Publication Information

{'id': 'https://openalex.org/W3014884427', 'doi': 'https://doi.org/10.3389/fendo.2020.00167', 'title': 'Quantitative Evaluation of the Transcriptional Activity of Steroid Hormone Receptor Mutants and Variants Using a Single Vector With Two Reporters and a Receptor Expression Cassette', 'display_name': 'Quantitative Evaluation of the Transcriptional Activity of Steroid Hormone Receptor Mutants and Variants Using a Single Vector With Two Reporters and a Receptor Expression Cassette', 'publication_year': 2020, 'publication_date': '2020-03-31', 'ids': {'openalex': 'https://openalex.org/W3014884427', 'doi': 'https://doi.org/10.3389/fendo.2020.00167', 'mag': '3014884427', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/32296391', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/7137763'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3389/fendo.2020.00167', 'pdf_url': 'https://www.frontiersin.org/articles/10.3389/fendo.2020.00167/pdf', 'source': {'id': 'https://openalex.org/S2597401208', 'display_name': 'Frontiers in Endocrinology', 'issn_l': '1664-2392', 'issn': ['1664-2392'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320527', 'host_organization_name': 'Frontiers Media', 'host_organization_lineage': ['https://openalex.org/P4310320527'], 'host_organization_lineage_names': ['Frontiers Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.frontiersin.org/articles/10.3389/fendo.2020.00167/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5112264839', 'display_name': 'Huimin Ji', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210119648', 'display_name': 'Beijing Hospital', 'ror': 'https://ror.org/02jwb5s28', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210119648']}, {'id': 'https://openalex.org/I200296433', 'display_name': 'Chinese Academy of Medical Sciences & Peking Union Medical College', 'ror': 'https://ror.org/02drdmm93', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I200296433']}, {'id': 'https://openalex.org/I4210146612', 'display_name': 'National Center for Clinical Laboratories', 'ror': 'https://ror.org/0530d6n45', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210146612']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Huimin Ji', 'raw_affiliation_strings': ['Beijing Engineering Research Center of Laboratory Medicine, Beijing Hospital, Beijing, China', 'Graduate School, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China', 'National Center for Clinical Laboratories, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China'], 'affiliations': [{'raw_affiliation_string': 'Beijing Engineering Research Center of Laboratory Medicine, Beijing Hospital, Beijing, China', 'institution_ids': ['https://openalex.org/I4210119648']}, {'raw_affiliation_string': 'Graduate School, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China', 'institution_ids': ['https://openalex.org/I200296433']}, {'raw_affiliation_string': 'National Center for Clinical Laboratories, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China', 'institution_ids': ['https://openalex.org/I4210146612', 'https://openalex.org/I200296433']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100414102', 'display_name': 'Ying Li', 'orcid': 'https://orcid.org/0000-0001-9560-2212'}, 'institutions': [{'id': 'https://openalex.org/I200296433', 'display_name': 'Chinese Academy of Medical Sciences & Peking Union Medical College', 'ror': 'https://ror.org/02drdmm93', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I200296433']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ying Li', 'raw_affiliation_strings': ['Graduate School, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China', 'The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commissions, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China'], 'affiliations': [{'raw_affiliation_string': 'Graduate School, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China', 'institution_ids': ['https://openalex.org/I200296433']}, {'raw_affiliation_string': 'The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commissions, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China', 'institution_ids': ['https://openalex.org/I200296433']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100364732', 'display_name': 'Zhao Liu', 'orcid': 'https://orcid.org/0009-0000-5103-9923'}, 'institutions': [{'id': 'https://openalex.org/I177388780', 'display_name': 'Xuzhou Medical College', 'ror': 'https://ror.org/04fe7hy80', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177388780']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhao Liu', 'raw_affiliation_strings': ['Department of Thyroid and Breast Surgery, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Thyroid and Breast