Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W3016459499', 'doi': 'https://doi.org/10.1096/fasebj.2020.34.s1.06952', 'title': 'Reduced sympathetic baroreflex sensitivity in individuals with multiple sclerosis during the Valsalva maneuver', 'display_name': 'Reduced sympathetic baroreflex sensitivity in individuals with multiple sclerosis during the Valsalva maneuver', 'publication_year': 2020, 'publication_date': '2020-04-01', 'ids': {'openalex': 'https://openalex.org/W3016459499', 'doi': 'https://doi.org/10.1096/fasebj.2020.34.s1.06952', 'mag': '3016459499'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1096/fasebj.2020.34.s1.06952', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S25293849', 'display_name': 'The FASEB Journal', 'issn_l': '0892-6638', 'issn': ['0892-6638', '1530-6860'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5109986310', 'display_name': 'Claire E. Trotter', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I178169726', 'display_name': 'Southern Methodist University', 'ror': 'https://ror.org/042tdr378', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I178169726']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Claire E. Trotter', 'raw_affiliation_strings': ['Southern Methodist University'], 'affiliations': [{'raw_affiliation_string': 'Southern Methodist University', 'institution_ids': ['https://openalex.org/I178169726']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053207194', 'display_name': 'Mu Huang', 'orcid': 'https://orcid.org/0000-0001-9526-7944'}, 'institutions': [{'id': 'https://openalex.org/I4388891891', 'display_name': 'Southwestern Medical Center', 'ror': 'https://ror.org/05d80e146', 'country_code': None, 'type': 'healthcare', 'lineage': ['https://openalex.org/I4388891891']}, {'id': 'https://openalex.org/I867280407', 'display_name': 'The University of Texas Southwestern Medical Center', 'ror': 'https://ror.org/05byvp690', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I867280407']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Mu Huang', 'raw_affiliation_strings': ['University of Texas Southwestern Medical Center'], 'affiliations': [{'raw_affiliation_string': 'University of Texas Southwestern Medical Center', 'institution_ids': ['https://openalex.org/I4388891891', 'https://openalex.org/I867280407']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103980582', 'display_name': 'David M. Keller', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I189196454', 'display_name': 'The University of Texas at Arlington', 'ror': 'https://ror.org/019kgqr73', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I189196454']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'David M. Keller', 'raw_affiliation_strings': ['University of Texas at Arlington'], 'affiliations': [{'raw_affiliation_string': 'University of Texas at Arlington', 'institution_ids': ['https://openalex.org/I189196454']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5025623747', 'display_name': 'Scott L. Davis', 'orcid': 'https://orcid.org/0000-0002-9290-7085'}, 'institutions': [{'id': 'https://openalex.org/I178169726', 'display_name': 'Southern Methodist University', 'ror': 'https://ror.org/042tdr378', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I178169726']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Scott L. Davis', 'raw_affiliation_strings': ['Southern Methodist University'], 'affiliations': [{'raw_affiliation_string': 'Southern Methodist University', 'institution_ids': ['https://openalex.org/I178169726']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 60}, 'biblio': {'volume': '34', 'issue': 'S1', 'first_page': '1', 'last_page': '1'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10745', 'display_name': 'Heart Rate Variability and Autonomic Control', 'score': 