Seizures are a druggable mechanistic link between TBI and subsequent tauopathy

Name: Work Video:
Duration: 3 min 30 s
Hadeel Alyenbaawi; Richard Kanyo; Laszlo F. Locskai; Razieh Kamali-Jamil; Michèle G. DuVal; Qing Bai; Holger Wille; Edward A. Burton; W. Ted Allison
{'id': 'https://openalex.org/W3024838580', 'doi': 'https://doi.org/10.1101/2020.05.12.091819', 'title': 'Seizures are a druggable mechanistic link between TBI and subsequent tauopathy', 'display_name': 'Seizures are a druggable mechanistic link between TBI and subsequent tauopathy', 'publication_year': 2020, 'publication_date': '2020-05-14', 'ids': {'openalex': 'https://openalex.org/W3024838580', 'doi': 'https://doi.org/10.1101/2020.05.12.091819', 'mag': '3024838580'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/2020.05.12.091819', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306402567', 'display_name': 'bioRxiv (Cold Spring Harbor Laboratory)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2750212522', 'host_organization_name': 'Cold Spring Harbor Laboratory', 'host_organization_lineage': ['https://openalex.org/I2750212522'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'type': 'preprint', 'type_crossref': 'posted-content', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://doi.org/10.1101/2020.05.12.091819', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5040373922', 'display_name': 'Hadeel Alyenbaawi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I154425047', 'display_name': 'University of Alberta', 'ror': 'https://ror.org/0160cpw27', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I154425047']}, {'id': 'https://openalex.org/I195631090', 'display_name': 'Majmaah University', 'ror': 'https://ror.org/01mcrnj60', 'country_code': 'SA', 'type': 'education', 'lineage': ['https://openalex.org/I195631090']}], 'countries': ['CA', 'SA'], 'is_corresponding': False, 'raw_author_name': 'Hadeel Alyenbaawi', 'raw_affiliation_strings': ['Centre for Prions & Protein Folding Disease, University of Alberta, Edmonton AB, T6G 2M8, Canada', 'Department of Medical Genetics, University of Alberta, Edmonton AB, T6G H7, Canada', 'Majmaah University, Majmaah,11952, Saudi Arabia'], 'affiliations': [{'raw_affiliation_string': 'Centre for Prions & Protein Folding Disease, University of Alberta, Edmonton AB, T6G 2M8, Canada', 'institution_ids': ['https://openalex.org/I154425047']}, {'raw_affiliation_string': 'Majmaah University, Majmaah,11952, Saudi Arabia', 'institution_ids': ['https://openalex.org/I195631090']}, {'raw_affiliation_string': 'Department of Medical Genetics, University of Alberta, Edmonton AB, T6G H7, Canada', 'institution_ids': ['https://openalex.org/I154425047']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5074967678', 'display_name': 'Richard Kanyo', 'orcid': 'https://orcid.org/0000-0002-8059-9628'}, 'institutions': [{'id': 'https://openalex.org/I154425047', 'display_name': 'University of Alberta', 'ror': 'https://ror.org/0160cpw27', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I154425047']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Richard Kanyo', 'raw_affiliation_strings': ['Centre for Prions & Protein Folding Disease, University of Alberta, Edmonton AB, T6G 2M8, Canada', 'Department of Biological Sciences, University of Alberta, Edmonton AB, T6G 2E9, Canada'], 'affiliations': [{'raw_affiliation_string': 'Centre for Prions & Protein Folding Disease, University of Alberta, Edmonton AB, T6G 2M8, Canada', 'institution_ids': ['https://openalex.org/I154425047']}, {'raw_affiliation_string': 'Department of Biological Sciences, University of Alberta, Edmonton AB, T6G 2E9, Canada', 'institution_ids': ['https://openalex.org/I154425047']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050162156', 'display_name': 'Laszlo F. Locskai', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I154425047', 'display_name': 'University of Alberta', 'ror': 'https://ror.org/0160cpw27', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I154425047']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Laszlo