Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W3016342831', 'doi': 'https://doi.org/10.3390/ijms21082872', 'title': 'Non-Coding RNAs as Key Regulators of Glutaminolysis in Cancer', 'display_name': 'Non-Coding RNAs as Key Regulators of Glutaminolysis in Cancer', 'publication_year': 2020, 'publication_date': '2020-04-20', 'ids': {'openalex': 'https://openalex.org/W3016342831', 'doi': 'https://doi.org/10.3390/ijms21082872', 'mag': '3016342831', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/32326003', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/7216265'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/ijms21082872', 'pdf_url': 'https://www.mdpi.com/1422-0067/21/8/2872/pdf?version=1587482037', 'source': {'id': 'https://openalex.org/S10623703', 'display_name': 'International Journal of Molecular Sciences', 'issn_l': '1422-0067', 'issn': ['1422-0067', '1661-6596'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.mdpi.com/1422-0067/21/8/2872/pdf?version=1587482037', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5053529151', 'display_name': 'Yunuen Ortiz-Pedraza', 'orcid': 'https://orcid.org/0000-0002-1193-1922'}, 'institutions': [{'id': 'https://openalex.org/I4210153971', 'display_name': 'Instituto Nacional de Cancerología', 'ror': 'https://ror.org/04z3afh10', 'country_code': 'MX', 'type': 'government', 'lineage': ['https://openalex.org/I4210095685', 'https://openalex.org/I4210153971']}, {'id': 'https://openalex.org/I8961855', 'display_name': 'Universidad Nacional Autónoma de México', 'ror': 'https://ror.org/01tmp8f25', 'country_code': 'MX', 'type': 'education', 'lineage': ['https://openalex.org/I8961855']}, {'id': 'https://openalex.org/I200362191', 'display_name': 'Universidad Autónoma Metropolitana', 'ror': 'https://ror.org/02kta5139', 'country_code': 'MX', 'type': 'education', 'lineage': ['https://openalex.org/I200362191']}], 'countries': ['MX'], 'is_corresponding': False, 'raw_author_name': 'Yunuen Ortiz-Pedraza', 'raw_affiliation_strings': ['Departamento de Ciencias de la Salud, Universidad Autónoma Metropolitana-Iztapalapa, Mexico City 09340, Mexico', 'Posgrado en Biología Experimental, DCBS, Universidad Autónoma Metropolitana-Iztapalapa, Mexico City 09340, Mexico', 'Unidad de Investigación Biomédica en Cáncer, Instituto Nacional de Cancerología-Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City 14080, Mexico'], 'affiliations': [{'raw_affiliation_string': 'Unidad de Investigación Biomédica en Cáncer, Instituto Nacional de Cancerología-Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City 14080, Mexico', 'institution_ids': ['https://openalex.org/I4210153971', 'https://openalex.org/I8961855']}, {'raw_affiliation_string': 'Posgrado en Biología Experimental, DCBS, Universidad Autónoma Metropolitana-Iztapalapa, Mexico City 09340, Mexico', 'institution_ids': ['https://openalex.org/I200362191']}, {'raw_affiliation_string': 'Departamento de Ciencias de la Salud, Universidad Autónoma Metropolitana-Iztapalapa, Mexico City 09340, Mexico', 'institution_ids': ['https://openalex.org/I200362191']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5039760211', 'display_name': 'J. Omar Muñoz-Bello', 'orcid': 'https://orcid.org/0000-0002-6809-0212'}, 'institutions': [{'id': 'https://openalex.org/I4210153971', 'display_name': 'Instituto Nacional de Cancerología', 'ror': 'https://ror.org/04z3afh10', 'country_code': 'MX', 'type': 'government', 'lineage': ['https://openalex.org/I4210095685', 'https://openalex.org/I4210153971']}, {'id': 'https://openalex.org/I8961855', 'display_name': 'Universidad Nacional Autónoma de México', 'ror': 'https://ror.org/01tmp8f25', 'country_code': 'MX', 'type': 'education', 