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499, 553, 615, 734, 847, 869, 885, 1283, 1379, 1723, 1736, 2273], 'www.jacionline.org).': [323, 430], 'First,': [324], 'explored': [326, 481, 1301, 1618], '3': [327, 477, 1621, 1781, 2099, 2245, 2285], 'issued': [329], 'from': [330, 492, 1260, 1660, 1694, 1753, 1808, 1916, 2024, 2187, 2255, 2393], 'first': [332, 525, 1620, 1639], 'COVID': [333, 491, 1431], 'cluster': [334], 'diagnosed': [335, 1624], 'France': [337, 1626], '(Les': [338, 1627], 'Contamines,': [339, 1628], 'Haute': [340], 'Savoie,': [341], 'France)': [342, 1629, 2205], 'February': [344, 1631], '2020.': [345, 1632], 'We': [346, 479, 544, 662, 1328, 1392, 1408, 1419, 1617], 'took': [347], 'advantage': [348], 'new': [351, 930, 1360, 1387], 'digital': [352], 'ELISA': [353, 2016], 'technology': [354, 2116, 2390], 'single-molecule': [355, 1931], 'arrays': [356], '(Simoa)4Rodero': [357], 'M.P.': [358], 'Decalf': [359], 'Bondet': [361], 'V.': [362], 'Hunt': [363], 'D.': [364], 'Rice': [365], 'G.I.': [366], 'Werneke': [367], 'S.': [368, 623, 625], 'al.Detection': [370], 'interferon': [372, 637, 1047, 1099, 1159, 1217, 2166, 2334], 'alpha': [373], 'protein': [374, 403, 407, 2068, 2071], 'reveals': [375], 'differential': [376], 'levels': [377], 'cellular': [379], 'sources': [380], 'disease.J': [382], 'Exp': [383], 'Med.': [384], '2017;': [385], '214:': [386], '1547-1555Crossref': [387], '(250)': [390], 'analyzed': [394], 'inflammatory': [399, 1049, 1161, 1219], 'cytokines.': [400], 'IL-6,': [401, 442, 672, 1964], 'C-reactive': [402], '(CRP),': [404], 'IFN-γ–induced': [406], '10': [408, 557, 687], '(IP-10)': [409], 'were': [410, 468, 511, 740, 896, 934, 1760, 1787, 1806, 1843, 1928, 1969, 2342, 2407, 2428], 'elevated': [411], 'symptomatic': [415], '(patients': [417], '1': [418, 493, 988, 2097, 2249], '3)': [420], 'Fig': [422, 607, 760], 'E1': [423], 'Strikingly,': [431], 'no': [432, 471, 695, 753, 1783], 'IFN-α2': [433, 463, 552, 575, 597, 757, 1109, 1368, 1939], 'detectable': [435, 574], 'these': [437, 1780], 'patients.': [439, 478, 994], 'contrast,': [441], 'CRP,': [443, 1965], 'IP-10': [445, 1967], 'remained': [446, 679], 'low': [447, 571, 743], 'during': [448, 801, 872, 1697], 'hospital': [450, 1730], 'isolation': [451], 'stay': [452, 719], 'individual': [456, 1296], 'significant': [459], 'elevation': [460], 'plasmatic': [462], 'observed.': [465], 'Viral': [466, 845, 1293, 2183], 'loads': [467], 'low,': [469], 'obvious': [472], 'quantitative': [473, 902, 940, 2348], 'difference': [474], 'between': [475, 791, 2417], 'all': [476, 508, 669, 701, 750, 1757, 1830], 'further': [480], 'larger': [483], 'cohort': [484, 2371], '26': [486, 2434], 'critically': [487, 534, 992, 1835, 2368], 'ill': [488, 535, 993, 1836, 2369], 'intensive': [496, 716, 770, 923, 963, 1840, 2421], 'care': [497, 516, 717, 771, 924, 964, 1841, 2422], 'unit': [498, 718, 2423], 'Hospices': [500, 1450, 1454, 1500, 1534, 1588], 'Civils': [501, 1451, 1455, 1501, 1535, 1589, 1820], 'Lyon': [503, 1458, 1606, 1818], '(Lyon,': [504], 'France).': [505, 1616], 'Of': [506], 'note,': [507], 'treated': [512], 'standard': [514], 