Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W3013777135', 'doi': 'https://doi.org/10.1158/1538-7445.sabcs19-pd5-03', 'title': 'Abstract PD5-03: Relationship between tumor-infiltrating lymphocytes (TILs) and outcomes in the KEYNOTE-119 study of pembrolizumab vs chemotherapy for previously treated metastatic triple-negative breast cancer (mTNBC)', 'display_name': 'Abstract PD5-03: Relationship between tumor-infiltrating lymphocytes (TILs) and outcomes in the KEYNOTE-119 study of pembrolizumab vs chemotherapy for previously treated metastatic triple-negative breast cancer (mTNBC)', 'publication_year': 2020, 'publication_date': '2020-02-15', 'ids': {'openalex': 'https://openalex.org/W3013777135', 'doi': 'https://doi.org/10.1158/1538-7445.sabcs19-pd5-03', 'mag': '3013777135'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.sabcs19-pd5-03', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5010278367', 'display_name': 'Sherene Loi', 'orcid': 'https://orcid.org/0000-0001-6137-9171'}, 'institutions': [{'id': 'https://openalex.org/I2800555584', 'display_name': 'Peter MacCallum Cancer Centre', 'ror': 'https://ror.org/02a8bt934', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800555584']}, {'id': 'https://openalex.org/I165779595', 'display_name': 'University of Melbourne', 'ror': 'https://ror.org/01ej9dk98', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I165779595']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Sherene Loi', 'raw_affiliation_strings': ['1Peter MacCallum Cancer Centre, University of Melbourne, Melbourne, Victoria, Australia'], 'affiliations': [{'raw_affiliation_string': '1Peter MacCallum Cancer Centre, University of Melbourne, Melbourne, Victoria, Australia', 'institution_ids': ['https://openalex.org/I2800555584', 'https://openalex.org/I165779595']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070245248', 'display_name': 'Eric P. Winer', 'orcid': 'https://orcid.org/0000-0002-8819-1723'}, 'institutions': [{'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Eric Winer', 'raw_affiliation_strings': ['2Dana-Farber Cancer Institute, Boston, MA;'], 'affiliations': [{'raw_affiliation_string': '2Dana-Farber Cancer Institute, Boston, MA;', 'institution_ids': ['https://openalex.org/I4210117453']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5042452774', 'display_name': 'Oleg Lipatov', 'orcid': 'https://orcid.org/0000-0002-8867-504X'}, 'institutions': [{'id': 'https://openalex.org/I4210124327', 'display_name': 'Republican Oncological Clinical Dispensary', 'ror': 'https://ror.org/0244v0536', 'country_code': 'RU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210124327']}], 'countries': ['RU'], 'is_corresponding': False, 'raw_author_name': 'Oleg Lipatov', 'raw_affiliation_strings': ['3Republican Clinical Oncology Dispensary, Republic of Tatarstan, Russian Federation'], 'affiliations': [{'raw_affiliation_string': '3Republican Clinical Oncology Dispensary, Republic of Tatarstan, Russian Federation', 'institution_ids': ['https://openalex.org/I4210124327']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069050806', 'display_name': 'Seock‐Ah Im', 'orcid': 'https://orcid.org/0000-0002-5396-6533'}, 'institutions': [{'id': 'https://openalex.org/I2800555584', 'display_name': 'Peter MacCallum Cancer Centre', 'ror': 'https://ror.org/02a8bt934', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800555584']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Seock-Ah Im', 'raw_affiliation_strings': ['4Peter MacCallum Cancer Institute, Melbourne, Australia'], 'affiliations': [{'raw_affiliation_string': '4Peter MacCallum Cancer Institute, Melbourne, Australia', 'institution_ids': ['https://openalex.org/I2800555584']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006642161', 