'lineage': ['https://openalex.org/I8961855']}, {'id': 'https://openalex.org/I59361560', 'display_name': 'Instituto Politécnico Nacional', 'ror': 'https://ror.org/059sp8j34', 'country_code': 'MX', 'type': 'education', 'lineage': ['https://openalex.org/I59361560']}], 'countries': ['MX'], 'is_corresponding': False, 'raw_author_name': 'J. Omar Muñoz-Bello', 'raw_affiliation_strings': ['Departamento de Farmacobiología, Centro de Investigación y Estudios Avanzados del Instituto Politécnico Nacional, Sede sur, Mexico City 14330, Mexico', 'Unidad de Investigación Biomédica en Cáncer, Instituto Nacional de Cancerología-Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City 14080, Mexico'], 'affiliations': [{'raw_affiliation_string': 'Unidad de Investigación Biomédica en Cáncer, Instituto Nacional de Cancerología-Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City 14080, Mexico', 'institution_ids': ['https://openalex.org/I4210153971', 'https://openalex.org/I8961855']}, {'raw_affiliation_string': 'Departamento de Farmacobiología, Centro de Investigación y Estudios Avanzados del Instituto Politécnico Nacional, Sede sur, Mexico City 14330, Mexico', 'institution_ids': ['https://openalex.org/I59361560']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001527057', 'display_name': 'Leslie Olmedo‐Nieva', 'orcid': 'https://orcid.org/0000-0002-9000-0877'}, 'institutions': [{'id': 'https://openalex.org/I8961855', 'display_name': 'Universidad Nacional Autónoma de México', 'ror': 'https://ror.org/01tmp8f25', 'country_code': 'MX', 'type': 'education', 'lineage': ['https://openalex.org/I8961855']}, {'id': 'https://openalex.org/I4210153971', 'display_name': 'Instituto Nacional de Cancerología', 'ror': 'https://ror.org/04z3afh10', 'country_code': 'MX', 'type': 'government', 'lineage': ['https://openalex.org/I4210095685', 'https://openalex.org/I4210153971']}], 'countries': ['MX'], 'is_corresponding': False, 'raw_author_name': 'Leslie Olmedo-Nieva', 'raw_affiliation_strings': ['Programa de Doctorado en Ciencias Bioquímicas, Universidad Nacional Autónoma de México, Ciudad Universitaria, Mexico City 04510, Mexico', 'Unidad de Investigación Biomédica en Cáncer, Instituto Nacional de Cancerología-Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City 14080, Mexico'], 'affiliations': [{'raw_affiliation_string': 'Unidad de Investigación Biomédica en Cáncer, Instituto Nacional de Cancerología-Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City 14080, Mexico', 'institution_ids': ['https://openalex.org/I8961855', 'https://openalex.org/I4210153971']}, {'raw_affiliation_string': 'Programa de Doctorado en Ciencias Bioquímicas, Universidad Nacional Autónoma de México, Ciudad Universitaria, Mexico City 04510, Mexico', 'institution_ids': ['https://openalex.org/I8961855']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5082248615', 'display_name': 'Adriana Contreras‐Paredes', 'orcid': 'https://orcid.org/0000-0001-9965-4108'}, 'institutions': [{'id': 'https://openalex.org/I4210153971', 'display_name': 'Instituto Nacional de Cancerología', 'ror': 'https://ror.org/04z3afh10', 'country_code': 'MX', 'type': 'government', 'lineage': ['https://openalex.org/I4210095685', 'https://openalex.org/I4210153971']}, {'id': 'https://openalex.org/I8961855', 'display_name': 'Universidad Nacional Autónoma de México', 'ror': 'https://ror.org/01tmp8f25', 'country_code': 'MX', 'type': 'education', 'lineage': ['https://openalex.org/I8961855']}], 'countries': ['MX'], 'is_corresponding': False, 'raw_author_name': 'Adriana Contreras-Paredes', 'raw_affiliation_strings': ['Unidad de Investigación Biomédica en Cáncer, Instituto Nacional de Cancerología-Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City 