Homeostatic and pathogenic roles of <scp>GM</scp> 3 ganglioside molecular species in <scp>TLR</scp> 4 signaling in obesity

Name: Work Video:
Duration: 3 min 30 s
Hirotaka Kanoh; Takahiro Nitta; Shinji Go; Kei‐ichiro Inamori; Lucas Veillon; Wataru Nihei; Mayu Fujii; Kazuya Kabayama; Atsushi Shimoyama; Koichi Fukase; Umeharu Ohto; Toshiyuki Shimizu; Taku Watanabe; Hiroki Shindo; Sorama Aoki; Kenichi Sato; Masao Nagasaki; Yutaka Yatomi; Naoko Komura; Hiromune Ando; Hideharu Ishida; Makoto Kiso; Yoshihiro Natori; Yuichi Yoshimura; Asia Zonca; Anna Giulia Cattaneo; Marilena Letizia; Maria Grazia Ciampa; Laura Mauri; Alessandro Prinetti; Sandro Sonnino; Akemi Suzuki; Jin‐ichi Inokuchi
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'Graduate': [187, 209, 231, 253, 272, 293, 418, 444, 1011, 1033, 1055, 1077, 1096, 1117, 1242, 1268, 1755, 1796, 1811], 'School': [188, 210, 232, 254, 273, 294, 419, 445, 1012, 1034, 1056, 1078, 1097, 1118, 1243, 1269, 1756, 1764, 1797, 1812], 'Science,': [190, 212, 234, 256, 318, 341, 365, 388, 1014, 1036, 1058, 1080, 1142, 1165, 1189, 1212, 1758, 1777], 'Osaka': [191, 213, 235, 257, 1015, 1037, 1059, 1081, 1759], 'Osaka,': [193, 215, 237, 259, 1017, 1039, 1061, 1083, 1761], 'Kazuya': [202, 204, 1026, 1028, 1682], 'Kabayama': [203, 205, 1027, 1029], 'Atsushi': [224, 226, 1048, 1050, 1684], 'Shimoyama': [225, 227, 1049, 1051], 'Koichi': [246, 248, 1070, 1072, 1686], 'Fukase': [247, 249, 1071, 1073], 'Umeharu': [268, 270, 1092, 1094, 1688], 'Ohto': [269, 271, 1093, 1095], 'Sciences,': [276, 297, 541, 1100, 1121, 1365, 1767, 1845], 'University': [277, 298, 423, 449, 633, 656, 679, 702, 725, 748, 771, 1101, 1122, 1247, 1273, 1457, 1480, 1503, 1526, 1549, 1572, 1595, 1768, 1801, 1816, 1880, 1906], 'Tokyo,': [279, 280, 300, 301, 425, 426, 451, 452, 1103, 1104, 1124, 1125, 1249, 1250, 1275, 1276, 1770, 1771, 1803, 1804, 1818, 1819, 1920], 'Toshiyuki': [289, 291, 1113, 1115, 1690], 'Shimizu': [290, 292, 1114, 1116], 'Taku': [310, 312, 1134, 1136, 1692], 'Watanabe': [311, 313, 1135, 1137], 'Information': [317, 340, 364, 387, 1141, 1164, 1188, 1211, 1667, 1776], 'Hiroki': [333, 335, 1157, 1159, 1694], 'Shindo': [334, 336, 1158, 1160], 'Sorama': [356, 358, 1180, 1182, 1696], 'Aoki': [357, 359, 1181, 1183], 'orcid.org/0000-0002-1148-2688': [360, 1184], 'Kenichi': [380, 382, 1204, 1206, 1698], 'Sato': [381, 383, 1205, 1207], 'Mika': [403, 405, 1227, 1229, 1700], 'Nagasaki': [404, 406, 1228, 1230, 1918], 'Cardiovascular': [409, 1233, 1787], 'Medicine': [410, 1234, 1788], 'Computational': [412, 1236, 1790, 1903, 3028], 'Diagnostic': [413, 1237, 1791], 'Radiology': [414, 1238, 1792], '&': [415, 1239, 1793, 1979, 2348, 2476, 2868], 'Preventive': [416, 1240, 1794], 'Medicine,': [417, 421, 443, 447, 632, 655, 678, 701, 724, 747, 770, 1241, 1245, 1267, 1271, 1456, 1479, 1502, 1525, 1548, 1571, 1594, 1795, 1799, 1810, 1814, 1879], 'The': [422, 448, 1246, 1272, 1800, 1815, 1905, 1939, 3366], 'Yutaka': [435, 437, 1259, 1261, 1702], 'Yatomi': [436, 438, 1260, 1262], 'Clinical': [441, 1265, 1808], 'Laboratory': [442, 1266, 1809], 'Naoko': [461, 463, 1285, 1287, 1704], 'Komura': [462, 464, 1286, 1288], 'Center': [465, 491, 517, 1289, 1315, 1341], 'Highly': [467, 493, 519, 1291, 1317, 1343, 1823], 'Advanced': [468, 494, 520, 1292, 1318, 1344, 1824], 'Integration': [469, 495, 521, 1293, 1319, 1345, 1825], 'Nano': [471, 497, 523, 1295, 1321, 1347, 1827], 'Life': [473, 499, 525, 1297, 1323, 1349, 1829], 'Sciences': [474, 500, 526, 1298, 1324, 1350, 1830], '(G-CHAIN),': [475, 501, 527, 1299, 1325, 1351, 1831], 'Gifu': [476, 502, 528, 542, 563, 1300, 1326, 1352, 1366, 1387, 1832, 1846, 1856], 'Gifu,': [478, 504, 530, 