Surgery, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China', 'institution_ids': ['https://openalex.org/I177388780']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001891565', 'display_name': 'Min Moon Tang', 'orcid': 'https://orcid.org/0000-0001-7760-3238'}, 'institutions': [{'id': 'https://openalex.org/I200296433', 'display_name': 'Chinese Academy of Medical Sciences & Peking Union Medical College', 'ror': 'https://ror.org/02drdmm93', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I200296433']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Min Tang', 'raw_affiliation_strings': ['Department of Oncology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Oncology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China', 'institution_ids': ['https://openalex.org/I200296433']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006828330', 'display_name': 'Lihui Zou', 'orcid': 'https://orcid.org/0000-0002-6681-407X'}, 'institutions': [{'id': 'https://openalex.org/I200296433', 'display_name': 'Chinese Academy of Medical Sciences & Peking Union Medical College', 'ror': 'https://ror.org/02drdmm93', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I200296433']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Lihui Zou', 'raw_affiliation_strings': ['The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commissions, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China'], 'affiliations': [{'raw_affiliation_string': 'The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commissions, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China', 'institution_ids': ['https://openalex.org/I200296433']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101431610', 'display_name': 'Fei Su', 'orcid': 'https://orcid.org/0000-0003-4737-4651'}, 'institutions': [{'id': 'https://openalex.org/I200296433', 'display_name': 'Chinese Academy of Medical Sciences & Peking Union Medical College', 'ror': 'https://ror.org/02drdmm93', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I200296433']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Fei Su', 'raw_affiliation_strings': ['Clinical Biobank, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China'], 'affiliations': [{'raw_affiliation_string': 'Clinical Biobank, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China', 'institution_ids': ['https://openalex.org/I200296433']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101607212', 'display_name': 'Yaqun Zhang', 'orcid': 'https://orcid.org/0000-0003-1140-7247'}, 'institutions': [{'id': 'https://openalex.org/I200296433', 'display_name': 'Chinese Academy of Medical Sciences & Peking Union Medical College', 'ror': 'https://ror.org/02drdmm93', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I200296433']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yaqun Zhang', 'raw_affiliation_strings': ['Department of Urology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Urology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China', 'institution_ids': ['https://openalex.org/I200296433']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100377750', 'display_name': 'Junhua Zhang', 'orcid': 'https://orcid.org/0000-0003-4043-1967'}, 'institutions': [{'id': 'https://openalex.org/I200296433', 'display_name': 'Chinese Academy of Medical Sciences & Peking Union Medical College', 'ror': 'https://ror.org/02drdmm93', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I200296433']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Junhua Zhang', 'raw_affiliation_strings': ['The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commissions, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China'], 'affiliations': [{'raw_affiliation_string': 'The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commissions, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China', 'institution_ids': ['https://openalex.org/I200296433']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008873722', 'display_name': 'Hexin Li', 'orcid': 'https://orcid.org/0009-0006-5625-2540'}, 'institutions': [{'id': 'https://openalex.org/I200296433', 'display_name': 'Chinese Academy of Medical Sciences & Peking Union Medical College', 'ror': 'https://ror.org/02drdmm93', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I200296433']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Hexin Li', 'raw_affiliation_strings': ['Clinical Biobank, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China'], 'affiliations': [{'raw_affiliation_string': 'Clinical Biobank, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China', 'institution_ids': ['https://openalex.org/I200296433']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017322165', 'display_name': 'Lin Li', 'orcid': 'https://orcid.org/0000-0003-2934-650X'}, 'institutions': [{'id': 