F. Locskai', 'raw_affiliation_strings': ['Centre for Prions & Protein Folding Disease, University of Alberta, Edmonton AB, T6G 2M8, Canada', 'Department of Biological Sciences, University of Alberta, Edmonton AB, T6G 2E9, Canada'], 'affiliations': [{'raw_affiliation_string': 'Centre for Prions & Protein Folding Disease, University of Alberta, Edmonton AB, T6G 2M8, Canada', 'institution_ids': ['https://openalex.org/I154425047']}, {'raw_affiliation_string': 'Department of Biological Sciences, University of Alberta, Edmonton AB, T6G 2E9, Canada', 'institution_ids': ['https://openalex.org/I154425047']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090613061', 'display_name': 'Razieh Kamali-Jamil', 'orcid': 'https://orcid.org/0000-0003-2333-8197'}, 'institutions': [{'id': 'https://openalex.org/I154425047', 'display_name': 'University of Alberta', 'ror': 'https://ror.org/0160cpw27', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I154425047']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Razieh Kamali-Jamil', 'raw_affiliation_strings': ['Centre for Prions & Protein Folding Disease, University of Alberta, Edmonton AB, T6G 2M8, Canada', 'Department of Biochemistry, University of Alberta, Edmonton, AB, Canada'], 'affiliations': [{'raw_affiliation_string': 'Centre for Prions & Protein Folding Disease, University of Alberta, Edmonton AB, T6G 2M8, Canada', 'institution_ids': ['https://openalex.org/I154425047']}, {'raw_affiliation_string': 'Department of Biochemistry, University of Alberta, Edmonton, AB, Canada', 'institution_ids': ['https://openalex.org/I154425047']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086420998', 'display_name': 'Michèle G. DuVal', 'orcid': 'https://orcid.org/0000-0001-6975-8117'}, 'institutions': [{'id': 'https://openalex.org/I154425047', 'display_name': 'University of Alberta', 'ror': 'https://ror.org/0160cpw27', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I154425047']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Michèle G. DuVal', 'raw_affiliation_strings': ['Department of Biological Sciences, University of Alberta, Edmonton AB, T6G 2E9, Canada'], 'affiliations': [{'raw_affiliation_string': 'Department of Biological Sciences, University of Alberta, Edmonton AB, T6G 2E9, Canada', 'institution_ids': ['https://openalex.org/I154425047']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101599704', 'display_name': 'Qing Bai', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I170201317', 'display_name': 'University of Pittsburgh', 'ror': 'https://ror.org/01an3r305', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I170201317']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Qing Bai', 'raw_affiliation_strings': ['Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA', 'institution_ids': ['https://openalex.org/I170201317']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084432831', 'display_name': 'Holger Wille', 'orcid': 'https://orcid.org/0000-0001-5102-8706'}, 'institutions': [{'id': 'https://openalex.org/I154425047', 'display_name': 'University of Alberta', 'ror': 'https://ror.org/0160cpw27', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I154425047']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Holger Wille', 'raw_affiliation_strings': ['Centre for Prions & Protein Folding Disease, University of Alberta, Edmonton AB, T6G 2M8, Canada', 'Department of Biochemistry, University of Alberta, Edmonton, AB, Canada'], 'affiliations': [{'raw_affiliation_string': 'Centre for Prions & Protein Folding Disease, University of Alberta, Edmonton AB, T6G 2M8, Canada', 'institution_ids': ['https://openalex.org/I154425047']}, {'raw_affiliation_string': 'Department of Biochemistry, University of Alberta, Edmonton, AB, Canada', 'institution_ids': ['https://openalex.org/I154425047']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068065538', 'display_name': 'Edward A. Burton', 'orcid': 'https://orcid.org/0000-0002-8072-4636'}, 'institutions': [{'id': 'https://openalex.org/I4210110523', 'display_name': 