Title: Matrix Gla Protein in Meningiomas: An Immunohistochemical Study
Abstract: Calcified meningiomas have a slower growth rate and a better outcome than non-calcified meningiomas. Matrix Gla Protein (MGP) acts as an inhibitor of soft tissue calcification. Depending on its carboxylation status MGP may occur in two conformations: uncarboxylated (ucMGP) or carboxylated (cMGP). Low levels of serum ucMGP have been described to be a sign of tissue calcification. In calcified tumoral tissue samples we identified both ucMGP (r = 0.957, p[0.001) and cMGP (r = 1, p[0.001), while non-calcified tumors were negative for both MGP conformation deposits. The concentration of serum t-ucMGP in patients with calcified and non-calcified meningiomas were not significantly different (3499�1388 vs. 3882�2558).
Publication Year: 2001
Publication Date: 2001-01-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 1
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