'display_name': 'Anthony Gonçalvès', 'orcid': 'https://orcid.org/0000-0001-7570-7439'}, 'institutions': [{'id': 'https://openalex.org/I4210150365', 'display_name': 'Institut Paoli-Calmettes', 'ror': 'https://ror.org/04s3t1g37', 'country_code': 'FR', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210150365']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Anthony Goncalves', 'raw_affiliation_strings': ['5Institut Paoli-Calmettes, Marseille, France'], 'affiliations': [{'raw_affiliation_string': '5Institut Paoli-Calmettes, Marseille, France', 'institution_ids': ['https://openalex.org/I4210150365']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051629490', 'display_name': 'Javier Cortés', 'orcid': 'https://orcid.org/0000-0001-7623-1583'}, 'institutions': [{'id': 'https://openalex.org/I4387155398', 'display_name': "Vall d'Hebron Institute of Oncology", 'ror': 'https://ror.org/054xx3904', 'country_code': None, 'type': 'healthcare', 'lineage': ['https://openalex.org/I4387153040', 'https://openalex.org/I4387155398']}], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Javier Cortes', 'raw_affiliation_strings': ["6OB Institute of Oncology, Quiron Group; Vall d'Hebron Institute of Oncology (VHIO), Madrid & Barcelona, Spain", 'OB Institute of Oncology, Quiron Group'], 'affiliations': [{'raw_affiliation_string': "6OB Institute of Oncology, Quiron Group; Vall d'Hebron Institute of Oncology (VHIO), Madrid & Barcelona, Spain", 'institution_ids': ['https://openalex.org/I4387155398']}, {'raw_affiliation_string': 'OB Institute of Oncology, Quiron Group', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037398735', 'display_name': 'Keun S Lee', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210120052', 'display_name': 'National Cancer Center', 'ror': 'https://ror.org/02tsanh21', 'country_code': 'KR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1290491151', 'https://openalex.org/I2801339556', 'https://openalex.org/I4210120052']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Keun S Lee', 'raw_affiliation_strings': ['7National Cancer Center Hospital, Goyang, Korea, Republic of'], 'affiliations': [{'raw_affiliation_string': '7National Cancer Center Hospital, Goyang, Korea, Republic of', 'institution_ids': ['https://openalex.org/I4210120052']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111951182', 'display_name': 'Peter Schmid', 'orcid': None}, 'institutions': [], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Peter Schmid', 'raw_affiliation_strings': ['8Barts Cancer Institute, Centre for Experimental Cancer Medicine, London, United Kingdom'], 'affiliations': [{'raw_affiliation_string': '8Barts Cancer Institute, Centre for Experimental Cancer Medicine, London, United Kingdom', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036420234', 'display_name': 'Laura Testa', 'orcid': 'https://orcid.org/0000-0001-6080-7429'}, 'institutions': [{'id': 'https://openalex.org/I4210088998', 'display_name': 'Instituto do Câncer do Estado de São Paulo', 'ror': 'https://ror.org/005vqqr19', 'country_code': 'BR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210088998']}], 'countries': ['BR'], 'is_corresponding': False, 'raw_author_name': 'Laura Testa', 'raw_affiliation_strings': ['9Instituto do Câncer do Estado de São Paulo - Faculdade de Medicina da Universidade do Estado de São Paulo, São Paulo, Brazil'], 'affiliations': [{'raw_affiliation_string': '9Instituto do Câncer do Estado de São Paulo - Faculdade de Medicina da Universidade do Estado de São Paulo, São Paulo, Brazil', 'institution_ids': ['https://openalex.org/I4210088998']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5021290996', 'display_name': 'Isabell Witzel', 'orcid': 'https://orcid.org/0000-0002-8734-4521'}, 