Publication Information

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626, 668, 679, 689, 718, 729, 739, 790, 820, 831, 841, 896, 907, 917, 946, 957, 967, 1040, 1051, 1061, 1090, 1101, 1111, 1157, 1168, 1178, 1234, 1245, 1255, 1303, 1326, 1337, 1347, 1363, 1449, 1467, 1498, 1516, 1546, 1555, 1595, 1624, 1648, 1679, 1698, 1759, 1763, 1782, 1785, 1803, 1825, 1858, 1863, 1894, 1949, 1967, 2003, 2048, 2069, 2083, 2086, 2107, 2133, 2159, 2218, 2359, 2380, 2386, 2414, 2450, 2466, 2470, 2526, 2552, 2572, 2600, 2751, 2791, 2825, 2874, 2908, 2957, 2961, 3006, 3061, 3108, 3123, 3138, 3174, 3256, 3279, 3341, 3348, 3378, 3382, 3390, 3397, 3422, 3431, 3440, 3521, 3540, 3546, 3558, 3629, 3703, 3739, 3794, 3842, 3849, 3861, 3865, 3887, 3889, 3914, 4013, 4032, 4041, 4055, 4062], 'New': [40, 48, 90, 98, 192, 200, 268, 276, 318, 326, 412, 420, 462, 470, 529, 537, 606, 614, 669, 677, 719, 727, 821, 829, 897, 905, 947, 955, 1041, 1049, 1091, 1099, 1158, 1166, 1235, 1243, 1327, 1335], 'Drug': [41, 49, 61, 91, 99, 111, 193, 201, 213, 269, 277, 289, 319, 327, 339, 413, 421, 433, 463, 471, 483, 530, 538, 550, 607, 615, 627, 670, 678, 690, 720, 728, 740, 822, 830, 842, 898, 906, 918, 948, 956, 968, 1042, 1050, 1062, 1092, 1100, 1112, 1159, 1167, 1179, 1236, 1244, 1256, 1328, 1336, 1348], 'Evaluation,': [42, 92, 194, 270, 320, 414, 464, 531, 608, 671, 721, 823, 899, 949, 1043, 1093, 1160, 1237, 1329], 'National': [43, 93, 195, 271, 321, 415, 465, 532, 609, 672, 722, 824, 900, 950, 1044, 1094, 1161, 1238, 1330], 'Research': [45, 95, 197, 273, 323, 417, 467, 534, 611, 674, 724, 826, 902, 952, 1046, 1096, 1163, 1240, 1332], 'Center': [46, 96, 198, 274, 324, 418, 468, 535, 561, 612, 675, 725, 827, 903, 953, 1047, 1097, 1164, 1190, 1241, 1333], 'for': [47, 73, 97, 123, 147, 175, 199, 225, 251, 275, 301, 325, 351, 371, 395, 419, 445, 469, 495, 536, 562, 571, 613, 639, 676, 702, 726, 752, 776, 804, 828, 854, 880, 904, 930, 954, 980, 1000, 1024, 1048, 1074, 1098, 1124, 1165, 1191, 1200, 1242, 1268, 1334, 1414, 1639, 1834, 1843, 1851, 1998, 2009, 2294, 2920, 2925, 2948, 3003, 3472, 3532, 3566, 3648, 3677, 3710, 3806, 3811], '(cultivation),': [52, 102, 204, 280, 330, 424, 474, 541, 618, 681, 731, 833, 909, 959, 1053, 1103, 1170, 1247, 1339], 'Guangdong': [53, 103, 205, 281, 331, 425, 475, 542, 619, 682, 732, 834, 910, 960, 1054, 1104, 1171, 1248, 1340], 'Province': [54, 104, 206, 282, 332, 426, 476, 543, 620, 683, 733, 835, 911, 961, 1055, 1105, 1172, 1249, 1341], 'Key': [55, 105, 207, 283, 333, 427, 477, 544, 621, 684, 734, 836, 912, 962, 1056, 1106, 1173, 1250, 1342], 'Chiral': [58, 108, 210, 286, 336, 430, 480, 547, 624, 687, 737, 839, 915, 965, 1059, 1109, 1176, 1253, 1345], 'Molecule': [59, 109, 211, 287, 337, 431, 481, 548, 625, 688, 738, 840, 916, 966, 1060, 1110, 1177, 1254, 1346], 'Discovery,': [62, 112, 214, 290, 340, 434, 484, 551, 628, 691, 741, 843, 919, 969, 1063, 1113, 1180, 1257, 1349], 'School': [63, 113, 215, 291, 341, 361, 435, 485, 552, 629, 692, 742, 844, 920, 970, 990, 1064, 1114, 1181, 1258, 1350], 'Pharmaceutical': [65, 115, 217, 293, 343, 437, 487, 554, 631, 694, 744, 846, 922, 972, 1066, 1116, 1183, 1260, 1352], 'Sciences,': [66, 116, 218, 294, 344, 438, 488, 555, 632, 695, 745, 847, 923, 973, 1067, 1117, 1184, 1261, 1353], 'Search': [72, 122, 146, 174, 224, 250, 300, 350, 370, 394, 444, 494, 570, 638, 701, 751, 775, 803, 853, 879, 929, 979, 999, 1023, 1073, 1123, 1199, 1267], 'more': [74, 124, 148, 176, 226, 252, 302, 352, 372, 396, 446, 496, 572, 640, 703, 753, 777, 805, 855, 881, 931, 981, 1001, 1025, 1075, 1125, 1201, 1269, 2332], 'papers': [75, 125, 149, 177, 227, 253, 303, 353, 373, 397, 447, 497, 573, 641, 704, 754, 778, 806, 856, 882, 932, 982, 1002, 1026, 1076, 1126, 1202, 1270], 'by': [76, 126, 150, 178, 228, 254, 304, 354, 374, 398, 448, 498, 574, 642, 705, 755, 779, 807, 857, 883, 933, 983, 1003, 1027, 1077, 1127, 1203, 1271, 1616, 1775, 1960, 2431, 2536, 2661, 2878, 2992, 3011, 3031, 3415, 3457, 3501, 3606, 3746, 3949, 4057], 