Publication Information

{'id': 'https://openalex.org/W3021357190', 'doi': 'https://doi.org/10.3892/etm.2020.8696', 'title': 'Protective effect of puerarin against burn‑induced heart injury in rats', 'display_name': 'Protective effect of puerarin against burn‑induced heart injury in rats', 'publication_year': 2020, 'publication_date': '2020-04-29', 'ids': {'openalex': 'https://openalex.org/W3021357190', 'doi': 'https://doi.org/10.3892/etm.2020.8696', 'mag': '3021357190', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/32536996', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/7282049'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3892/etm.2020.8696', 'pdf_url': 'https://www.spandidos-publications.com/10.3892/etm.2020.8696/download', 'source': {'id': 'https://openalex.org/S151424340', 'display_name': 'Experimental and Therapeutic Medicine', 'issn_l': '1792-0981', 'issn': ['1792-0981', '1792-1015'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320412', 'host_organization_name': 'Spandidos Publishing', 'host_organization_lineage': ['https://openalex.org/P4310320412'], 'host_organization_lineage_names': ['Spandidos Publishing'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.spandidos-publications.com/10.3892/etm.2020.8696/download', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100701947', 'display_name': 'Junling Liu', 'orcid': 'https://orcid.org/0000-0002-2510-790X'}, 'institutions': [{'id': 'https://openalex.org/I4210114785', 'display_name': 'Gansu Provincial Hospital', 'ror': 'https://ror.org/02axars19', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210114785']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Junling Liu', 'raw_affiliation_strings': ['Department of Burn, Gansu Provincial Hospital, Lanzhou, Gansu 730000, P.R. China'], 'affiliations': [{'raw_affiliation_string': 'Department of Burn, Gansu Provincial Hospital, Lanzhou, Gansu 730000, P.R. China', 'institution_ids': ['https://openalex.org/I4210114785']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037743019', 'display_name': 'Jianyun Liu', 'orcid': 'https://orcid.org/0000-0003-4738-2870'}, 'institutions': [{'id': 'https://openalex.org/I4210114785', 'display_name': 'Gansu Provincial Hospital', 'ror': 'https://ror.org/02axars19', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210114785']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jianyun Liu', 'raw_affiliation_strings': ['Department of Burn, Gansu Provincial Hospital, Lanzhou, Gansu 730000, P.R. China'], 'affiliations': [{'raw_affiliation_string': 'Department of Burn, Gansu Provincial Hospital, Lanzhou, Gansu 730000, P.R. China', 'institution_ids': ['https://openalex.org/I4210114785']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017063264', 'display_name': 'Mingming Bai', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210114785', 'display_name': 'Gansu Provincial Hospital', 'ror': 'https://ror.org/02axars19', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210114785']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Mingming Bai', 'raw_affiliation_strings': ['Department of Burn, Gansu Provincial Hospital, Lanzhou, Gansu 730000, P.R. China'], 'affiliations': [{'raw_affiliation_string': 'Department of Burn, Gansu Provincial Hospital, Lanzhou, Gansu 730000, P.R. China', 'institution_ids': ['https://openalex.org/I4210114785']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5100460897', 'display_name': 'Hui Wang', 'orcid': 'https://orcid.org/0000-0003-1450-6320'}, 'institutions': [{'id': 'https://openalex.org/I4210114785', 'display_name': 'Gansu Provincial Hospital', 'ror': 'https://ror.org/02axars19', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210114785']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Hui Wang', 'raw_affiliation_strings': ['Department of Burn, Gansu Provincial Hospital, Lanzhou, Gansu 730000, P.R. China'], 'affiliations': [{'raw_affiliation_string': 'Department of Burn, Gansu Provincial Hospital, Lanzhou, Gansu 730000, P.R. China', 'institution_ids': ['https://openalex.org/I4210114785']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.392, 'has_fulltext': False, 'cited_by_count': 4, 'citation_normalized_percentile': {'value': 0.622304, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 77, 'max': 79}, 'biblio': {'volume': '20', 'issue': '1', 'first_page': '275', 'last_page': '282'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11386', 'display_name': 'Bee Products Chemical Analysis', 'score': 0.9955, 'subfield': {'id': 'https://openalex.org/subfields/1109', 'display_name': 'Insect Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11386', 'display_name': 'Bee Products Chemical Analysis', 'score': 0.9955, 'subfield': {'id': 'https://openalex.org/subfields/1109', 'display_name': 