'https://openalex.org/I200296433', 'display_name': 'Chinese Academy of Medical Sciences & Peking Union Medical College', 'ror': 'https://ror.org/02drdmm93', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I200296433']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Lin Li', 'raw_affiliation_strings': ['Department of Oncology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Oncology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China', 'institution_ids': ['https://openalex.org/I200296433']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003708121', 'display_name': 'Bin Ai', 'orcid': 'https://orcid.org/0000-0001-7257-751X'}, 'institutions': [{'id': 'https://openalex.org/I200296433', 'display_name': 'Chinese Academy of Medical Sciences & Peking Union Medical College', 'ror': 'https://ror.org/02drdmm93', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I200296433']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Bin Ai', 'raw_affiliation_strings': ['Department of Oncology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Oncology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China', 'institution_ids': ['https://openalex.org/I200296433']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052880029', 'display_name': 'Jie Ma', 'orcid': 'https://orcid.org/0000-0002-2938-818X'}, 'institutions': [{'id': 'https://openalex.org/I200296433', 'display_name': 'Chinese Academy of Medical Sciences & Peking Union Medical College', 'ror': 'https://ror.org/02drdmm93', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I200296433']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jie Ma', 'raw_affiliation_strings': ['Center for Biotherapy, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China', 'State Key Lab of Molecular Oncology, National Cancer Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China'], 'affiliations': [{'raw_affiliation_string': 'State Key Lab of Molecular Oncology, National Cancer Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China', 'institution_ids': ['https://openalex.org/I200296433']}, {'raw_affiliation_string': 'Center for Biotherapy, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China', 'institution_ids': ['https://openalex.org/I200296433']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033775362', 'display_name': 'Lunan Wang', 'orcid': 'https://orcid.org/0000-0003-3163-7891'}, 'institutions': [{'id': 'https://openalex.org/I200296433', 'display_name': 'Chinese Academy of Medical Sciences & Peking Union Medical College', 'ror': 'https://ror.org/02drdmm93', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I200296433']}, {'id': 'https://openalex.org/I4210146612', 'display_name': 'National Center for Clinical Laboratories', 'ror': 'https://ror.org/0530d6n45', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210146612']}, {'id': 'https://openalex.org/I4210119648', 'display_name': 'Beijing Hospital', 'ror': 'https://ror.org/02jwb5s28', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210119648']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Lunan Wang', 'raw_affiliation_strings': ['Beijing Engineering Research Center of Laboratory Medicine, Beijing Hospital, Beijing, China', 'Graduate School, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China', 'National Center for Clinical Laboratories, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China'], 'affiliations': [{'raw_affiliation_string': 'Graduate School, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China', 'institution_ids': ['https://openalex.org/I200296433']}, {'raw_affiliation_string': 'National Center for Clinical Laboratories, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China', 'institution_ids': ['https://openalex.org/I4210146612', 'https://openalex.org/I200296433']}, {'raw_affiliation_string': 'Beijing Engineering Research Center of Laboratory Medicine, Beijing Hospital, Beijing, China', 'institution_ids': ['https://openalex.org/I4210119648']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100347788', 'display_name': 'Ming Liu', 'orcid': 'https://orcid.org/0000-0002-4770-4449'}, 'institutions': [{'id': 'https://openalex.org/I200296433', 'display_name': 'Chinese Academy of Medical Sciences & Peking Union Medical College', 'ror': 'https://ror.org/02drdmm93', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I200296433']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Ming Liu', 'raw_affiliation_strings': ['Department of Urology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Urology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China', 'institution_ids': ['https://openalex.org/I200296433']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5018437473', 'display_name': 'Fei Xiao', 'orcid': 'https://orcid.org/0000-0003-2054-901X'}, 