14080, Mexico'], 'affiliations': [{'raw_affiliation_string': 'Unidad de Investigación Biomédica en Cáncer, Instituto Nacional de Cancerología-Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City 14080, Mexico', 'institution_ids': ['https://openalex.org/I4210153971', 'https://openalex.org/I8961855']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045570883', 'display_name': 'Imelda Martínez-Ramírez', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210153971', 'display_name': 'Instituto Nacional de Cancerología', 'ror': 'https://ror.org/04z3afh10', 'country_code': 'MX', 'type': 'government', 'lineage': ['https://openalex.org/I4210095685', 'https://openalex.org/I4210153971']}, {'id': 'https://openalex.org/I8961855', 'display_name': 'Universidad Nacional Autónoma de México', 'ror': 'https://ror.org/01tmp8f25', 'country_code': 'MX', 'type': 'education', 'lineage': ['https://openalex.org/I8961855']}], 'countries': ['MX'], 'is_corresponding': False, 'raw_author_name': 'Imelda Martínez-Ramírez', 'raw_affiliation_strings': ['Unidad de Investigación Biomédica en Cáncer, Instituto Nacional de Cancerología-Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City 14080, Mexico'], 'affiliations': [{'raw_affiliation_string': 'Unidad de Investigación Biomédica en Cáncer, Instituto Nacional de Cancerología-Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City 14080, Mexico', 'institution_ids': ['https://openalex.org/I4210153971', 'https://openalex.org/I8961855']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012199796', 'display_name': 'Elizabeth Langley', 'orcid': 'https://orcid.org/0000-0001-6180-8036'}, 'institutions': [{'id': 'https://openalex.org/I4210153971', 'display_name': 'Instituto Nacional de Cancerología', 'ror': 'https://ror.org/04z3afh10', 'country_code': 'MX', 'type': 'government', 'lineage': ['https://openalex.org/I4210095685', 'https://openalex.org/I4210153971']}, {'id': 'https://openalex.org/I8961855', 'display_name': 'Universidad Nacional Autónoma de México', 'ror': 'https://ror.org/01tmp8f25', 'country_code': 'MX', 'type': 'education', 'lineage': ['https://openalex.org/I8961855']}], 'countries': ['MX'], 'is_corresponding': False, 'raw_author_name': 'Elizabeth Langley', 'raw_affiliation_strings': ['Unidad de Investigación Biomédica en Cáncer, Instituto Nacional de Cancerología-Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City 14080, Mexico'], 'affiliations': [{'raw_affiliation_string': 'Unidad de Investigación Biomédica en Cáncer, Instituto Nacional de Cancerología-Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City 14080, Mexico', 'institution_ids': ['https://openalex.org/I4210153971', 'https://openalex.org/I8961855']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5058350399', 'display_name': 'Marcela Lizano', 'orcid': 'https://orcid.org/0000-0002-7553-2541'}, 'institutions': [{'id': 'https://openalex.org/I4210153971', 'display_name': 'Instituto Nacional de Cancerología', 'ror': 'https://ror.org/04z3afh10', 'country_code': 'MX', 'type': 'government', 'lineage': ['https://openalex.org/I4210095685', 'https://openalex.org/I4210153971']}, {'id': 'https://openalex.org/I8961855', 'display_name': 'Universidad Nacional Autónoma de México', 'ror': 'https://ror.org/01tmp8f25', 'country_code': 'MX', 'type': 'education', 'lineage': ['https://openalex.org/I8961855']}], 'countries': ['MX'], 'is_corresponding': True, 'raw_author_name': 'Marcela Lizano', 'raw_affiliation_strings': ['Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad Universitaria, Mexico City 04510, Mexico', 'Unidad de Investigación Biomédica en Cáncer, Instituto Nacional de