'Geriatric Research Education and Clinical Center', 'ror': 'https://ror.org/01nh3sx96', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1322918889', 'https://openalex.org/I2799886695', 'https://openalex.org/I4210110523', 'https://openalex.org/I4210133905', 'https://openalex.org/I4210147340']}, {'id': 'https://openalex.org/I170201317', 'display_name': 'University of Pittsburgh', 'ror': 'https://ror.org/01an3r305', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I170201317']}, {'id': 'https://openalex.org/I4210133905', 'display_name': 'VA Pittsburgh Healthcare System', 'ror': 'https://ror.org/02qm18h86', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1322918889', 'https://openalex.org/I2799886695', 'https://openalex.org/I4210133905', 'https://openalex.org/I4210147340']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Edward A. Burton', 'raw_affiliation_strings': ['Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA', 'Geriatric Research, Education and Clinical Center, Pittsburgh VA Healthcare System, Pittsburgh, PA, USA'], 'affiliations': [{'raw_affiliation_string': 'Geriatric Research, Education and Clinical Center, Pittsburgh VA Healthcare System, Pittsburgh, PA, USA', 'institution_ids': ['https://openalex.org/I4210110523', 'https://openalex.org/I4210133905']}, {'raw_affiliation_string': 'Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA', 'institution_ids': ['https://openalex.org/I170201317']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5058385239', 'display_name': 'W. Ted Allison', 'orcid': 'https://orcid.org/0000-0002-8461-4864'}, 'institutions': [{'id': 'https://openalex.org/I154425047', 'display_name': 'University of Alberta', 'ror': 'https://ror.org/0160cpw27', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I154425047']}], 'countries': ['CA'], 'is_corresponding': True, 'raw_author_name': 'W. Ted Allison', 'raw_affiliation_strings': ['Centre for Prions & Protein Folding Disease, University of Alberta, Edmonton AB, T6G 2M8, Canada', 'Department of Biological Sciences, University of Alberta, Edmonton AB, T6G 2E9, Canada', 'Department of Medical Genetics, University of Alberta, Edmonton AB, T6G H7, Canada'], 'affiliations': [{'raw_affiliation_string': 'Centre for Prions & Protein Folding Disease, University of Alberta, Edmonton AB, T6G 2M8, Canada', 'institution_ids': ['https://openalex.org/I154425047']}, {'raw_affiliation_string': 'Department of Medical Genetics, University of Alberta, Edmonton AB, T6G H7, Canada', 'institution_ids': ['https://openalex.org/I154425047']}, {'raw_affiliation_string': 'Department of Biological Sciences, University of Alberta, Edmonton AB, T6G 2E9, Canada', 'institution_ids': ['https://openalex.org/I154425047']}]}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 5, 'corresponding_author_ids': ['https://openalex.org/A5058385239'], 'corresponding_institution_ids': ['https://openalex.org/I154425047'], 'apc_list': None, 'apc_paid': None, 'fwci': None, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 5, 'citation_normalized_percentile': {'value': 0.868406, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 79, 'max': 81}, 'biblio': {'volume': None, 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10706', 'display_name': 'Traumatic Brain Injury and Neurovascular Disturbances', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10706', 'display_name': 'Traumatic Brain Injury and Neurovascular Disturbances', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11184', 'display_name': 'Neonatal and fetal brain pathology', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/2735', 'display_name': 'Pediatrics, Perinatology and Child Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11685', 'display_name': 'Zebrafish Biomedical Research Applications', 'score': 0.9981, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/tauopathy', 'display_name': 'Tauopathy', 'score': 0.9882625}, {'id': 'https://openalex.org/keywords/phenocopy', 'display_name': 'Phenocopy', 'score': 0.57367116}, {'id': 