'institutions': [{'id': 'https://openalex.org/I200296433', 'display_name': 'Chinese Academy of Medical Sciences & Peking Union Medical College', 'ror': 'https://ror.org/02drdmm93', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I200296433']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Fei Xiao', 'raw_affiliation_strings': ['Clinical Biobank, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China', 'Department of Pathology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China', 'The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commissions, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China', 'institution_ids': ['https://openalex.org/I200296433']}, {'raw_affiliation_string': 'The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commissions, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China', 'institution_ids': ['https://openalex.org/I200296433']}, {'raw_affiliation_string': 'Clinical Biobank, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China', 'institution_ids': ['https://openalex.org/I200296433']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': ['https://openalex.org/A5033775362', 'https://openalex.org/A5100347788', 'https://openalex.org/A5018437473'], 'corresponding_institution_ids': ['https://openalex.org/I200296433', 'https://openalex.org/I4210146612', 'https://openalex.org/I4210119648', 'https://openalex.org/I200296433', 'https://openalex.org/I200296433'], 'apc_list': {'value': 2950, 'currency': 'USD', 'value_usd': 2950, 'provenance': 'doaj'}, 'apc_paid': {'value': 2950, 'currency': 'USD', 'value_usd': 2950, 'provenance': 'doaj'}, 'fwci': 0.428, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 3, 'citation_normalized_percentile': {'value': 0.693116, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 74, 'max': 77}, 'biblio': {'volume': '11', 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10756', 'display_name': 'Estrogen and related hormone effects', 'score': 0.9987, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10756', 'display_name': 'Estrogen and related hormone effects', 'score': 0.9987, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11178', 'display_name': 'Receptor Mechanisms and Signaling', 'score': 0.9809, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10423', 'display_name': 'Neurobiology and Insect Physiology Research', 'score': 0.9746, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/hormone-response-element', 'display_name': 'Hormone response element', 'score': 0.581986}, {'id': 'https://openalex.org/keywords/sanger-sequencing', 'display_name': 'Sanger sequencing', 'score': 0.5292734}, {'id': 'https://openalex.org/keywords/steroid-hormone-receptor', 'display_name': 'Steroid hormone receptor', 'score': 0.43460798}], 'concepts': [{'id': 'https://openalex.org/C161733203', 'wikidata': 'https://www.wikidata.org/wiki/Q911828', 'display_name': 'Reporter gene', 'level': 4, 'score': 0.76324964}, {'id': 'https://openalex.org/C1292079', 'wikidata': 'https://www.wikidata.org/wiki/Q3817769', 'display_name': 'Transactivation', 'level': 4, 'score': 0.75440454}, {'id': 'https://openalex.org/C61367390', 'wikidata': 'https://www.wikidata.org/wiki/Q416601', 'display_name': 'Androgen receptor', 'level': 4, 'score': 0.6225749}, {'id': 'https://openalex.org/C143065580', 'wikidata': 'https://www.wikidata.org/wiki/Q3285695', 'display_name': 'Mutant', 'level': 3, 'score': 0.61007875}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.59276307}, {'id': 'https://openalex.org/C51445715', 'wikidata': 'https://www.wikidata.org/wiki/Q410477', 'display_name': 'Hormone response element', 'level': 5, 'score': 0.581986}, {'id': 'https://openalex.org/C76818968', 'wikidata': 'https://www.wikidata.org/wiki/Q181940', 'display_name': 'Sanger sequencing', 'level': 4, 'score': 0.5292734}, {'id': 'https://openalex.org/C84606932', 'wikidata': 'https://www.wikidata.org/wiki/Q416496', 'display_name': 'Estrogen receptor', 'level': 4, 'score': 0.52125126}, {'id': 'https://openalex.org/C59493245', 'wikidata': 'https://www.wikidata.org/wiki/Q14877410', 'display_name': 'Glucocorticoid receptor', 'level': 3, 'score': 0.47259054}, {'id': 'https://openalex.org/C111335760', 'wikidata': 'https://www.wikidata.org/wiki/Q95385166', 'display_name': 'Luciferase', 'level': 4, 'score': 0.45998257}, {'id': 'https://openalex.org/C2779544216', 'wikidata': 'https://www.wikidata.org/wiki/Q411546', 'display_name': 'Steroid hormone receptor', 'level': 5, 'score': 0.43460798}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.43212143}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.39176518}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.36579445}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.35863817}, {'id': 