096, 3417, 3727, 3768], 'among': [1215, 1440, 1458, 1492, 1506, 1662, 1921, 1986, 2254], 'patients': [1216, 1285, 1415, 1441, 1459, 1493, 1507, 1646, 1663, 1702, 1834, 1922, 1988, 2008, 2117, 2205, 2255, 2290, 2334, 2667, 3102, 3506, 3729], 'preexisting': [1217], 'different': [1218, 1443, 1831], 'indications.To': [1219], 'address': [1220], 'critical': [1222], 'question,': [1223], 'multi-centered': [1226], 'retrospective': [1227, 1967, 2075, 2102, 2954], 'study,': [1228, 1968, 2675, 2956], 'we': [1229, 1969], 'enrolled': [1230], '15': [1231], '504': [1232], 'participants': [1233, 1260, 1788], 'diagnosed': [1234], 'as': [1235, 2436], 'admitted': [1238], '17': [1240], 'hospitals': [1241], 'located': [1242], 'at': [1243, 1598, 2169, 4143], 'China,': [1246], 'from': [1247, 1373, 1712, 2018, 2073], 'December': [1248], '31,': [1249], 'April': [1252], '21,': [1253], '2020.': [1254], 'A': [1255, 1784, 2506, 2615, 2703, 2966, 2973, 3043, 3106, 3407, 3573, 3655, 3700, 3757, 4111, 4140, 4235], 'total': [1256, 1785], '3572': [1258], 'eligible': [1259], '(aged': [1261, 1792, 1807], '66': [1262], '[interquartile': [1263, 1794, 1809], 'range,': [1264, 1795, 1810], '58–72]': [1265], 'years,': [1266, 1797, 1812], '51.1%': [1267], 'male': [1268], 'sex)': [1269], 'with': [1270, 1401, 1434, 1442, 1460, 1487, 1588, 1592, 1621, 1640, 1664, 1675, 1703, 1717, 1776, 1802, 1875, 1888, 1901, 1923, 1979, 1989, 2000, 2009, 2066, 2118, 2124, 2206, 2252, 2256, 2259, 2291, 2335, 2940, 3103, 3284, 3290, 3507, 3648, 3730, 3767], 'indications': [1273, 1294, 1495, 1924, 2121], 'hospitalized': [1275, 1987, 2258, 2668], 'were': [1279, 1304, 1313, 1332, 1340, 1356, 1577, 1585, 1800, 2071], 'included': [1280], 'our': [1282], 'analysis,': [1283, 4044], 'whereas': [1284, 1894], 'without': [1286, 3509], 'taking': [1287, 1497, 1713, 1789, 1805, 1835, 1841, 2019, 2052], 'any': [1288], 'drugs': [1289, 1909, 3647], 'treating': [1291, 1735, 2116], 'or': [1295, 1342, 1481, 1483, 2944, 3186, 3193, 3911, 4336], 'recorded': [1296], 'hypotension': [1297], 'shock': [1298], 'within': [1299], '24': [1300], 'hours': [1301], 'after': [1302, 1514], 'admission': [1303], 'excluded': [1305], '(Figure': [1306], '[A]).': [1307], 'Data': [1308], 'collection,': [1309], 'extraction,': [1310], 'analysis': [1312, 1564], 'conducted': [1314], 'standard': [1317], 'procedure': [1318], 'team': [1321], 'physicians,': [1323], 'analysts,': [1324], 'statisticians.': [1326], 'study': [1328, 1370, 2076, 2103], 'design': [1329], 'procedures': [1331], 'approved': [1333, 1343], 'ethics': [1337, 1347, 1360], 'committee': [1338], 'accepted': [1341], 'local': [1346], 'committees': [1348], 'all': [1350, 1461], 'participating': [1351], 'hospitals.': [1352], 'Informed': [1353], 'consent': [1354], 'forms': [1355], 'waived': [1357], 'each': [1359], 'committee.': [1361], 'data': [1363, 1938, 2005], 'that': [1364, 1848, 1940, 1971, 2007, 4085], 