0.9983, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10745', 'display_name': 'Heart Rate Variability and Autonomic Control', 'score': 0.9983, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12580', 'display_name': 'Vagus Nerve Stimulation Research', 'score': 0.951, 'subfield': {'id': 'https://openalex.org/subfields/2808', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10137', 'display_name': 'Multiple Sclerosis Research Studies', 'score': 0.9483, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/valsalva-maneuver', 'display_name': 'Valsalva maneuver', 'score': 0.86581385}, {'id': 'https://openalex.org/keywords/microneurography', 'display_name': 'Microneurography', 'score': 0.50476325}, {'id': 'https://openalex.org/keywords/sympathetic-nervous-system', 'display_name': 'Sympathetic nervous system', 'score': 0.46077555}], 'concepts': [{'id': 'https://openalex.org/C2777517520', 'wikidata': 'https://www.wikidata.org/wiki/Q1427231', 'display_name': 'Valsalva maneuver', 'level': 3, 'score': 0.86581385}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.83291703}, {'id': 'https://openalex.org/C191237925', 'wikidata': 'https://www.wikidata.org/wiki/Q808725', 'display_name': 'Baroreflex', 'level': 4, 'score': 0.82003415}, {'id': 'https://openalex.org/C84393581', 'wikidata': 'https://www.wikidata.org/wiki/Q82642', 'display_name': 'Blood pressure', 'level': 2, 'score': 0.7504184}, {'id': 'https://openalex.org/C2780640218', 'wikidata': 'https://www.wikidata.org/wiki/Q8277', 'display_name': 'Multiple sclerosis', 'level': 2, 'score': 0.6276876}, {'id': 'https://openalex.org/C2777953023', 'wikidata': 'https://www.wikidata.org/wiki/Q1073121', 'display_name': 'Heart rate', 'level': 3, 'score': 0.614692}, {'id': 'https://openalex.org/C164705383', 'wikidata': 'https://www.wikidata.org/wiki/Q10379', 'display_name': 'Cardiology', 'level': 1, 'score': 0.5594052}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.55170655}, {'id': 'https://openalex.org/C2775898464', 'wikidata': 'https://www.wikidata.org/wiki/Q3312240', 'display_name': 'Microneurography', 'level': 5, 'score': 0.50476325}, {'id': 'https://openalex.org/C2777372248', 'wikidata': 'https://www.wikidata.org/wiki/Q171064', 'display_name': 'Autonomic nervous system', 'level': 4, 'score': 0.49167663}, {'id': 'https://openalex.org/C2776533406', 'wikidata': 'https://www.wikidata.org/wiki/Q187215', 'display_name': 'Sympathetic nervous system', 'level': 3, 'score': 0.46077555}, {'id': 'https://openalex.org/C79752029', 'wikidata': 'https://www.wikidata.org/wiki/Q808732', 'display_name': 'Baroreceptor', 'level': 4, 'score': 0.44074428}, {'id': 'https://openalex.org/C42219234', 'wikidata': 'https://www.wikidata.org/wiki/Q131130', 'display_name': 'Anesthesia', 'level': 1, 'score': 0.3668759}, {'id': 'https://openalex.org/C118552586', 'wikidata': 'https://www.wikidata.org/wiki/Q7867', 'display_name': 'Psychiatry', 'level': 1, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1096/fasebj.2020.34.s1.06952', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S25293849', 'display_name': 'The FASEB Journal', 'issn_l': '0892-6638', 'issn': ['0892-6638', '1530-6860'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.86, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W2784470254', 'https://openalex.org/W2417049126', 'https://openalex.org/W2329025098', 'https://openalex.org/W2326594690', 'https://openalex.org/W2149895566', 'https://openalex.org/W2115073568', 'https://openalex.org/W2093524238', 'https://openalex.org/W2034533245', 'https://openalex.org/W1989672093', 'https://openalex.org/W1986472926'], 'abstract_inverted_index': {'Multiple': [0], 'sclerosis': [1], '(MS)': [2], 'is': [3], 'a': [4, 34, 44, 80, 95, 137, 145, 149, 281], 'neurodegenerative': [5], 'autoimmune': [6], 'disease': [7], 'characterized': [8], 