544, 565, 1302, 1328, 1354, 1368, 1389, 1834, 1848, 1858], 'Hiromune': [487, 489, 1311, 1313, 1706], 'Ando': [488, 490, 1312, 1314], 'Hideharu': [513, 515, 1337, 1339, 1708], 'Ishida': [514, 516, 1338, 1340], 'Applied': [534, 539, 1358, 1363, 1838, 1843], 'Bio-organic': [535, 1359, 1839], 'Faculty': [537, 1361, 1841], 'Biological': [540, 1364, 1844], 'Makoto': [553, 555, 1377, 1379, 1710], 'Kiso': [554, 556, 1378, 1380], 'Organization': [557, 1381], 'Research': [559, 1383, 1852], 'Community': [561, 1385, 1854], 'Development,': [562, 1386, 1855], 'Yoshihiro': [574, 576, 1398, 1400, 1712], 'Natori': [575, 577, 1399, 1401], 'Organic': [580, 604, 1404, 1428, 1862], 'Yuichi': [598, 600, 1422, 1424, 1714], 'Yoshimura': [599, 601, 1423, 1425], 'Asia': [622, 624, 1446, 1448, 1716], 'Zonca': [623, 625, 1447, 1449], 'Biotechnology': [629, 652, 675, 698, 721, 744, 767, 1453, 1476, 1499, 1522, 1545, 1568, 1591, 1876], 'Translational': [631, 654, 677, 700, 723, 746, 769, 1455, 1478, 1501, 1524, 1547, 1570, 1593, 1878], 'Milan,': [635, 658, 681, 704, 727, 750, 773, 1459, 1482, 1505, 1528, 1551, 1574, 1597, 1882], 'Milano,': [636, 659, 682, 705, 728, 751, 774, 1460, 1483, 1506, 1529, 1552, 1575, 1598, 1883], 'Italy': [637, 660, 683, 706, 729, 752, 775, 1461, 1484, 1507, 1530, 1553, 1576, 1599, 1884], 'Anna': [645, 647, 1469, 1471, 1718], 'Cattaneo': [646, 648, 1470, 1472], 'Marilena': [668, 670, 1492, 1494, 1720], 'Letizia': [669, 671, 1493, 1495], 'Maria': [691, 693, 1515, 1517, 1722], 'Ciampa': [692, 694, 1516, 1518], 'Laura': [714, 716, 1538, 1540, 1724], 'Mauri': [715, 717, 1539, 1541], 'Alessandro': [737, 739, 1561, 1563, 1726], 'Prinetti': [738, 740, 1562, 1564], 'Sandro': [760, 762, 1584, 1586, 1728], 'Sonnino': [761, 763, 1585, 1587], 'Akemi': [783, 785, 1607, 1609, 1730], 'Suzuki': [784, 786, 1608, 1610], 'Jin-ichi': [810, 814, 1634, 1638, 1733], 'Inokuchi': [811, 815, 1635, 1639, 1734], 'Corresponding': [812, 1636], 'Author': [813, 1637, 1666], '[email': [816, 1640, 1937], 'protected]': [817, 1641, 1938], 'orcid.org/0000-0002-0703-5746': [818, 1642], 'Kanoh1,‡,': [1669], 'Nitta1,‡,': [1671], 'Go1,†,': [1673], 'Inamori1,': [1675], 'Veillon1,†,': [1677], 'Nihei1,': [1679], 'Fujii2,': [1681], 'Kabayama2,': [1683], 'Shimoyama2,': [1685], 'Fukase2,': [1687], 'Ohto3,': [1689], 'Shimizu3,': [1691], 'Watanabe4,': [1693], 'Shindo4,': [1695], 'Aoki4,': [1697], 'Sato4,': [1699], 'Nagasaki5,†,': [1701], 'Yatomi6,': [1703], 'Komura7,': [1705], 'Ando7,': [1707], 'Ishida7,8,': [1709], 'Kiso9,': [1711], 'Natori10,': [1713], 'Yoshimura10,': [1715], 'Zonca11,': [1717], 'Cattaneo11,': [1719], 'Letizia11,': [1721], 'Ciampa11,': [1723], 'Mauri11,': [1725], 'Prinetti11,': [1727], 'Sonnino11,': [1729], 'Suzuki1': [1731], '*,1': [1735], '1Division': [1736], '2Department': [1752], '3Graduate': [1763], '4Medical': [1773], '5Department': [1785], '6Department': [1806], '7Center': [1821], '8Department': [1836], '9Organization': [1850], '10Division': [1860], '11Department': [1873], '†Present': [1885, 1897, 1916], 'address:': [1886, 1898, 1917], 'Pathophysiology': [1889], 'Metabolism,': [1891], 'Kawasaki': [1892], 'School,': [1894], 'Okayama,': [1895], 'Bioinformatics': [1901], 'Biology,': [1904], 'Texas': [1908], 'MD': [1909], 'Anderson': [1910], 'Cancer': [1911], 'Center,': [1912], 'Houston,': [1913], 'TX,': [1914], 'USA': [1915], 'Clinic,': [1919], '‡These': [1922], 'authors': [1923], 'contributed': [1924], 'equally': [1925], 'to': [1926, 1969, 1972, 2002, 2129, 2152, 2294, 2440, 2558, 2667, 2980, 3040, 3265, 3372, 3452, 3468, 3541, 3819, 3945, 3957, 4038, 4128], 'work': [1928], '*Corresponding': [1929], 'author.': [1930], 