Title: Racial variations in COVID‐19 deaths may be due to androgen receptor genetic variants associated with prostate cancer and androgenetic alopecia. Are anti‐androgens a potential treatment for COVID‐19?
Abstract: Journal of Cosmetic DermatologyVolume 19, Issue 7 p. 1542-1543 LETTER TO THE EDITOR Racial variations in COVID-19 deaths may be due to androgen receptor genetic variants associated with prostate cancer and androgenetic alopecia. Are anti-androgens a potential treatment for COVID-19? John McCoy PhD, Corresponding Author John McCoy PhD [email protected] orcid.org/0000-0003-1577-9910 Applied Biology, Irvine, CA, USA Correspondence John McCoy, Applied Biology, Irvine, CA, USA. Email: [email protected]Search for more papers by this authorCarlos G. Wambier MD, PhD, Carlos G. Wambier MD, PhD Department of Dermatology, The Warren Alpert Medical School of Brown University, Providence, RI, USASearch for more papers by this authorSergio Vano-Galvan MD, Sergio Vano-Galvan MD Trichology Unit, Dermatology Department, Ramon y Cajal Hospital, IRYCIS, University of Alcala, Madrid, SpainSearch for more papers by this authorJerry Shapiro MD, Jerry Shapiro MD Department of Dermatology, New York University Langone Medical Center, New York City, NY, USASearch for more papers by this authorRodney Sinclair MD, Rodney Sinclair MD Department of Medicine, University of Melbourne, Melbourne, Vic., AustraliaSearch for more papers by this authorPaulo Müller Ramos MD, Paulo Müller Ramos MD Department of Dermatology, São Paulo State University–UNESP, São Paulo, BrazilSearch for more papers by this authorKenneth Washenik MD, Kenneth Washenik MD Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, NY, USASearch for more papers by this authorMurilo Andrade MD, MSc, Murilo Andrade MD, MSc Division of Urology, Department of Surgery and Anatomy, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, BrazilSearch for more papers by this authorSabina Herrera MD, PhD, Sabina Herrera MD, PhD Infectious Diseases Department, Hospital Universitario Ramón y Cajal, Madrid, SpainSearch for more papers by this authorAndy Goren MD, Andy Goren MD Applied Biology, Irvine, CA, USA Department of Dermatology and Venereology, Clinical Hospital Center Sestre Milosrdnice, Zagreb, CroatiaSearch for more papers by this author John McCoy PhD, Corresponding Author John McCoy PhD [email protected] orcid.org/0000-0003-1577-9910 Applied Biology, Irvine, CA, USA Correspondence John McCoy, Applied Biology, Irvine, CA, USA. Email: [email protected]Search for more papers by this authorCarlos G. Wambier MD, PhD, Carlos G. Wambier MD, PhD Department of Dermatology, The Warren Alpert Medical School of Brown University, Providence, RI, USASearch for more papers by this authorSergio Vano-Galvan MD, Sergio Vano-Galvan MD Trichology Unit, Dermatology Department, Ramon y Cajal Hospital, IRYCIS, University of Alcala, Madrid, SpainSearch for more papers by this authorJerry Shapiro MD, Jerry Shapiro MD Department of Dermatology, New York University Langone Medical Center, New York City, NY, USASearch for more papers by this authorRodney Sinclair MD, Rodney Sinclair MD Department of Medicine, University of Melbourne, Melbourne, Vic., AustraliaSearch for more papers by this authorPaulo Müller Ramos MD, Paulo Müller Ramos MD Department of Dermatology, São Paulo State University–UNESP, São Paulo, BrazilSearch for more papers by this authorKenneth Washenik MD, Kenneth Washenik MD Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, NY, USASearch for more papers by this authorMurilo Andrade MD, MSc, Murilo Andrade MD, MSc Division of Urology, Department of Surgery and Anatomy, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, BrazilSearch for more papers by this authorSabina Herrera MD, PhD, Sabina Herrera MD, PhD Infectious Diseases Department, Hospital Universitario Ramón y Cajal, Madrid, SpainSearch for more papers by this authorAndy Goren MD, Andy Goren MD Applied Biology, Irvine, CA, USA Department of Dermatology and Venereology, Clinical Hospital Center Sestre Milosrdnice, Zagreb, CroatiaSearch for more papers by this author First published: 25 April 2020 https://doi.org/10.1111/jocd.13455Citations: 67Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. REFERENCES 1Thebault R, Tran AB, Williams V. African Americans are at higher risk of death from coronavirus - The Washington Post [Internet]. Washington Post. 2020 [cited 2020 Apr 8]; Available from: https://www.washingtonpost.com/nation/2020/04/07/coronavirus-is-infecting-killing-black-americans-an-alarmingly-high-rate-post-analysis-shows/?arc404=true Google Scholar 2Kim HS, Moreira DM, Jayachandran J, et al. Prostate biopsies from black men express higher levels of aggressive disease biomarkers than prostate biopsies from white men. Prostate Cancer Prostatic Dis. 2011; 14(3): 262-265. 