'https://openalex.org/keywords/chronic-traumatic-encephalopathy', 'display_name': 'Chronic traumatic encephalopathy', 'score': 0.5163311}], 'concepts': [{'id': 'https://openalex.org/C2777739294', 'wikidata': 'https://www.wikidata.org/wiki/Q2397106', 'display_name': 'Tauopathy', 'level': 4, 'score': 0.9882625}, {'id': 'https://openalex.org/C2781017439', 'wikidata': 'https://www.wikidata.org/wiki/Q1995526', 'display_name': 'Traumatic brain injury', 'level': 2, 'score': 0.710472}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.6017908}, {'id': 'https://openalex.org/C12387725', 'wikidata': 'https://www.wikidata.org/wiki/Q937024', 'display_name': 'Phenocopy', 'level': 4, 'score': 0.57367116}, {'id': 'https://openalex.org/C2911139526', 'wikidata': 'https://www.wikidata.org/wiki/Q5114004', 'display_name': 'Chronic traumatic encephalopathy', 'level': 5, 'score': 0.5163311}, {'id': 'https://openalex.org/C31573885', 'wikidata': 'https://www.wikidata.org/wiki/Q304484', 'display_name': 'Programmed cell death', 'level': 3, 'score': 0.437989}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.42424217}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.40002543}, {'id': 'https://openalex.org/C2776925932', 'wikidata': 'https://www.wikidata.org/wiki/Q1755122', 'display_name': 'Neurodegeneration', 'level': 3, 'score': 0.37556198}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.34371832}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.1948008}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.18930611}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.1883097}, {'id': 'https://openalex.org/C3017944768', 'wikidata': 'https://www.wikidata.org/wiki/Q1450463', 'display_name': 'Poison control', 'level': 2, 'score': 0.11917105}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.11205974}, {'id': 'https://openalex.org/C118552586', 'wikidata': 'https://www.wikidata.org/wiki/Q7867', 'display_name': 'Psychiatry', 'level': 1, 'score': 0.10406169}, {'id': 'https://openalex.org/C127716648', 'wikidata': 'https://www.wikidata.org/wiki/Q104053', 'display_name': 'Phenotype', 'level': 3, 'score': 0.10137123}, {'id': 'https://openalex.org/C99454951', 'wikidata': 'https://www.wikidata.org/wiki/Q932068', 'display_name': 'Environmental health', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C190385971', 'wikidata': 'https://www.wikidata.org/wiki/Q373494', 'display_name': 'Injury prevention', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C2778426673', 'wikidata': 'https://www.wikidata.org/wiki/Q326921', 'display_name': 'Concussion', 'level': 4, 'score': 0.0}], 'mesh': [], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/2020.05.12.091819', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306402567', 'display_name': 'bioRxiv (Cold Spring Harbor Laboratory)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2750212522', 'host_organization_name': 'Cold Spring Harbor Laboratory', 'host_organization_lineage': ['https://openalex.org/I2750212522'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.7554/elife.58744', 'pdf_url': None, 'source': None, 'license': 'public-domain', 'license_id': 'https://openalex.org/licenses/public-domain', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/2020.05.12.091819', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306402567', 'display_name': 'bioRxiv (Cold Spring Harbor Laboratory)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2750212522', 'host_organization_name': 'Cold Spring Harbor Laboratory', 'host_organization_lineage': ['https://openalex.org/I2750212522'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'sustainable_development_goals': [{'score': 0.81, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 97, 'referenced_works': ['https://openalex.org/W1506138247', 'https://openalex.org/W1526128150', 'https://openalex.org/W1556198965', 'https://openalex.org/W1580520973', 'https://openalex.org/W1655460658', 'https://openalex.org/W1720280203', 'https://openalex.org/W1888623186', 'https://openalex.org/W1899132045', 'https://openalex.org/W1977627126', 