Non-alcoholic fatty liver diseases in patients with COVID-19: A retrospective study

Name: Work Video:
Duration: 3 min 30 s
Dong Ji; Enqiang Qin; Jing Xu; Dawei Zhang; Gregory Cheng; Yu Wang; George Lau
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1663, 1680, 1896, 1912, 1916, 1919, 2023, 2029, 2033, 2050, 2073, 2089, 2093, 2096, 2152, 2164, 2241, 2262, 2279, 2303, 2313, 2329, 2340, 2353, 2366, 2392, 2404, 2476, 2486, 2504, 2529, 2554, 2576, 2590, 2598, 2605, 2639, 2645, 2659, 2674, 2710, 2727, 2761, 2764, 2782, 2801, 2843], 'severe': [11, 59, 120, 140, 175, 710, 1234, 1955, 2136, 2579, 2606], 'COVID-19': [12, 60, 141, 184, 217, 282, 442, 552, 662, 711, 767, 811, 871, 890, 916, 1176, 1182, 1198, 1217, 1227, 1503, 1640, 1647, 2213, 2494, 2530, 2580, 2698, 2767, 2804], 'illness:': [13, 712], 'A': [14, 177, 204, 713], 'multicenter': [15, 714], 'preliminary': [16, 715], "analysis'Journal": [17], 'HepatologyVol.': [19, 150, 249, 366, 461, 571, 718, 830, 933], '73Issue': [20, 250, 367, 462, 719, 934], '3PreviewWe': [21, 251, 368, 720, 935], 'read': [22, 252, 369, 574, 721, 833], 'interest': [24, 254, 371, 576, 724, 836, 942, 2341, 2844], 'the': [25, 33, 72, 78, 81, 86, 94, 97, 132, 146, 156, 255, 264, 302, 341, 372, 458, 470, 489, 502, 506, 509, 531, 535, 562, 577, 593, 602, 649, 656, 691, 725, 736, 758, 821, 837, 850, 886, 898, 930, 953, 956, 973, 991, 997, 1005, 1121, 1143, 1204, 1231, 1243, 1257, 1422, 1430, 1450, 1457, 1482, 1664, 1685, 1825, 1839, 1884, 1900, 1975, 1989, 2034, 2055, 2064, 2077, 2307, 2363, 2384, 2389, 2421, 2433, 2502, 2622, 2632, 2646, 2649, 2656, 2662, 2665, 2671, 2679, 2707, 2762, 2777, 2797, 2814, 2825, 2831, 2836, 2853], 'letter': [26, 373, 838], 'by': [27, 71, 259, 374, 579, 727, 772, 799, 839, 1208, 1230, 1246, 1319, 1361, 1449, 1473, 1838, 1988, 2425, 2484, 2776], 'YJ': [28], 'Zhou': [29], 'et': [30, 376, 467, 581, 644, 729, 774, 841, 938, 1073, 1111, 1376, 2259, 2297, 2447, 2526], 'al.': [31, 468, 645, 730, 939], 'stressing': [32], 'finding': [34, 430], 'that,': [35], 'in': [36, 62, 155, 219, 229, 243, 263, 360, 412, 481, 505, 513, 551, 626, 673, 696, 745, 782, 810, 870, 914, 918, 943, 965, 976, 996, 1014, 1024, 1085, 1114, 1158, 1178, 1201, 1242, 1516, 2111, 2210, 2218, 2271, 2300, 2430, 2474, 2493, 2556, 2631, 2678, 2697, 2703, 2733, 2766, 2796, 2805], 'their': [37, 379, 584, 618, 697, 941, 948], 'own': [38], 'series,': [39], 'metabolic-associated': [40, 244, 272, 361, 415, 740], 'fatty': [41, 48, 164, 245, 273, 342, 362, 416, 423, 474, 741, 854, 961, 1151, 1386, 1951, 2132, 2737], 'liver': [42, 49, 165, 239, 246, 274, 290, 315, 343, 356, 363, 417, 424, 475, 549, 732, 742, 778, 808, 855, 861, 962, 1144, 1152, 1289, 1387, 1531, 1552, 1952, 2133, 2166, 2208, 2330, 2472, 2491, 2561, 2663, 2669, 2738], 'disease': [43, 50, 121, 166, 198, 275, 283, 418, 425, 476, 559, 615, 636, 641, 663, 743, 818, 856, 862, 963, 1443, 1487, 1573, 1854, 2004, 2153], '(MAFLD,': [44, 419], 'also': [45, 210, 765, 882, 2571], 'termed': [46], 'non-alcoholic': [47, 422, 473, 853, 960, 1150, 1950, 2131, 2736], '[NAFLD])': [51, 426], 'is': [52, 168, 431, 457, 495, 538, 545, 610, 780, 804, 844, 865, 906, 929, 2339, 2495, 2611, 2653, 2682, 2774], 'associated': [53, 866, 1638, 2531], 'an': [55, 237, 354, 611, 907, 1029], 'illness': [61, 1654, 2024], 'younger': [63, 220], 'but': [64, 227, 555, 814, 2216, 2613], 'not': [65, 228, 408, 556, 631, 815], 'older': [66, 89, 230], 'patients.1': [67], 'As': [68], 'pointed': [69, 647, 770], 'out': [70, 648, 771], 'authors,': [73], 'a': [74, 110, 116, 169, 193, 278, 322, 337, 496, 521, 546, 598, 632, 785, 805, 845, 876, 1115, 1291, 1380, 1580, 2112, 2149, 2301, 2359, 2573, 2595, 2683, 2694, 2758], 'notable': [75], 'limitation': [76], 'study': [79, 179, 206, 532, 