'support': [1365], 'findings': [1367], 'available': [1372], 'corresponding': [1375], 'author': [1376], 'upon': [1377], 'reasonable': [1378], 'request.Download': [1379], 'figureDownload': [1380], 'PowerPointFigure.': [1381], 'flowchart': [1383], 'patient': [1385], 'enrollment': [1386], 'associations': [1389, 1424, 1475, 1540, 1775], '28-d': [1402, 1435, 1488], 'all-cause': [1403, 1436, 1549, 1626, 1658, 1824, 3726], 'death': [1404, 1437, 1489, 1550, 1852, 1985], '(COVID-19).': [1409], 'A,': [1410, 2478, 2484, 2486, 2611, 2649, 2811, 2827, 2859, 2865, 2870, 2876, 2895, 2911, 2929, 2995, 3172, 3210, 3252, 3261, 3378, 3440, 3489, 3868, 3999, 4005, 4015, 4169, 4253], 'Flow': [1411], 'chart': [1412], 'enrolling': [1414], 'study.': [1418], 'B,': [1419, 2312, 3013, 3216, 3257, 3350, 3388, 3435], 'Forest': [1420, 1470], 'plots': [1421, 1471], 'in-hospital': [1426, 1542, 1610, 1613, 1869, 1972, 2033, 2938], 'use': [1427, 1543, 1556, 1614, 1870, 1973, 2241, 2373, 3034, 4469], 'vs': [1431], 'non-ACE': [1432, 1455, 1558, 1593, 1642, 1719, 1907, 2025], 'indications.': [1444, 1464], 'C,': [1445, 2761, 2903, 2909, 2913, 3003, 3024, 3229, 3332, 3485, 3491, 3712, 3989, 3993, 4019, 4123, 4179, 4215, 4255, 4287], 'Kaplan-Meier': [1446, 1501], 'curves': [1447, 1502], 'percent': [1449, 1504], 'survivals': [1450], 'groups': [1457, 1510, 1651], 'blips': [1466, 1517], 'indicate': [1467, 1518], 'censoring.': [1468, 1519], 'D,': [1469, 2878, 2880, 3170, 3338, 3364, 3444, 3789, 3866, 3964, 4023, 4067], 'comparative': [1474], 'inpatients': [1477], 'receiving': [1478], 'other': [1484, 3098], 'therapeutic': [1485], 'agents': [1486, 1560, 1595, 1890], 'having': [1494], 'inhibitors/ARBs.': [1499], 'E,': [1500, 2652, 2907, 2919, 2921, 3018, 3020, 3126, 3207, 3376, 4061, 4065, 4069, 4257], 'survival': [1505], 'ARBs/ARBs': [1509], 'during': [1511, 1596, 1843, 1891], '28': [1512], 'd': [1513], 'admission.': [1515], 'ACEI': [1520], 'indicates': [1521], 'inhibitors;': [1523], 'CAD,': [1524], 'coronary': [1525, 1676, 1687, 1706, 1994, 2001, 2012], 'artery': [1526, 1677, 1688, 1707, 1995, 2002, 2013], 'disease;': [1527], 'EMR,': [1528], 'electronic': [1529], 'medical': [1530], 'records;': [1531], 'HYP,': [1532], 'hypertension;': [1533], 'PSM,': [1535], 'propensity': [1536, 1562, 1816], 'score–matched.We': [1537], 'analyzed': [1538], 'between': [1541, 1832, 3182, 4146], '28-day': [1548, 1625, 1657, 1780, 1823, 1892, 1903, 1984, 2047], 'compared': [1553, 1639, 1716, 1887, 1905, 2022], 'score–matched': [1563], 'where': [1565], 'age,': [1566], 'sex,': [1567], 'severity,': [1569], 'comorbidities,': [1570], 'calcium': [1572], 'channel': [1573], 'medication': [1575, 1942], 'usage': [1576, 2034], 'matched.': [1578], 'And': [1579], '906': [1580], 'treated': [1583, 1591], 'subjects': [1584, 1590, 1804], 'successfully': [1586], 'matched': [1587, 1801], '1812': [1589], 'hospitalization': [1597], 'ratio': [1600, 