'Tel:': [1931], '+81': [1932], '22': [1933], '727': [1934], '0117;': [1935], 'E-mail:': [1936], 'EMBO': [1940], 'Journal': [1941], '(2020)39:e101732https://doi.org/10.15252/embj.2019101732': [1942], 'PDFDownload': [1943], 'PDF': [1944], 'article': [1946], 'text': [1947], 'main': [1949], 'figures.': [1950], 'Peer': [1951], 'ReviewDownload': [1952], 'a': [1953, 2019, 2164, 2214, 2302, 2318, 2461, 2482, 2511, 2521, 2738, 2803, 2852, 3079, 3092, 3232, 3482, 3561, 3753, 3831, 3987, 4151], 'summary': [1954], 'the': [1956, 1996, 2077, 2123, 2153, 2186, 2195, 2469, 2547, 2671, 2775, 2785, 2954, 3047, 3054, 3087, 3114, 3236, 3258, 3261, 3295, 4034], 'editorial': [1957, 1961], 'decision': [1958, 1962], 'process': [1959], 'including': [1960, 2024, 2219, 2323, 2428, 2673, 2720], 'letters,': [1963], 'reviewer': [1964], 'comments': [1965], 'responses': [1968], 'feedback.': [1970], 'ToolsAdd': [1971], 'favoritesDownload': [1973], 'CitationsTrack': [1974], 'CitationsPermissions': [1975], 'ShareFacebookTwitterLinked': [1976], 'InMendeleyWechatReddit': [1977], 'Figures': [1978], 'Info': [1980], 'Abstract': [1981], 'Innate': [1982], 'immune': [1983, 2340, 2947], 'via': [1985, 2200], 'plays': [1987, 2312, 2788, 3078], 'critical': [1988, 2313], 'pathogenesis': [1991, 2316, 2792, 3757], 'metabolic': [1993, 2003, 2058, 2235, 2324, 2359, 2758, 2794, 2983, 3026, 3110, 3122, 3386, 3663, 3759, 3777, 3815, 3837, 4072, 4140], 'disorders,': [1994, 2059, 2360, 3123, 4141], 'but': [1995, 2924, 3360], 'contribution': [1997], 'different': [1999, 2042, 2972], 'lipid': [2000, 2446], 'disorders': [2004, 2325, 2759, 2795, 3111, 3387, 3664, 3778, 3838, 4073], 'inflammatory': [2006, 2196, 2976], 'diseases': [2007], 'is': [2008, 2016, 2085, 2163, 2211, 2529, 2648, 2665, 2801, 2811, 2892, 2897, 3066, 3091, 4084], 'less': [2009], 'clear.': [2010], 'human': [2014, 2035, 2178, 2209, 2321, 2544, 2567, 2580, 2652, 3133, 3146], 'serum': [2015, 2036, 2062, 2179, 2210, 2370, 2545, 2618, 2653, 2691, 2968, 3076, 3129, 3204, 3277, 3317, 3413, 3473, 3622, 3657, 3939, 3948, 3962], 'composed': [2017, 2212, 2694], 'variety': [2020, 2215, 2319, 2483], 'fatty': [2022, 2187, 2217, 2396, 2473, 2697, 2705], 'acids,': [2023], 'long-chain': [2025, 2220, 2224, 2696], '(LCFA)': [2026, 2221], 'very-long-chain': [2028, 2704], '(VLCFA).': [2029, 2225], 'Analysis': [2030, 2172], 'circulating': [2032], 'levels': [2033, 2052, 2063, 2074, 2228, 2232, 3275], 'from': [2039, 2413, 2555, 2817, 3145], 'patients': [2040, 2756], 'at': [2041, 3461], 'stages': [2043], 'insulin': [2045, 2441, 2879, 2890, 2922, 2951, 3200, 3213, 3269, 4018, 4105], 'resistance': [2046, 2442, 2923, 3201, 3214, 3270, 4019], 'chronic': [2048, 2181, 2356, 2926, 3107, 3216, 3272, 3406, 3840, 4021, 4062, 4102], 'inflammation': [2049, 2182, 2311, 2927, 3108, 3407, 3841, 4022, 4103], 'reveals': [2050, 2184], 'that': [2051, 2136, 2161, 2185, 2278, 2782, 2940, 2988, 3034, 3062, 3075, 3257, 3743, 3806], 'VLCFA-GM3': [2054, 2073, 2103, 2116, 2137, 2162, 2227, 2247, 2259, 2299, 2996, 3013, 3018, 3043, 3090, 3100, 3567, 3570, 3574, 3746, 3787, 3855, 3984, 4010], 'increase': [2055, 2075, 2229, 3055, 3088, 3234, 3301, 3732, 3795, 3989, 4098], 'significantly': [2056, 3020], 'while': [2060, 2112], 'LCFA-GM3': [2061, 2113, 2139, 2231, 2281, 3022, 3565], 'decrease.': [2064], 'Specific': [2065], 'also': [2068, 2802, 2925, 3044, 4012], 'correlates': [2069], 'with': [2070, 2122, 2265, 2621, 2656, 2757, 3169, 3176, 3184, 3225, 3312, 3682, 3721, 3893, 3991, 4002, 4015, 4045, 4101], 'disease': [2071, 2169, 2307, 3097, 3403, 3579, 3860, 4129], 'symptoms.': [2072, 3042], 'adipose': [2078, 2416, 2818, 2929, 3048], 'tissue': [2079, 2819, 2930, 3049], 'obese': [2081, 