Title: [Prospect for chimeric antigen receptor-engineered T cell immunotherapy for solid tumors].
Abstract: Chimeric antigen receptor modified T cell (CAR T) cytotherapy is a modified technology of T cell immunotherapy. It has achieved encouraging breakthroughs in the treatment of hematological malignancies. Recent studies had shown that CAR T cells can also be used in the treatment of solid tumors. However, it's indispensable to understand its bottlenecks, including regulating CAR T cell expansion, survival time, metastasis, and prognosis in vivo, to establish a feasible and effective CART-based solid tumor therapy model. Therefore, we summarized the advances, challenges and possible solutions for CAR T therapy to treat solid tumors, and then prospected in the future clinical treatment.嵌合抗原受体修饰T细胞(CAR T)技术是经过改造后的T细胞免疫治疗,在治疗血液系统恶性肿瘤中取得显著效果。近年来,CAR T细胞同样可应用于实体肿瘤的治疗。然而,如何有效地将CAR T细胞免疫疗法转化到实体肿瘤治疗中,需要认识其在实体肿瘤临床治疗中的瓶颈,包括调节CAR T细胞体内扩增、存活时间、转移以及在肿瘤组织内的转归等因素。文章阐述了近年来CAR T细胞治疗实体肿瘤的研究现状、CAR T细胞治疗过程中遇到的一些瓶颈以及可能的解决办法,并对未来CAR T细胞治疗实体肿瘤的发展趋势进行分析和展望。.
Publication Year: 2018
Publication Date: 2018-07-23
Language: en
Type: article
Indexed In: ['pubmed']
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