10.1038/pcan.2011.18 CASPubMedWeb of Science®Google Scholar 3Ellis JA, Stebbing M, Harrap SB. Polymorphism of the androgen receptor gene is associated with male pattern baldness. J Invest Dermatol. 2001; 116(3): 452-455. 10.1046/j.1523-1747.2001.01261.x CASPubMedWeb of Science®Google Scholar 4Guan W, Ni Z, Hu Y, et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. 2020; 382: 1708-1720. 10.1056/NEJMoa2002032 CASPubMedWeb of Science®Google Scholar 5Goren A, McCoy J, Wambier CG, et al. What does androgenetic alopecia have to do with COVID-19? An insight into a potential new therapy. Dermatol Ther. 2020;e13365. 10.1111/dth.13365 PubMedWeb of Science®Google Scholar 6Goren A, Vaño-Galván S, Wambier CG, et al. A preliminary observation: Male pattern hair loss among hospitalized COVID-19 patients in Spain – A potential clue to the role of androgens in COVID-19 severity. J Cosmet Dermatol. 2020. https://doi.org/10.1111/jocd.13443 10.1111/jocd.13443 Web of Science®Google Scholar 7Shieh WJ, Hsiao CH, Paddock CD, et al. Immunohistochemical, in situ hybridization, and ultrastructural localization of SARS-associated coronavirus in lung of a fatal case of severe acute respiratory syndrome in Taiwan. Hum Pathol. 2005; 36(3): 303-309. 10.1016/j.humpath.2004.11.006 PubMedWeb of Science®Google Scholar 8Hoffmann M, Kleine-Weber H, Schroeder S, et al. SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell. 2020; 181(2): 271-280.e8. 10.1016/j.cell.2020.02.052 CASPubMedWeb of Science®Google Scholar 9Glowacka I, Bertram S, Muller MA, et al. Evidence that TMPRSS2 activates the severe acute respiratory syndrome coronavirus spike protein for membrane fusion and reduces viral control by the humoral immune response. J Virol. 2011; 85(9): 4122-4134. 10.1128/JVI.02232-10 PubMedWeb of Science®Google Scholar 10Lucas JM, Heinlein C, Kim T, et al. The androgen-regulated protease TMPRSS2 activates a proteolytic cascade involving components of the tumor microenvironment and promotes prostate cancer metastasis. Cancer Discov. 2014; 4(11): 1310-1325. 10.1158/2159-8290.CD-13-1010 CASPubMedWeb of Science®Google Scholar 11 National Institutes of Health. TMPRSS2 transmembrane serine protease 2 [Homo sapiens (human) ] Gene ID: 7113 [Internet]. Gene ID 7113, Updat. 13-Mar-2020. 2020 [cited 2020 Apr 2];Available from: https://www.ncbi.nlm.nih.gov/gene/7113 Google Scholar 12Lin B, Ferguson C, White JT, et al. Prostate-localized and androgen-regulated expression of the membrane- bound serine protease TMPRSS2. Cancer Res. 1999; 59(17): 4180-4184. CASPubMedWeb of Science®Google Scholar 13Dalpiaz PLM, Lamas AZ, Caliman IF, et al. Sex hormones promote opposite effects on ACE and ACE2 activity, hypertrophy and cardiac contractility in spontaneously hypertensive rats. PLoS ONE. 2015; 10(5):e0127515. 10.1371/journal.pone.0127515 CASPubMedWeb of Science®Google Scholar 14Tirabassi G, Cignarelli A, Perrini S, et al. Influence of CAG repeat polymorphism on the targets of testosterone action. Int J Endocrinol. 2015; 2015: 1-12. 10.1155/2015/298107 Web of Science®Google Scholar 15Sartor O, Zheng Q, Eastham JA. Androgen receptor gene CAG repeat length varies in a race-specific fashion in men without prostate cancer. Urology. 1999; 53(2): 378-380. 10.1016/S0090-4295(98)00481-6 CASPubMedWeb of Science®Google Scholar 16Bennett CL, Price DK, Kim S, et al. Racial variation in CAG repeat lengths within the androgen receptor gene among prostate cancer patients of lower socioeconomic status. J Clin Oncol. 2002; 20(17): 3599-3604. 10.1200/JCO.2002.11.085 CASPubMedWeb of Science®Google Scholar 17Vom Steeg LG, Vermillion MS, Hall OJ, et al. Age and testosterone mediate influenza pathogenesis in male mice. Am J Physiol Lung Cell Mol Physiol. 2016; 311(6): L1234-L1244. 10.1152/ajplung.00352.2016 PubMedWeb of Science®Google Scholar Citing Literature Volume19, Issue7July 2020Pages 1542-1543 This article also appears in:Journal of Cosmetic Dermatology COVID-19 Articles ReferencesRelatedInformation