3051], 'mice,': [2082, 3060], 'blocked': [2086, 2898], 'TLR4-mutant': [2088, 3059], 'mice.': [2089], 'In': [2090, 2358, 2962, 3761, 4032, 4080], 'cultured': [2091], 'monocytes,': [2092], 'itself': [2095, 2239, 3065], 'has': [2096, 2240, 2752, 2779], 'no': [2097, 2241, 3583, 3864], 'effect': [2098], 'on': [2099, 2243, 2784, 2872], 'activation;': [2101, 2245], 'however,': [2102, 2246, 2764, 2953], 'synergistically': [2104, 2248, 2997], 'selectively': [2106, 2250, 2999], 'enhances': [2107], 'activation': [2109, 2197, 2253, 2333, 3002], 'LPS/HMGB1,': [2111], 'unsaturated': [2115, 2258, 2712, 2734, 3012, 3375, 3533, 3569, 3797, 3849], 'suppresses': [2117], 'activation.': [2119, 2262, 3016], 'interacts': [2121, 2264], 'extracellular': [2124, 2266, 2844], 'region': [2125], 'TLR4/MD2': [2127, 2269], 'complex': [2128, 2534, 2559], 'modulate': [2130], 'dimerization/oligomerization.': [2131, 2273], 'Ligand-molecular': [2132], 'docking': [2133, 2275], 'analysis': [2134, 2562, 2616, 3284, 3411], 'supports': [2135], 'act': [2140, 2282], 'as': [2141, 2283, 2343, 2584, 2632, 2636, 2851, 2991, 3210, 3352, 3455, 3457, 3481, 3549, 3560, 3830, 4112], 'agonist': [2142, 2284], 'antagonist': [2144, 2286], 'activity,': [2147], 'respectively,': [2148, 2290], 'differentially': [2150, 2292], 'binding': [2151, 2293], 'hydrophobic': [2154, 2295], 'pocket': [2155, 2296], 'MD2.': [2157, 2298], 'Our': [2158, 3072], 'findings': [2159, 3073, 3255, 3741, 3804], 'suggest': [2160, 3074, 3742], 'risk': [2165, 2303, 3093], 'factor': [2166, 2304, 3094], 'TLR4-mediated': [2168, 2306, 3096], 'progression.': [2170, 2308, 3098], 'Synopsis': [2171], 'composition': [2176], 'under': [2180], 'conditions': [2183], 'acid': [2188, 2474, 2523, 2698, 2706], 'chain': [2189], 'length': [2190], 'impacts': [2194], 'macrophages': [2199, 2414, 2820], 'direct': [2201], 'modulation': [2202], 'signaling.': [2205], 'acids': [2218, 2397, 2689], 'very': [2223], 'Serum': [2226, 3017], 'decrease': [2233, 3306], 'disorders.': [2236, 2984, 3027, 3760, 3816], 'effects': [2242], 'enhanced': [2251], 'LPS/HMGB1while': [2255], 'LCFA-': [2256], 'suppress': [2260], 'regions': [2267], 'complex,': [2270], 'modulates': [2272], 'Ligand-macromolecular': [2274], 'study': [2276], 'suggested': [2277, 2781], 'VLCFA-': [2279], 'against': [2287], 'activation,': [2289], 'could': [2300, 4116], 'be': [2301, 2943], 'Introduction': [2309], 'Chronic': [2310], 'diseases,': [2322], '(Lumeng,': [2326, 2450], '2011;': [2327, 2350, 2451], 'Hotamisligil,': [2328, 2452], '2017).': [2329, 2453], 'Prolonged': [2330], 'abnormal': [2332, 3584, 3865, 4046], 'pattern': [2335], 'recognition': [2336], 'receptors': [2337, 2345, 2880], 'innate': [2339, 2946], 'system,': [2341], 'such': [2342, 2958, 4111], 'Toll-like': [2344], '(TLR;': [2346], 'Kawai': [2347], 'Akira,': [2349], 'Moresco': [2351], 'et': [2352, 2372, 2388, 2392, 2400, 2407, 2488, 2681, 2685, 2761, 2797, 2822, 2826, 2830, 2886, 2908, 2912, 2932, 2936, 3136], 'al,': [2353, 2373, 2389, 2393, 2401, 2408, 2489, 2682, 2686, 2762, 2798, 2823, 2827, 2831, 2887, 2909, 2913, 2933, 2937, 3137], '2011),': [2354, 2478], 'causes': [2355], 'inflammation.': [2357, 3273, 4063], 'various': [2361, 2425, 2749, 3417, 3478, 3557, 3827], 'ligands': [2362, 2421], 'activate': [2363], 'TLR4:': [2364], '(i)': [2365], 'exogenous': [2366], 'lipopolysaccharides': [2367], 'elevated': [2368], '(Cani': [2371], '2007),': [2374], '(ii)': [2375], 'endogenous': [2376, 2420, 2993], 'damage-associated': [2377], 'patterns': [2379, 3127], '(DAMPs),': [2380], 'e.g.,': [2381, 2902], 'high-mobility': [2382], 'group': [2383], 'box-1': [2384], 'protein': [2385, 2405, 3206], '(HMGB1;': [2386], 