Publication Information

{'id': 'https://openalex.org/W3025125197', 'doi': 'https://doi.org/10.1053/j.gastro.2020.05.030', 'title': 'Age, Inflammation, and Disease Location Are Critical Determinants of Intestinal Expression of SARS-CoV-2 Receptor ACE2 and TMPRSS2 in Inflammatory Bowel Disease', 'display_name': 'Age, Inflammation, and Disease Location Are Critical Determinants of Intestinal Expression of SARS-CoV-2 Receptor ACE2 and TMPRSS2 in Inflammatory Bowel Disease', 'publication_year': 2020, 'publication_date': '2020-05-12', 'ids': {'openalex': 'https://openalex.org/W3025125197', 'doi': 'https://doi.org/10.1053/j.gastro.2020.05.030', 'mag': '3025125197', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/32413354', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/7217073'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1053/j.gastro.2020.05.030', 'pdf_url': 'http://www.gastrojournal.org/article/S0016508520306533/pdf', 'source': {'id': 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2048, 2055, 2140, 2218, 2229, 2309, 2329, 2339, 2381, 2401, 2411, 2447, 2484, 2490, 2517, 2527], 'highly': [30, 192], 'persistent': [31], 'viral': [32, 161, 1071, 2475, 2497], 'particle': [33, 1072], 'shedding': [34], 'in': [35, 78, 194, 201, 204, 215, 220, 238, 294, 300, 304, 310, 328, 348, 355, 359, 367, 379, 392, 400, 405, 457, 489, 551, 651, 667, 681, 711, 722, 745, 753, 781, 796, 808, 818, 825, 855, 863, 887, 900, 924, 935, 948, 958, 963, 1007, 1029, 1032, 1049, 1076, 1093, 1095, 1098, 1115, 1155, 1198, 1579, 1598, 1610, 1615, 1875, 1981, 2046, 2068, 2073, 2116, 2127, 2136, 2142, 2209, 2220, 2360, 2375, 2432, 2461, 2529], 'feces.1Xiao': [36], 'F.': [37], 'et': [38, 54, 108, 137, 165, 1054, 2509], 'al.Gastroenterology.': [39], '2020;': [40, 56, 113, 139, 167], '158:': [41], '1831-1833.e3Abstract': [42], 'Full': [43, 45, 170, 172], 'Text': [44, 46, 171, 173], 'PDF': [47, 174, 2537], 'PubMed': [48, 59, 116, 142, 175], 'Scopus': [49, 60, 117, 143, 176], '(2037)': [50], 'Google': [51, 62, 119, 145, 178], 'Scholar,2Jin': [52], 'X.': [53], 'al.Gut.': [55], '69:': [57], '1002-1009Crossref': [58], '(942)': [61], 'Scholar': [63, 120, 146, 179, 1060], 'There': [64], 'critical': [66, 225], 'need': [67], 'to': [68, 73, 91, 151, 190, 448, 462, 688, 980, 1109, 1134, 1153, 1168, 1177, 1187, 1583, 1675, 1716, 1776, 1806, 1919, 1972, 2014, 2024], 'establish': [69], 'factors': [70, 984, 1150], 'determining': [71], 'susceptibility': [72, 150], 'Coronavirus': [74], 'Disease': [75], '2019': [76], '(COVID-19)': [77], 'patients': [79, 250, 420, 557, 723, 966, 1008, 1156, 2530], 'inflammatory': [81, 898, 1085, 2532], 'bowel': [82, 2533], 'disease': [83, 87, 382, 505, 757, 973, 1018, 1145, 1629, 2534], '(IBD).': [84, 2535], 'Age,': [85], 'comorbidity,': [86], 'activity,': [88], 'exposure': [90], 'immuno-modulatory': [92], 'biological': [94], 'therapies': [95], 'provide': [96], 'basis': [98], 'for': [99, 102, 181, 1017, 1022, 1195, 1697, 1808, 1851, 1902, 1917, 1951, 1967, 1992, 2008, 2026, 2043], 'new': [100, 2211, 2377], 'guidelines': [101], 'risk': [103, 1149], 'stratification': [104], 'shielding.3Danese': [106], 'S.': [107, 1257], 'al.Nat': [109], 'Rev': [110], 'Gastroenterol': [111], 'Hepatol.': [112], '17:': [114], '253-255Crossref': [115], '(98)': [118], 'We': [121, 207, 230, 676, 691, 987], 'hypothesize': [122], 'that': [123, 989, 1066, 1081, 2039, 2512], 'expression': [124, 214, 233, 299, 327, 347, 376, 442, 456, 562, 598, 658, 685, 702, 780, 805, 847, 854, 910, 957, 1002, 1031, 1048, 2016, 2045, 2113, 2494, 2524], 'levels': [125, 200, 501], 'SARS-CoV-2': [128, 1203, 2457], 'spike': [129, 162], 'protein': [130, 