585, 619, 675, 1446, 2205], 'was': [80, 492, 533, 630, 968, 989, 1228, 1252, 1262, 1311, 1334, 1410, 1447, 1514, 1533, 1655, 1881, 2025, 2061, 2214, 2332], 'smaller': [82], 'sample': [83], 'size': [84], 'cohort': [87, 1295], 'patients,': [90, 209, 311], 'which': [91, 494], 'might': [92, 796, 2614, 2692, 2713], 'influence': [93], 'validity': [95], 'results.': [98], 'Actually,': [99], 'if': [100, 446, 1256, 1307, 1324, 1349, 1356], 'both': [101, 1325], 'age': [102, 1606], 'groups': [103], 'were': [104, 406, 1188, 1199, 1330, 1436, 1471, 1492, 1510, 1574, 1637, 1817, 1831, 1967, 1981], 'combined': [105], 'together': [106], 'and': [107, 261, 285, 403, 586, 592, 668, 690, 735, 750, 755, 864, 881, 946, 979, 999, 1147, 1183, 1192, 1220, 1267, 1327, 1425, 1456, 1475, 1497, 1504, 1519, 1525, 1561, 1566, 1579, 1585, 1590, 1628, 1674, 1822, 1836, 1855, 1863, 1921, 1972, 1986, 2005, 2013, 2044, 2098, 2179, 2565, 2581, 2635, 2642, 2681, 2735, 2786, 2799, 2811, 2818, 2823, 2828, 2834], 'analyzed': [108], 'as': [109, 389, 597, 676, 769, 1002, 1254, 1336, 1657, 1819, 1833, 1883, 1969, 1983, 2027, 2063, 2342, 2508], 'whole,': [111], 'had': [115, 192, 443, 448, 1541, 1549, 1564, 1576, 1860, 2010, 2148, 2344, 2563, 2572, 2830], 'high': [117, 497, 522, 877, 970, 2351, 2360, 2566], 'likelihood': [118, 287, 2163], 'compared': [122, 971, 1823, 1837, 1973, 1987, 2195], 'to': [123, 138, 143, 174, 295, 329, 336, 344, 409, 436, 501, 518, 655, 660, 678, 784, 972, 1004, 1173, 1480, 1507, 1556, 1754, 1886, 2066, 2170, 2196, 2201, 2397, 2420, 2432, 2578, 2617, 2621, 2661, 2720, 2725, 2847, 2852], 'those': [124, 187], 'without': [125, 202, 299, 2198], '(26.9%': [127], 'vs.': [128, 1009, 2157, 2174, 2188], 'Full-Text': [129, 232, 347, 451, 540, 699, 801, 921, 1017], 'PDF': [130, 233, 348, 452, 541, 700, 802, 922, 1018, 1398, 2464, 2546, 2751], 'Is': [131], 'for': [135, 172, 216, 236, 353, 601, 624, 693, 849, 911, 940, 947, 1216, 1265, 1270, 1287, 1408, 2362, 2510, 2833, 2858], 'develop': [139], 'linked': [142], 'perturbation': [144], 'gut-liver': [147], 'axis?Journal': [148], '74Issue': [151, 572, 831], '2PreviewTwo': [152], 'recent': [153], 'studies': [154], 'Journal': [157, 265], 'Hepatology': [159], 'suggest': [160, 2594], 'that': [161, 186, 269, 439, 456, 488, 608, 621, 791, 904, 928, 955, 981, 1596, 2207, 2347, 2490, 2702, 2845], 'metabolic': [162, 859], 'dysfunction-associated': [163, 860], '(MAFLD)': [167, 276, 744, 863], 'factor': [171, 848, 910], 'progression': [173, 199, 218, 284, 565, 824, 2154, 2577, 2726], 'COVID-19.': [176, 1162, 1433, 2607], 'Chinese': [178, 1159, 1210], '202': [181], 'found': [185, 213, 407, 607], 'indicators': [189], 'higher': [194, 279, 286, 338, 1577, 1581, 1614, 2150, 2162, 2574], 'respiratory': [197, 682, 1236, 1666, 1913, 1957, 2036, 2090, 2138, 2413, 2513, 2534], 'than': [200, 297, 2336, 2500], 'MAFLD.1': [203, 300], 'subsequent': [205], '327': [208], 'from': [211, 293, 516, 1032, 1419, 1554, 1889, 2069, 2168, 2664, 2716], 'China,': [212, 529], '(<60': [221], 'years': [222, 1608, 1706], 'old)': [223], 'ones.': [231], 'No': [234, 1747], 'evidence': [235, 352], 'uptake': [240, 357], 'SARS-CoV-2': [242, 345, 359, 384, 484, 1888, 1930, 2068, 2107], 'diseaseJournal': [247], 'research': [256], 'article': [257, 578, 726], 'published': [258], 'Ji': [260, 466, 728, 773, 840], 'colleagues,': [262], 'Hepatology,': [267], 'showing': [268], 'have': [277, 984, 2350, 2769], 'abnormal': [289, 1551, 2165], 'blood': [291, 316, 2660], 'tests': [292, 1923, 2100], 'admission': [294, 1470, 1524, 1555, 2169], 'discharge': [296, 1417, 1897, 2074, 2171], 'Given': [301], 'absence': [303], 'data': [305, 2381, 2822], 'on': [306, 478, 561, 731, 794, 820, 1155, 1185, 1416, 1469, 1523, 1648, 1651, 1865, 2015, 2383], 