Cancerología-Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City 14080, Mexico'], 'affiliations': [{'raw_affiliation_string': 'Unidad de Investigación Biomédica en Cáncer, Instituto Nacional de Cancerología-Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City 14080, Mexico', 'institution_ids': ['https://openalex.org/I4210153971', 'https://openalex.org/I8961855']}, {'raw_affiliation_string': 'Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad Universitaria, Mexico City 04510, Mexico', 'institution_ids': ['https://openalex.org/I8961855']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': ['https://openalex.org/A5058350399'], 'corresponding_institution_ids': ['https://openalex.org/I4210153971', 'https://openalex.org/I8961855'], 'apc_list': {'value': 2300, 'currency': 'CHF', 'value_usd': 2490, 'provenance': 'doaj'}, 'apc_paid': {'value': 2300, 'currency': 'CHF', 'value_usd': 2490, 'provenance': 'doaj'}, 'fwci': 0.618, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 25, 'citation_normalized_percentile': {'value': 0.999775, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '21', 'issue': '8', 'first_page': '2872', 'last_page': '2872'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11482', 'display_name': 'RNA modifications and cancer', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11482', 'display_name': 'RNA modifications and cancer', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10515', 'display_name': 'Cancer-related molecular mechanisms research', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10631', 'display_name': 'Cancer, Hypoxia, and Metabolism', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/glutaminolysis', 'display_name': 'Glutaminolysis', 'score': 0.9990554}, {'id': 'https://openalex.org/keywords/metabolic-pathway', 'display_name': 'Metabolic pathway', 'score': 0.5509429}, {'id': 'https://openalex.org/keywords/glutamine-amidotransferase', 'display_name': 'Glutamine amidotransferase', 'score': 0.54480755}, {'id': 'https://openalex.org/keywords/glutaminase', 'display_name': 'Glutaminase', 'score': 0.48131764}], 'concepts': [{'id': 'https://openalex.org/C2778160063', 'wikidata': 'https://www.wikidata.org/wiki/Q1532402', 'display_name': 'Glutaminolysis', 'level': 4, 'score': 0.9990554}, {'id': 'https://openalex.org/C2779349466', 'wikidata': 'https://www.wikidata.org/wiki/Q181619', 'display_name': 'Glutamine', 'level': 3, 'score': 0.6555505}, {'id': 'https://openalex.org/C96232424', 'wikidata': 'https://www.wikidata.org/wiki/Q4118072', 'display_name': 'Cancer cell', 'level': 3, 'score': 0.56613916}, {'id': 'https://openalex.org/C192989942', 'wikidata': 'https://www.wikidata.org/wiki/Q68685', 'display_name': 'Metabolic pathway', 'level': 3, 'score': 0.5509429}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.54501426}, {'id': 'https://openalex.org/C75972863', 'wikidata': 'https://www.wikidata.org/wiki/Q5572442', 'display_name': 'Glutamine amidotransferase', 'level': 4, 'score': 0.54480755}, {'id': 'https://openalex.org/C165135838', 'wikidata': 'https://www.wikidata.org/wiki/Q133895', 'display_name': 'Citric acid cycle', 'level': 3, 'score': 0.5232317}, {'id': 'https://openalex.org/C20251656', 'wikidata': 'https://www.wikidata.org/wiki/Q162643', 'display_name': 'Glycolysis', 'level': 3, 'score': 0.49682}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.48508373}, {'id': 'https://openalex.org/C109549099', 'wikidata': 'https://www.wikidata.org/wiki/Q24773687', 'display_name': 'Glutaminase', 'level': 4, 'score': 0.48131764}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.45587817}, {'id': 'https://openalex.org/C34905852', 'wikidata': 'https://www.wikidata.org/wiki/Q3943646', 'display_name': 'Stable