568], 'receptor,': [131], 'angiotensin-converting': [132, 2480], 'enzyme': [133, 2481], '2': [134, 157, 2473, 2482, 2488], '(ACE2),4Wrapp': [135], 'D.': [136, 1215, 1380], 'al.Science.': [138], '367:': [140], '1260-1263Crossref': [141], '(95)': [144], 'may': [147, 1069, 1087, 1107, 1129], 'also': [148, 715, 1101], 'determine': [149], 'SARS-CoV-2-inflicted': [152], 'damage.': [153], 'Transmembrane': [154], 'serine': [155, 2486], 'protease': [156, 2487], '(TMPRSS2)': [158], 'primes': [159], 'protein,5Hoffmann': [163], 'M.': [164, 1391], 'al.Cell.': [166], '181:': [168], '271-280.e8Abstract': [169], '(13677)': [177], 'allowing': [180], 'potent': [183], 'binding': [184], 'ACE2.': [186], 'Both': [187], 'are': [188, 292, 998, 1175, 2312, 2358, 2384, 2430, 2519], 'known': [189], 'be': [191, 1131, 2105], 'expressed': [193, 472], 'healthy': [195], 'ileal': [196, 428, 2099], 'epithelium,': [197, 1123], 'lower': [199, 353, 387, 962], 'epithelial': [202, 1113], 'cells': [203], 'colon.': [206], 'report': [208], 'dysregulated': [209], 'mucosal': [210, 245, 484, 696], 'ACE2': [211, 235, 298, 378, 415, 441, 480, 485, 500, 561, 597, 637, 682, 697, 717, 844, 852, 955, 1004, 1030, 1047, 1094, 1119, 2044, 2072, 2112, 2217, 2526], 'TMPRSS2': [213, 237, 346, 397, 429, 455, 525, 684, 699, 846, 909, 1006, 2219, 2460, 2528], 'colon': [217, 312, 338, 459, 811, 857, 1034], 'ileum': [219, 303, 331, 351, 384, 635, 960, 1097], 'IBD,': [221, 326, 559, 1158, 1185], 'identify': [223, 1140], 'determinants': [226, 1000, 2521], 'altered': [228], 'expression.': [229, 1163], 'compared': [231, 335, 828, 2313, 2333, 2385, 2405], 'RNA': [232, 1710, 1713, 1719, 1737, 1746, 1750, 1765, 1805, 1872, 1878], 'blood': [239, 701, 720, 783, 1864, 1871, 2118], '(paired-end': [240], 'sequencing),': [241], 'ileal,': [242], 'colonic': [244, 440, 470, 560, 596, 657, 826, 2076], 'biopsies': [246, 819, 1666], '(microarray)': [247], 'from': [248, 669, 1574, 1649, 1703, 2356, 2428], '138': [249], 'treatment-naïve': [252], 'IBD': [253, 368, 787, 827, 949, 1068, 1575, 1934, 1937, 2047, 2098], '(cases)': [254], '154': [256], 'controls,': [257, 426, 595], 'predominantly': [258], 'functional': [260], 'disorders': [262], '(Supplementary': [263, 850, 2052], 'Table': [264, 319, 2053, 2145, 2214], '1).': [265], 'They': [266, 1672], 'were': [267, 848, 985, 1667, 1673, 1727, 1752, 1796, 1828, 1838, 1938, 1942, 2021, 2125], 'recruited': [268, 1578], 'at': [269, 875, 1585, 1618, 1669, 1694, 1818], '6': [270, 1586], 'European': [271, 1587], 'centers,': [272], 'between': [273, 419, 695], '2012': [274, 1582], '2015,': [276], 'part': [278], 'IBD-Character': [281, 1205], 'program': [282, 1192], '(EU': [283], 'Character': [284, 1576], 'reference': [285, 1662], 'no.': [286], '305676).': [287], 'Demographics': [288], 'further': [290, 1103], 'details': [291], 'given': [293, 2040], 'supplementary': [296], 'information.': [297], 'terminal': [302, 330, 350], 'controls': [305, 360, 393, 406, 463, 830, 864, 925, 2051, 2082, 2315, 2387], 'was': [306, 332, 352, 385, 398, 430, 443, 460, 486, 526, 547, 648, 664, 806, 816, 823, 858, 911, 961, 1577, 1603, 1630, 1640, 1654, 1767, 1849, 1867, 1873, 1885, 1900, 1915, 1924, 1965, 1990, 2000, 2006, 2066, 2088, 2114, 2371, 2443], '25-fold': [307], 'higher': [308, 399, 432, 488, 666], 'than': [309, 354, 391, 404], '(P': [313, 339, 361, 370, 388, 433, 450, 475, 494, 530, 553, 653, 673, 740, 812], '=': [314, 340, 362, 371, 389, 410, 434, 451, 476, 495, 515, 518, 531, 542, 554, 571, 574, 578, 581, 589, 592, 604, 607, 610, 616, 619, 622, 627, 630, 642, 645, 654, 674, 727, 730, 741, 749, 762, 765, 772, 775, 792, 799, 813, 833, 839, 866, 