Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W3014893425', 'doi': 'https://doi.org/10.21037/atm.2020.03.195', 'title': 'MicroRNA-18a induces epithelial-mesenchymal transition like cancer stem cell phenotype via regulating RKIP pathway in pancreatic cancer', 'display_name': 'MicroRNA-18a induces epithelial-mesenchymal transition like cancer stem cell phenotype via regulating RKIP pathway in pancreatic cancer', 'publication_year': 2020, 'publication_date': '2020-04-01', 'ids': {'openalex': 'https://openalex.org/W3014893425', 'doi': 'https://doi.org/10.21037/atm.2020.03.195', 'mag': '3014893425', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/32395477', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/7210200'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.21037/atm.2020.03.195', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2755174949', 'display_name': 'Annals of Translational Medicine', 'issn_l': '2305-5839', 'issn': ['2305-5839', '2305-5847'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310321814', 'host_organization_name': 'AME Publishing Company', 'host_organization_lineage': ['https://openalex.org/P4310321814'], 'host_organization_lineage_names': ['AME Publishing Company'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://doi.org/10.21037/atm.2020.03.195', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5070327738', 'display_name': 'Honggang Kang', 'orcid': 'https://orcid.org/0000-0001-8693-9497'}, 'institutions': [{'id': 'https://openalex.org/I4210160222', 'display_name': "Liaocheng People's Hospital", 'ror': 'https://ror.org/052vn2478', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210160222']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Honggang Kang', 'raw_affiliation_strings': ["Department of Oncology, Liaocheng People's Hospital, Liaocheng 252000, China"], 'affiliations': [{'raw_affiliation_string': "Department of Oncology, Liaocheng People's Hospital, Liaocheng 252000, China", 'institution_ids': ['https://openalex.org/I4210160222']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101832762', 'display_name': 'Dan Ma', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210160222', 'display_name': "Liaocheng People's Hospital", 'ror': 'https://ror.org/052vn2478', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210160222']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Dan Ma', 'raw_affiliation_strings': ["Department of Oncology, Liaocheng People's Hospital, Liaocheng 252000, China"], 'affiliations': [{'raw_affiliation_string': "Department of Oncology, Liaocheng People's Hospital, Liaocheng 252000, China", 'institution_ids': ['https://openalex.org/I4210160222']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100345373', 'display_name': 'Jing Zhang', 'orcid': 'https://orcid.org/0000-0002-2488-5021'}, 'institutions': [{'id': 'https://openalex.org/I4210160222', 'display_name': "Liaocheng People's Hospital", 'ror': 'https://ror.org/052vn2478', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210160222']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jing Zhang', 'raw_affiliation_strings': ["Department of Oncology, Liaocheng People's Hospital, 67 Dongchang West Road, Liaocheng 252000, China.", "Department of Oncology, Liaocheng People's Hospital, Liaocheng 252000, China"], 'affiliations': [{'raw_affiliation_string': "Department of Oncology, Liaocheng People's Hospital, Liaocheng 252000, China", 'institution_ids': ['https://openalex.org/I4210160222']}, {'raw_affiliation_string': "Department of Oncology, Liaocheng People's Hospital, 67 Dongchang West Road, Liaocheng 252000, China.", 'institution_ids': ['https://openalex.org/I4210160222']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030638246', 'display_name': 'Jun Zhao', 'orcid': 'https://orcid.org/0000-0001-8903-8205'}, 'institutions': [{'id': 'https://openalex.org/I4210160222', 'display_name': "Liaocheng People's Hospital", 'ror': 'https://ror.org/052vn2478', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210160222']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jun