'medical': [307], 'history': [308], 'these': [310], 'this': [312, 464, 2592, 2848], 'persistence': [313], 'test': [317, 1841, 1991], 'abnormalities': [318, 327], 'could': [319, 332, 2601], 'be': [320, 334, 410, 653, 797, 994, 2602, 2615, 2714], 'either': [321, 1412], 'mere': [323], 'reflection': [324], 'pre-existing': [326], 'related': [328, 2419, 2616], 'or': [331, 427, 454, 564, 638, 823, 858, 926, 1418, 1442, 1543, 1678, 1842, 1992, 2048], 'alternatively': [333], 'due': [335, 654], 'susceptibility': [339], 'infection.': [346, 485], "'No": [351], "disease'Journal": [364], 'Biquard': [375], 'al.1': [377, 582, 775, 842], 'In': [378, 527, 2411, 2624], 'study,': [380], 'mRNA': [381], 'expression': [382, 2352, 2387], 'infection': [385], 'critical': [386, 2695], 'genes,': [387], 'such': [388], 'angiotensin-converting': [390, 2354], 'enzyme': [391, 2355], '2': [392, 397, 1174, 1239, 1348, 1351, 1355], '(ACE2),': [393], 'transmembrane': [394], 'protease': [395], 'serine': [396], '(TMPRSS2),': [398], 'phosphatidylinositol': [399], '3-phosphate': [400], '5-kinase': [401], '(PIKFYVE)': [402], 'cathepsin': [404], 'L': [405], 'enhanced': [411], 'previously': [420], 'called': [421], 'obesity.': [428], 'This': [429, 2338, 2772], 'potential': [433, 2390], 'added': [434], 'value': [435, 1406], 'our': [437, 674, 919, 944, 966, 1015, 2204, 2477, 2557, 2599, 2806], 'observation': [438], 'worse': [444, 912], 'outcomes': [445, 480, 869, 913, 1157], 'they': [447], 'underlying': [449, 1621, 2609], 'MAFLD.': [450], 'NAFLD': [453, 491, 512, 609, 629, 803, 905, 988, 1186, 1333, 1508, 1586, 1629, 2147, 2564, 2570, 2765], 'comorbidities,': [455, 927], 'questionJournal': [459], '3PreviewIn': [463], 'study,1': [465], 'describe': [469], 'implication': [471, 1148], '(NAFLD)': [477, 857, 964, 1154], 'clinical': [479, 737, 1156, 1193, 1467], 'They': [486, 951], 'reported': [487, 536, 975], 'prevalence': [490, 510, 537, 878, 958, 992, 2589], '37.6%,': [493], 'percentage': [498, 1582], 'respect': [500], 'population': [503, 874, 2600], 'included': [504, 1847, 1997], 'study.': [507, 698, 1016, 2837], 'Indeed,': [508], 'China': [514, 978, 1179], 'ranges': [515], '15%': [517], '40%,2': [519], 'variability': [523], 'between': [524], 'different': [525, 650, 657, 2393], 'regions.': [526], 'northeastern': [528], 'where': [530], 'conducted,': [534], '26.9%.3': [539], '"NAFLD': [544], 'predictor': [547, 613, 633, 806], 'injury': [550, 733, 809, 1020, 1044, 1145, 1251, 1513, 1532, 2209, 2230, 2331, 2492, 2562], 'hospitalized': [553, 812, 915, 1078, 2264], 'mortality,': [558, 635, 817], 'severity': [560, 759, 795, 819], 'presentation': [563, 822], '–': [566, 825], 'The': [567, 826, 1190, 1209, 1404, 1434, 1445, 1464, 1964, 2071, 2327, 2470, 2552, 2608, 2668, 2838], 'debate': [568, 827], 'continues"Journal': [569], '2PreviewWe': [573, 832], 'Mushtaq': [580, 643], 'Both': [583], 'ours1,2': [587], 'used': [588, 659, 1407], 'similar': [589, 995], 'inclusion': [590], 'criteria': [591, 658, 1895, 2072], 'hepatic': [594, 1337, 2650, 2688, 2711], 'steatosis': [595, 1338, 1378], 'index': [596, 1339], 'surrogate': [599], 'marker': [600], 'presence': [603], 'NAFLD.': [605, 986, 2199], 'We': [606, 902, 1141, 2700, 2790], 'independent': [612, 908, 1483], 'progression.': [616, 642, 1444, 1488], 'However,': [617, 2757], 'showed': [620, 1595, 2206, 2479], 'when': [622], 'controlled': [623], 'covariates': [625], 'multivariate': [627, 1476, 1591], 'analysis,': [628], 'severity,': [637, 768], 'markers': [639], 'correctly': [646], 'conclusions': [651], 'may': [652, 983, 2593, 2768], 'define': [661], 'progression,': [664], 'development': [665, 679, 851, 1658, 2028], 'tachypnea': [667], 'requirement': [669], 'oxygen': [671, 1671, 2041], 'supplements': [672], 'opposed': [677, 