879, 890, 903, 916, 927, 938, 975, 2079, 2084, 2109], '7.0': [315], '×': [316, 342, 364, 373, 478, 497, 520, 612, 743, 751, 767, 777, 794, 801, 835], '10–14;': [317], 'Supplementary': [318, 2213], '2),': [320], 'consistent': [321, 1036], 'previous': [323], 'reports.': [324], 'In': [325, 344, 438, 466, 594, 632, 1137], 'increased': [333, 444, 638, 2491], '10-fold': [334], '7.9': [341], '10–14).': [343], 'contrast,': [345], 'colon,': [357, 747], 'both': [358], '3.6': [363], '10–16),': [365], 'overall': [369], '6.0': [372], '10–19).': [374], 'The': [375, 656, 1090, 1596, 1628, 1845, 1869, 1921, 1940, 2002, 2122, 2367, 2439], 'inflamed': [380, 469, 490, 809, 2074, 2097], "Crohn's": [381], '(CD)': [383], '60%': [386], '.0175)': [390], '(Figure': [394, 464, 507], '1A).': [395], 'Ileal': [396, 414], 'CD': [401, 458, 754, 797, 837, 901, 968, 1100, 1135, 2308, 2380], 'noninflamed': [402, 492, 2330, 2402], 'tissue': [403, 738, 2077, 2331, 2403], '(by': [407], '70%,': [408], 'P': [409, 517, 541, 573, 580, 591, 609, 621, 629, 644, 729, 748, 764, 774, 791, 798, 832, 838, 1978, 2319, 2344, 2391, 2416], '.023,': [411, 435], 'Figure': [412, 436, 453, 522, 533, 544, 583, 732], '1B).': [413, 437], 'did': [416], 'not': [417, 662, 2120], 'differ': [418], 'ulcerative': [422], 'colitis': [423], '(UC)': [424], 'but': [427, 661, 803], '30%': [431, 446], 'CD,': [439, 1616, 2227], 'by': [445, 528, 549, 1121, 2337, 2409, 2507], 'relative': [447], 'control': [449, 634, 671, 2103, 2357, 2429], '.006;': [452], '1C).': [454], 'similar': [461], '1D).': [465], 'UC,': [467, 1611, 2228], 'mucosa': [471, 2100], '70%': [473], 'more': [474], '2.1': [477], '10–11)': [479], 'transcript': [481], 'copies.': [482], 'UC': [483, 725, 746, 790, 810, 888, 936, 2075, 2310, 2382], '50%': [487], 'vs': [491, 538, 2081], 'sites': [493, 1194], '6.3': [496], '10–5).': [498], 'Colonic': [499, 524, 713, 908], 'Montreal': [504, 1634], 'extent': [506, 536, 886], '1E)': [508], 'Mayo': [511, 933, 1607], 'endoscopic': [512, 897, 1608], 'subscore': [513, 760, 899, 934, 1609, 2199], '(rho': [514, 570, 577, 588, 626, 641, 726], '0.43,': [516], '3.2': [519], '10–5,': [521, 836], '1F).': [523], 'upregulated': [527], 'inflammation': [529, 739, 874, 1597], '.0179,': [532], '1D),': [534], '(E1': [537], 'E3:': [539], '150%,': [540], '.0002,': [543], '1G),': [545], 'greater': [548, 650, 807], '20%': [550, 665], 'men': [552, 652], '.03).': [555], 'Among': [556], 'correlated': [563, 599, 718, 736], 'weakly': [564], 'high-sensitivity': [566], 'C-reactive': [567], '(hsCRP)': [569], '0.23,': [572, 904, 939], '.0043),': [575], 'age': [576, 625, 640, 862, 2518], '0.19,': [579], '.014,': [582], '1H)': [584], 'serum': [586], 'albumin': [587], '−0.17,': [590], '.037).': [593], 'fecal': [601], 'calprotectin': [602], '(n': [603, 615, 2078, 2083], '136,': [605], 'rho': [606, 618, 761, 771], '0.39,': [608, 773], '2.7': [611], '10–6),': [613], 'hsCRP': [614, 914], '180,': [617], '0.25,': [620], '.00083),': [623], '0.20,': [628], '.0066).': [631], 'tissue,': [636], '0.64,': [643], '.0099)': [646], '130%': [649], '.0256).': [655], 'TMPRSS2,': [660], 'ACE2,': [663], 'smokers': [668], 'group': [672, 2338, 2410], '.0034).': [675, 840], 'found': [677], 'no': [678], 'important': [679], 'differences': [680], 'regard': [687], 'recruitment': [689], 'centers.': [690], 'examined': [692], 'relationship': [694], 'or': [698, 971, 1128, 1623, 1935], 'TNF,': [704], 'OSM,': [705], 'IL10,': [706], 'TGFB1,': [707], 'GATA3,': [708], 'STAT6': [710], 'IBD.': [712, 1011], '(and': [714], 'ileal)': [716], 'OSM': [721], '0.35,': [728], '.00076,': [731], '1I).': [733], 'Mucosal': [734, 1665, 2448], 