'institutions': [{'id': 'https://openalex.org/I4210108711', 'display_name': 'University Medical Center Hamburg-Eppendorf', 'ror': 'https://ror.org/01zgy1s35', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I159176309', 'https://openalex.org/I4210108711']}, {'id': 'https://openalex.org/I159176309', 'display_name': 'Universität Hamburg', 'ror': 'https://ror.org/00g30e956', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I159176309']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Isabell Witzel', 'raw_affiliation_strings': ['10University Medical Center Hamburg, Hamburg, Germany'], 'affiliations': [{'raw_affiliation_string': '10University Medical Center Hamburg, Hamburg, Germany', 'institution_ids': ['https://openalex.org/I4210108711', 'https://openalex.org/I159176309']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110811411', 'display_name': 'Shoichiro Ohtani', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210104416', 'display_name': 'Hiroshima City Asa Citizens Hospital', 'ror': 'https://ror.org/01hkncq81', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210104416']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Shoichiro Ohtani', 'raw_affiliation_strings': ['11Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan'], 'affiliations': [{'raw_affiliation_string': '11Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan', 'institution_ids': ['https://openalex.org/I4210104416']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5060044961', 'display_name': 'Nicholas C. Turner', 'orcid': 'https://orcid.org/0000-0001-8937-0873'}, 'institutions': [{'id': 'https://openalex.org/I125671874', 'display_name': 'National Health Service', 'ror': 'https://ror.org/02wnqcb97', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I125671874', 'https://openalex.org/I1311074006']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Nicholas Turner', 'raw_affiliation_strings': ['12Royal Marsden National Health Service Foundation Trust, London, United Kingdom'], 'affiliations': [{'raw_affiliation_string': '12Royal Marsden National Health Service Foundation Trust, London, United Kingdom', 'institution_ids': ['https://openalex.org/I125671874']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022820347', 'display_name': 'Stefania Zambelli', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I292310028', 'display_name': 'San Raffaele University of Rome', 'ror': 'https://ror.org/02rwycx38', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I292310028']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Stefania Zambelli', 'raw_affiliation_strings': ['13San Raffaele Scientific Institute, Milan, Italy'], 'affiliations': [{'raw_affiliation_string': '13San Raffaele Scientific Institute, Milan, Italy', 'institution_ids': ['https://openalex.org/I292310028']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027231412', 'display_name': 'Nadia Harbeck', 'orcid': 'https://orcid.org/0000-0002-9744-7372'}, 'institutions': [{'id': 'https://openalex.org/I8204097', 'display_name': 'Ludwig-Maximilians-Universität München', 'ror': 'https://ror.org/05591te55', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I8204097']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Nadia Harbeck', 'raw_affiliation_strings': ['14Breast Center, University of Munich (LMU), Munich, Germany'], 'affiliations': [{'raw_affiliation_string': '14Breast Center, University of Munich (LMU), Munich, Germany', 'institution_ids': ['https://openalex.org/I8204097']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001814176', 'display_name': 'Fabrice André', 'orcid': 'https://orcid.org/0000-0001-5795-8357'}, 'institutions': [{'id': 'https://openalex.org/I2801843802', 'display_name': 'Institut Gustave Roussy', 