1003], 'acute': [681, 1235, 1956, 2137, 2533], 'distress': [683, 2535], 'syndrome,': [684], 'intensive': [685], 'care': [686], 'unit': [687], '(ICU)': [688], 'admission,': [689], 'need': [692], 'mechanical': [694], 'ventilation': [695], 'Younger': [701], 'analysisJournal': [716], 'great': [723, 835], 'patterns': [734, 1146], 'implications': [738], 'COVID-19.1': [748], 'Metabolic': [749], 'cardiovascular': [751, 1850, 2000], 'comorbidities': [752], 'like': [753], 'diabetes': [754, 1352], 'hypertension': [756], 'aggravate': [757], 'COVID-19.2': [761], 'Another': [762, 1867, 2017], 'comorbidity,': [763], 'MAFLD,': [764], 'affects': [766], 'Since': [776], 'excess': [777], 'fat': [779], 'seen': [781], 'up': [783], 'quarter': [786], 'people,3': [788], 'we': [789, 982], 'hypothesized': [790, 903], 'its': [792], 'impact': [793], 'modulated': [798], 'age.': [800], 'continuesJournal': [828], 'Obesity': [843], 'well-recognized': [846], 'adverse': [868], 'patients.2,3': [872], "Qatar's": [873], 'has': [875, 883, 1021, 2417], 'obesity4': [880], 'one': [884, 896, 1662, 2032, 2475], 'highest': [887], 'rates': [888], 'cases': [891], 'per': [892], 'million': [893], 'population,': [894], 'lowest': [899], 'mortality': [900], 'rates.5': [901], 'population.': [920], "'NAFLD": [925], "question'Journal": [931], 'thank': [936], 'Ponziani': [937], 'manuscript': [945], 'thoughtful': [949], 'comments.1': [950], 'raised': [952, 1331], 'concern': [954], '37.6%': [957], 'cohorts': [967], 'rather': [969, 2335, 2499], '26.9%': [974], 'Northeastern': [977], 'suggested': [980], 'over-diagnosed': [985], 'If': [987], 'over-diagnosed,': [990], 'should': [993], 'stable': [998, 1567], 'progressive': [1000, 1565, 1572], 'groups,': [1001], 'marked': [1006], 'difference,': [1007], '25.8%': [1008], '87.2': [1010], '%,': [1011], 'respectively,': [1012], 'observed': [1013, 1023, 1515], 'Liver': [1019, 1043, 1250, 1389, 1512, 2229], 'been': [1022, 2345, 2418], 'COVID-19,': [1027], 'incidence': [1030], 'ranging': [1031], '14–53%.1Xu': [1033], 'L.': [1034, 2220, 2517, 2523], 'Liu': [1035, 1069, 2221, 2255], 'J.': [1036, 1072, 1274, 2222, 2258, 2372, 2376, 2521], 'Lu': [1037, 2223], 'M.': [1038, 2224], 'Yang': [1039, 1372, 2225], 'D.': [1040, 1062, 1367, 2226, 2248], 'Zheng': [1041, 2227], 'X.': [1042, 1070, 2228, 2256, 2368], 'during': [1045, 1526, 1684, 1870, 2020, 2054, 2231, 2452], 'highly': [1046, 2232], 'pathogenic': [1047, 2233], 'human': [1048, 2234, 2394], 'coronavirus': [1049, 1124, 1238, 1959, 2140, 2235, 2310], 'infections.Liver': [1050, 2236], 'Int.': [1051, 2237], '2020;': [1052, 1133, 2238, 2319, 2401, 2539], '([Epub': [1053, 1091, 2239, 2277, 2402], 'ahead': [1054, 1092, 2240, 2278, 2403], 'print])https://doi.org/10.1111/liv.14435Crossref': [1056, 2242], 'Scopus': [1057, 1095, 1137, 1302, 1400, 2243, 2281, 2323, 2407, 2466, 2548, 2753], '(613)': [1058, 2244], 'Google': [1059, 1097, 1139, 1304, 1402, 2245, 2283, 2325, 2409, 2468, 2550, 2755], 'Scholar,': [1060, 1098, 2246, 2284], '2Wang': [1061, 2247], 'Hu': [1063, 1065, 2249, 2251], 'B.': [1064, 2250], 'C.': [1066, 2252, 2525], 'Zhu': [1067, 2253], 'F.': [1068, 2254, 2731], 'Zhang': [1071, 2257, 2520, 2524], 'al.Clinical': [1074, 1112, 2260, 2298], 'characteristics': [1075, 1468, 1643, 1650, 2261], '138': [1077, 2263], '2019': [1081, 1122, 2267, 2308], 'novel': [1082, 1123, 2268, 2309], 'coronavirus-infected': [1083, 2269], 'pneumonia': [1084, 2270], 'Wuhan,': [1086, 1128, 2272, 2314], 'China.JAMA.': [1087, 2273], '2020': [1088, 2274], 'Feb': [1089, 2275], '7;': [1090, 2276], 'print])https://doi.org/10.1001/jama.2020.1585Crossref': [1094, 2280], '(16385)': [1096, 2282], '3Xu': [1099, 2285], 'X.W.': [1100, 2286], 'Wu': [1101, 2287], 'X.X.': [1102, 2288], 'Jiang': [1103, 2289], 