'angiotensinogen': [735], '4.7': [742, 2188], '10–11': [744], '2.0': [750], '10–5': [752], 'colon)': [755], 'severity': [758], '(Mayo': [759], '0.58,': [763], '5.3': [766], '10–22;': [768], 'Froslie': [769, 1613], 'score': [770, 1614, 2203], '3.4': [776], '10–9).': [778], 'ACE': [779, 804], 'negatively': [785], 'status': [788, 923, 1639], '(in': [789], '2.4': [793], '10–6,': [795], '8.2': [800], '10–5)': [802], '.019).': [814], 'Renin': [815], 'detectable': [817], 'only,': [820], 'where': [821], 'it': [822], 'reduced': [824, 1118], '(UC': [831], '1.4': [834], 'Multivariable': [841], 'analysis': [842, 2010], 'performed': [849], 'Methods).': [851], 'gene': [853, 956, 2015], 'increasing': [861], '(β': [865, 878, 889, 902, 915, 926, 937, 974, 2108], '0.17,': [867, 928], '95%': [868, 881, 892, 905, 918, 929, 940, 977], 'confidence': [869], 'interval': [870], '[CI]': [871], '0.02–0.32);': [872], 'biopsy': [876, 1620], 'site': [877, 1621], '0.30,': [880], 'CI': [882, 893, 906, 919, 930, 941, 978], '0.10–0.49)': [883], 'E3': [885], '0.40,': [891], '0.18–0.62)': [894], '0.00–0.46).': [907], '0.22,': [917], '0.07–0.37)': [920], 'smoking': [922, 1638, 1812], '0.02–0.32),': [931], '0.01–0.44)': [942], 'none': [944], 'parameters': [947, 2042], 'CD.': [951], 'On': [952, 2090], 'multivariable': [953], 'analysis,': [954], 'few': [965], 'B2': [970], 'B3': [972], '−1.09,': [976], '−1.57': [979], '−0.61).': [981], 'No': [982], 'other': [983, 2092], 'implicated.': [986], 'demonstrate': [988], 'age,': [990, 1141, 1811], 'presence': [992], 'inflammation,': [994, 2516], 'anatomic': [996, 2513], 'location': [997, 2340, 2412], 'key': [999, 2520], 'presenting': [1009], 'These': [1012, 1061], 'findings': [1013, 1165], 'have': [1014], 'potential': [1015, 1147], 'implications': [1016], 'management,': [1019], 'well': [1021], 'mechanistic': [1023, 1039], 'studies.': [1024], 'Thus,': [1025], 'inflammation-related': [1027], 'increase': [1028], 'recent': [1038], 'data': [1040, 1062, 1837, 1941, 2311, 2383], 'highlighting': [1041], 'influence': [1043], 'cytokines': [1045], 'on': [1046, 1184, 2479], 'epithelium.6Ziegler': [1052], 'C.': [1053, 1282, 1416], 'al.https://papers.ssrn.com/abstract=3555145Date': [1055], 'accessed:': [1056], 'March': [1057], '30,': [1058], '2020Google': [1059], 'raise': [1063], 'possibility': [1065], 'active': [1067, 1099, 1116, 1144], 'enhance': [1070], 'production': [1073, 1120], 'uptake': [1075], 'colon;': [1078], 'and,': [1079], 'furthermore,': [1080], 'infection': [1082], 'consequent': [1084, 1125], 'activation': [1086], 'exacerbate': [1088], 'colitis.': [1089], 'apparent': [1091], 'reduction': [1092], 'bears': [1102], 'investigation:': [1104], 'this': [1105], 'alteration': [1106], 'relate': [1108], 'loss': [1111], 'surface': [1114], 'ulceration,': [1117], 'maturating': [1122], 'sampling': [1126], 'effects;': [1127], 'indeed': [1130], 'directly': [1132], 'relevant': [1133], 'pathogenesis.': [1136], 'summary,': [1138], 'we': [1139, 2500], 'smoking,': [1142], 'additional': [1148, 2129], 'vulnerability': [1152], 'COVID-19': [1154, 1183], 'through': [1159], 'alterations': [1160], 'receptor': [1162, 2493], 'Our': [1164], 'lend': [1166], 'support': [1167, 2496], 'registry': [1169], 'initiatives': [1170], 'such': [1171], 'SECURE-IBD,': [1173], 'which': [1174, 1964], 'necessary': [1176], 'monitor': [1178], 'possible': [1180, 1933], 'impact': [1181], 'ongoing': [1189], 'translational': [1190], 'research': [1191], 'characterizing': [1193], 'therapeutic': [1196], 'intervention': [1197], 'molecular': [1200], 'pathways': [1201], 'recognition.': [1204], 'Consortium:': [1206], 'Alex': [1207], 'T.': [1208, 1410], 