Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W3022986877', 'doi': 'https://doi.org/10.1016/j.bpj.2011.11.2241', 'title': 'Pathway and Mechanism of Drug Binding to G-Protein-Coupled Receptors', 'display_name': 'Pathway and Mechanism of Drug Binding to G-Protein-Coupled Receptors', 'publication_year': 2012, 'publication_date': '2012-01-01', 'ids': {'openalex': 'https://openalex.org/W3022986877', 'doi': 'https://doi.org/10.1016/j.bpj.2011.11.2241', 'mag': '3022986877'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.bpj.2011.11.2241', 'pdf_url': 'https://www.cell.com/article/S0006349511035892/pdf', 'source': {'id': 'https://openalex.org/S98085912', 'display_name': 'Biophysical Journal', 'issn_l': '0006-3495', 'issn': ['0006-3495', '1542-0086'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.cell.com/article/S0006349511035892/pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5061322136', 'display_name': 'Ron O. Dror', 'orcid': 'https://orcid.org/0000-0002-6418-2793'}, 'institutions': [{'id': 'https://openalex.org/I2799548008', 'display_name': 'D. E. Shaw Research', 'ror': 'https://ror.org/02s04h872', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I2799548008']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ron O. Dror', 'raw_affiliation_strings': ['D E Shaw Research, New York, NY, USA'], 'affiliations': [{'raw_affiliation_string': 'D E Shaw Research, New York, NY, USA', 'institution_ids': ['https://openalex.org/I2799548008']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076110000', 'display_name': 'Albert C. Pan', 'orcid': 'https://orcid.org/0000-0001-5050-5603'}, 'institutions': [{'id': 'https://openalex.org/I2799548008', 'display_name': 'D. E. Shaw Research', 'ror': 'https://ror.org/02s04h872', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I2799548008']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Albert C. Pan', 'raw_affiliation_strings': ['D E Shaw Research, New York, NY, USA'], 'affiliations': [{'raw_affiliation_string': 'D E Shaw Research, New York, NY, USA', 'institution_ids': ['https://openalex.org/I2799548008']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072291778', 'display_name': 'Daniel H. Arlow', 'orcid': 'https://orcid.org/0000-0001-8245-2227'}, 'institutions': [{'id': 'https://openalex.org/I2799548008', 'display_name': 'D. E. Shaw Research', 'ror': 'https://ror.org/02s04h872', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I2799548008']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Daniel H. Arlow', 'raw_affiliation_strings': ['D E Shaw Research, New York, NY, USA'], 'affiliations': [{'raw_affiliation_string': 'D E Shaw Research, New York, NY, USA', 'institution_ids': ['https://openalex.org/I2799548008']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045606637', 'display_name': 'David W. Borhani', 'orcid': 'https://orcid.org/0000-0002-8486-8792'}, 'institutions': [{'id': 'https://openalex.org/I2799548008', 'display_name': 'D. E. Shaw Research', 'ror': 'https://ror.org/02s04h872', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I2799548008']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'David W. Borhani', 'raw_affiliation_strings': ['D E Shaw Research, New York, NY, USA'], 'affiliations': [{'raw_affiliation_string': 'D E Shaw Research, New York, NY, USA', 'institution_ids': ['https://openalex.org/I2799548008']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5064536779', 'display_name': 'Paul Maragakis', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2799548008', 'display_name': 'D. E. Shaw Research', 'ror': 'https://ror.org/02s04h872', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I2799548008']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Paul Maragakis', 'raw_affiliation_strings': ['D E Shaw Research, New York, NY, USA'], 'affiliations': [{'raw_affiliation_string': 'D E Shaw Research, New York, NY, USA', 'institution_ids': ['https://openalex.org/I2799548008']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062359517', 