1632], '1:2.': [1602], 'After': [1603], 'further': [1604, 1768], 'adjusting': [1605], 'imbalanced': [1607], 'variables': [1608], 'medications,': [1611], 'was': [1618, 1828, 1873, 1977, 2057], 'significantly': [1619, 1653, 1830, 1877], 'associated': [1620, 1874, 1978], 'lower': [1622, 1654, 1981], '(adjusted': [1630, 1666, 1679, 1690, 1860, 1880, 1910], 'hazard': [1631], '[HR],': [1633], '0.39': [1634], '[95%': [1635, 1669, 1682, 1693, 1863, 1883, 1913], 'CI,': [1636, 1670, 1683, 1694, 1864, 1884, 1914], '0.26–0.58];': [1637], 'P<0.001)': [1638, 1886], 'group.': [1644], 'Notably,': [1645, 2032], 'had': [1652], 'hypertension': [1665, 1673, 1704, 1998, 2010, 2257], 'HR,': [1667, 1680, 1691, 1861, 1881, 1911], '0.32': [1668], '0.15–0.66];': [1671], 'P=0.002),': [1672], 'combined': [1674, 1999], '0.11': [1681], '0.04–0.31];': [1684], 'P<0.001),': [1685], '0.38': [1692], '0.16–0.89];': [1695], 'P=0.03;': [1696], 'Figure': [1697, 1867, 1917], '[B]': [1698], '[C]).': [1700], 'Thus,': [1701], 'might': [1709, 2015, 2078], 'obtain': [1710, 2016], 'benefits': [1711, 1749, 2017], 'COVID-19.Although': [1725], 'commonly': [1731], 'considered': [1732], 'interchangeable': [1733], 'hypertension,': [1736, 1993, 2297], 'cardiac': [1737], 'diseases,': [1738], 'chronic': [1740, 2294, 2336], 'kidney': [1741, 2295], 'diseases': [1742], 'clinic': [1744], 'application,4': [1745], 'their': [1746], 'risks': [1747, 3501], 'must': [1750], 'be': [1751, 1959, 2064, 2079, 2406, 2415, 2432, 2447], 'reconsidered': [1752], 'when': [1753], 'facing': [1754], 'light': [1757], 'involvement': [1760], 'pulmonary': [1762, 2338], 'multiorgan': [1764], 'symptoms.5': [1765], 'We': [1766], 'thus': [1767], 'evaluated': [1769], 'specific': [1774, 1955], 'COVID-19.': [1783, 2031], '124': [1787], '65': [1793], '59–71]': [1796], '62.9%': [1798], 'male)': [1799, 1814], '248': [1803], '64': [1808], '56–72]': [1811], '59.7%': [1813], 'score': [1817, 3409], 'matching.': [1818], 'Importantly,': [1819], 'not': [1829, 2058, 2361, 2380, 2393, 2400], 'versus': [1838], 'ones': [1840], 'hospitalization,': [1844], 'despite': [1845], 'fact': [1847], 'trended': [1853], 'higher': [1854, 2042], 'group': [1859], '2.02': [1862], '0.56–7.27];': [1865], 'P=0.28;': [1866], '[D]).Notably,': [1868], 'reduced': [1878], '0.31': [1882], '0.18–0.53];': [1885], 'non-ARB': [1889], 'follow-up,': [1893], 'showed': [1897, 1944], 'significant': [1899], 'association': [1900, 3644], '0.49': [1912], '0.20–1.20];': [1915], 'P=0.12;': [1916], '[D]': [1918], '[E])': [1920], 'inhibitor/ARBs': [1927], 'infected': [1929, 2123], 'severe': [1931, 2125, 3194], 'acute': [1932, 2126], 'respiratory': [1933, 2127], 'syndrome': [1934, 2128], '2.': [1936], 'These': [1937, 2004], 'suggested': [1939, 2006], 'consistently': [1943], 'beneficial': [1945], 'effects': [1946, 1956], 'reducing': [1948], 'COVID-19,': [1951, 3291, 3468, 4157, 4277, 4381], 'but': [1952, 