Zhao', 'raw_affiliation_strings': ["Department of Oncology, Liaocheng People's Hospital, Liaocheng 252000, China"], 'affiliations': [{'raw_affiliation_string': "Department of Oncology, Liaocheng People's Hospital, Liaocheng 252000, China", 'institution_ids': ['https://openalex.org/I4210160222']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5006627921', 'display_name': 'Mengxiang Yang', 'orcid': 'https://orcid.org/0000-0003-2137-6309'}, 'institutions': [{'id': 'https://openalex.org/I4210160222', 'display_name': "Liaocheng People's Hospital", 'ror': 'https://ror.org/052vn2478', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210160222']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Mengxiang Yang', 'raw_affiliation_strings': ["Department of Oncology, Liaocheng People's Hospital, Liaocheng 252000, China"], 'affiliations': [{'raw_affiliation_string': "Department of Oncology, Liaocheng People's Hospital, Liaocheng 252000, China", 'institution_ids': ['https://openalex.org/I4210160222']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.63, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 11, 'citation_normalized_percentile': {'value': 0.999982, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 87, 'max': 88}, 'biblio': {'volume': '8', 'issue': '7', 'first_page': '433', 'last_page': '433'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11533', 'display_name': 'Melanoma and MAPK Pathways', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11533', 'display_name': 'Melanoma and MAPK Pathways', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13779', 'display_name': 'Cancer Mechanisms and Therapy', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12835', 'display_name': 'FOXO transcription factor regulation', 'score': 0.992, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C2780210213', 'wikidata': 'https://www.wikidata.org/wiki/Q212961', 'display_name': 'Pancreatic cancer', 'level': 3, 'score': 0.8614671}, {'id': 'https://openalex.org/C76419328', 'wikidata': 'https://www.wikidata.org/wiki/Q74419', 'display_name': 'Epithelial–mesenchymal transition', 'level': 4, 'score': 0.75934494}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.7092689}, {'id': 'https://openalex.org/C2779013556', 'wikidata': 'https://www.wikidata.org/wiki/Q181876', 'display_name': 'Metastasis', 'level': 3, 'score': 0.69595087}, {'id': 'https://openalex.org/C145059251', 'wikidata': 'https://www.wikidata.org/wiki/Q310899', 'display_name': 'microRNA', 'level': 3, 'score': 0.6680849}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.59371024}, {'id': 'https://openalex.org/C55427017', 'wikidata': 'https://www.wikidata.org/wiki/Q1638475', 'display_name': 'Cancer stem cell', 'level': 3, 'score': 0.51432765}, {'id': 'https://openalex.org/C127716648', 'wikidata': 'https://www.wikidata.org/wiki/Q104053', 'display_name': 'Phenotype', 'level': 3, 'score': 0.45424023}, {'id': 'https://openalex.org/C96232424', 'wikidata': 'https://www.wikidata.org/wiki/Q4118072', 'display_name': 'Cancer cell', 'level': 3, 'score': 0.43814066}, {'id': 'https://openalex.org/C85265743', 'wikidata': 'https://www.wikidata.org/wiki/Q885458', 'display_name': 'Blot', 'level': 3, 'score': 0.42907703}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3938526}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.33979297}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.32839417}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.32124558}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.07518765}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}], 'mesh': [], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.21037/atm.2020.03.195', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2755174949', 'display_name': 'Annals of Translational Medicine', 'issn_l': '2305-5839', 'issn': ['2305-5839', '2305-5847'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310321814', 'host_organization_name': 'AME Publishing Company', 'host_organization_lineage': ['https://openalex.org/P4310321814'], 'host_organization_lineage_names': ['AME Publishing Company'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc7210200', 'pdf_url': 'https://europepmc.org/articles/pmc7210200?