'this': [77, 127, 151, 179, 229, 255, 305, 355, 375, 399, 449, 499, 575, 643, 706, 756, 780, 808, 858, 884, 934, 984, 1004, 1028, 1078, 1128, 1204, 1272, 2921, 3807], 'author': [78, 128, 152, 180, 230, 256, 306, 356, 376, 400, 450, 500, 576, 644, 707, 757, 781, 809, 859, 885, 935, 985, 1005, 1029, 1079, 1129, 1205, 1273, 1468], 'Yi': [79, 81, 708, 710, 1278], 'Niu': [80, 82, 709, 711, 2252], 'Arabella': [129, 131, 758, 760, 1280], 'Wan': [130, 132, 578, 582, 759, 761, 1207, 1211, 1305], 'Dongshi': [153, 155, 782, 784, 1282], 'Chen': [154, 156, 232, 234, 358, 360, 783, 785, 861, 863, 987, 989], 'Division': [157, 786], 'Pulmonary,': [159, 788, 1361], 'Allergy': [160, 789, 1362], 'Critical': [162, 791, 1364], 'Care': [163, 792, 1365], 'Medicine,': [164, 167, 244, 564, 793, 796, 873, 1193, 1366, 1369, 1385, 1416], 'University': [168, 797, 1370], 'Pittsburgh,': [170, 171, 799, 800, 1372, 1373], 'PA,': [172, 801, 1374], 'USA': [173, 802, 1375], 'Heng': [181, 183, 810, 812, 1284], 'Liang': [182, 184, 811, 813], 'Xijun': [231, 233, 860, 862, 1286], 'Abdominal': [237, 866, 1378], 'Integrated': [239, 868, 1380], 'Hospital': [240, 869, 1381], 'Traditional': [242, 871, 1383], 'Chinese': [243, 872, 1384], 'Southern': [245, 874, 1386], 'Medical': [246, 875, 1387], 'Lei': [257, 259, 886, 888, 1288], 'Siyue': [307, 309, 936, 938, 1290], 'Zhan': [308, 310, 937, 939], 'Liutao': [357, 359, 986, 988, 1292], 'Life': [363, 992, 1393], 'Science,': [364, 993, 1394], 'Chao': [377, 379, 1006, 1008, 1294], 'Cheng': [378, 380, 1007, 1009], 'Thoracic': [383, 1012, 1402], 'Xiaolei': [401, 403, 1030, 1032, 1296], 'Zhang': [402, 404, 1031, 1033], 'Xianzhang': [451, 453, 1080, 1082, 1298], 'Bu': [452, 454, 1081, 1083], 'Weiling': [501, 505, 1130, 1134, 1300], 'He': [502, 506, 1131, 1135, 1301], 'Corresponding': [503, 579, 1132, 1208], 'Author': [504, 580, 1133, 1209, 1274], '[email': [507, 583, 1136, 1212, 1429, 1438], 'protected]': [508, 584, 1137, 1213, 1430, 1439], 'Precision': [563, 1192, 1415], 'Guohui': [577, 581, 1206, 1210, 1304], 'orcid.org/0000-0001-5170-7282': [585, 1214], 'Information': [1275], 'Lin1,2,': [1277], 'Niu2,': [1279], 'Wan1,': [1281], 'Chen3,': [1283], 'Liang2,': [1285], 'Chen4,': [1287], 'Sun2,': [1289], 'Zhan2,': [1291], 'Chen5,': [1293], 'Cheng6,': [1295], 'Zhang2,': [1297], 'Bu2,': [1299], '*,1,2,7': [1302], '*,1,2': [1306], '1Department': [1307], '2National-Local': [1320], '3Division': [1359], '4Department': [1376], '5School': [1391], '6Department': [1400], '7Center': [1413], '*Corresponding': [1422, 1431], 'author.': [1423, 1432], 'Tel:': [1424, 1433], '+86': [1425, 1434], '20': [1426, 1435], '87755766;': [1427], 'E-mail:': [1428, 1437], '39943495;': [1436], 'EMBO': [1441], 'Journal': [1442], '(2020)39:e103181https://doi.org/10.15252/embj.2019103181': [1443], 'PDFDownload': [1444], 'PDF': [1445], 'article': [1447], 'text': [1448], 'main': [1450], 'figures.': [1451], 'Peer': [1452], 'ReviewDownload': [1453], 'a': [1454, 1509, 1525, 1565, 1584, 1636, 1701, 1725, 1749, 1847, 1867, 1915, 1990, 2033, 2097, 2112, 2130, 2136, 2272, 2290, 2393, 2459, 2666, 2985, 3064, 3112, 3130, 3180, 3238, 3337, 3468, 3850, 3923, 3930, 4112], 'summary': [1455], 'the': [1457, 1513, 1575, 1618, 1644, 1659, 1670, 1793, 1838, 1876, 1950, 1954, 1975, 1984, 2010, 2014, 2043, 2058, 2076, 2120, 2144, 2154, 2157, 2283, 2302, 2305, 2320, 2336, 2340, 2351, 2368, 2411, 2427, 2437, 2440, 2474, 2487, 2501, 2532, 2559, 2565, 2637, 2690, 2698, 2738, 2935, 2945, 2949, 2976, 2994, 3009, 3017, 3022, 3034, 3153, 3187, 3209, 3225, 3247, 3353, 3356, 3384, 3401, 3423, 3448, 3488, 3640, 3696, 3715, 3822, 3899, 3941, 3945, 3968, 3973, 3987, 3995, 4008, 4049, 4130, 4151], 'editorial': [1458, 1462], 'decision': [1459, 1463], 'process': [1460], 'including': [1461, 2102, 2186, 2590], 'letters,': [1464], 'reviewer': [1465], 'comments': [1466], 'responses': [1469], 'to': [1470, 1473, 1493, 1663, 1693, 1778, 1809, 1875, 1891, 1900, 1924, 1953, 1993, 2004, 2150, 2375, 2530, 2538, 2564, 2593, 2597, 2602, 