2054], 'inhibitor': [1954], 'appeared': [1957], 'less': [1960], 'homogenous.In': [1961], 'conclusion,': [1962], 'based': [1963, 2104, 3410], 'large-scale': [1966, 2088], 'demonstrated': [1970], 'coexisting': [1992], 'disease.': [2003], 'tended': [2038], 'incidence': [2043, 3192], 'than': [2050, 2409], 'those': [2051], 'ARBs,': [2053], 'difference': [2056], 'statistically': [2059], 'significant.': [2060], 'Nevertheless,': [2061], 'should': [2063, 2349, 2405, 2446], 'interpreted': [2065], 'caution': [2067], 'since': [2068], 'observations': [2070], 'obtained': [2072], 'possibly': [2080], 'overcome': [2081], 'null': [2083], 'unmeasured': [2085], 'confounders.': [2086], 'geographically': [2090], 'diverse': [2091], 'prospective': [2092, 3045], 'randomized': [2095], 'controlled': [2096], 'trials': [2097], 'required,': [2100], 'large': [2107], 'cohort': [2108, 2674, 2955, 3046, 4043], 'provides': [2109], 'actionable': [2110], 'information': [2111], 'physicians': [2114], '2.Sources': [2130], 'FundingNone.DisclosuresNone.Footnotes*These': [2132], 'authors': [2133], 'contributed': [2134], 'equally.Correspondence': [2135], '[email protected].': [2155], 'Danser': [2156], 'AHJ,': [2157], 'Epstein': [2158], 'M,': [2159, 2188, 2310, 2558, 2647, 2755, 2813, 2888, 2893, 2897, 2923, 2989, 2991, 3022, 3221, 3233, 3254, 3320, 3342, 3380, 3797, 3837, 3966, 3978, 3991, 4007, 4134, 4217], 'Batlle': [2160], 'D.': [2161], 'Renin-angiotensin': [2162, 2200], 'system': [2163, 2180, 2202, 2287, 2536, 2625, 2662, 3037, 3515, 3765, 4033], 'pandemic:': [2168], 'present': [2171], 'there': [2172], 'evidence': [2175], 'abandon': [2177], 'renin': [2178], 'blockers.Hypertension.': [2181], '2020;': [2182, 2211, 2262], '75:1382–1385.': [2183], 'doi:': [2184, 2213, 2264, 2304, 2345], '10.1161/HYPERTENSIONAHA.120.15082LinkGoogle': [2185], 'Scholar2.': [2186], 'Vaduganathan': [2187], 'Vardeny': [2189], 'O,': [2190, 2882, 3011, 4063], 'Michel': [2191], 'T,': [2192, 2475, 2523, 3166, 3753, 3974, 3984, 3997, 4125], 'McMurray': [2193], 'JJV,': [2194], 'Pfeffer': [2195], 'MA,': [2196], 'Solomon': [2198], 'SD.': [2199], 'aldosterone': [2201], 'Covid-19.N': [2207], 'Engl': [2208], 'J': [2209, 2695, 3133, 3268, 3272, 3936, 4398, 4465], 'Med.': [2210, 2301], '382:1653–1659.': [2212], '10.1056/NEJMsr2005760CrossrefMedlineGoogle': [2214], 'Scholar3.': [2215], 'P,': [2217, 2560, 2759, 2815, 2917, 3026, 3348, 3352, 3714, 4009, 4025], 'Zhu': [2218, 3313], 'L,': [2219, 2235, 2482, 2735, 2737, 2884, 2886, 2905, 3005, 3015, 3314, 3326, 3346, 3370, 3538, 3629, 3932, 4017, 4129, 4167], 'J,': [2221, 2227, 2521, 2525, 2564, 2613, 2688, 2743, 2745, 2749, 2751, 2819, 2993, 2999, 3001, 3007, 3009, 3076, 3124, 3158, 3213, 3224, 3226, 3231, 3242, 3249, 3259, 3264, 3302, 3304, 3310, 3324, 3358, 3372, 3392, 3398, 3534, 3589, 3593, 3597, 3603, 3635, 3835, 4003, 4013, 4171, 4173, 4177], 'F,': [2223, 2690, 2821, 2857, 2868, 2925, 