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210200', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/32395477', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.21037/atm.2020.03.195', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2755174949', 'display_name': 'Annals of Translational Medicine', 'issn_l': '2305-5839', 'issn': ['2305-5839', '2305-5847'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310321814', 'host_organization_name': 'AME Publishing Company', 'host_organization_lineage': ['https://openalex.org/P4310321814'], 'host_organization_lineage_names': ['AME Publishing Company'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.83, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 18, 'referenced_works': ['https://openalex.org/W1984124720', 'https://openalex.org/W1987384939', 'https://openalex.org/W2000093333', 'https://openalex.org/W2013653563', 'https://openalex.org/W2030166934', 'https://openalex.org/W2043486373', 'https://openalex.org/W2078810029', 'https://openalex.org/W2112104218', 'https://openalex.org/W2124662474', 'https://openalex.org/W2131361386', 'https://openalex.org/W2143678301', 'https://openalex.org/W2155770085', 'https://openalex.org/W2171138151', 'https://openalex.org/W2787282733', 'https://openalex.org/W2994478049', 'https://openalex.org/W3014893425', 'https://openalex.org/W4249015842', 'https://openalex.org/W95463455'], 'related_works': ['https://openalex.org/W4361006991', 'https://openalex.org/W3154378828', 'https://openalex.org/W3151405604', 'https://openalex.org/W3030550923', 'https://openalex.org/W3006214768', 'https://openalex.org/W2737319532', 'https://openalex.org/W2343201566', 'https://openalex.org/W2227955965', 'https://openalex.org/W2131943779', 'https://openalex.org/W1989330519'], 'abstract_inverted_index': {'Pancreatic': [0, 49], 'cancer': [1, 15, 23, 103, 115, 143], 'is': [2, 16], 'a': [3, 38, 98, 135], 'devastating': [4], 'invasive': [5], 'disease.': [6], 'Understanding': [7], 'the': [8, 59, 139], 'molecular': [9], 'mechanism': [10], 'of': [11, 13, 61, 77, 127, 141], 'metastasis': [12], 'this': [14, 71], 'basis': [17], 'for': [18], 'its': [19, 125], 'treatment': [20, 140], 'and': [21, 25, 37, 41, 104], 'prevention.Pancreatic': [22], 'tissues': [24, 28], 'normal': [26], 'adjacent': [27], 'were': [29, 44, 55, 69], 'collected': [30], 'from': [31], 'patients': [32], 'tour': [33], 'hospital.': [34], 'Western': [35], 'blotting': [36], 'sphere': [39], 'growth': [40], 'invasion': [42], 'assay': [43], 'performed': [45], 'to': [46, 88], 'conduct': [47], 'analysis.': [48], 'ductal': [50], 'adenocarcinoma': [51], 'cell': [52], 'Line': [53], 'PANC-1': [54, 93, 116], 'cultured.': [56], 'To': [57], 'test': [58], 'level': [60], 'Raf-1': [62], 'kinase': [63], 'inhibitor': [64], 'protein': [65], '(RKIP),': [66], 'immunofluorescence': [67], 'analyses': [68], 'performed.In': [70], 'study,': [72], 'we': [73], 'showed': [74], 'that': [75, 119], 'expression': [76, 100], 'RKIP': [78, 84, 112, 128], 'was': [79], 'downregulated': [80], 'in': [81, 92, 101, 113, 129, 138, 144], 'pancreatic': [82, 102, 114, 130, 142], 'cancer.': [83, 131], 'can': [85, 105], 'inhibit': [86], 'epithelial': [87], 'mesenchymal': [89], 'transition': [90], '(EMT)': [91], 'cells.': [94], 'MicroRNA-181a': [95], '(miR-181a)': [96], 'has': [97], 'high': [99], 'induce': [106], 'EMT': [107, 122], 'phenotype': [108, 123], 'by': [109], 'directly': [110], 'degrading': [111], 'cells.We': [117], 'concluded': [118], 'miR-181a': [120], 'induces': [121], 'through': [124], 'regulation': [126], 'MicroRNA-18a': [132], 'may': [133], 'be': [134], 'novel': [136], 'target': [137], 'future.': [145]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3014893425', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 2}], 'updated_date': '2024-12-24T07:21:54.232636', 'created_date': '2020-04-10'}