'Harris': [2387], '2012;': [2390], 'Guzmán-Ruiz': [2391], '2014),': [2394], 'free': [2395], '(FFAs;': [2398], 'Shi': [2399], '2006),': [2402], 'fetuin-A': [2404], '(Pal': [2406], '2012),': [2409], 'which': [2410, 2438, 2528, 2860, 3291], 'are': [2411, 2455, 2693, 2771, 2861, 3038, 3102, 3400, 3512, 3670, 3884, 4074], 'released': [2412], 'tissue.': [2417], 'LPS': [2418, 3004], 'induce': [2422], 'production': [2423, 3069], 'effector': [2426], 'molecules': [2427], 'proinflammatory': [2429, 2814], 'cytokines': [2430, 2815], '(e.g.,': [2431, 2676], 'tumor': [2432], 'necrosis': [2433], 'factor-α': [2434], '[TNF-α],': [2435], 'interleukin-6': [2436], '[IL-6]),': [2437], 'contributes': [2439], 'dysregulation': [2444], 'energy': [2448], 'metabolisms': [2449], 'Gangliosides': [2454], 'important': [2456, 2789], 'downstream': [2457], 'metabolites': [2458], 'ceramide,': [2460, 2556], 'sphingolipid': [2462], 'formed': [2463], 'an': [2465, 2992, 4144], 'amide': [2466], 'linkage': [2467], 'between': [2468, 3656, 3697, 3908, 4065, 4136], 'sphingoid': [2470, 2599], 'base': [2471, 2600], '(Bikman': [2475], 'Summers,': [2477], 'involved': [2480, 2944, 3067, 3103, 3401], 'cellular': [2485], 'events': [2486], '(Inokuchi': [2487, 2796], '2018).': [2490, 2799], 'Glycosyltransferases,': [2491], 'UGCG': [2492], 'B4GALT5/6,': [2494], 'convert': [2495], 'ceramide': [2496], 'into': [2497, 2517, 2651, 2843], 'glucosylceramide': [2498], '(GlcCer)': [2499], 'lactosylceramide': [2501], '(LacCer),': [2502], 'precursor': [2503], 'glycosphingolipids': [2504], '(GSLs)': [2505], 'ganglioside.': [2508], 'Consecutively,': [2509], 'ST3GAL5,': [2510], 'synthase': [2513], '(GM3S),': [2514], 'converts': [2515], 'LacCer': [2516], 'conjugating': [2520], 'sialic': [2522], '(N-acetylneuraminic': [2524], 'acid)': [2525], '(Fig': [2526, 2654, 2662, 2724, 2744, 3319, 3333, 3344, 3354, 3364, 4005], '1A),': [2527], 'followed': [2530], 'biosynthesis': [2532, 2834, 2896], 'gangliosides.': [2535, 2560], 'Figure': [2536, 3391, 3823], '1.': [2537, 2633], 'acyl-chain': [2548, 2608, 2623], 'structures': [2549, 2592], 'Biosynthetic': [2550], 'pathway': [2551], '(schematic)': [2552], 'GM3,': [2554], 'TLC': [2561], 'serum.': [2568, 2581], 'Quantification': [2569, 2613], 'densitometry': [2571], 'major': [2573, 2804, 3297, 3545], 'GD1a': [2578], 'Data': [2582, 2634, 3510, 3666, 3668, 3882, 3965], 'expressed': [2583, 2635], 'mean': [2585, 2637, 3674, 3885], '±': [2586, 2638, 3675, 3886], 'SD,': [2587, 2639, 3676, 3887], 'n': [2588, 2640, 3155, 3162, 3172, 3179, 3191, 3651, 3970, 3974], '=': [2589, 2641, 3156, 3163, 3173, 3180, 3192, 3422, 3426, 3430, 3434, 3441, 3489, 3493, 3497, 3501, 3508, 3587, 3593, 3599, 3635, 3640, 3645, 3652, 3868, 3874, 3880, 3971, 3975], '6.': [2590, 2642], 'Detailed': [2591], 'species:': [2595], 'sialyllactose': [2596], 'head': [2597], 'group,': [2598], '(d18:1),': [2601], 'typical': [2602], 'fatty-acid': [2603], 'lengths': [2604], '(LCFA,': [2605], 'VLCFA),': [2606], 'modifications': [2609, 4110], '(α-hydroxylation,': [2610], 'ω-9': [2611], 'desaturation).': [2612], 'LC-MS/MS': [2615, 3283], 'differing': [2622], 'structures.': [2624], 'Total': [2625], 'abundance': [2626, 3396], '10': [2628], 'was': [2630, 3056, 3783, 4011, 4040], 'defined': [2631], 'Download': [2643, 2645, 3700, 3702, 3977, 3979], 'figure': [2644, 3701, 3978], 'PowerPoint': [2646, 3703, 3980], 'secreted': [2649, 2842], 'abundantly': [2650], '1B),': [2655], 'concentration': [2657], '10–15': [2658], 'μg/ml': [2659], '(~10': [2660], 'μM)': [2661], '1C),': [2663], 'circulated': [2666], 'all': [2668], 'parts': [2669], 'body,': [2672], 'insulin-sensitive': [2674], 'organs': [2675], 'liver,': [2677], 