'Adams,': [1209], 'MBChB,': [1210], 'PhD,': [1211, 1220, 1224, 1227, 1243, 1247, 1266, 1270, 1273, 1277, 1280, 1284, 1287, 1291, 1294, 1298, 1301, 1305, 1310, 1315, 1321, 1324, 1331, 1334, 1338, 1345, 1352, 1358, 1362, 1365, 1368, 1371, 1374, 1383, 1393, 1397, 1402, 1408, 1413], 'Erik': [1212, 1356], 'Andersson,': [1213], 'Ian': [1214], 'Arnott,': [1216], 'MD,': [1217, 1223, 1231, 1234, 1251, 1269, 1290, 1297, 1342, 1355, 1361, 1378, 1382, 1396, 1401, 1405, 1418, 1426, 1468, 1490, 1516, 1539], 'Monica': [1218], 'Bayes,': [1219], 'Daniel': [1221, 1260], 'Bergemalm,': [1222], 'Ferdinando': [1225], 'Bonfiglio,': [1226], 'Ray': [1228], 'K.': [1229], 'Boyapati,': [1230], 'Adam': [1232], 'Carstens,': [1233], 'Christina': [1235], 'Casén,': [1236], 'MSc,': [1237, 1240, 1259, 1262, 1318, 1349], 'Ewa': [1238], 'Ciemniejewska,': [1239], 'Mauro': [1241], "D'Amato,": [1242], 'Fredrik': [1244, 1285], 'A.': [1245, 1307], 'Dahl,': [1246], 'Trond': [1248], 'Espen': [1249], 'Detlie,': [1250], 'Hazel': [1252], 'E': [1253], 'Drummond,': [1254], 'BSc,': [1255, 1389], 'Gunn': [1256], 'Ekeland,': [1258], 'Ekman,': [1261], 'Anna': [1263], 'B.': [1264], 'Frengen,': [1265], 'Fernando': [1267], 'Gomollón,': [1268], 'Mats': [1271], 'Gullberg,': [1272], 'Ivo': [1274], 'G.': [1275, 1376], 'Gut,': [1276, 1279], 'Marta': [1278], 'Simon': [1281], 'Heath,': [1283], 'Hjelm,': [1286], 'Henrik': [1288], 'Hjortswang,': [1289], 'Gwo-Tzer': [1292], 'Ho,': [1293], 'Jørgen': [1295], 'Jahnsen,': [1296], 'Daisy': [1299], 'Jonkers,': [1300], 'Åsa': [1302], 'V.': [1303], 'Keita,': [1304], 'Nicholas': [1306, 1409], 'Kennedy,': [1308], 'MBBS,': [1309, 1414], 'FRACP,': [1311], 'Charles': [1312], 'W.': [1313], 'Lees,': [1314], 'Torbjørn': [1316], 'Lindahl,': [1317], 'Mårten': [1319], 'Lindqvist,': [1320], 'Angelika': [1322], 'Merkel,': [1323], 'Eddie': [1325], 'Modig,': [1326], 'Bsc,': [1327], 'Aina': [1328], 'E.F.': [1329], 'Moen,': [1330], 'Hilde': [1332], 'Nilsen,': [1333], 'Elaine': [1335], 'R.': [1336, 1347], 'Nimmo,': [1337], 'Colin': [1339], 'L.': [1340], 'Noble,': [1341], 'Niklas': [1343], 'Nordberg,': [1344], 'Kate': [1346], "O'Leary,": [1348], 'Anette': [1350], 'Ocklind,': [1351], 'Christine': [1353], 'Olbjørn,': [1354], 'Pettersson,': [1357], 'Marieke': [1359], 'Pierik,': [1360], 'Dominique': [1363], 'Poncelet,': [1364], 'Dirk': [1366], 'Repsilber,': [1367], 'Céline': [1369], 'Sabatel,': [1370], 'Renaud': [1372], 'Schoemans,': [1373], 'Alan': [1375], 'Shand,': [1377], 'Johan': [1379], 'Söderholm,': [1381], 'Janne': [1384], 'Sølvernes,': [1385], 'MS,': [1386], 'Mikael': [1387], 'Sundell,': [1388], 'Tone': [1390], 'Tannæs,': [1392], 'Leif': [1394], 'Törkvist,': [1395], 'Morten': [1398], 'H.': [1399], 'Vatn,': [1400, 1404], 'Simen': [1403], 'Anne-Clémence': [1406], 'Veillard,': [1407], 'Ventham,': [1411], 'MRCS(Eng)': [1412], 'David': [1415], 'Wilson,': [1417], 'MRCPCH,': [1419], 'Panpan': [1420], 'You,': [1421], 'MS.': [1422], 'Jan': [1423], 'Krzysztof': [1424, 2508], 'Nowak,': [1425], 'PhD': [1427, 1448, 1469, 1491, 1517, 1540], '(Formal': [1428, 1470, 1518], 'analysis:': [1429, 1453, 1471, 1496, 1519, 1544], 'Lead;': [1430, 1438, 1451, 1542, 1548, 1555, 1557, 1559], 'Investigation:': [1431, 1455, 1473, 1501, 1524, 1549], 'Equal;': [1432, 1434, 1454, 1456, 1458, 1460, 1472, 1474, 1476, 1481, 1497, 1500, 1502, 1505, 1507, 1520, 1523, 1525, 1528, 1530, 1545, 1550, 1552, 1564], 'Methodology:': [1433, 1457, 1475, 1551], 'Resources:': [1435, 1506, 1529, 1556], 'Supporting;': [1436, 1494], 'Visualization:': [1437, 1459], 'Writing': [1439, 1461, 1477, 1482, 1508, 1531, 1560, 1565], '–': [1440, 1462, 1478, 1483, 1509, 1532, 1561, 1566], 