2614, 2766, 2776, 3033, 3101, 3151, 3168, 3207, 3231, 3301, 3434, 3634, 3820, 3855, 3895, 4001, 4007, 4116, 4128], 'feedback.': [1471], 'ToolsAdd': [1472], 'favoritesDownload': [1474], 'CitationsTrack': [1475], 'CitationsPermissions': [1476], 'ShareFacebookTwitterLinked': [1477], 'InMendeleyWechatReddit': [1478], 'Figures': [1479], '&': [1480, 1971, 2165, 4099, 4103], 'Info': [1481], 'Abstract': [1482], 'N6-methyladenosine': [1483, 2017], '(m6A)': [1484, 2018], 'is': [1485, 1502, 1506, 1529, 1691, 1705, 1724, 1748, 1771, 1846, 1898, 1914, 1933, 1958, 2032, 3229], 'an': [1486, 1652, 1741, 2026, 2420, 3090, 3143, 3263], 'abundant': [1487], 'nucleotide': [1488], 'modification': [1489, 1573, 1642, 1657, 1690, 1734, 2036, 2178, 2285, 2307, 2353, 3358, 3947], 'mRNA,': [1491], 'known': [1492], 'regulate': [1494], 'mRNA': [1495, 1577, 1622, 1686, 1738, 2408, 2417, 2781, 3727], 'stability,': [1496], 'splicing,': [1497], 'translation,': [1499], 'but': [1500, 3269, 3616, 3876], 'it': [1501, 1505], 'unclear': [1503], 'whether': [1504, 3224, 4108], 'also': [1507, 3141], 'has': [1508, 2024, 2174, 2232, 2286, 2313], 'physiological': [1510], 'role': [1511, 2015, 2303, 2936, 2977, 3066, 3188, 3354, 3823, 3943, 4113], 'intratumoral': [1514, 1721, 1955, 1985, 2327, 3210], 'microenvironment': [1515, 1647, 1673, 1913, 1987, 2329, 3211], 'drug': [1518, 2309, 2588], 'resistance.': [1519, 1699, 1732, 1925, 2491, 2778], 'Here,': [1520], 'we': [1521, 1560, 2258, 2348, 2389, 2509, 2670, 2701, 2942, 2983, 3041, 3078, 3088, 3236, 3364, 3831, 3966], 'find': [1522], 'that': [1523, 1593, 2176, 2261, 2350, 2404, 2635, 2672, 2703, 2720, 2963, 3043, 3080, 3125, 3296, 3487, 3870, 3986, 4069, 4089, 4146], 'METTL3,': [1524, 1570, 1700, 2367, 2636, 3268, 3875, 3880], 'primary': [1526, 1702, 1750, 2369, 2638], 'methyltransferase,': [1528, 1704, 2371, 2642], 'significantly': [1530, 1610, 2644, 2708, 2804, 2966], 'down-regulated': [1531, 2645, 2709, 2736, 2805, 2967], 'human': [1533, 1919, 2238, 2753, 2796, 3977, 4096], 'sorafenib-resistant': [1534, 1708, 2324, 2357, 2361, 2428, 2497, 2560, 2647, 2658, 2739, 2752, 2792, 2826, 2836, 2854, 2875, 2958, 2969, 2986, 3049, 3584, 3594, 3630, 3661, 3843, 3890, 3935], 'hepatocellular': [1535, 1709], 'carcinoma': [1536, 1710, 1746], '(HCC).': [1537, 1711], 'Depletion': [1538, 1712, 2365], 'METTL3': [1540, 1594, 1608, 1667, 1714, 1729, 2063, 2125, 2132, 2141, 2161, 2405, 2432, 2495, 2656, 2675, 2704, 2723, 2734, 2785, 2802, 2815, 2852, 2938, 2952, 2964, 2979, 3044, 3068, 3190, 3216, 3245, 3276, 3282, 3285, 3310, 3318, 3329, 3507, 3518, 3522, 3578, 3582, 3599, 3604, 3615, 3620, 3666, 3671, 3744, 3840, 3848, 3853, 3856, 3909, 3950, 3960, 3971, 4018, 4070, 4139, 4149], 'under': [1541, 1720, 2326, 2468, 2842, 2860, 2882, 3464, 3478, 3569, 3651, 3680, 3707, 4037, 4141], 'hypoxia': [1542, 3134, 4038], 'promotes': [1543, 1674, 1737], 'expression': [1547, 2705, 2782, 2953, 3092, 3242, 3311, 3392, 3728, 4021], 'angiogenesis': [1549, 2379, 3731, 4026], 'genes': [1550, 2535, 2548, 2554, 2624, 2748, 2761, 2773, 3732], 'cultured': [1552, 3706], 'HCC': [1553, 1602, 1615, 1662, 1719, 1811, 1819, 1887, 1932, 2312, 2325, 2358, 2373, 2648, 2683, 2970, 3075, 3113, 3221, 3360, 3369, 3453, 3497, 3512, 3836, 3883, 3992, 4035, 4084], 'cells': [1554, 2821, 2828, 2838, 2856, 2956, 2971, 2995, 3028, 3037, 3051, 3122, 3150, 3261, 3289, 3304, 3321, 3332, 3433, 3454, 3531, 3556, 3560, 3596, 3624, 3627, 3632, 3641, 3663, 3737, 3741, 3837, 3845, 3884, 3892, 3937, 3981, 3993, 4036, 4135], 'activates': [1556, 2160], 'autophagy-associated': [1557], 'pathways.': [1558, 2382], 'Mechanistically,': [1559], 'have': [1561, 4087], 'identified': [1562, 1619, 2390, 2546, 2613, 2634], 'FOXO3': [1563, 1576, 1596, 1621, 1627, 1650, 1685, 1723, 1736, 2391, 2407, 2425], 'as': [1564, 1651, 1799, 1828, 2129, 2143, 2289, 2392, 2483, 2485, 2904, 3087, 3790, 3927, 3929, 4028], 'key': [1566, 2280], 'downstream': [1567, 2395], 'target': [1568, 1654, 1727, 2396], 'with': [1571, 1755, 1765, 1817, 