'muscle,': [2678], 'adipose;': [2679], 'Senn': [2680], '1989;': [2683], '2015).': [2687], 'Fatty': [2688], '(LCFA),': [2699], '16:0,': [2700], '18:0,': [2701, 3324, 3520], '20:0;': [2703], '(VLCFA),': [2707], '22:0,': [2708], '23:0,': [2709, 3339, 3527], '24:0;': [2711], 'VLCFA,': [2713, 2732], '22:1': [2714, 3356], '24:1;': [2716], 'α-hydroxy': [2718, 2742, 3573, 3854, 3928, 3983, 4009], 'VLCFA': [2719, 2735, 3303, 3336, 3347, 3370, 3376, 3524, 3534, 3734, 3809, 3846, 3850, 4096, 4119], 'h24:0': [2721, 3607, 3916, 3921, 3937, 4037, 4060], 'h24:1': [2723, 3358, 3956], '1D),': [2725], 'almost': [2727], 'same': [2728], 'abundances': [2729, 3514], 'LCFA,': [2731], 'species,': [2736, 2970, 3298], 'small': [2739], 'amount': [2740], '1E).': [2745], 'Altered': [2746], 'expression': [2747, 2810, 3126], 'been': [2753, 2780], 'observed': [2754], '(Veillon': [2760, 3135], '2015);': [2763], 'specific': [2765, 3035, 4127], 'biological': [2766], 'functions': [2767], 'these': [2769, 4066], 'poorly': [2772], 'understood.': [2773], 'On': [2774], 'other': [2776, 3227], 'hand,': [2777], 'it': [2778, 2839], 'plasma': [2786, 2849, 2873], 'membrane': [2787, 2850, 2855, 2874], 'adipocytes,': [2807], 'its': [2809], 'induced': [2812], 'derived': [2816], '(Tagami': [2821, 2907], '2002;': [2824, 2910], 'Nagafuku': [2825, 2935], '2015;': [2828, 3138], 'Wentworth': [2829], '2016).': [2832], 'occurs': [2835, 3811], 'Golgi,': [2837], 'subsequently': [2840], 'becomes': [2841], 'compartment': [2845], 'or': [2846, 3713], 'localized': [2847], 'component': [2853], 'microdomains': [2856], '(also': [2857], 'called': [2858], '"rafts"),': [2859], 'platforms': [2863], 'comprised': [2864], 'sphingolipids': [2866], '(Lingwood': [2867], 'Simons,': [2869], '2010).': [2870], 'affects': [2875], 'diffusion': [2876], 'kinetics': [2877], 'regulates': [2882], 'signal': [2883], 'transduction': [2884], '(Kabayama': [2885], '2007);': [2888], 'conversely,': [2889], 'restored': [2893], 'when': [2894], 'glycosyltransferase': [2900], 'inhibitors,': [2901], 'D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol': [2903], '(D-PDMP)': [2904], 'Genz-123346': [2906], 'Zhao': [2911], '2007).': [2914], 'Knockout': [2915], 'GM3S': [2917], 'diminishes': [2918], 'not': [2919], 'only': [2920], 'systemic': [2921], '(Yamashita': [2931], '2003;': [2934], '2015),': [2938], 'suggesting': [2939], 'might': [2942], 'upstream': [2949], 'resistance;': [2952, 4106], 'basis': [2956], 'relationship': [2959], 'remains': [2960], 'unclear.': [2961], 'study,': [2964], 'we': [2965, 2986, 3124, 4142], 'investigated': [2966], 'how': [2967], 'carrying': [2971], 'acyl': [2973], 'chains,': [2974], 'regulate': [2975], 'contribute': [2979], 'onset': [2981, 3813], 'Here,': [2985], 'demonstrate': [2987], 'acts': [2990], 'modulator.': [2995], 'augmented': [3000], 'HMGB1,': [3006], 'contrast,': [3009], 'LCFA': [3010, 3308, 3321, 3517, 3725, 3843], 'suppressed': [3014], 'increased': [3019, 3045, 3343, 3363, 3378], 'decreased': [3023, 3326], 'sharply': [3024, 3327], 'approaches': [3029, 4123], 'using': [3030, 4147], 'artificial': [3031, 4153], 'intelligence': [3032, 4154], 'revealed': [3033, 4124], 'related': [3039], 'clinical': [3041, 3834], 'mice': [3052], 'attenuated': [3057], 'implying': [3061], 'VLCFA-GM3.': [3071], 'role': [3080, 3115, 3754], 'rheostat': [3082], 'signaling,': [3085], 'Results': [3099], 'progression': [3105, 3404, 3661], 'To': [3112, 4131], 'elucidate': [3113], 'pathophysiology': [3120, 4070], 'analyzed': [3125, 3677, 3888], 'subjects': [3134, 3153, 4044], 'Appendix': [3139], 'Fig': [3140, 3229, 3250, 3286, 3389, 4078], 'S1A–I).': [3141], 'Sera': [3142], 'were': [3143, 3208, 3280, 