'https://openalex.org/W1979363343', 'https://openalex.org/W1983621019', 'https://openalex.org/W1984549959', 'https://openalex.org/W1995202691', 'https://openalex.org/W1998247429', 'https://openalex.org/W2005755021', 'https://openalex.org/W2017230571', 'https://openalex.org/W2019751519', 'https://openalex.org/W2023529808', 'https://openalex.org/W2025311386', 'https://openalex.org/W2025515174', 'https://openalex.org/W2026329836', 'https://openalex.org/W2033672635', 'https://openalex.org/W2035408187', 'https://openalex.org/W2038431888', 'https://openalex.org/W2057201755', 'https://openalex.org/W2062521762', 'https://openalex.org/W2064698007', 'https://openalex.org/W2067531054', 'https://openalex.org/W2075925092', 'https://openalex.org/W2078379881', 'https://openalex.org/W2081966615', 'https://openalex.org/W2082644527', 'https://openalex.org/W2089656194', 'https://openalex.org/W2094263548', 'https://openalex.org/W2095963715', 'https://openalex.org/W2096321704', 'https://openalex.org/W2099169745', 'https://openalex.org/W2105985886', 'https://openalex.org/W2106837589', 'https://openalex.org/W2112528263', 'https://openalex.org/W2128008503', 'https://openalex.org/W2135380777', 'https://openalex.org/W2135827933', 'https://openalex.org/W2136321913', 'https://openalex.org/W2136922708', 'https://openalex.org/W2140341262', 'https://openalex.org/W2150484897', 'https://openalex.org/W2159377066', 'https://openalex.org/W2161533644', 'https://openalex.org/W2163644656', 'https://openalex.org/W2165186407', 'https://openalex.org/W2414194618', 'https://openalex.org/W2415136027', 'https://openalex.org/W2472346278', 'https://openalex.org/W2513581974', 'https://openalex.org/W2515142743', 'https://openalex.org/W2521817318', 'https://openalex.org/W2523621893', 'https://openalex.org/W2525609444', 'https://openalex.org/W2528301026', 'https://openalex.org/W2534587007', 'https://openalex.org/W2545421204', 'https://openalex.org/W2552889151', 'https://openalex.org/W2557275668', 'https://openalex.org/W2574784626', 'https://openalex.org/W2589121062', 'https://openalex.org/W2606978132', 'https://openalex.org/W2608110367', 'https://openalex.org/W2618553145', 'https://openalex.org/W2734763051', 'https://openalex.org/W2736509962', 'https://openalex.org/W2737551950', 'https://openalex.org/W2763708652', 'https://openalex.org/W2766057155', 'https://openalex.org/W2779322228', 'https://openalex.org/W2782252286', 'https://openalex.org/W2785561172', 'https://openalex.org/W2795704013', 'https://openalex.org/W2800610610', 'https://openalex.org/W2808289287', 'https://openalex.org/W2886141281', 'https://openalex.org/W2888147664', 'https://openalex.org/W2895725541', 'https://openalex.org/W2896153567', 'https://openalex.org/W2908860826', 'https://openalex.org/W2916711365', 'https://openalex.org/W2922264813', 'https://openalex.org/W2941016933', 'https://openalex.org/W2951105374', 'https://openalex.org/W2989455730', 'https://openalex.org/W3012326435', 'https://openalex.org/W3041012431', 'https://openalex.org/W3197051897', 'https://openalex.org/W4286855106', 'https://openalex.org/W747624706', 'https://openalex.org/W812488793', 'https://openalex.org/W821579936'], 'related_works': ['https://openalex.org/W4315928364', 'https://openalex.org/W3103418467', 'https://openalex.org/W3034008742', 'https://openalex.org/W2971165305', 'https://openalex.org/W2774110492', 'https://openalex.org/W2616038736', 'https://openalex.org/W2576285411', 'https://openalex.org/W2086921006', 'https://openalex.org/W2041544905', 'https://openalex.org/W2034836821'], 'abstract_inverted_index': {'Summary': [0], 'Traumatic': [1, 261, 313], 'brain': [2, 39, 115, 290], 'injury': [3], '(TBI)': [4, 264], 'is': [5, 217], 'a': [6, 42, 98, 121, 197, 226], 'prominent': [7], 'risk': [8], 'factor': [9], 'for': [10, 77, 199], 'neurodegenerative': [11], 'diseases': [12], 'and': [13, 21, 50, 81, 138, 149, 202, 209, 244, 254, 269], 'dementias': [14], 'including': [15, 129], 'chronic': [16], 'traumatic': [17], 'encephalopathy': [18], '(CTE).': [19], 'TBI': [20, 57, 123, 127, 245, 272, 