Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W3023294154', 'doi': 'https://doi.org/10.1021/acs.bioconjchem.0c00183', 'title': 'Conjugated Protein Domains as Engineered Scaffold Proteins', 'display_name': 'Conjugated Protein Domains as Engineered Scaffold Proteins', 'publication_year': 2020, 'publication_date': '2020-05-06', 'ids': {'openalex': 'https://openalex.org/W3023294154', 'doi': 'https://doi.org/10.1021/acs.bioconjchem.0c00183', 'mag': '3023294154', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/32374984', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/7303964'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1021/acs.bioconjchem.0c00183', 'pdf_url': 'https://pubs.acs.org/doi/pdf/10.1021/acs.bioconjchem.0c00183', 'source': {'id': 'https://openalex.org/S155115410', 'display_name': 'Bioconjugate Chemistry', 'issn_l': '1043-1802', 'issn': ['1043-1802', '1520-4812'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://pubs.acs.org/doi/pdf/10.1021/acs.bioconjchem.0c00183', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5054177158', 'display_name': 'Lenne J. M. Lemmens', 'orcid': 'https://orcid.org/0000-0002-4364-3132'}, 'institutions': [{'id': 'https://openalex.org/I83019370', 'display_name': 'Eindhoven University of Technology', 'ror': 'https://ror.org/02c2kyt77', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I83019370']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Lenne J. M. Lemmens', 'raw_affiliation_strings': ['Laboratory of Chemical Biology, Department of Biomedical Engineering, and Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Chemical Biology, Department of Biomedical Engineering, and Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands', 'institution_ids': ['https://openalex.org/I83019370']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012574716', 'display_name': 'Christian Ottmann', 'orcid': 'https://orcid.org/0000-0001-7315-0315'}, 'institutions': [{'id': 'https://openalex.org/I83019370', 'display_name': 'Eindhoven University of Technology', 'ror': 'https://ror.org/02c2kyt77', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I83019370']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Christian Ottmann', 'raw_affiliation_strings': ['Laboratory of Chemical Biology, Department of Biomedical Engineering, and Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Chemical Biology, Department of Biomedical Engineering, and Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands', 'institution_ids': ['https://openalex.org/I83019370']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5082546186', 'display_name': 'Luc Brunsveld', 'orcid': 'https://orcid.org/0000-0001-5675-511X'}, 'institutions': [{'id': 'https://openalex.org/I83019370', 'display_name': 'Eindhoven University of Technology', 'ror': 'https://ror.org/02c2kyt77', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I83019370']}], 'countries': ['NL'], 'is_corresponding': True, 'raw_author_name': 'Luc Brunsveld', 'raw_affiliation_strings': ['Laboratory of Chemical Biology, Department of Biomedical Engineering, and Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Chemical Biology, Department of Biomedical Engineering, and Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands', 'institution_ids': ['https://openalex.org/I83019370']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5082546186'], 'corresponding_institution_ids': ['https://openalex.org/I83019370'], 'apc_list': None, 'apc_paid': None, 'fwci': 0.323, 'has_fulltext': False, 'cited_by_count': 14, 'citation_normalized_percentile': {'value': 0.322999, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 89, 'max': 90}, 'biblio': {'volume': '31', 'issue': '6', 'first_page': '1596', 'last_page': '1603'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T13157', 'display_name': 'Cancer-related gene regulation', 'score': 0.997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T13157', 'display_name': 'Cancer-related gene regulation', 'score': 0.997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12620', 'display_name': 'Signaling Pathways in Disease', 'score': 0.9946, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13526', 'display_name': '14-3-3 