3218, 3306, 3308, 3595, 3995, 4097], 'JJ,': [2225], 'YM,': [2229], 'Zhao': [2230, 3069, 3321], 'YC,': [2231, 2278], 'X,': [2233, 2729, 2747, 2763, 3066, 3164, 3312, 3328, 3330, 3336, 3362, 3366, 3386, 3390, 3442, 3540, 3591, 3599, 3668], 'Lin': [2234], 'et': [2236, 4422], 'al.': [2237], 'Association': [2238, 3610, 3762, 3882], 'inpatient': [2240], 'converting': [2244, 2945, 3086, 4300], 'enzyme': [2245, 2327, 2946, 3087, 3184, 4301, 4472], 'angtiotensin': [2248], 'COVID-19.Circ': [2260], 'Res.': [2261], '126:1671–1681.': [2263], '10.1161/CIRCRESAHA.120.317134LinkGoogle': [2265], 'Scholar4.': [2266], 'Hsu': [2267, 2279], 'TW,': [2268], 'JS,': [2270], 'Hung': [2271], 'SC,': [2272], 'Kuo': [2273], 'KL,': [2274], 'Chang': [2275], 'YK,': [2276], 'Chen': [2277, 2518, 2526, 3299, 3301, 3319, 3373, 3543], 'CC,': [2280], 'Tarng': [2281], 'DC.': [2282], 'Renoprotective': [2283], 'effect': [2284], 'renin-angiotensin-aldosterone': [2286], 'blockade': [2288], 'predialysis': [2292], 'advanced': [2293], 'disease,': [2296, 3195, 4308], 'anemia.JAMA': [2299], 'Intern': [2300], '2014;': [2302], '174:347–354.': [2303], '10.1001/jamainternmed.2013.12700CrossrefMedlineGoogle': [2305], 'Scholar5.': [2306], 'Mancini': [2307], 'GB,': [2308], 'Etminan': [2309], 'Levesque': [2313], 'LE,': [2314], 'FitzGerald': [2315], 'JM,': [2316], 'Brophy': [2317], 'JM.': [2318], 'Reduction': [2319], 'morbidity': [2321], 'statins,': [2325], 'angiotensin-converting': [2326, 3183, 4471], 'inhibitors,': [2328], 'obstructive': [2337], 'disease.J': [2339], 'Am': [2340], 'Coll': [2341], 'Cardiol.': [2342], '2006;': [2343], '47:2554–2560.': [2344], '10.1016/j.jacc.2006.04.039CrossrefMedlineGoogle': [2346], 'Scholar': [2347], 'eLetters(0)eLetters': [2348], 'relate': [2350], 'an': [2352, 2396, 3946, 4039], 'article': [2353, 2426], 'recently': [2354], 'published': [2355, 2394], 'journal': [2358, 2388], 'forum': [2363], 'providing': [2365], 'unpublished': [2366], 'data.': [2367], 'Comments': [2368, 2378, 2391, 2404], 'reviewed': [2370], 'appropriate': [2372], 'tone': [2375], 'language.': [2377], 'peer-reviewed.': [2381], 'Acceptable': [2382], 'comments': [2383], 'posted': [2385, 2416], 'website': [2389], 'only.': [2390], 'issue': [2397], 'indexed': [2401], 'PubMed.': [2403], 'longer': [2408], '500': [2410], 'words': [2411], 'will': [2413, 2431], 'only': [2414], 'online.': [2417], 'References': [2418], 'limited': [2420], '10.': [2422], 'Authors': [2423], 'cited': [2427], 'comment': [2430], 'invited': [2433], 'reply,': [2435], 'appropriate.Comments': [2437], 'feedback': [2439], 'AHA/ASA': [2441, 2451], 'Scientific': [2442], 'Statements': [2443], 'Guidelines': [2445], 'directed': [2448], 'Manuscript': [2452], 'Oversight': [2453], 'Committee': [2454], 'via': [2455], 'its': [2456, 4304], 'page.Sign': [2458], 'In': [2459], 'Submit': [2461], 'Response': [2463], 'This': [2465], 'Article': [2466, 4493], 'Back': [2468], 