'none': [518], 'received': [519], 'immunotherapies.': [522], 'Considering': [523], '28': [526, 887], 'days': [527, 1700], 'more': [530], 'than': [531], 'half': [532], 'required': [537], 'invasive': [538, 705], 'mechanical': [539], 'ventilation': [540, 706, 868], '(14': [541], '26).': [543, 2374], 'observed': [545], 'demonstrated': [548, 599], 'peak': [550], 'day': [554, 686, 886, 1266, 1728], '8': [555], 'symptom': [559, 792, 889, 1688, 2418], 'onset': [560, 793, 2419], 'corresponding': [561], 'replication': [565], 'phase,': [566], 'decreased': [568, 684], 'overtime': [569], 'but': [572], 'still': [573], 'concentrations.': [576], 'Conversely,': [577], 'subset': [579], '(n': [582, 707, 774, 777, 2372], '=': [583, 708, 775, 778, 2373], '5': [584, 709, 990, 2213, 2303], '[19%])': [585], 'presented': [586, 698], 'sustained': [588], 'abrogation': [589], 'production': [592, 697, 1015, 1251, 1308], '(Fig': [593, 690, 1666, 1701, 1776], '1,': [594, 691, 2079, 2105], 'A).': [595], 'Simoa': [596], 'measurement': [598, 1348, 2163], 'positive': [601, 1640], 'correlation': [602], 'IFN-stimulated': [604, 2065, 2385], 'genes': [605, 2066, 2134, 2386], 'E2,': [608, 761], 'A,': [609, 2375], 'www.jacionline.org)': [616], 'already': [618], 'shown': [619, 1186], 'infections.5Trouillet-Assant': [622], 'Viel': [624], 'Ouziel': [626], 'A.': [627, 2146], 'Boisselier': [628], 'Rebaud': [630], 'Basmaci': [632], 'al.Type': [635], 'children': [639], 'bacterial': [643], 'infections.': [644], '[published': [645], 'online': [646], 'ahead': [647], 'print,': [649], '2020': [650, 1102, 2337], 'May': [651], '2].Clin': [652], 'Chem.': [653], ':': [655], 'hvaa089https://doi.org/10.1093/clinchem/hvaa089Crossref': [656], '(9)': [659], 'noticed': [663], 'strong': [665], 'proinflammatory': [666], 'cases': [670], '(CRP,': [671], 'IP-10),': [674], 'started': [676], 'early': [677, 1025, 1106, 1261, 1364], 'positive,': [680], 'after': [685, 888], 'infection': [689], 'B-D).': [692], 'Patients': [693], 'IFN-α': [696, 975, 1272, 1307, 1925], 'poorer': [699], 'outcome,': [700, 1320], 'them': [703], 'requiring': [704], '5)': [711], 'longer': [715], '(Table': [720], 'I).': [721], 'The': [722, 1126, 1763, 1951], 'load': [724, 846, 1659, 2184], 'tended': [725], 'be': [727, 1001, 1111, 1132, 1192, 1281, 1300], 'higher': [728], 'IFN-negative': [730], 'diagnosis.': [736], 'IFN-β': [737, 1350, 1991], 'IFN-λ': [739], 'undetectable,': [741], 'amount': [744], 'IFN-γ': [746, 1989, 2364, 2427], 'detected': [748, 1752], 'evident': [754], 'link': [755], 'level': [758], 'B-D).Table': [762], 'IClinical': [763], 'characteristics': [764], 'unitClinical': [772], 'featureIFN-negative': [773], '5)IFN-positive': [776], '21)P': [779], 'valueAge': [780], '(y),': [781], 'median': [782, 843, 850, 880, 2415], '(min-max)81': [783], '(63-83)74': [784], '(28-91).696Sex': [785], '(male),': [786], 'n': [787, 804, 808, 815, 820, 824, 828, 833, 838, 855, 891], '(%)5': [788], '(100)18': [789], '(86)1.000Delay': [790], 'ICU': [795, 802, 873], 'admission': [796], '(d)7': [797], '(1-11)7': [798], '(0-15).769Bacterial': [799], 'coinfection': [800], 'stay,': [803, 879], '(%)3': [805, 