'ror': 'https://ror.org/0321g0743', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I2801843802']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Fabrice Andre', 'raw_affiliation_strings': ['15Faculté de Medicine Paris-Sud XI, Gustave Roussy, Villejuif, France'], 'affiliations': [{'raw_affiliation_string': '15Faculté de Medicine Paris-Sud XI, Gustave Roussy, Villejuif, France', 'institution_ids': ['https://openalex.org/I2801843802']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056387446', 'display_name': 'Rebecca Dent', 'orcid': 'https://orcid.org/0000-0001-6421-7602'}, 'institutions': [{'id': 'https://openalex.org/I185261750', 'display_name': 'University of Toronto', 'ror': 'https://ror.org/03dbr7087', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I185261750']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Rebecca Dent', 'raw_affiliation_strings': ['16University of Toronto, Toronto, ON, Canada'], 'affiliations': [{'raw_affiliation_string': '16University of Toronto, Toronto, ON, Canada', 'institution_ids': ['https://openalex.org/I185261750']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061102317', 'display_name': 'Lingkang Huang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'Merck & Co., Inc., Rahway, NJ, USA (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'LingKang Huang', 'raw_affiliation_strings': ['17Merck & Co., Inc., Kenilworth, NJ'], 'affiliations': [{'raw_affiliation_string': '17Merck & Co., Inc., Kenilworth, NJ', 'institution_ids': ['https://openalex.org/I1285764155']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5080084854', 'display_name': 'Jaime Mejia', 'orcid': 'https://orcid.org/0000-0002-1315-6878'}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'Merck & Co., Inc., Rahway, NJ, USA (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jaime Mejia', 'raw_affiliation_strings': ['17Merck & Co., Inc., Kenilworth, NJ'], 'affiliations': [{'raw_affiliation_string': '17Merck & Co., Inc., Kenilworth, NJ', 'institution_ids': ['https://openalex.org/I1285764155']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077520870', 'display_name': 'Vassiliki Karantza', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'Merck & Co., Inc., Rahway, NJ, USA (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Vassiliki Karantza', 'raw_affiliation_strings': ['17Merck & Co., Inc., Kenilworth, NJ'], 'affiliations': [{'raw_affiliation_string': '17Merck & Co., Inc., Kenilworth, NJ', 'institution_ids': ['https://openalex.org/I1285764155']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5016015665', 'display_name': 'Roberto Salgado', 'orcid': 'https://orcid.org/0000-0002-1110-3801'}, 'institutions': [{'id': 'https://openalex.org/I2800555584', 'display_name': 'Peter MacCallum Cancer Centre', 'ror': 'https://ror.org/02a8bt934', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800555584']}, {'id': 'https://openalex.org/I165779595', 'display_name': 'University of Melbourne', 'ror': 'https://ror.org/01ej9dk98', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I165779595']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Roberto Salgado', 'raw_affiliation_strings': ['1Peter MacCallum Cancer Centre, University of Melbourne, Melbourne, Victoria, Australia'], 'affiliations': [{'raw_affiliation_string': '1Peter MacCallum Cancer Centre, University of Melbourne, Melbourne, Victoria, Australia', 'institution_ids': ['https://openalex.org/I2800555584', 'https://openalex.org/I165779595']}]}], 'institution_assertions': [], 'countries_distinct_count': 11, 'institutions_distinct_count': 17, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 4.567, 'has_fulltext': False, 'cited_by_count': 54, 'citation_normalized_percentile': {'value': 