'top': [2470], 'Next': [2471], 'FiguresReferencesRelatedDetailsCited': [2472], 'By': [2473], 'Kashour': [2474], 'Abdulhak': [2477], 'Tlayjeh': [2479], 'H,': [2480, 2519, 2731, 2739, 2809, 3318, 3360, 3446, 3755, 3793, 4021], 'Hassett': [2481], 'Noman': [2483], 'Mohsen': [2485], 'Al-Mallah': [2487], 'M': [2488, 2569, 3799, 4030, 4074, 4136, 4181, 4401], 'Tleyjeh': [2490], 'I': [2491], '(2023)(2020)': [2492], 'Converting': [2494], 'Enzyme': [2495, 3275, 3558, 3805, 3909, 4334], 'Among': [2503, 4197, 4228], 'Patients:': [2505], 'Systematic': [2507, 2704, 2844, 3517, 3574, 4236], 'Review': [2508, 2539, 2705, 3575, 4237], 'Meta-Analysis,': [2510, 2846], 'American': [2511, 2720, 3147, 3469, 3951, 4201, 4240, 4385, 4497], 'Journal': [2512, 2717, 2792, 3112, 3144, 3196, 3292, 3470, 3522, 3657, 3740, 3775, 3952, 4090, 4202, 4241, 4279, 4382], 'Therapeutics,': [2514], '10.1097/MJT.0000000000001281,': [2515], '30:4,': [2516], '(e336-e346)': [2517], 'Wen': [2524], 'S,': [2527, 2753, 2807, 2817, 2861, 2872, 3070, 3074, 3128, 3160, 3236, 3437, 3487, 3631, 3791, 3795, 3831, 3934, 3968, 3976, 3980, 4213], 'Y': [2529, 2532, 3677], '(2023)': [2533], 'Counter-regulatory': [2534], 'renin-angiotensin': [2535], 'hypertension:': [2538], 'update': [2541], 'era': [2544], 'pandemic,': [2547], 'Biochemical': [2548], '10.1016/j.bcp.2022.115370,': [2550], '208,': [2551], '(115370),': [2552], 'Online': [2553, 2581, 2604, 2683, 2724, 2800, 2961, 2982, 3057, 3119, 3151, 3202, 3429, 3480, 3529, 3584, 3663, 3746, 3782, 3926, 3959, 4052, 4208, 4248, 4314, 4351, 4392, 4430, 4460], 'publication': [2554, 2582, 2605, 2684, 2725, 2801, 2962, 2983, 3058, 3120, 3152, 3203, 3430, 3481, 3530, 3585, 3664, 3747, 3783, 3927, 3960, 4053, 4209, 4249, 4315, 4352, 4393, 4431, 4461], 'date:': [2555, 2583, 2606, 2685, 2726, 2802, 2963, 2984, 3059, 3121, 3153, 3204, 3431, 3482, 3531, 3586, 3665, 3748, 3784, 3928, 3961, 4054, 4210, 4250, 4316, 4353, 4394, 4432, 4462], '1-Feb-2023.': [2556], 'Kebria': [2557], 'Milan': [2559], 'Peyravian': [2561], 'N,': [2562, 2987, 3062, 3970, 4131], 'Kiani': [2563], 'Khatibi': [2565], 'S': [2566, 3548, 3802, 4219, 4289], 'Mozafari': [2568], '(2022)': [2570, 2592, 2619, 2660, 2696, 2769, 2833], 'Stem': [2571], 'cell': [2572], 'therapy': [2573], 'pneumonia,': [2576], 'Molecular': [2577, 4160, 4281], 'Biomedicine,': [2578], '10.1186/s43556-021-00067-8,': [2579], '3:1,': [2580], '1-Dec-2022.': [2584], 'Tsampasian': [2585], 'V,': [2586, 2863, 2874, 2901, 3239, 4099, 4119], 'Corballis': [2587], 'N': [2588, 3637], 'Vassiliou': [2590], 'V': [2591, 2832, 3870], 'Renin–Angiotensin–Aldosterone': [2593], 'Infection,': [2597], 'Current': [2598, 3421], 'Hypertension': [2599, 2971], 'Reports,': [2600], '10.1007/s11906-022-01207-3,': [2601], '24:10,': [2602], '(425-433),': [2603], '1-Oct-2022.': [2607], 'Sharma': [2608], 'R,': [2609, 2805, 2899, 3245, 3266, 3546, 3787, 3864, 4001, 4011], 