'display_name': 'Yibing Shan', 'orcid': 'https://orcid.org/0000-0002-3865-8110'}, 'institutions': [{'id': 'https://openalex.org/I2799548008', 'display_name': 'D. E. Shaw Research', 'ror': 'https://ror.org/02s04h872', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I2799548008']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yibing Shan', 'raw_affiliation_strings': ['D E Shaw Research, New York, NY, USA'], 'affiliations': [{'raw_affiliation_string': 'D E Shaw Research, New York, NY, USA', 'institution_ids': ['https://openalex.org/I2799548008']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019096017', 'display_name': 'Huafeng Xu', 'orcid': 'https://orcid.org/0000-0001-5447-0452'}, 'institutions': [{'id': 'https://openalex.org/I2799548008', 'display_name': 'D. E. Shaw Research', 'ror': 'https://ror.org/02s04h872', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I2799548008']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Huafeng Xu', 'raw_affiliation_strings': ['D E Shaw Research, New York, NY, USA'], 'affiliations': [{'raw_affiliation_string': 'D E Shaw Research, New York, NY, USA', 'institution_ids': ['https://openalex.org/I2799548008']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5074305095', 'display_name': 'David E. Shaw', 'orcid': 'https://orcid.org/0000-0001-8265-5761'}, 'institutions': [{'id': 'https://openalex.org/I78577930', 'display_name': 'Columbia University', 'ror': 'https://ror.org/00hj8s172', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I78577930']}, {'id': 'https://openalex.org/I2799548008', 'display_name': 'D. E. Shaw Research', 'ror': 'https://ror.org/02s04h872', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I2799548008']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'David E. Shaw', 'raw_affiliation_strings': ['Center for Biology and Bioinformatics, Columbia University, New York, NY, USA', 'D E Shaw Research, New York, NY, USA'], 'affiliations': [{'raw_affiliation_string': 'Center for Biology and Bioinformatics, Columbia University, New York, NY, USA', 'institution_ids': ['https://openalex.org/I78577930']}, {'raw_affiliation_string': 'D E Shaw Research, New York, NY, USA', 'institution_ids': ['https://openalex.org/I2799548008']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 4.845, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 163, 'citation_normalized_percentile': {'value': 0.999985, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '102', 'issue': '3', 'first_page': '410a', 'last_page': '410a'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11178', 'display_name': 'Receptor Mechanisms and Signaling', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11178', 'display_name': 'Receptor Mechanisms and Signaling', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10814', 'display_name': 'Neuropeptides and Animal Physiology', 'score': 0.9972, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10911', 'display_name': 'Chemical Synthesis and Analysis', 'score': 0.993, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/binding-pocket', 'display_name': 'Binding pocket', 'score': 0.65940666}], 'concepts': [{'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.71356225}, {'id': 'https://openalex.org/C166342909', 'wikidata': 'https://www.wikidata.org/wiki/Q845326', 'display_name': 'Allosteric regulation', 'level': 3, 'score': 0.671937}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.6630641}, {'id': 'https://openalex.org/C3020299119', 'wikidata': 'https://www.wikidata.org/wiki/Q423026', 'display_name': 'Binding pocket', 'level': 3, 'score': 0.65940666}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.61611605}, {'id': 'https://openalex.org/C107824862', 'wikidata': 'https://www.wikidata.org/wiki/Q616005', 'display_name': 'Binding site', 'level': 2, 'score': 0.54489577}, {'id': 'https://openalex.org/C51639874', 'wikidata': 'https://www.wikidata.org/wiki/Q167149', 'display_name': 'Plasma protein binding', 'level': 2, 'score': 0.5266169}, {'id': 