isotope labeling by amino acids in cell culture', 'level': 4, 'score': 0.44766027}, {'id': 'https://openalex.org/C62231903', 'wikidata': 'https://www.wikidata.org/wiki/Q1057', 'display_name': 'Metabolism', 'level': 2, 'score': 0.37459853}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.34053424}, {'id': 'https://openalex.org/C515207424', 'wikidata': 'https://www.wikidata.org/wiki/Q8066', 'display_name': 'Amino acid', 'level': 2, 'score': 0.20952463}, {'id': 'https://openalex.org/C46111723', 'wikidata': 'https://www.wikidata.org/wiki/Q471857', 'display_name': 'Proteomics', 'level': 3, 'score': 0.08759853}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.07446185}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.060823232}], 'mesh': [{'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D005973', 'descriptor_name': 'Glutamine', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D022661', 'descriptor_name': 'RNA, Untranslated', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005973', 'descriptor_name': 'Glutamine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053858', 'descriptor_name': 'Metabolic Networks and Pathways', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D053858', 'descriptor_name': 'Metabolic Networks and Pathways', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D035683', 'descriptor_name': 'MicroRNAs', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D035683', 'descriptor_name': 'MicroRNAs', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058990', 'descriptor_name': 'Molecular Targeted Therapy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034622', 'descriptor_name': 'RNA Interference', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000079962', 'descriptor_name': 'RNA, Circular', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D000079962', 'descriptor_name': 'RNA, Circular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D022661', 'descriptor_name': 'RNA, Untranslated', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/ijms21082872', 'pdf_url': 'https://www.mdpi.com/1422-0067/21/8/2872/pdf?version=1587482037', 'source': {'id': 'https://openalex.org/S10623703', 'display_name': 'International Journal of Molecular Sciences', 'issn_l': '1422-0067', 'issn': ['1422-0067', '1661-6596'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/fda9c1b6c25748a7b155db8324e964d4', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc7216265', 'pdf_url': 'https://europepmc.org/articles/pmc7216265?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216265', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/32326003', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/ijms21082872', 'pdf_url': 'https://www.mdpi.com/1422-0067/21/8/2872/pdf?version=1587482037', 'source': {'id': 'https://openalex.org/S10623703', 'display_name': 'International Journal of Molecular Sciences', 'issn_l': '1422-0067', 'issn': ['1422-0067', '1661-6596'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/7', 'score': 0.57, 'display_name': 'Affordable and clean energy'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 133, 'referenced_works': ['https://openalex.org/W1511793991', 'https://openalex.org/W1772301402', 'https://openalex.org/W1806952617', 'https://openalex.org/W1966411071', 'https://openalex.org/W1972806358', 'https://openalex.org/W1976149758', 'https://openalex.org/W1977802164', 'https://openalex.org/W1977923848', 'https://openalex.org/W1992962914', 'https://openalex.org/W2000630389', 'https://openalex.org/W2004029499', 'https://openalex.org/W2004574994', 'https://openalex.org/W2014578524', 'https://openalex.org/W2017919052', 'https://openalex.org/W2025176940', 'https://openalex.org/W2027785297', 