825, 839], '(60)7': [806, 826], '(33).3402Diabetes,': [807], '(%)1': [809, 829], '(20)3': [810, 830], '(14).5043Chronic': [811], 'obstructive': [812], 'pulmonary': [813], 'disease,': [814, 819, 1385], '(%)0': [816, 834], '(0)3': [817], '(14)1.000Cardiovascular': [818], '(%)2': [821, 892], '(40)9': [822], '(43)1.000Hypertension,': [823], '(33).3402Cancer,': [827], '(14)1.000Active': [831], 'smokers,': [832], '(0)1(5)1.000BMI': [835], '>30': [836], 'kg/m2,': [837], '(60)8': [840], '(38).620Biological': [841], 'feature,': [842], '(min-max)': [844], 'diagnosis': [848, 2170], '(Ct),': [849], '(min-max)20.9': [851], '(18-28.2)25.1': [852], '(16.1-38.0).172': [853], 'Outcome,': [854], '(%)Standard': [856], 'oxygen': [857, 863], 'therapy': [858, 864], 'only0': [859, 865], '(0)5': [860], '(24).5451High': [861], 'flow': [862], '(0)7': [866], '(33).278Invasive': [867], 'any': [870, 1685], 'time': [871], 'stay5': [874], '(100)9': [875], '(42).0425ICU': [876], 'length': [877], '(min-max)20': [881], '(7-30)5': [882], '(0-35).0503': [883], 'Mortality': [884], 'onset,': [890], '(40)8': [893], '(38)1.000P': [894], 'values': [895, 903, 933, 941, 2341, 2349, 2403], 'calculated': [897, 935, 2140, 2343], 'using': [898, 905, 936, 943, 1934, 1959, 1971, 1995, 2114, 2125, 2206, 2344, 2351, 2388], 'Mann-Whitney': [899, 937, 2345], 'test': [900, 907, 938, 945, 1641, 2346, 2353], 'Fisher-exact': [906, 944, 2352], 'qualitative': [909, 947, 2355], 'ones.Statistical': [910], 'significance': [911, 950], 'defined': [913, 952, 2382], 'P': [915, 932, 954, 2340], '<': [916, 955], '.05': [917, 956], '(boldface).BMI,': [918], 'Body': [919, 959], 'mass': [920, 960], 'index;': [921, 961], 'ICU,': [922, 962], 'unit.': [925, 965], 'Open': [926], 'table': [927], 'tab': [931], 'ones.': [948], 'Statistical': [949], '(boldface).': [957], 'BMI,': [958], 'Taken': [966], 'together,': [967], 'our': [968], 'data': [969, 1244, 1901], 'demonstrate': [970, 1121], 'heterogeneous': [972], 'pattern': [973], 'COVID-19,': [980, 1116], 'being': [984], 'impaired': [985], 'about': [987], 'defective': [996, 1123], 'may': [1000, 1131], 'poor': [1005], 'outcome.': [1006], 'murine': [1008], 'models': [1009], 'SARS-CoV-1': [1011, 1084, 1200], 'delayed': [1013, 1188], 'lung': [1019, 1030], 'lesions': [1020], 'fatal': [1022, 1319], 'outcome': [1023], 'administration': [1026, 1107], 'prevents': [1029], 'lesions.6Channappanavar': [1031], 'Fehr': [1033, 1145, 1203], 'A.R.': [1034, 1146, 1204], 'Vijay': [1035, 1147, 1205], 'Mack': [1037, 1149, 1207], 'Meyerholz': [1041, 1153, 1211], 'D.K.': [1042, 1154, 1212], 'al.Dysregulated': [1044, 1156, 1214], 'type': [1045, 1097, 1157, 1215, 2172, 2332], 'monocyte-macrophage': [1050, 1162, 1220], 'responses': [1051, 1163, 1221], 'cause': [1052, 1164, 1222], 'lethal': [1053, 1165, 1223], 'SARS-CoV-infected': [1056, 1168, 1226], 'mice.Cell': [1057, 1169, 1227], 'Host': [1058, 1170, 1228], 'Microbe.': [1059, 1171, 1229], '2016;': [1060, 1172, 1230], '19:': [1061, 1173, 1231], '181-193Abstract': [1062, 1174, 1232], '(1118)': [1070, 1182, 1240], 'SARS-CoV-2': [1073, 1094, 1693, 1715, 1750, 2329], 'displays': [1074], 