'original': [1441, 1463, 1479, 1562], 'draft:': [1442, 1464, 1480, 1563], 'Lead).': [1443, 1570], 'Jonas': [1444, 1514], 'Christoffer': [1445], 'Lindstrøm,': [1446], 'Msc,': [1447], '(Data': [1449, 1492], 'curation:': [1450, 1493], 'Formal': [1452, 1495, 1543], 'Equal).': [1465, 1487, 1536], 'Rahul': [1466], 'Kalla,': [1467], 'review': [1484, 1510, 1533, 1567, 1652], '&': [1485, 1511, 1534, 1568], 'editing:': [1486, 1512, 1535, 1569], 'Petr': [1488], 'Ricanek,': [1489], 'Funding': [1498, 1521, 1546], 'acquisition:': [1499, 1522, 1547], 'Project': [1503, 1526, 1553], 'administration:': [1504, 1527, 1554], 'Supporting).': [1513], 'Halfvarson,': [1515], 'Jack': [1537], 'Satsangi,': [1538], '(Conceptualization:': [1541], 'Supervision:': [1558], 'This': [1571], 'inception': [1572], 'cohort': [1573], 'years': [1581], '2015': [1584], 'centers:': [1588], 'Oslo,': [1589], 'Örebro,': [1590], 'Edinburgh,': [1591], 'Linköping,': [1592], 'Zaragoza,': [1593], 'Maastricht.': [1595], 'endoscopically': [1600], 'inspected': [1601, 2023], 'segments': [1602], 'assessed': [1604, 1728], 'using': [1605, 1830, 1944], 'qualitatively': [1617], '(inflamed': [1622], 'noninflamed),': [1624], 'systemically': [1626], '(hsCRP).': [1627], 'characterized': [1631], 'classification.': [1635], 'Self-declared': [1636], 'current': [1637], 'noted.': [1641], 'Study': [1642], 'participants': [1643], 'provided': [1644], 'informed': [1645], 'written': [1646], 'consent;': [1647], 'approval': [1648], 'local': [1650], 'institutional': [1651], 'boards': [1653], 'obtained': [1655], '(including': [1656], 'South': [1657], 'Eastern': [1658], 'Norway': [1659], 'Bioethical': [1660], 'Committee,': [1661], 'number': [1663], 'S-04209).': [1664], 'collected': [1668, 1674], 'index': [1670], 'colonoscopy.': [1671], 'vials': [1676], 'a': [1678, 2210, 2376], 'stabilizing': [1679], 'solution': [1680], '(Allprotect;': [1681], 'Qiagen,': [1682], 'Hilden,': [1683], 'Germany).': [1684], 'Following': [1685], 'homogenization': [1686], '(RLT': [1687], 'Pluss': [1688], 'Buffer,': [1689], '5': [1690], 'mm': [1691], 'steal': [1692], 'bead': [1693], '4': [1695], 'm/s': [1696], '30': [1698], 'seconds,': [1699], 'FastPrep-24': [1700], 'Classic': [1701], 'Instrument': [1702], 'MP': [1704], 'Biomedicals,': [1705], 'Santa': [1706, 1742], 'Ana,': [1707], 'CA)': [1708], 'isolation': [1711], '(QIAsymphony': [1712], 'Kit': [1714], 'according': [1715, 1775], 'protocol': [1718], 'CT': [1720], '400;': [1721], 'Qiagen),': [1722], 'its': [1723], 'purity': [1724], 'quality': [1726, 1903], '(Agilent': [1729], '2100': [1730, 1733], 'Bioanalyser,': [1731], 'Agilent': [1732, 1736, 1778, 1787, 1832, 1841], 'Expert': [1734], 'software,': [1735], '6000': [1738], 'Nano': [1739], 'Kit;': [1740], 'Agilent,': [1741], 'Clara,': [1743], 'CA).': [1744], 'Cutoff': [1745], 'Integrity': [1747], 'Number': [1748], 'concentration': [1751], '7.2': [1753], '67': [1755], 'ng/μL,': [1756], 'respectively.': [1757], 'A': [1758], 'total': [1759], '100': [1761], 'ng': [1762, 1801], 'messenger': [1764], '(mRNA)': [1766], 'amplified,': [1768], 'labeled': [1769], 'Cy3': [1771], 'cyanine,': [1772], 'hybridized': [1774], 'One-Color': [1779], 'Microarray-Based': [1780], 'Gene': [1781, 1791, 1892], 'Expression': [1782, 1792, 1893, 2362, 2434, 2455], 'Analysis': [1783], 'workflow': [1784], '(version': [1785], '6.9).': [1786], 'SurePrint': [1788], 'G3': [1789], 'human': [1790], '8x60k': [1793], 'v2': [1794], 'Microarrays': [1795], 'randomly': [1797], 'filled': [1798], '600': [1800], 'fragmented': [1803], 'complementary': [1804], 'compensate': [1807], 'diagnosis,': [1809], 'sex,': [1810], 'status,': [1813], 'center.': [1815], 