'X.G.': [1104, 2290], 'Xu': [1105, 2291], 'K.J.': [1106, 2292], 'Ying': [1107, 2293], 'L.J.': [1108, 2294], 'Ma': [1109, 2295], 'C.L.': [1110, 2296], 'findings': [1113, 2299, 2528], 'group': [1116, 2302], 'infected': [1119, 2305], '(SARS-Cov-2)': [1125, 2311], 'outside': [1126, 2312], 'China:': [1129, 2315], 'retrospective': [1130, 2316], 'case': [1131, 2317], 'series.BMJ.': [1132, 2318], '368:': [1134, 2320], 'm606Crossref': [1135, 2321], 'PubMed': [1136, 1399, 2322, 2406, 2465, 2547, 2752], '(1461)': [1138, 2324], 'Scholar': [1140, 1226, 1403, 2326, 2410, 2469, 2551, 2756], 'examined': [1142], 'diseases': [1153], 'From': [1163], 'January': [1164, 1223], '20': [1165], 'through': [1166], 'February': [1167], '17,': [1168], '2020,': [1169], 'consecutive': [1170, 1499], 'admitted': [1172], 'designated': [1175], 'Hospitals': [1177], 'confirmed': [1181, 1229, 1502], 'information': [1184, 1505], 'status': [1187, 1509, 2691, 2709], 'studied.': [1189, 1511], 'diagnosis': [1191, 1431, 2798], 'management': [1194], 'conducted': [1200], 'accordance': [1202], 'practice': [1205], 'guidelines': [1206], 'issued': [1207], 'National': [1211], 'Health': [1212], 'Commission.4Chinese': [1213], 'Clinical': [1214], 'Guidance': [1215], 'Pheumonia': [1218], 'Diagnosis': [1219], 'Treatment.http://kjfy.meetingchina.org/msite/news/show/cn/3337.htmlDate': [1221], 'accessed:': [1222], '23,': [1224], '2020Google': [1225], 'detection': [1232], 'syndrome': [1237, 1958, 2139], '(SARS-CoV-2)': [1240], 'sequences': [1241], 'throat': [1244], 'swab': [1245], 'reverse': [1247], 'transcription': [1248], 'PCR.': [1249], 'defined': [1253, 1656, 1882, 2026, 2062], 'hepatocellular': [1255, 1326, 1536, 2334], 'alanine': [1258, 1284, 1938, 2119], 'aminotransferase': [1259, 1285], '(ALT)': [1260], 'level': [1261], '>30': [1263], 'IU/L': [1264, 1269], 'males': [1266], '>19': [1268], 'females5Park': [1271], 'J.H.': [1272, 1365], 'Choi': [1273], 'Jun': [1275], 'D.W.': [1276], 'Han': [1277, 2373, 2377], 'S.W.': [1278], 'Yeo': [1279], 'Y.H.': [1280], 'Nguyen': [1281], 'M.H.': [1282], 'Low': [1283], 'cut-off': [1286], 'predicting': [1288], 'outcomes;': [1290], 'nationwide': [1292], 'population-based': [1293], 'longitudinal': [1294], 'study.J': [1296], 'Clin': [1297], 'Med.': [1298, 2400, 2538], '2019;': [1299, 2744], '8:': [1300, 2540], '1445Crossref': [1301], '(13)': [1303], 'Scholar;': [1305], 'ductular': [1306, 1328, 1542], 'alkaline': [1308, 1935, 2116], 'phosphatase': [1309], '(ALP)': [1310], '>the': [1312], 'upper': [1313], 'limit': [1314], 'normal': [1316, 1906, 2083], '(ULN)': [1317], 'accompanied': [1318, 2483], 'gamma-glutamyltransferase': [1320], '(GGT)': [1321], '>ULN;': [1322], 'mixed': [1323, 1544], 'enzymes': [1329], '>ULN.': [1332], 'identified': [1335], '(HSI': [1340], '=': [1341, 1689, 1691, 1693], '8': [1342], '×': [1343], '[ALT/AST]': [1344], '+': [1345, 1354], 'BMI': [1346, 1615], '[+': [1347], 'type': [1350], 'yes,': [1353], 'female])': [1357], '>36': [1358], 'points': [1359], 'and/or': [1360], 'abdominal': [1362, 2640], 'ultrasound': [1363], 'examination.6Lee': [1364], 'Kim': [1366, 1368, 1374], 'H.J.': [1369], 'Lee': [1370], 'C.H.': [1371], 'J.I.': [1373], 'W.': [1375], 'al.Hepatic': [1377], 'index:': [1379], 'simple': [1381], 'screening': [1382], 'tool': [1383], 'reflecting': [1384], 'nonalcoholic': [1385], 'disease.Dig': [1388], 'Dis.': [1390], '2010;': [1391], '42:': [1392], '503-508Abstract': [1393], 'Full': [1394, 1396, 2460, 2462, 2542, 2544, 2747, 2749], 'Text': [1395, 1397, 2461, 2463, 2543, 2545, 2748, 2750], '(887)': [1401], 'ALT/AST': [1405], 'HSI': [1409], 'taken': [1411], 'complete': [1414], 'recovery': [1415, 1441], 'records': [1420], 'before': [1424], 'within': [1426], '12': [1427], 'months': [1428], 'followed': [1437], 