'better': [1076], 'sensitivity': [1077], 'vitro': [1081], 'compared': [1082], 'cell': [1087], 'lines.7Lokugamage': [1088], 'K.G.': [1089, 2324], 'Schindewolf': [1090, 2325], 'Menachery': [1092, 2327], 'V.D.': [1093, 2328], 'sensitive': [1095, 2330], 'pretreatment.bioRxiv.': [1100, 2335], '(03.07.982264)Google': [1103, 2338], 'Therefore,': [1105], 'might': [1110], 'promising': [1112], 'especially': [1117], 'those': [1119, 1256], 'who': [1120, 1257], 'response.': [1125], 'timing': [1127], 'exposition': [1130], 'virus': [1137], 'avoid': [1139], 'immunopathogenesis.': [1140], 'Channappanavar': [1141], 'al6Channappanavar': [1143], 'expression': [1190], 'detrimental': [1193], 'mice': [1195], 'context': [1198], 'infection.6Channappanavar': [1201], 'Our': [1243], 'suggest': [1245], 'screening': [1247], 'instrumental': [1253], 'select': [1255], 'could': [1258, 1280], 'benefit': [1259], 'intervention': [1262, 1365], 'IFN.': [1264], 'Following': [1265], '10,': [1267], 'remains': [1269], 'increased': [1270], 'tapered.': [1273], 'highlight': [1276, 1372], 'inhibitors': [1279], 'helpful': [1282, 1414], 'second': [1285, 1381], 'phase': [1286, 1382], 'following': [1290], 'decrease.': [1292], 'characteristic': [1294], 'genetic': [1297], 'susceptibility': [1298], 'should': [1299], 'understand': [1303], 'defect': [1305], 'some': [1310], 'COVID.': [1313], 'Some': [1314], 'IFN-α2–positive': [1315], 'also': [1317, 1371, 1420], 'experienced': [1318], 'highlighting': [1321], 'multifactorial': [1323], 'severity.': [1327], 'acknowledge': [1329], 'limitations': [1330], 'related': [1334], 'small': [1337], 'number': [1338, 1862, 1882], 'included': [1340, 1844], 'technical': [1344], 'limitation': [1345], 'IFN-λ,': [1352, 2362], 'proof-of-concept': [1355], 'study.': [1356, 1848], 'Here,': [1357], 'provide': [1359], 'arguments': [1361], 'window': [1374], 'opportunity': [1376], 'immunosuppressors': [1378], 'opening': [1386], 'avenues': [1388], 'therapies.': [1391], 'thank': [1393, 1409, 1421], 'associates,': [1398], 'Gaelle': [1399], 'Cavillon': [1400], 'Salima': [1402], 'Merazga,': [1403], 'their': [1405], 'excellent': [1406], 'work.': [1407], 'Fabien': [1410], 'Subtil': [1411], 'his': [1413, 1920], 'advice': [1415], 'statistical': [1417], 'analysis.': [1418], 'LIFE': [1423], '(Lyon': [1424, 1521], 'Immunopathology': [1425], 'FEderation)': [1426], 'community': [1427], 'fruitful': [1429], 'discussion.': [1430], 'HCL': [1432], 'group': [1434], 'collaborators:': [1435], 'William': [1436], 'Mouton,': [1437], 'Guy': [1438], 'Oriol,': [1439], 'Christelle': [1440], 'Compagnon,': [1441], 'Laurence': [1442, 1552], 'Generenaz,': [1443], 'Valérie': [1445], 'Cheynet': [1446], '(Joint': [1447], 'Research': [1448, 1603], 'Unit,': [1449, 1533], 'Lyon-bioMérieux,': [1453], 'Lyon,': [1457, 1503, 1504, 1529, 1537, 1538, 1575, 1591, 1595, 1615], 'Sud': [1459], 'Hospital,': [1460, 1594], 'Pierre-Bénite,': [1461], 'France);': [1462, 1505, 1539, 1576, 1596], 'Florence': [1463, 1554], 'Ader,': [1464], 'Agathe': [1465], 'Becker,': [1466], 'Nicholas': [1467], 'Benech,': [1468], 'Pierre': [1469, 1519], 'Chauvelot,': [1470, 1509], 'Christian': [1471], 