1822, 1866, 1885, 1903, 1938, 2000, 2042, 2096, 2513, 2522, 2549, 2555, 2578, 2678, 2840, 2858, 2996, 3052, 3120, 3148, 3436, 3564, 3597, 3646, 3664, 3675, 3695, 3719, 3743, 3838, 3908, 4093, 4136], '3′-untranslated': [1578], 'region': [1579, 2413], 'increasing': [1580, 1772], 'its': [1581, 1769, 2416], 'stability': [1582, 1739, 2188, 2418], 'YTHDF1-dependent': [1585, 1742, 2421], 'mechanism.': [1586], 'Analysis': [1587], 'clinical': [1589, 2667], 'samples': [1590], 'furthermore': [1591], 'showed': [1592, 2260, 2403, 3400, 3869, 3922, 3998, 4145], 'levels': [1597, 2817, 3159, 3204, 3243, 3308, 3393, 3729, 3752, 3761, 4052], 'are': [1598, 1820, 1830, 2902, 2909, 2917, 3788, 3795, 3803], 'tightly': [1599], 'correlated': [1600], 'patients.': [1603], 'In': [1604, 1792, 2665, 2889, 3769], 'mouse': [1605], 'xenograft': [1606, 3147], 'models,': [1607], 'depletion': [1609, 1668, 3841, 4140], 'enhances': [1611, 1715], 'abolishing': [1617], 'METTL3-mediated': [1620, 1640, 1688, 2398, 3493], 'stabilization,': [1623], 'overexpression': [1625, 3286, 3327, 3523, 3600, 3605, 3667, 3672], 'restores': [1628], 'm6A-dependent': [1629], 'sensitivity.': [1631], 'Collectively,': [1632], 'our': [1633, 2456, 3193, 4066], 'work': [1634], 'reveals': [1635, 2458], 'critical': [1637, 1692, 1726, 2394], 'function': [1638, 2123], 'hypoxic': [1645, 1671, 1912, 1956, 1986, 2328, 2843, 2861, 2883, 3081, 3154, 3570, 3652, 3681, 3708], 'tumor': [1646, 1672, 1677, 1800, 2072, 2363, 3115, 3146, 3165], 'identifies': [1649], 'important': [1653, 2180, 3942], 'therapy.': [1665], 'Synopsis': [1666], 'resistance,': [1676, 2465, 2589, 2941, 2982, 3363], 'progression': [1678, 2266], 'induction': [1680, 1695], 'autophagy.': [1682], 'Stabilization': [1683], 'prevent': [1694], 'downregulated': [1706], 'environment.': [1722], 'during': [1730], 'manner.': [1743, 2422], 'Introduction': [1744], 'Hepatocellular': [1745], '(HCC)': [1747], 'malignancy': [1752], 'patients': [1754, 1884, 2521, 2684], 'chronic': [1756], 'disease': [1758], 'cirrhosis': [1760], '(Villanueva,': [1761], '2019),': [1762], 'compared': [1764, 1874, 1937, 2563, 3167, 4006], 'most': [1766], 'solid': [1767, 1921], 'tumors': [1768, 1922, 2512, 2541, 2562, 2568, 2660, 3098, 3128], 'incidence': [1770], 'worldwide': [1773], 'year': [1774, 1776], 'due': [1777], 'hepatitis': [1779], 'viruses': [1780], '(HBV': [1781], 'HCV)': [1783], 'infection': [1784], 'alcohol': [1786], 'use': [1787], '(Siegel': [1788], 'et': [1789, 1813, 1880, 1908, 1946, 2051, 2116, 2169, 2190, 2194, 2199, 2203, 2208, 2213, 2221, 2225, 2241, 2245, 2249, 2253, 2276, 2298], 'al,': [1790, 1814, 1881, 1909, 1947, 2052, 2117, 2170, 2191, 2195, 2200, 2204, 2209, 2214, 2222, 2226, 2242, 2246, 2250, 2254, 2277, 2299], '2019).': [1791, 1815, 2118, 2255, 2278], 'early': [1794], 'stages,': [1795], 'curative': [1796, 1835], 'treatments': [1797], 'such': [1798, 4027], 'resection,': [1801], 'ablation,': [1802], 'transplantation': [1805], 'can': [1806, 2330], 'be': [1807, 2725], 'used': [1808, 4127], 'treat': [1810], '(Yang': [1812], 'Patients': [1816], 'advanced': [1818, 1844, 1886, 1920, 2011, 2711, 2807], 'administrated': [1821], 'topical': [1823], 'treatment': [1824, 1842, 1893, 2296, 2525, 3435, 3474], 'systemic': [1826], 'chemotherapy': [1827], 'they': [1829], 'no': [1831, 3271, 3334], 'longer': [1832], 'eligible': [1833], 'therapies.': [1836], 'Sorafenib,': [1837], 'only': [1839], 'FDA-approved': [1840], 'first-line': [1841], 'HCC,': [1845, 2482, 2508, 3086, 3192, 3830, 3965, 4121], 'multi-target': [1848], 'kinase': [1849], 'inhibitor': [1850], 'Raf': [1852], 'kinases,': [1853], 'vascular': [1854], 'endothelial': [1855, 3980], 'growth': [1856, 1860, 3904], 'factor,': [1857], 'platelet-derived': [1859], 'factor': [1861, 1962], 'receptors,': [1862], 'improves': [1864], 'survival': [1865, 1896, 2680, 3459, 3516, 3658, 3932], 'median': [1868, 1927], 'OS': [1869], 'rate': [1870], '6.5': [1872], 'months': [1873, 1902], 'placebo': [1877], 'group': [1878, 