'Insect Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12554', 'display_name': 'Vitamin C and Antioxidants Research', 'score': 0.9949, 'subfield': {'id': 'https://openalex.org/subfields/2916', 'display_name': 'Nutrition and Dietetics'}, 'field': {'id': 'https://openalex.org/fields/29', 'display_name': 'Nursing'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13551', 'display_name': 'Biochemical effects in animals', 'score': 0.991, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/puerarin', 'display_name': 'Puerarin', 'score': 0.8895582}], 'concepts': [{'id': 'https://openalex.org/C2778356392', 'wikidata': 'https://www.wikidata.org/wiki/Q4392082', 'display_name': 'Puerarin', 'level': 3, 'score': 0.8895582}, {'id': 'https://openalex.org/C67082663', 'wikidata': 'https://www.wikidata.org/wiki/Q3523816', 'display_name': 'Molecular medicine', 'level': 4, 'score': 0.7073966}, {'id': 'https://openalex.org/C2781018059', 'wikidata': 'https://www.wikidata.org/wiki/Q207609', 'display_name': 'Oncogene', 'level': 4, 'score': 0.60295236}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.59139}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.53144944}, {'id': 'https://openalex.org/C2993242423', 'wikidata': 'https://www.wikidata.org/wiki/Q170518', 'display_name': 'Burn injury', 'level': 2, 'score': 0.5304961}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.51528525}, {'id': 'https://openalex.org/C29537977', 'wikidata': 'https://www.wikidata.org/wiki/Q188941', 'display_name': 'Cell cycle', 'level': 3, 'score': 0.42706418}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.37612733}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.31673533}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.27400845}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.22023812}, {'id': 'https://openalex.org/C141071460', 'wikidata': 'https://www.wikidata.org/wiki/Q40821', 'display_name': 'Surgery', 'level': 1, 'score': 0.18080682}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.08514479}, {'id': 'https://openalex.org/C204787440', 'wikidata': 'https://www.wikidata.org/wiki/Q188504', 'display_name': 'Alternative medicine', 'level': 2, 'score': 0.0}], 'mesh': [], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.3892/etm.2020.8696', 'pdf_url': 'https://www.spandidos-publications.com/10.3892/etm.2020.8696/download', 'source': {'id': 'https://openalex.org/S151424340', 'display_name': 'Experimental and Therapeutic Medicine', 'issn_l': '1792-0981', 'issn': ['1792-0981', '1792-1015'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320412', 'host_organization_name': 'Spandidos Publishing', 'host_organization_lineage': ['https://openalex.org/P4310320412'], 'host_organization_lineage_names': ['Spandidos Publishing'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc7282049', 'pdf_url': 'https://europepmc.org/articles/pmc7282049?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282049', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/32536996', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3892/etm.2020.8696', 'pdf_url': 'https://www.spandidos-publications.com/10.3892/etm.2020.8696/download', 'source': {'id': 'https://openalex.org/S151424340', 'display_name': 'Experimental and Therapeutic Medicine', 'issn_l': '1792-0981', 'issn': ['1792-0981', '1792-1015'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320412', 'host_organization_name': 'Spandidos Publishing', 'host_organization_lineage': ['https://openalex.org/P4310320412'], 'host_organization_lineage_names': ['Spandidos Publishing'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Clean water and sanitation', 'score': 0.47, 'id': 'https://metadata.un.org/sdg/6'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 55, 'referenced_works': ['https://openalex.org/W130424530', 'https://openalex.org/W1558352361', 'https://openalex.org/W1824340941', 'https://openalex.org/W1964511841', 'https://openalex.org/W1967160966', 'https://openalex.org/W1974008972', 'https://openalex.org/W1975136687', 'https://openalex.org/W1976881822', 'https://openalex.org/W1978957243', 'https://openalex.org/W1979269047', 'https://openalex.org/W1980010223', 'https://openalex.org/W1987956016', 'https://openalex.org/W2011214577', 'https://openalex.org/W2013204959', 'https://openalex.org/W2022642881', 'https://openalex.org/W2028111136', 'https://openalex.org/W2040872439', 'https://openalex.org/W2043142059', 'https://openalex.org/W2048020247', 'https://openalex.org/W2050625117', 'https://openalex.org/W2051597514', 'https://openalex.org/W2071941255', 'https://openalex.org/W2073051153', 'https://openalex.org/W2074359472', 'https://openalex.org/W2076287036', 'https://openalex.org/W2082188123', 'https://openalex.org/W2085832118', 'https://openalex.org/W2086840919', 'https://openalex.org/W2090219806', 