0.999965, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '80', 'issue': '4_Supplement', 'first_page': 'PD5', 'last_page': '03'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10158', 'display_name': 'Cancer Immunotherapy and Biomarkers', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10158', 'display_name': 'Cancer Immunotherapy and Biomarkers', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12829', 'display_name': 'Advanced Breast Cancer Therapies', 'score': 0.9984, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T14078', 'display_name': 'Multiple and Secondary Primary Cancers', 'score': 0.9974, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/taxane', 'display_name': 'Taxane', 'score': 0.66610575}, {'id': 'https://openalex.org/keywords/vinorelbine', 'display_name': 'Vinorelbine', 'score': 0.55118895}, {'id': 'https://openalex.org/keywords/tumor-infiltrating-lymphocytes', 'display_name': 'Tumor-infiltrating lymphocytes', 'score': 0.51461565}, {'id': 'https://openalex.org/keywords/triple-negative-breast-cancer', 'display_name': 'Triple-negative breast cancer', 'score': 0.45631206}, {'id': 'https://openalex.org/keywords/eribulin', 'display_name': 'Eribulin', 'score': 0.42514044}], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.84836185}, {'id': 'https://openalex.org/C2780057760', 'wikidata': 'https://www.wikidata.org/wiki/Q13896859', 'display_name': 'Pembrolizumab', 'level': 4, 'score': 0.75170696}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.6808026}, {'id': 'https://openalex.org/C2777511904', 'wikidata': 'https://www.wikidata.org/wiki/Q425227', 'display_name': 'Taxane', 'level': 4, 'score': 0.66610575}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.6627611}, {'id': 'https://openalex.org/C2780258809', 'wikidata': 'https://www.wikidata.org/wiki/Q414143', 'display_name': 'Gemcitabine', 'level': 3, 'score': 0.58719987}, {'id': 'https://openalex.org/C2780350996', 'wikidata': 'https://www.wikidata.org/wiki/Q420532', 'display_name': 'Vinorelbine', 'level': 4, 'score': 0.55118895}, {'id': 'https://openalex.org/C2778326572', 'wikidata': 'https://www.wikidata.org/wiki/Q7852668', 'display_name': 'Tumor-infiltrating lymphocytes', 'level': 4, 'score': 0.51461565}, {'id': 'https://openalex.org/C2777909004', 'wikidata': 'https://www.wikidata.org/wiki/Q420207', 'display_name': 'Capecitabine', 'level': 4, 'score': 0.4979887}, {'id': 'https://openalex.org/C530470458', 'wikidata': 'https://www.wikidata.org/wiki/Q128581', 'display_name': 'Breast cancer', 'level': 3, 'score': 0.4869024}, {'id': 'https://openalex.org/C2780110267', 'wikidata': 'https://www.wikidata.org/wiki/Q7843332', 'display_name': 'Triple-negative breast cancer', 'level': 4, 'score': 0.45631206}, {'id': 'https://openalex.org/C2776802502', 'wikidata': 'https://www.wikidata.org/wiki/Q417589', 'display_name': 'Anthracycline', 'level': 4, 'score': 0.448143}, {'id': 'https://openalex.org/C2776694085', 'wikidata': 'https://www.wikidata.org/wiki/Q974135', 'display_name': 'Chemotherapy', 'level': 2, 'score': 0.44698313}, {'id': 'https://openalex.org/C2776387010', 'wikidata': 'https://www.wikidata.org/wiki/Q408717', 'display_name': 'Eribulin', 'level': 5, 'score': 0.42514044}, {'id': 'https://openalex.org/C2775930923', 'wikidata': 'https://www.wikidata.org/wiki/Q12859063', 'display_name': 'Metastatic breast cancer', 'level': 4, 'score': 0.40711838}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.37632272}, {'id': 'https://openalex.org/C2777701055', 'wikidata': 'https://www.wikidata.org/wiki/Q1427096', 'display_name': 'Immunotherapy', 'level': 3, 'score': 0.22414699}, {'id': 'https://openalex.org/C526805850', 'wikidata': 'https://www.wikidata.org/wiki/Q188874', 'display_name': 'Colorectal cancer', 'level': 3, 'score': 