'https://openalex.org/C59593255', 'wikidata': 'https://www.wikidata.org/wiki/Q901663', 'display_name': 'Molecular dynamics', 'level': 2, 'score': 0.4294025}, {'id': 'https://openalex.org/C89611455', 'wikidata': 'https://www.wikidata.org/wiki/Q6804646', 'display_name': 'Mechanism (biology)', 'level': 2, 'score': 0.41348827}, {'id': 'https://openalex.org/C161624437', 'wikidata': 'https://www.wikidata.org/wiki/Q1988322', 'display_name': 'Small molecule', 'level': 2, 'score': 0.41114414}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.29534107}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.22336665}, {'id': 'https://openalex.org/C121332964', 'wikidata': 'https://www.wikidata.org/wiki/Q413', 'display_name': 'Physics', 'level': 0, 'score': 0.094766974}, {'id': 'https://openalex.org/C147597530', 'wikidata': 'https://www.wikidata.org/wiki/Q369472', 'display_name': 'Computational chemistry', 'level': 1, 'score': 0.07574612}, {'id': 'https://openalex.org/C62520636', 'wikidata': 'https://www.wikidata.org/wiki/Q944', 'display_name': 'Quantum mechanics', 'level': 1, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.bpj.2011.11.2241', 'pdf_url': 'https://www.cell.com/article/S0006349511035892/pdf', 'source': {'id': 'https://openalex.org/S98085912', 'display_name': 'Biophysical Journal', 'issn_l': '0006-3495', 'issn': ['0006-3495', '1542-0086'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.bpj.2011.11.2241', 'pdf_url': 'https://www.cell.com/article/S0006349511035892/pdf', 'source': {'id': 'https://openalex.org/S98085912', 'display_name': 'Biophysical Journal', 'issn_l': '0006-3495', 'issn': ['0006-3495', '1542-0086'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.56}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 37, 'referenced_works': ['https://openalex.org/W1485236458', 'https://openalex.org/W1556012018', 'https://openalex.org/W1605280622', 'https://openalex.org/W1833104430', 'https://openalex.org/W1906064124', 'https://openalex.org/W1908561802', 'https://openalex.org/W1976548894', 'https://openalex.org/W1988097700', 'https://openalex.org/W1989814214', 'https://openalex.org/W1996859443', 'https://openalex.org/W2003240840', 'https://openalex.org/W2003736358', 'https://openalex.org/W2004760419', 'https://openalex.org/W2014378919', 'https://openalex.org/W2024087232', 'https://openalex.org/W2027408247', 'https://openalex.org/W2040680919', 'https://openalex.org/W2044309821', 'https://openalex.org/W2054794561', 'https://openalex.org/W2060874643', 'https://openalex.org/W2067805628', 'https://openalex.org/W2076283533', 'https://openalex.org/W2080231167', 'https://openalex.org/W2085322299', 'https://openalex.org/W2086836468', 'https://openalex.org/W2098622919', 'https://openalex.org/W2104477830', 'https://openalex.org/W2117897850', 'https://openalex.org/W2129531151', 'https://openalex.org/W2148712714', 'https://openalex.org/W2150545125', 'https://openalex.org/W2161809826', 'https://openalex.org/W2168833646', 'https://openalex.org/W2291429474', 'https://openalex.org/W2327240276', 'https://openalex.org/W2397485333', 'https://openalex.org/W3025891904'], 'related_works': ['https://openalex.org/W4285478100', 'https://openalex.org/W4220697549', 'https://openalex.org/W4214840794', 'https://openalex.org/W3215749250', 'https://openalex.org/W3143642740', 'https://openalex.org/W3081426032', 'https://openalex.org/W2897563512', 'https://openalex.org/W2167226024', 'https://openalex.org/W2073626691', 'https://openalex.org/W1570348606'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3022986877', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 22}, {'year': 2019, 'cited_by_count': 21}, {'year': 2018, 'cited_by_count': 28}, {'year': 2017, 'cited_by_count': 22}, {'year': 2016, 'cited_by_count': 14}, {'year': 2015, 'cited_by_count': 11}, {'year': 2014, 'cited_by_count': 8}, {'year': 2013, 'cited_by_count': 10}, {'year': 2012, 'cited_by_count': 12}], 'updated_date': '2025-01-08T19:17:20.152647', 'created_date': '2020-05-13'}