3349, 3719], 'collected': [3144], 'subjects,': [3147], 'representing': [3148], 'five': [3149, 3262], 'pathological': [3150, 3418, 3465, 3485], 'phases:': [3151, 3419, 3486], 'healthy': [3152], '(control,': [3154], '24),': [3157, 3423, 3490], 'visceral': [3158], 'fat': [3159], 'accumulation': [3160], '(VFA,': [3161], '38)': [3164], 'presymptomatic': [3166, 3381, 4092], 'phase,': [3167], 'VFA': [3168, 3175, 3183, 3240, 3424, 3491], 'dyslipidemia': [3170, 3185], '(lipidemia,': [3171], '28),': [3174, 3431, 3498], 'hyperglycemia': [3177, 3187], '(glycemia,': [3178], '15),': [3181, 3435, 3502], '(lipidemia': [3188, 3779], '+': [3189, 3247, 3438, 3505, 3780], 'glycemia,': [3190], '17).': [3193, 3442, 3509], 'Scores': [3194], 'homeostatic': [3196], 'model': [3197], 'assessment': [3198], '(HOMA-IR)': [3202], 'C-reactive': [3205], '(CRP)': [3207], 'evaluated': [3209, 3281], 'indicators': [3211, 4016], 'inflammation,': [3217], 'respectively.': [3218], 'HOMA-IR': [3219, 3315, 3471, 3613, 3934], 'CRP': [3221, 3318, 3628, 3940, 3949, 3963, 4047], 'displayed': [3222], 'significant': [3223, 3794], 'correlation': [3224, 4004, 4100], 'each': [3226, 3449, 3552], '(Appendix': [3228, 3249, 3285, 3388], 'S1J),': [3230], 'gradual': [3233], 'order:': [3237], 'control': [3238, 3420, 3453, 3487], '<': [3239, 3241, 3243, 3245, 3686, 3689, 3693, 3897, 3900, 3904], 'lipidemia': [3242, 3246, 3428, 3437, 3495, 3504], 'glycemia': [3244, 3248, 3332, 3432, 3439, 3499, 3506], 'S1K': [3251], 'L).': [3253], 'These': [3254, 3740, 3803], 'indicate': [3256, 3444, 3578, 3625, 3805, 3859], 'order': [3259], 'phases': [3263, 3384, 3466], 'corresponds': [3264, 3467], 'increasing': [3266], 'severity': [3267], 'Circulating': [3274], 'S2A–K).': [3287], 'Heat': [3288, 3409], 'map': [3289, 3410, 4149], 'analysis,': [3290], 'summarizes': [3292], 'properties': [3293], 'ten': [3296, 3544], 'indicated': [3299, 3698, 3909], 'progressive': [3300], 'association': [3311], 'increases': [3313, 3705, 3744, 3992], '2A).': [3320, 3365], '(16:0,': [3323, 3519], '20:0)': [3325, 3521], 'VFA,': [3329], 'lipidemia,': [3330], '2B),': [3334], 'whereas': [3335], '(22:0,': [3338, 3526], '24:0,': [3340, 3528], 'h24:0)': [3341, 3529], 'largely': [3342], '2C).': [3345], 'Unsaturated': [3346], 'mostly': [3350], 'constant': [3351], 'total': [3353, 3369, 3373, 3516, 3523, 3532, 3542, 3926], '2D);': [3355], 'decreased,': [3359], '24:1': [3361], 'slightly': [3362], 'ratio': [3367, 4035], 'LCFA/': [3374], 'notably': [3379], 'early': [3383, 3756, 4094], 'S2L).': [3390], '2.': [3392], 'Alterations': [3393], 'relative': [3395, 3451, 3513, 3540], 'A.': [3408], '(n': [3421, 3425, 3429, 3433, 3440, 3488, 3492, 3496, 3500, 3507, 3586, 3592, 3598, 3634, 3639, 3644, 3867, 3873, 3879], '38),': [3427, 3494], 'Colors': [3443, 3577, 3624, 3858], 'fold': [3445], 'change': [3446], 'average': [3447], '(defined': [3454, 3548], '1),': [3456], 'shown': [3458, 3511, 3669, 3883], 'key': [3460], 'right.': [3462], 'Order': [3463], 'increments': [3469], 'CRP.': [3474, 3623], 'B–D.': [3475], 'Properties': [3476, 3555, 3825], 'function': [3483, 3562, 3832], '(B),': [3522, 3848], '(C),': [3530, 3852], '(22:1,': [3536], '24:1,': [3537], 'h24:1)': [3538, 3932], '(D)': [3539], '1)': [3550], 'subject.': [3553], 'E–H.': [3554], 'BMI:': [3564], '(E),': [3566, 3919], '(F),': [3568, 3925], '(G),': [3571, 3935], '(h24:0)': [3575, 3856, 3985], '(H).': [3576], 'severity:': [3580, 3861], 'light': [3581, 3631, 3862], 'blue,': [3582, 3632, 3863], 'scores': [3585, 3866], '25);': [3588], 'orange,': [3589, 3637, 3870], 'early-phase': [3590, 3871], '74);': [3594], 'purple,': [3595, 3876], 'severe': [3596, 3764, 3776, 3877], '23).': [3600], 