'Chidiac,': [1472], 'Anne': [1473], 'Conrad,': [1474], 'Tristan': [1475], 'Ferry,': [1476], 'Patrick': [1477], 'Miailhes,': [1478], 'Thomas': [1479], 'Perpoint,': [1480], 'Marielle': [1481], 'Perry,': [1482], 'Cécile': [1483], 'Pouderoux,': [1484], 'Sandrine': [1485], 'Roux,': [1486], 'Claire': [1487], 'Triffault-Fillit,': [1488], 'Florent': [1490], 'Valour': [1491], '(Infectious': [1492], 'Diseases': [1493], 'Department,': [1494, 1562], 'Hopital': [1495], 'la': [1497], 'Croix': [1498], 'Rousse,': [1499], 'Yonis': [1506], 'Hodane,': [1507], 'Louis': [1508], 'Paul': [1510], 'Chabert,': [1511], 'Judith': [1512], 'Provoost,': [1513], 'Guillaume': [1514], 'David,': [1515], 'Laure': [1516], 'Folliet,': [1517], 'Lecam': [1520], 'University,': [1522, 1607], 'CREATIS,': [1523], 'CNRS': [1524, 1610], 'UMR5220,': [1525], 'Inserm': [1526], 'U1044,': [1527], 'INSA,': [1528], 'France;': [1530], 'Intensive': [1531], 'Care': [1532], 'Geneviève': [1540], 'Billaud,': [1541], 'Maude': [1542], 'Bouscambert,': [1543], 'Vanessa': [1544], 'Escuret,': [1545], 'Emilie': [1546], 'Frobert,': [1547], 'Antonin': [1548], 'Bal,': [1549], 'Grégory': [1550], 'Destras,': [1551], 'Josset,': [1553], 'Morfin,': [1555], 'Clément': [1556], 'Munier,': [1557], 'Martine': [1559], 'Valette': [1560], '(Virology': [1561], 'Infective': [1563], 'Agents': [1564], 'Institute,': [1565], 'National': [1566, 1856], 'Reference': [1567], 'Center': [1568, 1601], 'Respiratory': [1570], 'Viruses,': [1571], 'North': [1572], 'Hospital': [1573, 1816], 'Network,': [1574], 'Fabienne': [1577], 'Venet,': [1578], 'Lorna': [1579], 'Garnier,': [1580], 'Rémi': [1581], 'Pescarmona,': [1582], 'Christine': [1584], 'Lombard': [1585], '(Immunology': [1586], 'Laboratory,': [1587], 'Edouard': [1592], 'Herriot': [1593], 'Thierry': [1598], 'Walzer': [1599], '(International': [1600], 'Infectiology,': [1605], 'INSERM': [1608], 'U1111,': [1609], 'UMR': [1611], '5308,': [1612], 'ENS,': [1613], 'UCBL,': [1614], 'SARS-COV-2–positive': [1622], 'Patient': [1633, 1674, 1704], '1:': [1634], 'One': [1635], 'week': [1636], 'before': [1637], 'result,': [1642], '46-year-old': [1644], 'man': [1645], 'developed': [1646, 1716], 'signs': [1648], 'symptoms': [1650], '(fever,': [1651], 'dry': [1652], 'cough,': [1653], 'asthenia,': [1654], 'chills).': [1655], 'Monitoring': [1656], 'consecutive': [1661, 1699], 'nasopharyngeal': [1662, 1695, 1758, 2188], 'swabs': [1663, 1696, 1759, 2189], 'performed': [1665, 2113, 2196, 2272], 'E1,': [1667, 1702, 1777], 'E).': [1668, 1703, 1778], 'He': [1669], 'had': [1670], 'benign': [1672], 'evolution.': [1673], '2:': [1675], 'A': [1676, 1706, 1732, 2209], '56-year-old': [1677], 'woman': [1678], 'did': [1682, 1791], 'develop': [1684], 'sign': [1686], 'despite': [1689], 'detection': [1691], 'several': [1698], '3:': [1705], 'high-risk': [1707], 'contact': [1708], '(a': [1709], '54-year-old': [1710], 'man)': [1711], 'initially': [1712], 'negative': [1713], 'fever': [1717], 'cough': [1719], 'crackles': [1722], 'auscultation': [1724], 'fifth': [1727], 'isolation.': [1731], 'bilateral': [1733, 1742], 'interstitial': [1734], 'computed': [1738], 'tomography': [1739], 