Abstract: Vascular dementia is a clinical pathological condition in which cerebral lesions of vascular origin lead to diverse cognitive symptoms. Such lesions may include infarcts, hemorrhages, and diffuse leukoencephalopathy. The most common vascular pathologies are atherosclerosis, lipohyalinosis, arteriolosclerosis, and cerebral amyloid angiopathy. Cortical involvement often translates into executive dysfunction, and is commonly seen in animal models of vascular dementia. Pure vascular dementia is a rare condition, and current emphasis is on vascular contributions to cognitive impairment and dementia. Although the mechanisms that underlie the impact of vascular disease on the clinical manifestations of dementia are still poorly understood and the focus of cutting-edge research, common conditions such as hypertension, diabetes, and obesity have been identified as modifiable vascular risk factors for dementia. The current challenge is to find effective interventions for individuals at high risk of developing vascular dementia, including stroke survivors, that will prevent, ameliorate, or delay the progression of cognitive impairment.
Publication Year: 2017
Publication Date: 2017-01-01
Language: en
Type: book-chapter
Indexed In: ['crossref']
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Cited By Count: 3
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