2609], '(Cheng': [1879], '2009).': [1882], 'However,': [1883, 2301, 3315], 'predominantly': [1888, 2034], 'develop': [1889, 1994], 'their': [1895], 'benefit': [1897], 'limited': [1899], '3–5': [1901], 'severe': [1904], 'side': [1905], 'effects': [1906, 2438, 3386], '(Llovet': [1907], '2008).': [1910], 'A': [1911, 2607], 'common': [1916, 3181], 'feature': [1917, 3182], 'linked': [1923], 'O2': [1928], 'partial': [1929], 'pressure': [1930], '6': [1934], 'mm': [1935, 1940], 'Hg': [1936, 1941], '30': [1939], 'normal': [1943, 3248, 3259, 3302, 3526], '(Vaupel': [1945], '2007),': [1948], 'homeostatic': [1951], 'response': [1952, 2592, 2596, 2601, 2765, 2775], 'environment': [1957], 'mediated': [1959, 3948, 4079], 'hypoxia-inducible': [1961], '(HIF-1),': [1963], 'consisting': [1964], 'HIF-1α': [1966, 3095, 3161], 'HIF-1β': [1968], 'subunits': [1969], '(Koh': [1970], 'Powis,': [1972], '2012).': [1973], 'Examining': [1974], 'underlying': [1976], 'mechanisms': [1977, 2338, 2477], 'acquired': [1979, 2514, 2981, 3023], 'toward': [1981, 3029, 3072, 3292, 3361, 3455], 'may': [1988, 2724], 'provide': [1989, 2331], 'new': [1991], 'approach': [1992, 2293], 'individualized': [1995], 'therapeutic': [1996, 2292], 'strategies': [1997], 'coping': [1999], 'investigate': [2005, 2500], 'potential': [2006, 2291, 3065, 3489], 'combination': [2007], 'therapies': [2008], 'HCC.': [2012, 2346, 2731, 3157, 3184, 3213, 3955, 4076], 'Recently,': [2013], 'regulation': [2019, 2322, 4110], 'various': [2021, 2183, 2237, 3241, 3307], 'biological': [2022], 'processes': [2023, 2185], 'been': [2025, 2233, 2287, 2315], 'emerging': [2027], 'focus': [2028], 'investigation.': [2030], 'internal': [2035], 'mammalian': [2040], 'cells,': [2041, 2960], 'features': [2044], 'being': [2046], 'dynamic': [2047], 'reversible': [2049], '(Niu': [2050, 2275, 2297], '2018).': [2053, 2300, 4105], 'functional': [2055, 2387, 3195], 'components': [2056], 'methyltransferase': [2060, 2122], 'complex': [2061], 'include': [2062, 2079], '(methyltransferase-like': [2064, 2067], '3),': [2065], 'METTL14': [2066, 2128, 2134, 2148], '14),': [2068], 'WTAP': [2070], '(Wilms': [2071], '1-associated': [2073], 'protein),': [2074], 'while': [2075, 2147, 3326], 'demethylases': [2078], 'FTO': [2080, 2262], '(fat': [2081], 'mass': [2082], 'obesity-associated': [2084], 'protein)': [2085], 'ALKBH5': [2087], '(a-ketoglutarate-dependent': [2088], 'dioxygenase': [2089], 'alkB': [2090], 'homolog': [2091], '5).': [2092], 'binding': [2094], 'proteins': [2095], 'YT521-B': [2098], 'homology': [2099], '(YTH)': [2100], 'domain,': [2101], 'YTHDC1,': [2103], 'YTHDC2,': [2104], 'YTHDF1,': [2105], 'YTHDF2,': [2106], 'YTHDF3,': [2108], 'recognize': [2109], 'methylation-dependent': [2113], 'manner': [2114, 2274], '(Zaccara': [2115], 'Furthermore,': [2119], 'strictly': [2126], 'requires': [2127], 'co-activator.': [2131], 'form': [2135], 'holoenzyme': [2138], 'complex,': [2139, 2158], 'where': [2140], 'functions': [2142], 'catalytic': [2145, 3580, 3602, 3618, 3669, 3851, 3878], 'subunit,': [2146], 'binds': [2149], 'substrates,': [2152], 'stabilizes': [2153], 'structure': [2155, 2206], 'via': [2162], 'allostery': [2163], '(Sledz': [2164], 'Jinek,': [2166], '2016;': [2167, 2223], 'Wang': [2168, 2193], '2016a,b).': [2171], 'Emerging': [2172], 'evidence': [2173], 'shown': [2175, 4088], 'plays': [2179], 'roles': [2181, 2616], 'cellular': [2184, 2591], '(Schwartz': [2189], '2014;': [2192], '2014),': [2196], 'translation': [2197], '(Wang': [2198], '2015;': [2201], 'Zhou': [2202], '2015),': [2205, 2210], '(Liu': [2207], 'localization': [2211], '(Fustin': [2212], '2013),': [2215], 'alternative': [2216], 'polyadenylation,': [2217], 'splicing': [2219], '(Haussmann': [2220], 'Lence': [2224], '2016).': [2227], 'Dysregulation': [2228], 'frequently': [2234], 'reported': [2235], 'cancers': [2239, 4097], '(Cui': [2240], '2017;': [2243, 2247], 'Li': [2244], 'Liu': [2248], '2018;': [2251], 'For': [2256], 'example,': [2257], 'previously': [2259], 'induced': [2263, 2430, 3290, 4050], 