'I,': [3601], 'J.': [3602], "Spearman's": [3603, 3912], 'correlations': [3604, 3913], 'vs.': [3608, 3612, 3621, 3917, 3922, 3933, 3938, 3947, 3961], 'ALT': [3609], '(I)': [3610], '(J).': [3614, 3964], 'K.': [3615], 'Plots': [3616], 'α-hydroxylation': [3618, 3942, 3952, 4115], 'rate': [3619, 3943, 3953], '(h24:0/24:0)': [3620], 'range': [3626], 'value': [3629, 4048], '(mg/dl):': [3630], '0.01–0.02': [3633], '21);': [3636], '0.03–0.09': [3638], '56);': [3641], 'gray,': [3642], '0.10–0.29': [3643], '29);': [3646], 'red,': [3647], '0.3–1.0': [3648], '(diagnostically': [3649], 'abnormal;': [3650], '15).': [3653], 'L.': [3654], 'Association': [3655], '(schematic).': [3665], 'information:': [3667, 3966], 'individual': [3671], 'values': [3672], 'two-tailed': [3679, 3890], 'unpaired': [3680, 3891], 't-test': [3681, 3892], "Bonferroni's": [3683, 3894], 'correction.': [3684, 3895], '*P': [3685, 3896], '0.05,': [3687, 3898], '**P': [3688, 3899], '0.01,': [3690, 3901], '***P': [3692, 3903], '0.001': [3694, 3905], 'comparisons': [3696, 3907], 'groups.': [3699, 3910], 'Early-phase': [3704], 'body': [3707], 'mass': [3708], 'index': [3709], '(BMI)': [3710], '(>': [3711, 3716, 4049], '25)': [3712], 'abdominal': [3714, 3770, 3923, 3996], 'circumference': [3715, 3771, 3924, 3997], '85': [3717], 'cm)': [3718, 3774], 'associated': [3720], 'sharp': [3722], 'reduction': [3723, 3785], '(Figs': [3727, 3736, 3789, 3799, 3998, 4026, 4052], '2E': [3728], 'EV1A)': [3730], '2F': [3737, 3790], 'EV1B).': [3739], 'occur': [3748, 4117], 'obesity,': [3750], 'play': [3752], 'cases': [3762], '(BMI': [3766], '>': [3767, 3772], '30': [3768], 'and/or': [3769], '100': [3773], 'glycemia),': [3781], 'there': [3782], 'moderate': [3784], 'EV1B)': [3792], '2G': [3800], 'EV1C).': [3802], 'desaturation': [3807, 4113], 'after': [3812], 'Click': [3817], 'here': [3818], 'expand': [3820], 'figure.': [3822], 'EV1.': [3824], 'markers': [3835], 'A–D.': [3842], '(A),': [3845], '(D).': [3857], '17);': [3869], '80);': [3875], '25).': [3881], 'E–J.': [3911], 'BMI': [3918, 3994], '(h24:0': [3930, 3944, 3954], '(H),': [3941], '24:0)': [3946], '(I),': [3950], '24:0': [3958, 4039], '24:1)': [3960], 'Sample': [3967], 'sizes:': [3968], '(A–G),': [3969], '122;': [3972], '(H-J),': [3973], '121.': [3976], 'Abundance': [3981], 'showed': [3986], 'linear': [3988], 'along': [3990], '2H': [3999], 'EV1D),': [4001], 'strong': [4003], 'EV1E': [4006], 'F).': [4008], 'strongly': [4013], 'correlated': [4014], '(ALT,': [4023], 'HOMA-IR,': [4024], 'CRP)': [4025], '2I': [4027], 'J,': [4029], 'EV1G–J).': [4031], 'particular,': [4033], 'much': [4041], 'higher': [4042], '0.3': [4050], 'mg/dl)': [4051], '2K': [4053], 'EV1I),': [4055], 'indicating': [4056], 'considerable': [4057], 'involvement': [4058], 'Relationships': [4064], 'summarized': [4075], 'schematically': [4076], '2L.': [4079], 'steady': [4081], 'state,': [4082], 'homeostasis': [4083], 'maintained': [4085], 'balance': [4087], 'species;': [4090], 'phases,': [4095, 4109], 'late': [4108], 'species.': [4120], 'Artificial': [4121], 'intelligence-based': [4122], 'symptoms': [4130], 'analyze': [4132], 'detailed': [4134], 'relationships': [4135], 'utilized': [4143], 'unbiased': [4145], 'approach': [4146], 'self-organization': [4148], '(SOM),': [4150], 'neural-network-type': [4152]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3020943501', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 10}, {'year': 2022, 'cited_by_count': 8}, {'year': 2021, 'cited_by_count': 10}, {'year': 2019, 'cited_by_count': 1}], 'updated_date': '2024-12-23T02:28:17.862525', 'created_date': '2020-05-13'}
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