'https://openalex.org/W2040408177', 'https://openalex.org/W2046217047', 'https://openalex.org/W2052384272', 'https://openalex.org/W2055255976', 'https://openalex.org/W2055493067', 'https://openalex.org/W2058835062', 'https://openalex.org/W2060592426', 'https://openalex.org/W2061251682', 'https://openalex.org/W2064165694', 'https://openalex.org/W2068275410', 'https://openalex.org/W2068884297', 'https://openalex.org/W2074873270', 'https://openalex.org/W2079983771', 'https://openalex.org/W2085834766', 'https://openalex.org/W2086816631', 'https://openalex.org/W2087718006', 'https://openalex.org/W2090406819', 'https://openalex.org/W2097259163', 'https://openalex.org/W2109227959', 'https://openalex.org/W2117473844', 'https://openalex.org/W2117692326', 'https://openalex.org/W2121691257', 'https://openalex.org/W2132117833', 'https://openalex.org/W2134640615', 'https://openalex.org/W2137785594', 'https://openalex.org/W2142682640', 'https://openalex.org/W2150767213', 'https://openalex.org/W2155124667', 'https://openalex.org/W2155319744', 'https://openalex.org/W2162295781', 'https://openalex.org/W2179994591', 'https://openalex.org/W2203864094', 'https://openalex.org/W2211215064', 'https://openalex.org/W2234115940', 'https://openalex.org/W2239158335', 'https://openalex.org/W2263613603', 'https://openalex.org/W2282084472', 'https://openalex.org/W2316171452', 'https://openalex.org/W2340510805', 'https://openalex.org/W2343904188', 'https://openalex.org/W2402737866', 'https://openalex.org/W2418959584', 'https://openalex.org/W2488747960', 'https://openalex.org/W2503851771', 'https://openalex.org/W2509738156', 'https://openalex.org/W2514258009', 'https://openalex.org/W2515129893', 'https://openalex.org/W2518235524', 'https://openalex.org/W2531816667', 'https://openalex.org/W2534904302', 'https://openalex.org/W2562634188', 'https://openalex.org/W2566944468', 'https://openalex.org/W2586742210', 'https://openalex.org/W2591443418', 'https://openalex.org/W2593315117', 'https://openalex.org/W2600581473', 'https://openalex.org/W2608190552', 'https://openalex.org/W2616072553', 'https://openalex.org/W2621874234', 'https://openalex.org/W2728879620', 'https://openalex.org/W2742225835', 'https://openalex.org/W2760056442', 'https://openalex.org/W2761314975', 'https://openalex.org/W2765243377', 'https://openalex.org/W2766057724', 'https://openalex.org/W2766969050', 'https://openalex.org/W2768096340', 'https://openalex.org/W2771345740', 'https://openalex.org/W2773957517', 'https://openalex.org/W2782620814', 'https://openalex.org/W2783764907', 'https://openalex.org/W2788131326', 'https://openalex.org/W2792104241', 'https://openalex.org/W2792523396', 'https://openalex.org/W2794021749', 'https://openalex.org/W2797145001', 'https://openalex.org/W2806411025', 'https://openalex.org/W2807334922', 'https://openalex.org/W2884392492', 'https://openalex.org/W2885597648', 'https://openalex.org/W2888727370', 'https://openalex.org/W2889762006', 'https://openalex.org/W2896786673', 'https://openalex.org/W2903690648', 'https://openalex.org/W2904206268', 'https://openalex.org/W2906635219', 'https://openalex.org/W2909876769', 'https://openalex.org/W2913184540', 'https://openalex.org/W2914531847', 'https://openalex.org/W2915075022', 'https://openalex.org/W2917251052', 'https://openalex.org/W2921455619', 'https://openalex.org/W2921597682', 'https://openalex.org/W2921882381', 'https://openalex.org/W2923648344', 'https://openalex.org/W2923966098', 'https://openalex.org/W2927609087', 'https://openalex.org/W2940296170', 'https://openalex.org/W2943835743', 'https://openalex.org/W2946599769', 'https://openalex.org/W2946784634', 'https://openalex.org/W2948707395', 