'scan': [1740], 'ground-glass': [1743], 'opacification': [1744], 'predominant': [1746], 'left.': [1749], 'endotracheal': [1754, 1774, 2191], 'aspirates,': [1755], 'always': [1761], 'negative.': [1762], 'daily': [1764], 'follow-up': [1765], 'revealed': [1766], 'short-lasting': [1768], 'excretion': [1769], 'only': [1771, 2431], 'successive': [1773], 'aspirates': [1775], 'For': [1779], 'patients,': [1782, 1837], 'other': [1784], 'pathogens': [1786], 'detected.': [1788], 'These': [1789], 'need': [1793], 'oxygenation,': [1794], 'nor': [1795], 'antibiotics,': [1796], 'steroids,': [1797], 'agents.': [1800], 'Plasma': [1801, 1924, 1988, 2005], 'samples': [1802, 1946], 'Paxgene': [1804, 2029, 2394], 'tubes': [1805, 2030, 2395], 'collected': [1807], 'hospitalized': [1812], 'University': [1815], '(Hospices': [1819], 'Lyon),': [1822], 'France.': [1823], 'Diagnosis': [1824], 'confirmed': [1828], 'RT-PCR.': [1833], 'All': [1834], 'admitted': [1838], 'unit,': [1842], 'MIR-COVID': [1847], 'registered': [1852], 'French': [1855, 1900], 'Data': [1857, 1889, 2121], 'Agency': [1859], 'under': [1860, 1880], '20-097': [1863], 'N°20-41.': [1883], 'agreement': [1885], 'General': [1888], 'Regulation': [1891], '(Regulation': [1892], '(EU)': [1893], '2016/679': [1894], 'Directive': [1896], '95/46/EC)': [1897], 'protection': [1902], 'law': [1903], '(Law': [1904], 'n°78-17': [1905], '06/01/1978': [1907], 'Décret': [1909], 'n°2019-536': [1910], '29/05/2019),': [1912], 'obtained': [1914, 2124, 2392], 'consent': [1915], 'each': [1917, 2242], 'patient': [1918, 2370], 'next': [1921], 'kin.': [1923], 'concentrations': [1926, 1968, 2365], '(fg/mL)': [1927], 'determined': [1929], 'array': [1932], '(Simoa)': [1933], 'commercial': [1936], 'kit': [1937], 'quantification': [1940, 2062], '(Quanterix,': [1941], 'Lexington,': [1942], 'Mass)': [1943], 'COVID-19.': [1950, 2400], 'assay': [1952, 1974, 2040], 'based': [1954, 2316], '3-step': [1957], 'protocol': [1958, 2321], 'HD-1': [1961], 'Analyzer': [1962], '(Quanterix).': [1963], 'measured': [1970], 'multiplexed': [1973], 'Ella': [1977, 1997], 'platform': [1978, 1998], '(Protein': [1979, 1999], 'simple,': [1980], 'San': [1981], 'Jose,': [1982], 'Calif),': [1983], 'according': [1984, 2001], "manufacturer's": [1986, 2003, 2207], 'instructions.': [1987, 2004, 2208], 'quantified': [1994, 2014, 2037, 2186, 2387, 2429], 'simple),': [2000], 'IL28A/B': [2006], 'IL-29': [2008], '(type': [2009], 'III': [2010, 2227], 'IFN)': [2011], '(PBL': [2017], 'Laboratories,': [2018], 'Piscataway,': [2019], 'NJ).': [2020], 'RNA': [2021, 2047, 2054, 2107, 2193], 'extracted': [2023], 'whole': [2025], 'blood': [2026, 2165], 'contained': [2027, 2212], '(Kit': [2031], 'PreAnalytix,': [2032], 'Qiagen,': [2033], 'Hilden,': [2034], 'Germany)': [2035], 'spectrophotometric': [2039], '(Nanodrop': [2041], '2000,': [2042], 'Thermo': [2043], 'Scientific,': [2044, 2308], 'Waltham,': [2045, 2309], 'Mass).': [2046, 2310], 'integrity': [2048], 'then': [2050, 2288], 'Agilent': [2053], 'microarray': [2055], '(Agilent': [2056], 'Technologies,': [2057, 2118], 'Santa': [2058], 'Clara,': [2059], 'Calif).': [2060], 