'breast': [2264], 'demethylation': [2268], 'BNIP3': [2270], 'YTHDF2-independent': [2273], 'Targeting': [2279], 'regulators': [2281], 'discussed': [2288], 'not': [2314, 3299, 3617, 3877], 'fully': [2316], 'described.': [2317], 'Thus,': [2318], 'examining': [2319], 'comprehensive': [2333], 'insights': [2334, 2472], 'into': [2335, 2473], 'molecular': [2337, 2476, 2502, 3490], 'occurrence': [2341], 'Herein,': [2347], 'discovered': [2349], 'was': [2354, 2612, 2643, 2676, 2707, 2735, 2803, 2965, 3045, 3179, 3298, 3498, 3642, 4091, 4126], 'decreased': [2355, 3054], 'cells.': [2364, 3076, 3586], 'enhanced': [2372, 2415, 3217, 3508, 4072], 'activating': [2378], 'Using': [2383], 'MeRIP-Seq': [2384], 'analysis': [2385, 2577, 2744], 'studies,': [2388], 'modification.': [2400], 'Our': [2401, 3867, 3983, 4143], 'results': [2402, 2718, 3868, 3900, 3984, 4067, 4144], 'promoted': [2406, 3323], '3′UTR': [2412], 'Overexpression': [2423, 3575], 'rescued': [2426], 'phenotype': [2429], 'depletion.': [2433], 'We': [2434, 2545, 2633, 2651, 3020, 3110, 3140, 3399, 3445, 3466, 4046], 'further': [2435, 2652, 3351, 3446, 3957, 4047], 'validated': [2436, 2653], 'METTL3/FOXO3': [2441], 'axis': [2442], 'on': [2443, 2745, 3972], 'both': [2447, 3388], 'vitro': [2449, 2991, 3198], 'vivo': [2452], 'experiments.': [2453, 2914, 3800], 'Taken': [2454, 4064], 'together,': [2455, 4065], 'study': [2457], 'connection': [2460], 'modification,': [2463], 'hypoxia,': [2469], 'provides': [2471], 'multiple': [2475], 'well': [2484, 3928], 'expanding': [2486], 'understanding': [2488], 'therapy': [2490], 'Results': [2492], 'Down-regulation': [2493], 'HCCs': [2498, 2714, 2740, 3477, 3702, 3705, 3907], 'To': [2499, 2933, 2974, 3185, 3222, 3350, 3956, 4106], 'mechanism': [2503, 3491], 'obtained': [2510], '(n': [2517, 2542, 2788, 2793, 2822, 2829], '=': [2518, 2543, 2789, 2794, 2823, 2830], '3)': [2519, 2790, 2795, 2824], 'from': [2520, 2812, 3700, 3991], 'long-term': [2523], 'performed': [2527, 3142, 3832], 'transcriptome': [2528], 'sequencing': [2529], 'examine': [2531, 3186], 'differentially': [2533, 2746], 'expressed': [2534, 2747, 2772], 'comparison': [2537], 'sorafenib-sensitive': [2539, 2566, 2750, 2787], '3).': [2544], '819': [2547], 'significant': [2550, 2556], 'up-regulation': [2551], '775': [2553], 'down-regulation': [2557, 2654, 2673, 2721], '(Appendix': [2569, 2685, 3105, 3135, 3171, 3253, 3312, 3345, 3394, 3419, 3461, 3483, 3858, 3911, 3919], 'Fig': [2570, 2686, 3106, 3136, 3172, 3254, 3313, 3346, 3395, 3420, 3443, 3462, 3484, 3859, 3912, 3920, 4044], 'S1A': [2571], 'Table': [2573], 'EV2).': [2574], 'Gene': [2575, 2742], 'enrichment': [2576, 2743], 'KOBAS': [2579], 'highlighted': [2580], 'dysregulation': [2581], 'several': [2583], 'signaling': [2584, 2629, 2763], 'pathways': [2585, 2630, 2764], 'involved': [2586], 'chemical': [2594], 'stimulus,': [2595], 'organic': [2598], 'substance,': [2599], 'nitrogen': [2603], 'compound': [2604], '(Fig': [2605, 2631, 2649, 2663, 2715, 2972, 3038, 3059, 3277, 3438, 3863, 3885, 3893, 3938, 4011, 4039, 4060, 4155], '1A).': [2606], 'novel': [2608], 'transferase': [2611], 'play': [2615], 'cancer.': [2622], '13': [2623], 'overlapped': [2625, 2760, 2771], 'these': [2627, 3026, 3409], 'four': [2628], '1B).': [2632], 'component': [2639], '1C).': [2650], 'RT–PCR': [2662, 3747], '1D).': [2664], 'outcome': [2668], 'analysis,': [2669], 'found': [2671, 2702, 2962, 3042, 3124], 'associated': [2677, 4092], 'lower': [2679], 'rates': [2681], 'S1B).': [2687], 'By': [2688], 'analyzing': [2689], 'pathological': [2691], 'stage': [2692, 2808], 'plot': [2693], 'TCGA': [2699], 'database,': [2700], 'level': [2706, 2783, 2850, 2870, 3058, 3093, 3132, 3228, 3407, 3592], 'stages': [2712], '1E).': [2716], 'These': [2717], 'indicate': [2719], 'implicated': [2726], 'Figure': [2732, 2926, 3503, 3812], '1.': [2733], 'A.': [2741], 'between': [2749, 2818], 'tumors.': [2755, 2798], 'B.': [2756, 3514], 'Venn': [2757], 'diagrams': [2758], 'show': [2759], 'sorafenib.': [2767], 