'Hybridization': [1816], 'occurred': [1817], '65°C': [1819], 'took': [1821], '17': [1822], 'hours;': [1823], 'after': [1824], 'washing,': [1825], 'microarrays': [1827], 'scanned': [1829], 'Microarray': [1833], 'Scanner': [1834], 'processed': [1839], 'Feature': [1842], 'Extraction': [1843], 'Software.': [1844], 'R': [1846, 1946, 1949], 'limma': [1847], 'package': [1848], 'used': [1850, 1901, 1916, 1966, 2007], 'array': [1852], 'normalization,': [1853], 'background': [1854], 'correction': [1855], '(offset': [1856], '16),': [1858], 'quantile': [1860], 'normalization.': [1861], 'Paired': [1862], 'whole': [1863, 1870, 2117], 'mRNA': [1865], 'sequencing': [1866], 'performed.': [1868], 'stabilized': [1874], 'PAXgene': [1877], 'tubes,': [1879], 'isolated,': [1880], 'then': [1882], 'quantified.': [1883], 'Sequencing': [1884], 'conducted': [1886], 'Ion': [1889, 1896], 'AmpliSeq': [1890], 'Human': [1891], 'Core': [1894], 'Panel.': [1895], 'Library': [1897], 'TaqmanTM': [1898], 'Quantitation': [1899], 'check.': [1904], 'Torrent': [1905], 'Software': [1906], 'v.': [1907, 1913], '4.6': [1908], 'ampliSeqRNA': [1911], 'plugin': [1912], '4.6.0.1': [1914], 'alignment': [1918], 'hg19.': [1920], 'counts': [1922], 'table': [1923, 2208, 2374], 'normalized': [1925], 'DESeq2.': [1927], 'Patients': [1928, 2225, 2462], 'diagnoses': [1931], 'unspecified': [1936], 'excluded.': [1939], 'analyzed': [1943], 'language': [1947], '(3.6.0;': [1948], 'Foundation': [1950], 'Statistical': [1952], 'Computing,': [1953], 'Vienna,': [1954], 'Austria)': [1955], 'Statistica': [1957], '13.3': [1958], '(TIBCO': [1959], 'Software,': [1960], 'Palo': [1961], 'Alto,': [1962], 'CA),': [1963], 'nonparametric': [1968], 'statistical': [1969], 'testing.': [1970], 'Due': [1971], 'lack': [1974], 'normality': [1976], "(Levene's": [1977], '<': [1979, 2320, 2323, 2326, 2345, 2348, 2351, 2392, 2395, 2398, 2417, 2420, 2423], '.05)': [1980], 'some': [1982], 'subgroups,': [1985], 'Mann-Whitney': [1987, 2368, 2440], 'U': [1988, 2369, 2441], 'test': [1989, 2370, 2442], 'applied': [1991], 'unpaired': [1993], 'comparisons': [1994], "Spearman's": [1997], 'correlation': [1998], 'coefficient': [1999], 'calculated.': [2001], 'forward': [2003], 'stepwise': [2004], 'regression': [2005], 'exploratory': [2009], 'factor': [2012], 'contribution': [2013], 'variability;': [2017], 'Q–Q': [2019], 'plots': [2020], 'visually': [2022], 'check': [2025], 'residual': [2027], 'normality.': [2028], 'Post': [2029], 'hoc': [2030], 'power': [2031, 2065, 2087], 'calculations': [2032], '(G∗Power,': [2033], 'University': [2034], 'Dusseldorf,': [2036], 'Germany)': [2037], 'reveal': [2038], 'symptomatic': [2049], 'non-IBD': [2050], '2)': [2054], 'assumed': [2057], 'α': [2058], 'level': [2059], '0.05': [2061], '(2-tailed),': [2062], 'achieved': [2064], '0.9998;': [2067], 'case': [2070], '27)': [2080], '191)': [2085], '0.8036.': [2089], 'hand,': [2093], 'comparison': [2095], 'must': [2104], 'considered': [2106], 'underpowered': [2107], '0.6513).': [2110], 'Negligible': [2111], 'detected': [2115], '(data': [2119], 'shown).': [2121], 'following': [2123], 'genes': [2124], 'included': [2126], 'analyses': [2130], 'renin-angiotensin': [2133], 'system:': [2134], 'ACE,': [2135], 'blood;': [2138], 'AGT': [2139], 'REN': [2141], 'mucosa.Supplementary': [2144], '1Group': [2146], 'CharacteristicsCDUCControlsn6474154Age,': [2147], 'y30.2': [2148], '±': [2149, 2151, 2153, 2201, 2205, 2231, 2233, 2235, 2237, 2239, 2241, 2243, 2245, 2247, 2249, 2251, 2253, 2255, 2257, 2259, 2261, 2263, 2265, 2267, 2269, 2272, 2274, 2276, 2278, 2280, 2282, 2284, 2286, 2288, 2290, 2292, 2294, 2296, 2298, 2300, 2302, 2304, 