'till': [1438], 'discharged': [1439], 'approved': [1448], 'Ethics': [1451], 'Committees': [1452], 'FYSPH': [1454], '(20200303006)': [1455], 'Fifth': [1458], 'Medical': [1459], 'Center': [1460], 'PLAGH': [1462], '(2020005D).': [1463], 'significance': [1465], 'assessed': [1472], 'univariate': [1474], 'logistic': [1477, 1592], 'regression': 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1695], '(odds': [1599], 'ratio': [1600], '[OR]': [1601], '3.1;': [1602], '95%': [1603, 1611, 1618, 1625, 1632], 'CI': [1604, 1612, 1619, 1626, 1633], '1.1–9.4),': [1605], '>60': [1607, 1705], '(OR': [1609, 1616, 1623, 1630], '4.8;': [1610], '1.5–16.2),': [1613], '1.3;': [1617], '1.0–1.8),': [1620], '6.3;': [1624], '2.3–18.8)': [1627], '6.4;': [1631], '1.5': [1634], '-': [1635], '31.2),': [1636], 'progression.Table': [1641], '1Baseline': [1642], 'admission.Clinical': [1649], 'admissionOverallStableProgressiveaProgression': [1652], 'least': [1661, 1925, 2031, 2102], 'following:': [1665, 2035], 'rate': [1667, 2037], '≥30': [1668, 2038], 'breaths/min,': [1669, 2039], 'resting': [1670, 2040], 'saturation': [1672, 2042], '≤93%': [1673, 2043], 'PaO2/FiO2': [1675, 2045], '≤300': [1676, 2046], 'mmHg': [1677, 2047], 'worsening': [1679, 2049], 'lung': [1681, 1853, 2003, 2051], 'CT': [1682, 2052], 'findings,': [1683, 2053], 'hospitalization': [1686, 2056], 'period.p': [1687], 'valuesn': [1688], '202n': [1690], '163n': [1692], '39Male': [1694], '(n,': [1696, 1707, 1719, 1724, 1729, 1734, 1740, 1745, 1764, 1783, 1789, 1795, 1801, 1807, 1872], '%)113': [1697], '(55.9)86': [1698], '(52.8)27': [1699], '(69.2)0.093Age': [1700], '(years)44.5': [1701], '(34.8–54.1)42.9': [1702], '(32.6–51.8)55.1': [1703], '(43.7–71.8)<0.001Age': [1704], '%)31': [1708], '(15.3)14': [1709], '(8.6)17': [1710], '(43.6)<0.001BMI': [1711], '(kg/m2)24.0': [1712], '±': [1713, 1715, 1717, 2185, 2190], '2.823.4': [1714], '2.526.6': [1716], '2.2<0.001Smoke': [1718], '%)19': [1720], '(9.4)15': [1721], '(9.2)4': [1722], '(10.3)1.000Drink': [1723], '%)6': [1725], '(3.0)5': [1726], '(3.1)1': [1727], '(2.6)1.000Comorbidity': [1728], '%)47': [1730], '(23.3)23': [1731], '(14.1)24': [1732], '(61.5)<0.001NAFLD': [1733], '%)76': [1735], '(37.6)42': [1736], '(25.8)34': [1737], '(87.2)<0.001HBsAg': [1738], 'positive': [1739], '%)7': [1741], '(3.5)5': [1742], '(3.1)2': [1743], '(5.1)0.885Epidemiology': [1744], '%)0.866': [1746], 'contact': [1748], 'history46': [1749], '(22.8)36': [1750], '(22.1)10': [1751], '(25.6)': [1752], 'Travel': [1753], 'Wuhan100': [1755], '(49.5)82': [1756], '(50.3)18': [1757], '(46.2)': [1758], 'Close': [1759], 'contact56': [1760], '(27.7)45': [1761], '(27.6)11': [1762], '(28.2)Severity': [1763], '%)<0.001': [1765], 'Mild5': [1766], '(2.5)4': [1767], '(2.5)1': [1768], '(2.6)': [1769], 'Moderate168': [1770], '(83.2)146': [1771], '(89.6)22': [1772], '(56.4)': [1773], 'Severe28': [1774], '(13.9)12': [1775], '(7.4)16': [1776], '(41.0)': [1777], 'Critical1': [1778], '(0.5)1': [1779, 1874], '(0.6)0': [1780, 1875], '(0.0)Elevated': [1781], 'ALT': [1782], '%)101': [1784], '(50.0)82': [1785], '(50.3)19': [1786], '(48.7)0.859Elevated': [1787], 'ALP': [1788, 1862, 2012], '%)5': [1790], '(2.5)5': [1791], '(3.1)0': [1792], '(0)0.585Elevated': [1793], 'AST': [1794], '%)34': [1796], '(16.8)24': [1797], '(14.7)10': [1798], '(25.6)0.102Elevated': [1799], 'GGT': [1800, 1812, 1864, 2014], '%)46': [1802], '(22.8)31': [1803], '(19.0)15': [1804], '(38.5)0.009Elevated': [1805], 'TBIL': [1806], '%)17': [1808], '(8.4)13': [1809], '(8.0)4': [1810], '(10.3)0.747Elevated': [1811], 'plus': [1813], 'ALP∗The': [1814], 'continuous': [1815, 1965], 'variables': [1816, 1830, 1966, 1980], 'expressed': [1818, 1968], 'median': [1820, 1970], '(IQR),': [1821, 1971], 'using': [1824, 1974], 'Mann-Whitney': [1826, 1976], 'U': [1827, 1977], 'test,': [1828, 1978], 'categorical': [1829, 1979], 'presented': [1832, 1982], 'numbers': [1834, 1984], '(percentage)': [1835, 1985], 'chi-square': [1840, 1990], "Fisher's": [1843, 1993], 'exact': [1844, 1994], 'test.