protein interactions', 'score': 0.9937, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/protein-engineering', 'display_name': 'Protein Engineering', 'score': 0.6126922}, {'id': 'https://openalex.org/keywords/synthetic-biology', 'display_name': 'Synthetic Biology', 'score': 0.44577858}], 'concepts': [{'id': 'https://openalex.org/C89429830', 'wikidata': 'https://www.wikidata.org/wiki/Q735710', 'display_name': 'Scaffold', 'level': 2, 'score': 0.9028314}, {'id': 'https://openalex.org/C53645450', 'wikidata': 'https://www.wikidata.org/wiki/Q907093', 'display_name': 'Scaffold protein', 'level': 3, 'score': 0.8505095}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.84363747}, {'id': 'https://openalex.org/C147816474', 'wikidata': 'https://www.wikidata.org/wiki/Q169525', 'display_name': 'Protein engineering', 'level': 3, 'score': 0.6126922}, {'id': 'https://openalex.org/C2779343474', 'wikidata': 'https://www.wikidata.org/wiki/Q3109175', 'display_name': 'Context (archaeology)', 'level': 2, 'score': 0.5640185}, {'id': 'https://openalex.org/C112613896', 'wikidata': 'https://www.wikidata.org/wiki/Q898370', 'display_name': 'Conjugated system', 'level': 3, 'score': 0.49855447}, {'id': 'https://openalex.org/C191908910', 'wikidata': 'https://www.wikidata.org/wiki/Q862838', 'display_name': 'Synthetic biology', 'level': 2, 'score': 0.44577858}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.40769884}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.37975347}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.35187528}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.32149893}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.31146225}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.232312}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.07684559}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C136229726', 'wikidata': 'https://www.wikidata.org/wiki/Q327092', 'display_name': 'Biomedical engineering', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C521977710', 'wikidata': 'https://www.wikidata.org/wiki/Q81163', 'display_name': 'Polymer', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C151730666', 'wikidata': 'https://www.wikidata.org/wiki/Q7205', 'display_name': 'Paleontology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D015202', 'descriptor_name': 'Protein Engineering', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020100', 'descriptor_name': 'Hydrogels', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D060847', 'descriptor_name': 'Metabolic Engineering', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000072417', 'descriptor_name': 'Protein Domains', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1021/acs.bioconjchem.0c00183', 'pdf_url': 'https://pubs.acs.org/doi/pdf/10.1021/acs.bioconjchem.0c00183', 'source': {'id': 'https://openalex.org/S155115410', 'display_name': 'Bioconjugate Chemistry', 'issn_l': '1043-1802', 'issn': ['1043-1802', '1520-4812'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc7303964', 'pdf_url': 'https://europepmc.org/articles/pmc7303964?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303964', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/32374984', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1021/acs.bioconjchem.0c00183', 'pdf_url': 'https://pubs.acs.org/doi/pdf/10.1021/acs.bioconjchem.0c00183', 'source': {'id': 'https://openalex.org/S155115410', 'display_name': 'Bioconjugate Chemistry', 'issn_l': '1043-1802', 'issn': ['1043-1802', '1520-4812'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [{'funder': 'https://openalex.org/F4320321800', 'funder_display_name': 'Nederlandse Organisatie voor Wetenschappelijk Onderzoek', 'award_id': '016.150.366'}, {'funder': 'https://openalex.org/F4320321800', 'funder_display_name': 'Nederlandse Organisatie voor Wetenschappelijk Onderzoek', 'award_id': '024.001.035'}], 'datasets': [], 'versions': [], 'referenced_works_count': 68, 'referenced_works': ['https://openalex.org/W1773642940', 'https://openalex.org/W1970762019', 'https://openalex.org/W1972771668', 'https://openalex.org/W1976172748', 'https://openalex.org/W1979802874', 'https://openalex.org/W1988752967', 'https://openalex.org/W1993783912', 