'https://openalex.org/W2958863468', 'https://openalex.org/W2966011293', 'https://openalex.org/W2966205177', 'https://openalex.org/W2969668486', 'https://openalex.org/W2971808888', 'https://openalex.org/W2979693741', 'https://openalex.org/W2980237995', 'https://openalex.org/W2980249524', 'https://openalex.org/W2982780080', 'https://openalex.org/W2988671424', 'https://openalex.org/W2999279033', 'https://openalex.org/W2999860839', 'https://openalex.org/W3003897690', 'https://openalex.org/W3009792425', 'https://openalex.org/W3010778905'], 'related_works': ['https://openalex.org/W4307823918', 'https://openalex.org/W4231382750', 'https://openalex.org/W3095609398', 'https://openalex.org/W2913642205', 'https://openalex.org/W2563696845', 'https://openalex.org/W2244659270', 'https://openalex.org/W2090333491', 'https://openalex.org/W2074873270', 'https://openalex.org/W2060450593', 'https://openalex.org/W2046560945'], 'abstract_inverted_index': {'Cancer': [0], 'cells': [1, 91], 'exhibit': [2], 'exacerbated': [3], 'metabolic': [4], 'activity': [5], 'to': [6, 16, 61, 105, 119, 152], 'maintain': [7], 'their': [8, 34, 158, 178], 'accelerated': [9], 'proliferation': [10], 'and': [11, 28, 66, 76, 83, 127, 134, 157], 'microenvironmental': [12], 'adaptation': [13], 'in': [14, 25, 122, 143, 155, 172, 180, 183, 187], 'order': [15], 'survive': [17], 'under': [18], 'nutrient-deficient': [19], 'conditions.': [20], 'Tumors': [21], 'display': [22], 'an': [23, 102], 'increase': [24], 'glycolysis,': [26], 'glutaminolysis': [27, 49, 114, 145], 'fatty': [29, 77], 'acid': [30], 'biosynthesis,': [31], 'which': [32], 'provide': [33], 'energy': [35], 'source.': [36], 'Glutamine': [37], 'is': [38, 185], 'critical': [39], 'for': [40, 52, 80, 160], 'fundamental': [41], 'cellular': [42, 81], 'processes,': [43], 'where': [44], 'intermediate': [45], 'metabolites': [46], 'produced': [47], 'through': [48], 'are': [50, 92, 166], 'necessary': [51], 'the': [53, 67, 70, 84, 107, 113, 140, 144, 173], 'maintenance': [54], 'of': [55, 69, 86, 112, 125, 175], 'mitochondrial': [56], 'metabolism.': [57], 'These': [58], 'include': [59], 'antioxidants': [60], 'remove': [62], 'reactive': [63], 'oxygen': [64], 'species,': [65], 'generation': [68], 'nonessential': [71], 'amino': [72], 'acids,': [73], 'purines,': [74], 'pyrimidines': [75], 'acids': [78], 'required': [79], 'replication': [82], 'activation': [85], 'cell': [87], 'signaling.': [88], 'Some': [89], 'cancer': [90, 156, 161, 184], 'highly': [93], 'dependent': [94], 'on': [95], 'glutamine': [96, 181], 'consumption': [97], 'since': [98], 'its': [99], 'catabolism': [100], 'provides': [101], 'anaplerotic': [103], 'pathway': [104, 115], 'feed': [106], 'Krebs': [108], 'cycle.': [109], 'Intermediate': [110], 'members': [111], 'have': [116, 128, 149], 'been': [117, 129, 150], 'found': [118, 151], 'be': [120, 153], 'deregulated': [121, 154], 'several': [123], 'types': [124], 'cancers': [126], 'proposed': [130], 'as': [131, 169], 'therapeutic': [132], 'targets': [133], 'prognostic': [135], 'biomarkers.': [136], 'This': [137], 'review': [138], 'summarizes': [139], 'main': [141], 'players': [142], 'pathway,': [146], 'how': [147], 'they': [148], 'implications': [159], 'maintenance.': [162], 'Furthermore,': [163], 'non-coding': [164], 'RNAs': [165], 'now': [167], 'recognized': [168], 'new': [170], 'participants': [171], 'regulation': [174], 'glutaminolysis;': [176], 'therefore,': [177], 'involvement': [179], 'metabolism': [182], 'discussed': [186], 'detail.': [188]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3016342831', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 1}], 'updated_date': '2024-12-08T14:51:48.784735', 'created_date': '2020-04-24'}