'Kumar': [2610], 'Majeed': [2612], 'Thakur': [2614], 'Aggarwal': [2617], 'G': [2618, 3718, 4027, 4071, 4362], 'Drugs': [2620], 'acting': [2621], 'renin–angiotensin–aldosterone': [2624, 3514], '(RAAS)': [2626], 'deaths': [2628], 'patients:': [2631, 2952], 'systematic': [2633, 3733, 4479], 'review': [2634, 3108, 3518, 3734], 'meta-analysis': [2636, 3736], 'observational': [2638, 3738], 'studies,': [2639, 3739], 'Egyptian': [2641], 'Journal,': [2643, 4483], '10.1186/s43044-022-00303-8,': [2644], '74:1': [2645], 'Landolfo': [2646], 'Maino': [2648], 'Di': [2650], 'Salvo': [2651], 'Fiorini': [2653], 'G,': [2654, 2915, 2927, 3064, 3156, 3368, 3374, 3382, 3384, 3542, 3716, 3833, 4127, 4358, 4360], 'Peterlana': [2655], 'D': [2656, 2765, 3028, 3081, 3896, 3939, 4321], 'Borghi': [2658], 'C': [2659, 2931, 4262, 4438], 'Renin–angiotensin': [2661, 4032], 'modulation': [2663], 'outcomes': [2665, 3100, 3504], 'interstitial': [2670], 'SARS-CoV2': [2671], 'pneumonia:': [2672], 'Internal': [2676, 3921, 4346], '10.1007/s11739-022-02929-7,': [2680], '17:5,': [2681], '(1335-1341),': [2682], '1-Aug-2022.': [2686], 'Loader': [2687, 3123], 'Taylor': [2689], 'Lampa': [2691, 3125], 'E': [2692, 2934, 3031, 3842], 'Sundström': [2694, 3132], 'Renin‐Angiotensin': [2697, 3135], 'Aldosterone': [2698, 3136], 'System': [2699, 3137, 3685, 3850, 3875, 4107, 4233, 4454], 'COVID‐19:': [2702, 3042, 3105, 3773], 'Meta‐Analysis': [2707], 'Revealing': [2708], 'Critical': [2709], 'Bias': [2710], 'Across': [2711], 'Body': [2713], 'Observational': [2715, 3703], 'Research,': [2716, 2796], 'Association,': [2722, 3149, 4499], '11:11,': [2723], '7-Jun-2022.': [2727], 'Jiang': [2728], 'Y,': [2733, 3068, 3316, 3322, 3340, 3394, 3400, 3536, 3544, 3751, 4356], 'Bao': [2734], 'Zhan': [2736], 'Gao': [2738], 'Deng': [2740], 'W,': [2741, 2757, 3072, 3162, 3334, 3344, 3633], 'Xue': [2742], 'Yan': [2754, 3339], 'Luo': [2756, 3351], 'Jose': [2758], 'Z': [2768, 3674], 'Effects': [2771], 'ATIR': [2773], 'Blocker': [2774, 3563], 'Severity': [2777, 2836, 4194, 4227], 'Hypertensive': [2781, 2788], 'Inpatients': [2782], 'Virulence': [2784], 'SARS-CoV-2': [2786, 3915, 4078, 4307, 4340], 'hACE2': [2789], 'Transgenic': [2790], 'Mice,': [2791], 'Translational': [2795], '10.1007/s12265-021-10147-3,': [2797], '15:1,': [2798], '(38-48),': [2799], '1-Feb-2022.': [2803], 'Singh': [2804, 3865], 'Rathore': [2806], 'Khan': [2808], 'Bhurwal': [2810], 'Sheraton': [2812], 'Ghosh': [2814], 'Anand': [2816], 'Makadia': [2818], 'Ayesha': [2820], 'Mahapure': [2822], 'K,': [2823, 3894, 3972, 3982, 3987, 4059, 4319], 'Mehra': [2824], 'I,': [2825, 2891, 3174, 4057], 'Tekin': [2826], 'Kashyap': [2828], 'R': [2829, 3448, 4104], 'Bansal': [2831], 'Patients': [2839, 3289, 3619, 3697, 3821, 4230], 'ACEIs': [2841], 'ARBs—A': [2843], 'Review,': [2845, 4112], 'Meta-Regression': [2848], 'Analysis,': [2849], 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