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'对猪主动脉瓣进行了酶水化法去细胞的研究,探讨应用猪去细胞瓣膜支架体外构建组织工程心脏瓣膜的可行性.方法应用胰蛋白酶/乙二胺四乙酸去除猪主动脉瓣组织中的细胞,对处理后的组织进行组织学与免疫组化,扫描电子显微镜观察,并进行理化性能测定.结果酶水化法去细胞效果良好,且能较好地保持胶原纤维和弹性纤维原有的排列和分布.与新鲜猪主动脉瓣比较,热皱缩温度、抗张强度差异无统计学意义(P>0.05).结论酶水化法去细胞效果良好,初步制造了猪主动脉瓣脱细胞基质材料,为进一步制作组织工程瓣膜提供了较合适的支架材料。': [1]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3028929024', 'counts_by_year': [], 'updated_date': '2024-09-18T09:35:50.219461', 'created_date': '2020-06-05'}