0.14731327}, {'id': 'https://openalex.org/C2778239845', 'wikidata': 'https://www.wikidata.org/wiki/Q412415', 'display_name': 'Cisplatin', 'level': 3, 'score': 0.0986982}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.sabcs19-pd5-03', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.68, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4287448171', 'https://openalex.org/W4281805317', 'https://openalex.org/W4248980160', 'https://openalex.org/W4205733538', 'https://openalex.org/W2401602145', 'https://openalex.org/W2142058321', 'https://openalex.org/W2083736362', 'https://openalex.org/W1999247228', 'https://openalex.org/W1937628254', 'https://openalex.org/W1753522318'], 'abstract_inverted_index': {'Abstract': [0], 'Background:': [1], 'Several': [2], 'studies': [3], 'show': [4], 'that': [5, 514], 'the': [6, 24, 52, 55, 62, 242, 263, 309, 334, 368, 373, 393, 397, 422, 506, 581, 658, 677], 'presence': [7, 56, 275], 'of': [8, 35, 43, 57, 68, 128, 135, 167, 195, 206, 258, 276, 287, 407, 412, 480, 517, 533, 661, 676], 'TILs': [9, 58, 277, 299, 312, 325, 338, 352, 404, 420, 441, 456, 471, 481, 490, 534], 'has': [10], 'prognostic': [11], 'significance': [12], 'in': [13, 61, 75, 241, 262, 278, 341, 363, 367, 392, 580, 657], 'TNBC,': [14, 102], 'with': [15, 20, 78, 120, 142, 201, 387, 403, 419, 440, 455, 494, 498, 521], 'greater': [16], 'lymphocytic': [17], 'infiltration': [18], 'associated': [19, 386, 493], 'clinical': [21, 389, 496], 'outcomes.': [22], 'In': [23], 'phase': [25, 63], '2': [26, 105], 'KEYNOTE-086': [27], 'study,': [28], 'TIL': [29, 358, 376, 509], 'levels': [30, 359, 377], 'were': [31, 40, 94, 146, 149, 180, 239, 254, 339, 360, 382, 491], 'a': [32, 124, 129, 162, 202, 293, 379, 410, 515, 578], 'surrogate': [33], 'marker': [34], 'preexisting': [36], 'antitumor': [37], 'immunity': [38], 'and': [39, 59, 126, 138, 165, 231, 248, 260, 269, 272, 289, 300, 302, 313, 324, 431, 448, 464, 482, 558, 655], 'independent': [41, 485], 'predictors': [42], 'response': [44], 'to': [45, 86, 184], 'pembrolizumab': [46, 662], '(pembro)': [47], 'monotherapy.': [48], 'Here,': [49], 'we': [50], 'analyzed': [51, 305, 316], 'relationship': [53, 297, 310], 'between': [54, 298, 311, 322, 470, 651], 'outcomes': [60, 390, 497, 656], '3': [64], 'KEYNOTE-119': [65, 659], '(NCT02555657)': [66], 'study': [67, 330, 660], 'pembro': [69, 185, 369, 394, 499, 529, 557], 'monotherapy': [70], 'vs': [71, 155, 171, 365, 436, 445, 450, 461, 466, 472, 567, 663], 'single-agent': [72, 190], 'chemotherapy': [73, 664], '(chemo)': [74], 'patients': [76], '(pts)': [77], 'previously': [79, 666], 'treated': [80, 344, 667], 'mTNBC.': [81], 'Methods:': [82], 'From': [83], 'October': [84], '2015': [85], 'April': [87], '2017,': [88], '622': [89], 'pts': [90, 345, 402, 418, 439, 454, 520], 'from': [91, 528], '31': [92], 'countries': [93], 'enrolled.': [95], 'Key': [96], 'eligibility': [97], 'criteria': [98], 'included': [99], 'centrally': [100], 'confirmed': [101], '1': [103, 229], 'or': [104, 189, 199, 219], 'prior': [106, 118, 168, 564], 'systemic': [107], 'treatments': [108], 'for': [109, 132, 208, 228, 333, 417, 438, 453, 556, 560, 665], 'metastatic': [110, 174, 570, 668], 'disease,': [111], 'documented': [112], 'progression': [113], 'on': [114], 'most': [115], 'recent': [116], 'therapy,': [117], 'treatment': [119, 170, 323], 'an': [121], 'anthracycline': [122], 'and/or': [123], 'taxane,': [125], 'provision': [127], 'tumor': [130, 280], 'sample': [131], 'central': [133], 'determination': [134], 'triple-negative': [136, 669], 'status': [137, 153], 'PD-L1': [139, 152, 157, 243, 264], 'expression.': [140], 'Pts': [141, 148, 179], 'active': [143], 'brain': [144], 'metastases': [145], 'excluded.': [147], 'stratified': [150], 'by': [151, 