'C.': [2768], 'Heatmap': [2769], 'D.': [2779, 3550], 'E.': [2799, 3574], 'Expression': [2800], 'TCGA.': [2813], 'F.': [2814, 3587], 'naïve': [2819, 2872, 3035], 'HepG-2': [2820, 2827, 2837, 2855, 2873, 2876, 2955, 2959, 3036, 3050, 3379, 3432, 3585, 3595, 3631, 3662, 3844, 3891, 3936], '10).': [2831], 'G.': [2832], 'IC50': [2834, 3018, 3471, 3552, 3638], 'treated': [2839, 2857, 3563, 3645, 3674, 3694], 'condition': [2844, 2862, 2884, 3082, 3155, 3480, 3537, 3571, 3653, 3682], '(1%': [2845, 2863, 2885, 3205, 3572, 3654, 3683], 'O2).': [2846, 2864, 2886, 3573, 3655, 3684], 'H.': [2847], 'protein': [2849, 3389, 3751, 3760, 4051], 'I.': [2865], 'global': [2867, 3055, 3226, 3404, 3589], 'determined': [2877, 3967], 'dot': [2879, 3416, 3607], 'blotting': [2880, 3608], 'assay': [2881, 3340, 3418, 3659, 3905, 3933], 'Data': [2887, 2901, 2924, 3767, 3787, 3810], 'information:': [2888, 3768], 'all': [2890, 3770], 'relevant': [2891, 3771], 'panels,': [2892, 3772], '***P': [2893, 3779], '<': [2894, 2897, 3774, 3777, 3780, 3783], '0.001;': [2895, 3781], '****P': [2896, 3782], '0.0001;': [2898, 3784], 'two-tailed': [2899, 3785], 't-test.': [2900, 3786], 'presented': [2903, 3789], 'mean': [2905, 3791], '±': [2906, 3792], 'SD': [2907, 3793], 'representative': [2910, 3796], 'three': [2912, 3798], 'independent': [2913, 3799], 'Source': [2915, 2923, 3801, 3809], 'data': [2916, 3802], 'available': [2918, 3804], 'online': [2919, 3805], 'figure.': [2922, 3808], '1': [2927, 3687], '[embj2019103181-sup-0005-SDataFig1.pdf]': [2928], 'Download': [2929, 2931, 3815, 3817], 'figure': [2930, 3816], 'PowerPoint': [2932, 3818], 'confirm': [2934], 'systematically': [2943], 'analyzed': [2944], 'GSE62813': [2946], 'database': [2947], 'change': [2950, 3273], '1F).': [2973], 'validate': [2975, 3152], 'generated': [2984, 3237], 'HepG2': [2987, 3027], 'cell': [2988, 3250, 3324, 3338, 3342, 3370, 3413, 3458, 3528, 3903, 3931], 'line': [2989, 3251, 3529], 'exposing': [2993], 'at': [2998, 3201], '5%': [2999, 3012], 'IC': [3001, 3014], 'concentration': [3002, 3010], '3': [3004], 'days': [3005, 3534], 'gradually': [3007], 'increased': [3008, 3424, 3470, 3999, 4150], 'until': [3015], 'reaching': [3016], 'concentration.': [3019], 'confirmed': [3021, 3383, 3447, 4048], 'comparing': [3032, 3100], '1G).': [3039], 'Importantly,': [3040], 'markedly': [3046], 'reduced': [3047], 'consistently': [3053], '1H': [3060], 'I),': [3062], 'indicating': [3063, 3176, 3295, 3940], 'mediating': [3070], 'Moreover,': [3077, 3819, 4015], 'noticed': [3079, 3467], 'extensively': [3083], 'existed': [3084], 'observed': [3089], 'elevated': [3091], 'when': [3099], 'non-tumor': [3102, 3169], 'tissues': [3104], 'S1C': [3107], 'D).': [3109], 'established': [3111], 'subcutaneous': [3114], 'model': [3116], 'nude': [3118], 'mice': [3119], 'SMMC-7721': [3121, 3555, 3623, 3736, 4134], '80%': [3126], 'exhibited': [3129], 'higher': [3131], 'S1E': [3137], 'F).': [3139, 3866], 'orthotopic': [3144], 'Bel-7402': [3149, 3375, 3559, 3626, 3740], 'Higher': [3158], 'were': [3162, 3199, 3733], 'detected': [3163, 3734], 'tissue': [3166, 3170], 'S1G': [3173], 'G1),': [3175], 'oxygen': [3177, 3203], 'deprivation': [3178], 'following': [3194], 'experiments': [3196, 3834], 'conducted': [3200], 'low': [3202], 'O2)': [3206, 3482, 3539], 'mimic': [3208], 'Knockdown': [3214, 3505], 'evaluate': [3223], 'related': [3230], 'tumorigenesis': [3232], 'cancer,': [3235], 'series': [3239], 'WRL68': [3252, 3288, 3320, 3331, 3530], 'S2A': [3255], 'B).': [3257, 3280], 'formed': [3262], 'enlarged': [3264], 'colony': [3265], 'after': [3266, 3274, 3562, 3644, 3673], 'silencing': [3267], 'had': [3270, 3333], 'meaningful': [3272], 'overexpressing': [3275], '2A': [3278], 'Neither': [3281], 'knockdown': [3283, 3316, 3385, 3519, 3745, 3910, 4016, 4147], 'nor': [3284], 'sensitivity': [3291, 3425], 'treatment,': [3294], 'toxic': [3300], 'regardless': [3305], 'S2C).': [3314], 'moderately': [3322, 3469], 'growth,': [3325], 'effect': [3335], 'proliferation': [3339], 