†': [1845, 1995], 'Comorbidity': [1846, 1996], 'hypertension,': [1848, 1998], 'diabetes,': [1849, 1999], 'chronic': [1852, 2002], 'HIV': [1856, 2006], 'infections.': [1857, 2007], 'One': [1858, 2008], 'patient': [1859, 2009], 'elevated': [1861, 2011], 'admission.': [1866, 2016], '3': [1868, 1908, 2018, 2085], 'developed': [1869, 2019], 'hospitalization.': [1871], '%)1': [1873], '(0)1.000Viral': [1876], 'shedding': [1877, 1879, 2059, 2182, 2584], 'daysbViral': [1878], 'period': [1880, 2060], 'time': [1885, 2065, 2183], 'undetectable': [1887, 2067], 'admission.13.0': [1890], '(10.0–17.0)12.0': [1891], '(10.0–16.0)17.0': [1892], '(16.0–19.5)<0.001Hospitalization': [1893], 'dayscThe': [1894], 'include': [1898, 2075], 'following': [1901, 2078], 'conditions:': [1902, 2079], 'body': [1903, 1944, 2080, 2125, 2680], 'temperatures': [1904, 2081], 'remain': [1905, 2082], 'over': [1907, 2084], 'days,': [1909, 2086], 'significant': [1910, 2087], 'improvement': [1911, 2088], 'symptoms,': [1914, 2091], 'resolution': [1915, 2092], 'pulmonary': [1917, 2094, 2434], 'imaging': [1918, 2095], 'inflammation,': [1920, 2097], 'repeated': [1922, 2099], '24': [1926, 2103], 'hours': [1927, 2104], 'apart': [1928, 2105], 'confirms': [1929, 2106], 'clearance.16.0': [1931], '(12.0–22.0)15.0': [1932], '(12.0–20.0)21.0': [1933], '(16.5–27.0)0.001ALP,': [1934], 'phosphatase;': [1936, 2117], 'ALT,': [1937, 2118], 'aminotransferase;': [1939, 1942, 2120, 2123], 'AST,': [1940, 2121], 'aspartate': [1941, 2122], 'mass': [1945, 2126], 'index;': [1946, 2127], 'GGT,': [1947, 2128], 'gamma-glutamyltransferase;': [1948, 2129], 'NAFLD,': [1949, 2130, 2591, 2706], 'disease;': [1953, 2134], 'SARS-CoV-2,': [1954, 2135], '2;': [1960, 2141], 'TBIL,': [1961, 2142], 'total': [1962, 2143], 'bilirubin.∗': [1963], 'hospitalization.a': [2021], 'Progression': [2022], 'period.b': [2057], 'Viral': [2058], 'admission.c': [2070], 'clearance.': [2108], 'Open': [2109], 'table': [2110], 'new': [2113], 'tab': [2114], 'ALP,': [2115], 'bilirubin.': [2144], '(6.6%': [2155], '[5/126]': [2156], '44.7%': [2158], '[34/76]': [2159], '<0.0001),': [2161], '(70%': [2172], '[53/76]': [2173], '11.1%': [2175], '[14/126];': [2176], '<0.0001)': [2178, 2194], 'longer': [2180, 2582], 'viral': [2181, 2414, 2512, 2583], '(17.5': [2184], '5.2': [2186], 'days': [2187, 2192], '12.1': [2189], '4.4': [2191], 'Similar': [2200], 'other': [2202, 2412, 2511], 'reports,': [2203], 'frequent': [2215], 'nature.1Xu': [2219], 'pattern': [2328], 'mostly': [2333], 'cholestatic.': [2337], 'it': [2343], 'shown': [2346], 'biliary': [2348], 'cells': [2349, 2428], '(ACE2)': [2356], 'receptor': [2357, 2385], 'affinity': [2361], 'spike': [2364], 'protein': [2365], 'SARS-CoV-2.7Zou': [2367], 'Chen': [2369], 'K.': [2370], 'Zou': [2371], 'P.': [2374], 'Hao': [2375], 'Z.': [2378, 2515], 'Single-cell': [2379], 'RNA-seq': [2380], 'ACE2': [2386, 2629], 'reveals': [2388], 'organs': [2395], 'vulnerable': [2396], '2019-nCoV': [2398], 'infection.Front': [2399], 'print])https://doi.org/10.1007/s11684-020-0754-0Crossref': [2405], '(1640)': [2408], 'infection,': [2415], 'hepatitis': [2416, 2450], 'collateral': [2422], 'damage': [2423], 'mediated': [2424, 2498], 'virus-specific': [2426], 'effector': [2427], 'generated': [2429], 'response': [2431], 'infection.8Polakos': [2435], 'N.K.': [2436], 'Cornejo': [2437], 'J.C.': [2438], 'Murray': [2439], 'D.A.': [2440], 'Wright': [2441], 'K.O.': [2442], 'Treanor': [2443], 'J.J.': [2444], 'Crispe': [2445], 