'https://openalex.org/W1995574044', 'https://openalex.org/W1999237781', 'https://openalex.org/W2006862494', 'https://openalex.org/W2008472371', 'https://openalex.org/W2013191626', 'https://openalex.org/W2022453152', 'https://openalex.org/W2032755148', 'https://openalex.org/W2058276503', 'https://openalex.org/W2060799292', 'https://openalex.org/W2063354556', 'https://openalex.org/W2063999180', 'https://openalex.org/W2064179925', 'https://openalex.org/W2067330392', 'https://openalex.org/W2069720793', 'https://openalex.org/W2076231710', 'https://openalex.org/W2076931029', 'https://openalex.org/W2078149273', 'https://openalex.org/W2079260562', 'https://openalex.org/W2085978470', 'https://openalex.org/W2091664616', 'https://openalex.org/W2102171946', 'https://openalex.org/W2102424174', 'https://openalex.org/W2107601356', 'https://openalex.org/W2114065822', 'https://openalex.org/W2120855545', 'https://openalex.org/W2125340100', 'https://openalex.org/W2137112302', 'https://openalex.org/W2139748923', 'https://openalex.org/W2147516046', 'https://openalex.org/W2148561437', 'https://openalex.org/W2149603427', 'https://openalex.org/W2152854378', 'https://openalex.org/W2172098255', 'https://openalex.org/W2278531951', 'https://openalex.org/W2461977200', 'https://openalex.org/W2496869172', 'https://openalex.org/W2512242558', 'https://openalex.org/W2524666749', 'https://openalex.org/W2558479656', 'https://openalex.org/W2590568317', 'https://openalex.org/W2612841535', 'https://openalex.org/W2779879953', 'https://openalex.org/W2790305103', 'https://openalex.org/W2795052524', 'https://openalex.org/W2800527820', 'https://openalex.org/W2810746044', 'https://openalex.org/W2883694650', 'https://openalex.org/W2885749951', 'https://openalex.org/W2888005868', 'https://openalex.org/W2891407926', 'https://openalex.org/W2897623376', 'https://openalex.org/W2898859622', 'https://openalex.org/W2917526814', 'https://openalex.org/W2944705132', 'https://openalex.org/W2960879452', 'https://openalex.org/W2964154812', 'https://openalex.org/W2966261754', 'https://openalex.org/W2973533038', 'https://openalex.org/W2992590952', 'https://openalex.org/W3007987670', 'https://openalex.org/W3024546497'], 'related_works': ['https://openalex.org/W4283702325', 'https://openalex.org/W3023294154', 'https://openalex.org/W2883694650', 'https://openalex.org/W2558479656', 'https://openalex.org/W2264903906', 'https://openalex.org/W2081717811', 'https://openalex.org/W2017334119', 'https://openalex.org/W2002269843', 'https://openalex.org/W1973300115', 'https://openalex.org/W141012896'], 'abstract_inverted_index': {'Assembly': [0], 'of': [1, 34, 42, 44, 50, 62, 70, 80, 93], 'proteins': [2, 20, 53, 66, 85], 'into': [3, 58], 'higher-order': [4], 'complexes': [5], 'generates': [6], 'specificity': [7], 'and': [8, 32, 67, 102], 'selectivity': [9], 'in': [10, 90], 'cellular': [11], 'signaling.': [12], 'Signaling': [13], 'complex': [14], 'formation': [15], 'is': [16], 'facilitated': [17], 'by': [18], 'scaffold': [19, 47, 65, 84], 'that': [21], 'use': [22, 79], 'modular': [23], 'scaffolding': [24], 'domains,': [25], 'which': [26], 'recruit': [27], 'specific': [28], 'pathway': [29], 'enzymes.': [30], 'Multimerization': [31], 'recombination': [33], 'these': [35, 51, 71], 'conjugated': [36, 82], 'native': [37, 64], 'domains': [38], 'allows': [39], 'the': [40, 59, 63, 68, 78, 91], 'generation': [41], 'libraries': [43], 'engineered': [45, 52], 'multidomain': [46, 83], 'proteins.': [48], 'Analysis': [49], 'has': [54], 'provided': [55], 'molecular': [56], 'insight': [57], 'regulatory': [60], 'mechanism': [61], 'applicability': [69], 'synthetic': [72, 94], 'variants.': [73], 'This': [74], 'topical': [75], 'review': [76], 'highlights': [77], 'engineered,': [81], 'on': [86], 'different': [87], 'length': [88], 'scales': [89], 'context': [92], 'signaling': [95], 'pathways,': [96], 'metabolic': [97], 'engineering,': [98], 'liquid–liquid': [99], 'phase': [100], 'separation,': [101], 'hydrogel': [103], 'formation.': [104]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3023294154', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 1}], 'updated_date': '2024-12-19T10:46:52.345247', 'created_date': '2020-05-13'}