'mRNA': [2061], '6': [2064, 2384], '(IFN-α–inducible': [2067], '27,': [2069], 'IFN-induced': [2070], '44': [2072], 'like,': [2073], 'IFN-Induced': [2074], 'Protein': [2075], 'With': [2076], 'Tetratricopeptide': [2077], 'Repeats': [2078], 'ISG15': [2080], 'Ubiquitin': [2081], 'Like': [2082, 2095], 'Modifier,': [2083], 'Radical': [2084], 'S-Adenosyl': [2085], 'Methionine': [2086], 'Domain': [2087], 'Containing': [2088], '2,': [2089], 'Sialic': [2091], 'Acid': [2092], 'Binding': [2093], 'Ig': [2094], 'Lectin': [2096], 'housekeeping': [2100, 2133], 'genes—Actin': [2101], 'Beta,': [2102], 'Hypoxanthine': [2103], 'Phosphoribosyltransferase': [2104], 'Polymerase': [2108, 2234], 'II': [2109], 'Subunit': [2110], 'A)': [2111], 'nanostring': [2115, 2389], '(Nanostring': [2117], 'Seattle,': [2119], 'Wash).': [2120], 'standardization': [2122], 'geometric': [2127], 'mean': [2128], 'internal': [2130], 'count': [2135], 'number.': [2136], 'score': [2138, 2358, 2377], 'previously': [2142], 'described.E1Pescarmona': [2143], 'Belot': [2145], 'Villard': [2147], 'Besson': [2149], 'Lopez': [2151], 'Mosnier': [2153], 'I.': [2154], 'al.Comparison': [2156], 'RT-qPCR': [2158], 'Nanostring': [2160], 'interferonopathies.Cytokine.': [2174], '2019;': [2175], '113:': [2176], '446-452Crossref': [2177], '(48)': [2180], 'aspirates.': [2192], 'extraction': [2194], 'automated': [2199], 'NucliSENS': [2200], 'easyMAG': [2201], '(BioMérieux,': [2202], 'Marcy': [2203], "l'Etoile,": [2204], '25-μL': [2210], 'reaction': [2211, 2221], 'μL': [2214, 2218, 2250, 2260], 'RNA,': [2216], '12.5': [2217], '2×': [2220], 'buffer': [2222], 'provided': [2223], 'Superscript': [2226], '1-step': [2228], 'RT-PCR': [2229], 'Platinum': [2232], 'Taq': [2233], '(Invitrogen,': [2235], 'Darmstadt,': [2236], 'Germany;': [2237], 'containing': [2238], '0.4': [2239, 2259], 'mM': [2240, 2246, 2264], 'dNTPs': [2243], 'magnesium': [2247, 2265], 'sulfate),': [2248], 'reverse': [2252, 2279], 'transcriptase/Taq': [2253], 'mixture': [2254], 'kit,': [2257], '50': [2263, 2289], 'sulfate': [2266], 'solution': [2267], '(Invitrogen).': [2268], 'Thermal': [2269], 'cycling': [2270], '55°C': [2274], '20': [2276], 'minutes': [2277, 2286], 'transcription,': [2280], 'followed': [2281], '95°C': [2283, 2292], 'cycles': [2290], '15': [2294], 'seconds,': [2295, 2299], '58°C': [2296], '30': [2298], 'QuantStudio': [2302], 'rtPCR': [2304], 'Systems': [2305], '(Thermo': [2306], 'Fisher': [2307], 'Primer': [2311], 'probe': [2313], 'used': [2314], 'Institut': [2319], 'Pasteur': [2320], '(Paris,': [2322], 'France).E2Lokugamage': [2323], 'ones.Fig': [2356], 'E2IFN': [2357], 'IFN-β,': [2361], 'transcriptional': [2380], 'signature': [2381], '4': [2397], 'B-D,': [2401], 'Normal': [2402], 'healthy': [2405], 'volunteers': [2406], 'indicated': [2408], 'gray': [2410], 'area.': [2411], 'Vertical': [2412], 'bar': [2413], 'indicates': [2414], 'delay': [2416], 'admission.': [2424], 'Concentrations': [2425], '16': [2432], 'because': [2436], 'lack': [2438], 'material.View': [2440], 'Large': [2441], 'Image': [2442], 'Figure': [2443], 'ViewerDownload': [2444], 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