'I.N.': [2446], 'al.Kupffer': [2448], 'cell-dependent': [2449], 'occurs': [2451], 'influenza': [2453], 'infection.Am': [2454], 'J': [2455], 'Pathol.': [2456], '2006;': [2457], '168:': [2458], '1169-1178Abstract': [2459], '(130)': [2467], 'postmortem': [2471], 'biopsy': [2473], 'microvesicular': [2481], 'steatosis,': [2482], 'overactivation': [2485], 'T': [2487], 'cells,': [2488], 'suggesting': [2489], 'likely': [2496], 'immune': [2497, 2690], 'being': [2501], 'result': [2503], 'direct': [2505], 'cytopathic': [2506], 'damage,': [2507], 'described': [2509], 'diseases.9Xu': [2514], 'Shi': [2516], 'Wang': [2518], 'Y.': [2519], 'Huang': [2522], 'al.Pathological': [2527], 'syndrome.Lancet': [2536], 'Respir': [2537], '420-422Abstract': [2541], '(6406)': [2549], 'majority': [2553], 'series': [2558], 'BMI.': [2567], 'time.': [2585], 'With': [2586], 'increasing': [2587], 'global': [2588], 'large': [2596], 'proportion': [2597], 'mechanism': [2610], 'unknown': [2612], 'impaired': [2618], 'innate': [2619, 2689], 'immunity': [2620], 'virus.': [2623], 'particular,': [2625], 'there': [2626], 'abundant': [2628], 'receptors': [2630], 'small': [2633, 2666], 'intestine': [2634], 'clinically,': [2636], 'complain': [2638], 'pain': [2641], 'diarrhea.': [2643], 'Circulation': [2644], 'virus': [2647], 'via': [2648], 'reticular': [2651], 'system': [2652], 'expected,': [2654], 'given': [2655], 'rich': [2657], 'supply': [2658], 'bowel.': [2667], 'contains': [2670], 'largest': [2672], 'number': [2673], 'macrophages': [2675, 2712, 2719], '(Kupffer': [2676], 'cells)': [2677], 'potent': [2684], 'cytokine': [2685], 'producer.': [2686], 'Impaired': [2687], 'play': [2693], 'role': [2696, 2763], 'outcome.': [2699], 'postulate': [2701], 'polarization': [2708], 'skewed': [2715], 'inflammation-promoting': [2717], 'M1': [2718], 'inflammation-suppressing': [2721], 'M2': [2722], 'macrophages,': [2723], 'leading': [2724], 'COVID-19.10Lefere': [2728], 'S.': [2729], 'Tacke': [2730], 'Macrophages': [2732], 'obesity': [2734], 'disease:': [2739], 'crosstalk': [2740], 'metabolism.JHEP': [2742], 'Rep.': [2743], '1:': [2745], '30-43Abstract': [2746], '(162)': [2754], 'better': [2759], 'understanding': [2760], 'therapeutic': [2770], 'implications.': [2771], 'work': [2773], 'funded': [2775], 'Capital': [2778], 'characteristic': [2779], 'clinic': [2780], 'project': [2781], 'Beijing': [2783], 'Municipal': [2784], 'Science': [2785], 'Technology': [2787], 'Commission': [2788], '(Z181100001718034).': [2789], 'acknowledge': [2791], 'health-care': [2793], 'workers': [2794], 'involved': [2795], 'treatment': [2800], 'hospital.': [2807], 'DJ,': [2808], 'DZ,': [2809], 'JX,': [2810], 'EQ': [2812], 'treated': [2813], 'patients.DJ,': [2815], 'GC,': [2816], 'YW': [2817], 'GL': [2819, 2829], 'processed': [2820], 'statistical': [2821], 'drafted': [2824], 'manuscript.': [2826], 'DJ': [2827], 'idea': [2832], 'designed': [2835], 'authors': [2839], 'declare': [2840], 'no': [2841], 'conflicts': [2842], 'pertain': [2846], 'work.': [2849], 'Please': [2850], 'refer': [2851], 'accompanying': [2854], 'ICMJE': [2855], 'disclosure': [2856], 'forms': [2857], 'further': [2859], 'details.': [2860], 'Download': [2861], '.pdf': [2862], '(.2': [2863], 'MB)': [2864], 'Help': [2865], 'pdf': [2867], 'files': [2868], 'disclosures.pdf': [2869]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3016151265', 'counts_by_year': [{'year': 2024, 'cited_by_count': 23}, {'year': 2023, 'cited_by_count': 82}, {'year': 2022, 'cited_by_count': 99}, {'year': 2021, 'cited_by_count': 153}, {'year': 2020, 'cited_by_count': 146}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 1}], 'updated_date': '2024-12-09T01:48:07.041381', 'created_date': '2020-04-17'}
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