'number': [3343, 3716, 4152], 'counting': [3344], 'S2D': [3347], 'E).': [3349], 'explore': [3352], 'constructed': [3365], 'six': [3366, 3410], 'stable': [3367, 3411, 3839], 'METTL3-depeleted': [3368], 'lines': [3371, 3414], '(SMMC-7721': [3372], '#sh1': [3373, 3376, 3380], '#sh2,': [3374, 3377], '#sh2)': [3381], 'S2F': [3396], 'G).': [3398], 'decrease': [3402], 'METTL3-depleted': [3412], 'blot': [3417, 4059], 'S2H),': [3421], '(IC50)': [3426], 'METTL3-knockdown': [3428, 3452, 3476, 3554, 3622, 3704, 3756, 3765, 3882, 3996], 'SMMC-7721,': [3429], 'Bel-7402,': [3430], '2C': [3439], 'D,': [3441], 'Appendix': [3442, 4043], 'S2I).': [3444], 'resistant': [3449], 'phenotypes': [3450], 'assays': [3460], 'S2J–L)': [3463], 'hypoxia.': [3465, 3502, 4142], 'normoxic': [3479, 3536], '(21%': [3481, 3538], 'S2M–O),': [3485], 'excluding': [3486], 'mainly': [3499], 'caused': [3500], '2.': [3504], 'A,': [3513], 'Clonogenic': [3515], '(A)': [3520], '(B)': [3524], '7': [3533], 'quantification': [3541], 'clusters': [3543], 'A-1': [3545], 'B-1,': [3547], 'respectively.': [3548], 'C,': [3549], '(C)': [3557], '(D)': [3561], '24': [3567, 3649, 3678], 'h': [3568, 3650, 3679], 'wild-type': [3577, 3598, 3614, 3665, 3847, 3874], 'or': [3579, 3601, 3668, 3916, 4137], 'mutant': [3581, 3603, 3619, 3670, 3852, 3879], 'assay.': [3609, 3748], 'G–I.': [3610], 'Rescue': [3611], 'shRNA-resistant': [3613, 3873], 'sensitized': [3621], '(G),': [3625], '(H),': [3628], '(I)': [3633], 'treatment.': [3636, 3897], 'measured': [3643], 'J.': [3656], 'Cell': [3657], 'Scale': [3685], 'bar,': [3686], 'mm.': [3688], 'K.': [3689], 'Capillary-like': [3690], 'structures': [3691], 'HUVECs': [3693], 'tumor-conditioned': [3697, 3988], 'medium': [3698, 3989], '(TCM)': [3699, 3990], 'control': [3701, 4009], 'conditions': [3709], '48': [3711], 'h.': [3712], 'Quantification': [3713], 'tubes': [3718], 'ImageJ': [3720], 'K-1.': [3722], 'L,': [3723], 'M.': [3724], 'relative': [3726], '(L)': [3738], '(M)': [3742], 'N.': [3749], 'VEGF-A': [3754, 4033, 4054], 'HCCs.': [3757, 3766], 'O.': [3758], 'PDGF-B': [3763, 4056], '*P': [3773], '0.05;': [3775], '**P': [3776], '0.01;': [3778], '2': [3813], '[embj2019103181-sup-0006-SDataFig2.pdf]': [3814], 'determine': [3821, 3958, 4107], 'rescue': [3833, 3871], 'using': [3846], '(resistant': [3854], 'shRNA)': [3857], 'S2P': [3860], 'Q)': [3862], '2E': [3864], 'sensitizes': [3881], '2G': [3886], 'H)': [3888], '2I)': [3894], 'Consistently,': [3898], 'CCK8': [3902], 'S2R': [3913], 'S)': [3915], 'S2T)': [3921], 'similar': [3924], 'rescuing': [3925], 'tendency,': [3926], '2J),': [3939], 'how': [3959], 'controls': [3961], 'influence': [3969], 'tube-forming': [3974], 'ability': [3975], 'umbilical': [3978], 'vein': [3979], '(HUVECs).': [3982], 'revealed': [3985], 'groups': [3997, 4010], 'capacity': [4000], 'stimulate': [4002], 'HUVEC': [4003], 'tube': [4004], 'formation': [4005], '2K': [4012], 'K-1).': [4014], 'up-regulated': [4019], 'some': [4023], 'biomarkers': [4024], 'FGF,': [4029], 'PDGF-B,': [4030], 'STAT3,': [4031], '2L': [4040], 'M,': [4042], 'S2U).': [4045], 'Western': [4058], '2N': [4061], 'O).': [4063], 'demonstrate': [4068], 'deletion': [4071], 'Autophagy': [4077], 'aberration': [4078], 'METTL3-dependent': [4080], 'Previous': [4085], 'reports': [4086], 'chemo-resistance': [4094], '(Levine': [4098], 'Kroemer,': [4100], '2008;': [4101], 'Doherty': [4102], 'Baehrecke,': [4104], 'played': [4111], 'mediate': [4117], 'transmission': [4122], 'electron': [4123], 'microscopy': [4124], '(TEM)': [4125], 'observe': [4129], 'morphological': [4131], 'changes': [4132], 'without': [4138], 'autophagosomes': [4154], '3A),': [4156], 'sugg': [4157]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3020963897', 'counts_by_year': [{'year': 2024, 'cited_by_count': 68}, {'year': 2023, 'cited_by_count': 89}, {'year': 2022, 'cited_by_count': 96}, {'year': 2021, 'cited_by_count': 64}, {'year': 2020, 'cited_by_count': 11}], 'updated_date': '2024-12-22T03:12:47.097311', 'created_date': '2020-05-13'}