2306], '15.938.6': [2150], '15.533.6': [2152], '14.4Sex,': [2154], '%': [2155, 2157, 2162, 2168], 'female,': [2156], '(n)46.9': [2158], '(30)40.5': [2159], '(30)55.8': [2160], '(86)Smoker,': [2161], '(n)19.0': [2163], '(12)5.4': [2164], '(4)19.7': [2165], '(30)CRP,': [2166], 'mg/L22.7±36.933.6±58.74.82±12.5Characteristics,': [2167], '(n)L1': [2169], '25.0': [2170, 2178, 2182], '(16)L2': [2171], '31.2': [2172], '(20)L3': [2173], '43.7': [2174], '(28)L4': [2175], '21.8': [2176], '(14)A1': [2177], '(16)A2': [2179], '50.0': [2180], '(32)A3': [2181], '(16)B1': [2183], '82.8': [2184], '(53)B2': [2185], '9.4': [2186], '(6)B3': [2187], '(3)P': [2189], '7.8': [2190], '(5)E1': [2191], '25.7': [2192], '(19)E2': [2193], '29.7': [2194], '(22)E3': [2195], '44.6': [2196], '(33)Endoscopic': [2197], 'assessmentMayo': [2198], '4.74': [2200], '2.90Froslie': [2202], '6.73': [2204], '4.78': [2206], 'Open': [2207, 2373], 'tab': [2212, 2378], '2Expression': [2215], 'Intestinal': [2222, 2454], 'Mucosa': [2223], 'With': [2226], 'ControlsIBDCDUCControlsColonAll1637489191ACE210.35': [2230], '0.66∗10.17': [2232], '0.63∗10.50': [2234], '0.64∗9.94': [2236], '0.72TMPRSS212.75': [2238], '0.5612.72': [2240], '0.5412.77': [2242], '0.5812.69': [2244], '0.51Noninflamed784731ACE210.10': [2246], '0.6210.07': [2248], '0.6410.12': [2250], '0.58TMPRSS212.67': [2252], '0.5012.67': [2254], '0.5112.64': [2256], '0.50Inflamed852758ACE210.58': [2258], '0.61∗,†10.32': [2260], '0.5810.69': [2262], '0.59∗,†TMPRSS212.82': [2264], '0.60∗,†12.80': [2266], '0.5912.83': [2268], '0.61∗T.': [2270], 'ileumAll29171215ACE213.84': [2271], '1.86∗13.24': [2273], '2.2414.68': [2275], '0.3514.61': [2277], '1.43TMPRSS211.21': [2279], '0.75∗11.18': [2281], '0.8711.25': [2283], '0.5710.89': [2285], '0.55Noninflamed17611ACE214.12': [2287], '1.5913.05': [2289], '2.3814.70': [2291], '0.36TMPRSS211.42': [2293], '0.7011.69': [2295], '0.87∗11.27': [2297], '0.59∗Inflamed12111ACE213.44': [2299], '2.19∗13.34': [2301], '2.27∗14.51TMPRSS210.91': [2303], '0.7410.91': [2305], '0.7811.03NOTE.': [2307], '∗': [2317, 2389], 'denoting': [2318, 2343, 2390, 2415], '.05,': [2321, 2346, 2393, 2418], '∗∗': [2322, 2394], '.01,': [2324, 2349, 2396, 2421], '∗∗∗': [2325, 2397], '.001.': [2327, 2352, 2399, 2424], 'Inflamed': [2328, 2400], 'within': [2334, 2406], 'subgroups': [2335, 2407], 'defined': [2336, 2408], '†': [2342, 2414], '††': [2347, 2419], '†††': [2350, 2422], 'Values': [2353, 2425], 'significantly': [2354, 2426], 'different': [2355, 2427], 'printed': [2359, 2431], 'bold.': [2361, 2433], 'represented': [2364, 2436], 'log2(16+intensity).': [2366, 2438], 'used.': [2372, 2444], 'NOTE.': [2379], 'TNFα-Antagonist': [2445], 'Use': [2446], 'Inflammation': [2449], 'Are': [2450], 'Associated': [2451], 'Increased': [2453], 'Host': [2458], 'Protease': [2459], 'Inflammatory': [2464], 'Bowel': [2465], 'DiseaseGastroenterologyVol.': [2466], '160Issue': [2467], '7PreviewSevere': [2468], 'coronavirus': [2472], '(SARS-CoV-2)': [2474], 'transfection': [2476], 'dependent': [2478], '(ACE2)': [2483], 'transmembrane': [2485], '(TMPRSS2),': [2489], 'intestinal': [2492, 2515, 2523], 'might': [2495], 'replication.1–3': [2498], 'Therefore,': [2499], 'read': [2501], 'great': [2503], 'interest': [2504], 'work': [2506], 'al,': [2510], 'reporting': [2511], 'location,': [2514], 'Full-Text': [2536]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3025125197', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 13}, {'year': 2022, 'cited_by_count': 7}, {'year': 2021, 'cited_by_count': 25}, {'year': 2020, 'cited_by_count': 21}], 'updated_date': '2024-12-30T03:06:07.393129', 'created_date': '2020-05-21'}