Publication Information

{'id': 'https://openalex.org/W3025969212', 'doi': 'https://doi.org/10.3760/cma.j.issn.0254-6450.2019.04.015', 'title': '[Study on the safety and immunogenicity of simultaneous vaccination on both hepatitis E and hepatitis B vaccines].', 'display_name': '[Study on the safety and immunogenicity of simultaneous vaccination on both hepatitis E and hepatitis B vaccines].', 'publication_year': 2019, 'publication_date': '2019-04-10', 'ids': {'openalex': 'https://openalex.org/W3025969212', 'doi': 'https://doi.org/10.3760/cma.j.issn.0254-6450.2019.04.015', 'mag': '3025969212', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/31006207'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/31006207', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 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'raw_affiliation_strings': ['Beijing Chaoyang District Center for Disease Control and Prevention, Beijing 100021, China.'], 'affiliations': [{'raw_affiliation_string': 'Beijing Chaoyang District Center for Disease Control and Prevention, Beijing 100021, China.', 'institution_ids': ['https://openalex.org/I4210161151']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049071684', 'display_name': 'Yang Liu', 'orcid': 'https://orcid.org/0000-0003-2503-1631'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Y Y Liu', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5023709013', 'display_name': 'Q Li', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Q Li', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009905256', 'display_name': 'Shengxiang Ge', 'orcid': 'https://orcid.org/0000-0002-7165-3004'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'S Ge', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5035698441', 'display_name': 'Z Zhang', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Z Zhang', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 3, 'citation_normalized_percentile': {'value': 0.597744, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 74, 'max': 77}, 'biblio': {'volume': '40', 'issue': '4', 'first_page': '451', 'last_page': '456'}, 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'WU/ml).': [261, 288], 'Positive': [262], 'GMC': [265], 'HEV': [268], 'IgG': [269], 'vaccinated': [279], '(98.8%': [281], '100.0%,': [283], '11.0': [284], '18.0': [287], 'Conclusions:': [289], 'Simultaneous': [290], 'strategy': [292], 'showed': [300], 'good': [301], 'safety': [302], 'immunogenicity.': [304], 'It': [305], 'is': [306], 'recommended': [307], 'should': [315], 'be': [316], 'administered': [317], 'susceptible': [320], 'population': [321], 'same': [324], 'time,': [325], 'order': [327], 'protect': [329], 'liver': [331], 'functions.目的：': [332], '分析戊型肝炎（戊肝）疫苗和乙型肝炎（乙肝）疫苗联合接种（联合接种）的安全性及免疫原性。': [333], '方法：': [334], '2015年9月至2016年12月在北京市朝阳区招募18~60岁健康受试者720人，将符合纳入标准的受试者随机化分为3组：联合接种（联合接种）组、乙肝疫苗接种组和戊肝疫苗接种组。3组均按照0、1、6个月程序接种，比较联合接种与单独接种的安全性及全程免疫1个月后的免疫原性。': [335], '结果：': [336], '接种疫苗的受试者共601人（戊肝疫苗接种组150人，乙肝疫苗接种组159人，联合接种组292人）。联合接种组的局部不良反应有疼痛（25.0%，73/292）、红（12.7%，37/292）、瘙痒（9.2%，27/292）、硬结（8.9%，26/292）、肿（8.2%，24/292），全身不良反应有发热（7.2%，21/292）、头痛（5.8%，17/292）、肌肉痛（5.5%，16/292）、疲倦乏力（3.4%，10/292）。联合接种组除局部疼痛发生率高于单独接种组以外，其余不良反应与单独接种组均无明显差异，3组均无严重不良反应。全程接种1个月后，联合接种组的HBsAb阳转率、抗体几何平均浓度（GMC）非劣效于乙肝疫苗接种组（94.2%比93.8%，611.6': [337], 'WU/ml比745.1': [338], 'WU/ml），HEV': [339], 'IgG抗体阳转率、GMC非劣效于戊肝疫苗接种组（98.8%比100.0%，11.0': [340], 'WU/ml比18.0': [341], 'WU/ml）。': [342], '结论：': [343], '联合接种具有良好的安全性和免疫原性，建议肝炎易感人群联合接种戊、乙肝疫苗，更好地保护肝脏。.': [344]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3025969212', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 2}], 'updated_date': '2024-12-16T15:00:25.746201', 'created_date': '2020-05-21'}