'by': [9, 157], 'demyelination': [10], 'in': [11, 19, 41, 89, 176, 197, 257, 287, 291, 309], 'central': [12], 'nervous': [13], 'system': [14], 'leading': [15], 'to': [16, 37, 43, 57, 71, 87, 99, 172, 184, 188, 234, 284, 289], 'potential': [17], 'impairments': [18], 'the': [20, 62, 67, 73, 164, 170, 173, 185, 189, 192, 201, 229, 295], 'autonomic': [21], 'control': [22, 304], 'of': [23, 61, 66, 169, 191, 300, 305], 'cardiovascular': [24], 'function.': [25], 'We': [26], 'have': [27, 79, 280], 'previously': [28], 'demonstrated': [29], 'individuals': [30, 76, 258], 'with': [31, 52, 77, 105, 221, 259, 278], 'MS': [32, 78, 107, 222, 260, 279, 320], 'exhibit': [33], 'diminished': [35], 'ability': [36, 283], 'increase': [38, 285], 'blood': [39, 91, 129, 292, 307], 'pressure': [40, 92, 130, 199, 293, 308], 'response': [42, 85, 288], 'simulated': [45], 'hypotensive': [46], 'stimulus': [47], '(carotid': [48], 'neck': [49], 'pressure)': [50], 'compared': [51, 98, 233], 'healthy': [53, 101, 120, 235], 'controls': [54, 121, 236], 'likely': [55], 'due': [56], 'impaired': [58], 'sympathetic': [59, 83, 160, 302], 'modulation': [60], 'vasculature.': [63], 'The': [64], 'aim': [65], 'current': [68], 'investigation': [69], 'was': [70, 155, 255], 'test': [72], 'hypothesis': [74], 'that': [75], 'blunted': [81], 'muscle': [82], 'nerve': [84], '(MSNA)': [86], 'drops': [88], 'arterial': [90, 128, 306], 'induced': [93], 'via': [94], 'Valsalva': [96, 138, 202], 'maneuver': [97, 139], 'matched': [100], 'controls.': [102], 'Four': [103], 'patients': [104], 'relapsing‐remitting': [106], '(2': [108], 'females/2': [109], 'males,': [110], 'EDSS': [111], '<': [112], '4)': [113], 'and': [114, 118, 132], '4': [115], 'sex‐,': [116], 'age‐': [117], 'mass‐matched': [119], 'were': [122, 203], 'instrumented': [123], 'for': [124, 144], 'MSNA': [125, 226, 286], '(peroneal': [126], 'nerve),': [127], '(Finometer),': [131], 'heart': [133], 'rate.': [134], 'Participants': [135], 'performed': [136], '(VM)': [140], 'at': [141], '40': [142], 'mmHg': [143], '15': [146, 165, 215, 230], 's': [147, 166, 231], 'after': [148], 'normal': [150], 'inspiration.': [151], 'Sympathetic': [152, 252], 'baroreflex': [153, 253, 303], 'function': [154], 'assessed': [156], 'relating': [158], 'all': [159], 'burst': [161], 'occurring': [162], 'during': [163, 200, 228, 294], 'straining': [167], 'period': [168], 'VM': [171, 193, 232, 296], 'maximum': [174], 'fall': [175], 'DBP': [177], 'measured': [178], 'from': [179], 'highest': [180], 'values': [181], '(Phase': [182, 194], 'I)': [183], 'nadir': [186], 'prior': [187], 'end': [190], 'III).': [195], 'Drops': [196], 'diastolic': [198], 'similar': [204], 'between': [205], 'groups': [206], '(MS:': [207, 237, 261], '−31': [208], '±': [209, 214, 239, 245, 263, 270], '10': [210], 'mmHg:': [211], 'CON:': [212, 243, 268], '−25': [213], 'mmHg;': [216], 'P': [217, 249, 274], '=': [218, 250, 275], '0.30).': [219], 'Individuals': [220, 277], 'produced': [223], 'less': [224], 'total': [225], 'bursts': [227], '8.3': [238], '4.1': [240, 246], 'bursts/15': [241, 247, 265, 272], 's;': [242, 248], '15.0': [244], '0.003).': [251], 'sensitivity': [254], 'reduced': [256, 282], '−0.32': [262], '0.25': [264], 's/mmHg)': [266], 'vs.': [267], '−0.77': [269], '0.43': [271], 's/mmHg;': [273], '0.048).': [276], 'decreases': [290], 'confirming': [297], 'previous': [298], 'speculations': [299], 'abnormal': [301], 'this': [310], 'clinical': [311], 'population.': [312], 'Support': [313], 'or': [314], 'Funding': [315], 'Information': [316], 'NIH': [317], 'R15HL117224;': [318], 'National': [319], 'Society': [321], 'RG4696A3': [322]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3016459499', 'counts_by_year': [], 'updated_date': '2024-12-24T18:20:13.821857', 'created_date': '2020-04-24'}