'https://openalex.org/C501734568', 'wikidata': 'https://www.wikidata.org/wiki/Q42918', 'display_name': 'Mutation', 'level': 3, 'score': 0.33594036}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.33591717}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.29084557}, {'id': 'https://openalex.org/C54009773', 'wikidata': 'https://www.wikidata.org/wiki/Q1429031', 'display_name': 'Transfection', 'level': 3, 'score': 0.22728187}, {'id': 'https://openalex.org/C2780192828', 'wikidata': 'https://www.wikidata.org/wiki/Q181257', 'display_name': 'Prostate cancer', 'level': 3, 'score': 0.08278665}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.082663774}, {'id': 'https://openalex.org/C530470458', 'wikidata': 'https://www.wikidata.org/wiki/Q128581', 'display_name': 'Breast cancer', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001681', 'descriptor_name': 'Biological Assay', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D005822', 'descriptor_name': 'Genetic Vectors', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019556', 'descriptor_name': 'COS Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002522', 'descriptor_name': 'Chlorocebus aethiops', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003001', 'descriptor_name': 'Cloning, Molecular', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}, {'descriptor_ui': 'D047628', 'descriptor_name': 'Estrogen Receptor alpha', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D017930', 'descriptor_name': 'Genes, Reporter', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D057809', 'descriptor_name': 'HEK293 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D056945', 'descriptor_name': 'Hep G2 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006728', 'descriptor_name': 'Hormones', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049409', 'descriptor_name': 'Luciferases, Firefly', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D050505', 'descriptor_name': 'Mutant Proteins', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011401', 'descriptor_name': 'Promoter Regions, Genetic', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D011944', 'descriptor_name': 'Receptors, Androgen', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D018160', 'descriptor_name': 'Receptors, Cytoplasmic and Nuclear', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011965', 'descriptor_name': 'Receptors, Glucocorticoid', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015533', 'descriptor_name': 'Transcriptional Activation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D014162', 'descriptor_name': 'Transfection', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.3389/fendo.2020.00167', 'pdf_url': 'https://www.frontiersin.org/articles/10.3389/fendo.2020.00167/pdf', 'source': {'id': 'https://openalex.org/S2597401208', 'display_name': 'Frontiers in Endocrinology', 'issn_l': '1664-2392', 'issn': ['1664-2392'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320527', 'host_organization_name': 'Frontiers Media', 'host_organization_lineage': ['https://openalex.org/P4310320527'], 'host_organization_lineage_names': ['Frontiers Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/0396e502e4344ab49a7d51454bcbe0fa', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc7137763', 'pdf_url': 'https://europepmc.org/articles/pmc7137763?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137763', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/32296391', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3389/fendo.2020.00167', 'pdf_url': 'https://www.frontiersin.org/articles/10.3389/fendo.2020.00167/pdf', 'source': {'id': 'https://openalex.org/S2597401208', 'display_name': 'Frontiers in Endocrinology', 'issn_l': '1664-2392', 'issn': ['1664-2392'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320527', 'host_organization_name': 'Frontiers Media', 'host_organization_lineage': ['https://openalex.org/P4310320527'], 'host_organization_lineage_names': ['Frontiers Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.58}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 58, 'referenced_works': ['https://openalex.org/W1585121352', 'https://openalex.org/W1816722347', 'https://openalex.org/W1836013023', 'https://openalex.org/W1925305957', 'https://openalex.org/W1969747128', 'https://openalex.org/W1975609403', 'https://openalex.org/W1976835862', 'https://openalex.org/W1981742600', 'https://openalex.org/W1982289244', 'https://openalex.org/W1982453454', 'https://openalex.org/W1988574944', 'https://openalex.org/W1993060456', 'https://openalex.org/W2006138763', 'https://openalex.org/W2013893023', 'https://openalex.org/W2021145743', 'https://openalex.org/W2024763965', 'https://openalex.org/W2025252016', 'https://openalex.org/W2030819637', 