'https://openalex.org/W2100006160', 'https://openalex.org/W2100535000', 'https://openalex.org/W2106745343', 'https://openalex.org/W2108466323', 'https://openalex.org/W2134125096', 'https://openalex.org/W2135871453', 'https://openalex.org/W2137623306', 'https://openalex.org/W2168494840', 'https://openalex.org/W2170954628', 'https://openalex.org/W2175932919', 'https://openalex.org/W2200726735', 'https://openalex.org/W2220333480', 'https://openalex.org/W2315812152', 'https://openalex.org/W2317319605', 'https://openalex.org/W2337217513', 'https://openalex.org/W2395661713', 'https://openalex.org/W2398448054', 'https://openalex.org/W2418872028', 'https://openalex.org/W2426108333', 'https://openalex.org/W2605401406', 'https://openalex.org/W2731731772', 'https://openalex.org/W2768063423', 'https://openalex.org/W2811111926', 'https://openalex.org/W2900112088', 'https://openalex.org/W2984573872', 'https://openalex.org/W3024825219'], 'related_works': ['https://openalex.org/W4231595276', 'https://openalex.org/W3161809393', 'https://openalex.org/W2967566052', 'https://openalex.org/W2945902321', 'https://openalex.org/W2802089617', 'https://openalex.org/W2586428200', 'https://openalex.org/W2165801694', 'https://openalex.org/W2120086268', 'https://openalex.org/W2020643427', 'https://openalex.org/W1990949341'], 'abstract_inverted_index': {'The': [0], 'present': [1], 'study': [2], 'evaluated': [3], 'the': [4, 131, 166, 173, 200, 247, 256], 'potential': [5], 'protective': [6], 'effects': [7], 'of': [8, 20, 45, 81, 92, 110, 145, 157, 181, 202, 239, 259], 'puerarin': [9, 142, 146, 220], 'and': [10, 40, 52, 61, 77, 83, 96, 120, 160, 184, 192, 206, 242, 249], 'its': [11], 'associated': [12], 'mechanism': [13, 258], 'on': [14], 'burn-induced': [15], 'myocardial': [16, 68, 196, 236], 'damage.': [17], 'A': [18], 'total': [19], '40': [21], 'healthy': [22], 'adult': [23], 'Wistar': [24], 'rats': [25, 225], 'were': [26, 54, 65, 85, 98, 125, 139, 162], 'randomly': [27], 'divided': [28], 'into': [29], 'four': [30], 'groups:': [31], 'i)': [32], 'Sham;': [33], 'ii)': [34], 'burn;': [35], 'iii)': [36], 'burn': [37, 132, 148, 167, 228], '+': [38], 'puerarin;': [39], 'iv)': [41], 'puerarin.': [42], 'Serum': [43, 155], 'levels': [44, 64, 124, 156, 180, 194], 'interleukin': [46], '(IL)-1β,': [47], 'tumor': [48], 'necrosis': [49], 'factor-α': [50], '(TNF-α)': [51], 'IL-6': [53, 161], 'measured': [55, 99], 'using': [56, 70, 100], 'ELISA.': [57], 'Myeloperoxidase': [58], '(MPO)': [59], 'activity': [60, 119, 191], 'malondialdehyde': [62], '(MDA)': [63], 'determined': [66], 'in': [67, 112, 130, 165, 172, 186, 195, 224], 'homogenates': [69], 'a': [71], 'commercial': [72], 'assay': [73], 'kit.': [74], 'TUNEL': [75], 'staining': [76], 'western': [78, 101], 'blot': [79, 102], 'analysis': [80], 'cleaved': [82], 'pro-caspase-3': [84], 'also': [86, 150], 'performed': [87], 'to': [88, 127, 188, 234, 255], 'assess': [89], 'apoptosis.': [90], 'Activation': [91], 'p38-MAPK,': [93], 'ERK,': [94], 'JNK': [95, 207], 'AKT': [97, 250], 'analysis.': [103], 'Left': [104], 'ventricular': [105, 114], 'systolic': [106], 'pressure,': [107, 115], 'maximum': [108], 'rates': [109], 'increase/decrease': [111], 'left': [113], 'creatine': [116], 'kinase': [117], 'MB': [118], 'cardiac': [121, 222], 'troponin': [122], 'T': [123], 'found': [126], 'be': [128, 232], 'altered': [129], 'group': [133, 168], '12': [134], 'h': [135], 'after': [136], 'burn,': [137, 210], 'which': [138, 230], 'reversed': [140], 'by': [141], 'treatment.': [143], 'Injection': [144], 'following': [147, 208, 215, 226], 'injury': [149], 'reduced': [151, 178, 235, 243], 'heart': [152], 'water': [153], 'content.': [154], 'IL-1β,': [158, 182], 'TNF-α': [159, 183], 'significantly': [163], 'higher': [164], 'compared': [169], 'with': [170], 'those': [171], 'sham': [174], 'group.': [175], 'Puerarin': [176, 198], 'treatment': [177], 'serum': [179], 'IL-6,': [185], 'addition': [187], 'reducing': [189], 'MPO': [190], 'MDA': [193], 'tissues.': [197], 'inhibited': [199], 'activation': [201, 214], 'caspase-3,': [203], 'p38,': [204], 'ERK': [205], 'severe': [209, 216, 227], 'but': [211], 'elevated': [212], 'Akt': [213], 'burn.': [217], 'In': [218], 'conclusion,': [219], 'improved': [221], 'function': [223], 'injury,': [229, 237], 'may': [231], 'due': [233], 'inhibition': [238], 'cardiomyocyte': [240], 'apoptosis': [241], 'oxidative': [244], 'inflammatory': [245], 'stress;': [246], 'MAPK': [248], 'signaling': [251], 'pathways': [252], 'are': [253], 'proposed': [254], 'underlying': [257], 'these': [260], 'findings.': [261]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3021357190', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 2}], 'updated_date': '2024-12-16T08:15:55.675815', 'created_date': '2020-05-13'}