286], 'CTE,': [22], 'like': [23], 'all': [24], 'tauopathies,': [25], 'are': [26, 58], 'characterized': [27], 'by': [28], 'accumulation': [29, 106], 'of': [30, 53, 67, 90, 107, 143, 158, 163, 211, 238, 302], 'Tau': [31, 101, 139, 242], 'into': [32], 'aggregates': [33], 'that': [34, 47, 103, 221], 'progressively': [35], 'spread': [36, 89], 'to': [37, 65, 120, 156, 182, 228, 311], 'other': [38], 'regions': [40], 'in': [41, 62, 84, 87, 205, 240, 247, 266, 289, 299], 'prion-like': [43, 207, 303], 'manner.': [44], 'The': [45], 'mechanisms': [46], 'promote': [48], 'spreading': [49, 210], 'cellular': [51], 'uptake': [52], 'tau': [54, 109, 304], 'seeds': [55], 'after': [56], 'not': [59], 'fully': [60], 'understood,': [61], 'part': [63], 'due': [64, 181], 'lack': [66], 'tractable': [68], 'animal': [69], 'models.': [70], 'Here,': [71], 'we': [72], 'test': [73], 'the': [74, 86, 206, 233, 236], 'putative': [75], 'roles': [76], 'excess': [78], 'neuronal': [79], 'activity': [80, 201, 291], 'dynamin-dependent': [82, 203], 'endocytosis': [83, 187, 204], 'promoting': [85], 'vivo': [88, 241, 300], 'tauopathy.': [91, 231], 'We': [92], 'introduce': [93], '‘tauopathy': [94], 'reporter’': [95], 'zebrafish': [96, 118], 'expressing': [97], 'genetically-encoded': [99], 'fluorescent': [100], 'biosensor': [102, 243], 'reliably': [104], 'reports': [105], 'human': [108], 'species': [110], 'when': [111], 'seeded': [112], 'via': [113, 190], 'intra-ventricular': [114], 'injections.': [116], 'Subjecting': [117], 'larvae': [119], 'novel': [122], 'paradigm': [124], 'produced': [125], 'various': [126], 'symptoms': [128], 'cell': [130, 150, 276], 'death,': [131, 277], 'hemorrhage,': [132], 'blood': [133], 'flow': [134], 'abnormalities,': [135], 'post–traumatic': [136], 'seizures,': [137], 'inclusions.': [140], 'Bath': [141], 'application': [142], 'anticonvulsant': [144], 'drugs': [145], 'rescued': [146], 'TBI-induced': [147, 176], 'tauopathy': [148, 177, 212], 'death;': [151], 'these': [152, 166], 'benefits': [153], 'were': [154], 'attributable': [155], 'inhibition': [157], 'post-traumatic': [159, 223, 280], 'seizures': [160, 224, 281, 294], 'because': [161], 'co-application': [162], 'convulsants': [164], 'reversed': [165], 'beneficial': [167], 'effects.': [168], 'However,': [169], 'one': [170], 'convulsant': [171], 'drug,': [172], '4-Aminopyridine,': [173], 'unexpectedly': [174], 'abrogated': [175], '-': [178], 'this': [179], 'was': [180], 'its': [183, 270], 'inhibitory': [184], 'action': [185], 'on': [186], 'as': [188, 225], 'confirmed': [189], 'additional': [191], 'dynamin': [192], 'inhibitors.': [193], 'These': [194], 'data': [195, 234], 'suggest': [196], 'role': [198], 'seizure': [200], 'seeding': [208], 'following': [213], 'TBI.': [214], 'Further': [215], 'work': [216], 'warranted': [218], 'regarding': [219, 251], 'anti-convulsants': [220], 'dampen': [222], 'route': [227], 'moderating': [229], 'subsequent': [230], 'Moreover,': [232], 'highlight': [235], 'utility': [237], 'deploying': [239], 'methods': [246], 'larval': [248, 267], 'zebrafish,': [249, 268], 'especially': [250], 'drug': [252], 'screening': [253], 'intervention.': [255], 'Graphical': [256], 'Abstract': [257], 'Highlights': [258], 'Introduces': [259], 'first': [260], 'Brain': [262], 'Injury': [263], 'model': [265], 'easy': [271], 'induces': [273], 'clinically': [274], 'relevant': [275], 'haemorrhage': [278], '&amp;': [279], 'Ca': [282], '2+': [283], 'imaging': [284], 'during': [285], 'reveals': [287], 'spike': [288], 'concomitant': [292], 'with': [293], 'Tau-GFP': [295], 'Biosensor': [296], 'allows': [297], 'repeated': [298], 'measures': [301], 'aggregation': [305], 'post-TBI,': [306], 'anticonvulsants': [307], 'stop': [308], 'tauopathies': [309], 'akin': [310], 'Chronic': [312], 'Encephalopathy': [314]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3024838580', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 1}], 'updated_date': '2025-01-03T10:42:29.632489', 'created_date': '2020-05-21'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