'https://openalex.org/W2042619042', 'https://openalex.org/W2043029683', 'https://openalex.org/W2053772520', 'https://openalex.org/W2061271065', 'https://openalex.org/W2064201020', 'https://openalex.org/W2065346432', 'https://openalex.org/W2065890957', 'https://openalex.org/W2070368588', 'https://openalex.org/W2073367400', 'https://openalex.org/W2083926838', 'https://openalex.org/W2085847636', 'https://openalex.org/W2090845446', 'https://openalex.org/W2097226696', 'https://openalex.org/W2104146340', 'https://openalex.org/W2106470286', 'https://openalex.org/W2111324624', 'https://openalex.org/W2126309037', 'https://openalex.org/W2130189600', 'https://openalex.org/W2137899652', 'https://openalex.org/W2151489466', 'https://openalex.org/W2152123169', 'https://openalex.org/W2157495622', 'https://openalex.org/W2165854061', 'https://openalex.org/W2177855755', 'https://openalex.org/W2213687129', 'https://openalex.org/W2257497411', 'https://openalex.org/W2331953902', 'https://openalex.org/W2374277491', 'https://openalex.org/W2461148724', 'https://openalex.org/W2514365970', 'https://openalex.org/W2525190534', 'https://openalex.org/W2565707423', 'https://openalex.org/W2587667345', 'https://openalex.org/W2611741716', 'https://openalex.org/W2742262891', 'https://openalex.org/W2781566872', 'https://openalex.org/W2810631142', 'https://openalex.org/W2841328798', 'https://openalex.org/W2889289357', 'https://openalex.org/W4250454093'], 'related_works': ['https://openalex.org/W5360043', 'https://openalex.org/W2589188006', 'https://openalex.org/W2144316559', 'https://openalex.org/W2087742925', 'https://openalex.org/W2074489367', 'https://openalex.org/W2051553009', 'https://openalex.org/W2038527518', 'https://openalex.org/W1974791065', 'https://openalex.org/W1973768589', 'https://openalex.org/W1484741277'], 'abstract_inverted_index': {'Although': [0], 'the': [1, 10, 72, 96, 118, 144, 170, 174, 180, 209], 'rapid': [2, 67], 'development': [3], 'of': [4, 12, 16, 37, 71, 75, 98, 120, 157, 163, 169, 192, 213], 'high-throughput': [5], 'sequencing': [6], 'has': [7], 'led': [8], 'to': [9, 29], 'identification': [11], 'a': [13, 61, 83, 87, 99, 108, 154, 161], 'large': [14, 155], 'number': [15], 'truncated': [17], 'or': [18, 138, 205], 'mutated': [19], 'steroid': [20, 103, 132], 'hormone': [21, 104], 'receptor': [22, 172, 176, 182], '(SHR)': [23], 'variants,': [24], 'their': [25, 49], 'clinical': [26], 'relevance': [27], 'remains': [28], 'be': [30, 44], 'defined.': [31], 'A': [32], 'platform': [33], 'for': [34, 46, 208], 'functional': [35, 190], 'analysis': [36, 191], 'these': [38], 'SHR': [39, 76, 136, 193], 'variants': [40, 77, 196], 'in': [41, 78, 197], 'cells': [42], 'would': [43], 'instrumental': [45], 'better': [47], 'assessing': [48], 'impact': [50], 'on': [51], 'normal': [52], 'physiology': [53], 'and': [54, 68, 107, 127, 167, 179, 195, 199, 211], 'SHR-associated': [55], 'diseases.': [56, 215], 'Here': [57], 'we': [58, 152], 'have': [59], 'developed': [60], 'new': [62], 'reporter': [63, 81, 90, 111, 150, 187], 'system': [64, 188], 'that': [65, 113], 'allows': [66], 'accurate': [69], 'assessment': [70], 'transcriptional': [73], 'activity': [74], 'cells.': [79], 'The': [80, 134], 'is': [82, 94, 114, 128, 140], 'single': [84], 'construct': [85], 'containing': [86], 'firefly': [88], 'luciferase': [89, 110], 'gene,': [91, 112], 'whose': [92], 'expression': [93], 'under': [95, 117], 'control': [97, 119], 'promoter': [100], 'with': [101], 'multiple': [102], 'responsive': [105], 'elements,': [106], 'Renilla': [109], 'constitutively': [115], 'expressed': [116, 142], 'an': [121], 'internal': [122], 'ribosome': [123], 'entry': [124], 'site': [125], '(IRES)': [126], 'not': [129], 'regulated': [130], 'by': [131], 'hormones.': [133], 'corresponding': [135], '(wildtype': [137], 'mutant/variant)': [139], 'also': [141], 'from': [143], 'same': [145], 'construct.': [146], 'Using': [147], 'this': [148], 'improved': [149], 'system,': [151], 'revealed': [153], 'spectrum': [156], 'transactivation': [158], 'activities': [159], 'within': [160], 'set': [162], 'previously': [164], 'identified': [165], 'mutations': [166], 'variations': [168], 'androgen': [171], '(AR),': [173], 'estrogen': [175], 'α': [177], '(ERα)': [178], 'glucocorticoid': [181], '(GR)': [183], '.': [184], 'This': [185], 'novel': [186], 'enables': [189], 'mutants': [194], 'physiological': [198], 'pathological': [200], 'settings,': [201], 'offering': [202], 'valuable': [203], 'preclinical': [204], 'diagnostic': [206], 'information': [207], 'understanding': [210], 'treatment': [212], 'associated': [214]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3014884427', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}], 'updated_date': '2024-12-09T23:51:42.616991', 'created_date': '2020-04-10'}