284], '(positive': [154], 'negative;': [156], 'positivity': [158], 'was': [159, 223, 282, 304, 315, 326, 331, 354, 424, 443, 459, 474, 575, 583], 'defined': [160], 'as': [161, 378, 577], 'CPS': [163, 244, 246, 265, 267, 473, 483], '≥1)': [164], 'history': [166], 'neoadjuvant/adjuvant': [169], 'de': [172, 568], 'novo': [173, 569], 'disease': [175, 571, 593], 'at': [176, 476, 505, 572], 'initial': [177, 573], 'diagnosis.': [178], 'randomly': [181], 'assigned': [182], '1:1': [183], '200': [186], 'mg': [187], 'Q3W': [188], 'chemo': [191, 374, 398], 'per': [192, 211], 'investigator’s': [193], 'choice': [194], 'capecitabine,': [196], 'eribulin,': [197], 'gemcitabine,': [198], 'vinorelbine,': [200], 'maximum': [203], 'enrollment': [204], 'cap': [205], '60%': [207], 'each,': [209], 'administered': [210], 'local': [212], 'product': [213], 'label,': [214], 'until': [215], 'progression,': [216], 'intolerable': [217], 'toxicity,': [218], 'investigator/patient': [220], 'decision.': [221], 'Response': [222], 'assessed': [224, 283], 'every': [225, 232], '9': [226], 'wk': [227, 234], 'y': [230], '12': [233], 'thereafter.': [235], 'Primary': [236], 'end': [237, 252, 336], 'points': [238, 253], 'OS': [240, 301, 408, 430, 433], '≥10,': [245, 266], '≥1,': [247, 268], 'total': [249, 270], 'populations.': [250], 'Secondary': [251], 'PFS,': [255, 601], 'ORR,': [256], 'duration': [257], 'response,': [259], 'DCR': [261], 'populations,': [271], 'safety.': [273], 'The': [274, 296, 320, 329, 350, 468], 'archival': [279], 'samples': [281], 'light': [285], 'microscopy': [286], 'hematoxylin': [288], 'eosin-stained': [290], 'sections': [291], 'using': [292, 306, 317], 'predefined': [294], 'method.': [295], 'PFS': [303], 'Cox': [307], 'regression;': [308], 'ORR': [314], 'logistic': [318], 'regression.': [319], 'interaction': [321], 'assessed.': [327], 'Results:': [328], 'negative': [332], 'primary': [335], 'point.': [337], 'evaluable': [340], '536/622': [342], '(86.2%)': [343], '(273': [346], '[pembro];': [347], '263': [348], '[chemo]).': [349], 'median': [351, 508], 'distribution': [353], '5%': [355], '(IQR,': [356], '14%).': [357], 'significantly': [361, 383, 492], 'higher': [362], 'responders': [364], 'nonresponders': [366], 'arm,': [370], 'but': [371, 395, 500], 'not': [372, 396, 501], 'arm.': [375], 'continuous': [380], 'variable': [381], '(P<': [384], '0.05)': [385], 'all': [388], 'tested': [391], 'arm': [399], '(Table).': [400], 'For': [401], '<5%,': [405], 'assessment': [406], 'yielded': [409], 'HR': [411, 423], '1.50': [413], '(95%': [414, 426], 'CI,': [415, 427], '1.14-1.97);': [416], '≥5%,': [421, 457], '0.75': [425], '0.59-0.96).': [428], 'Median': [429], '18-month': [432], 'rate': [434], '(pembro': [435], 'chemo)': [437], '<5%': [442], '5.9': [444], '8.8': [446], 'mo': [447, 463], '15%': [449], '27%,': [451], 'respectively;': [452], 'this': [458], '12.5': [460], '11.3': [462], '35%': [465], '27%.': [467], 'correlation': [469], 'moderate': [475], '0.45;': [477], 'multivariate': [478], 'modeling': [479], 'showed': [484], 'predictive': [486], 'value.': [487], 'Conclusions:': [488], 'High': [489], 'better': [495], 'chemo.': [502, 531], 'Efficacy': [503], 'estimates': [504], 'prespecified': [507], 'cut': [510], 'point': [511], '(≥5%)': [512], 'suggest': [513], 'subset': [516], 'later-line': [518], 'advanced': [519], 'TNBC': [522], 'can': [523], 'derive': [524], 'prolonged': [525], 'survival': [526], 'benefit': [527], 'over': [530], 'Association': [532], 'With': [535], 'Clinical': [536], 'OutcomesTreatment': [537], 'ArmContinuousBORDCRPFSOSVariableORRP*DCRP*Event': [538], 'RateP*Event': [539], 'RateP*Pembro': [540], '(n=273),TILs25': [541], '(9.2)0.000732': [542], '(11.7)0.0058241': [543], '(88.3)0.0002239': [544], '(87.5)0.0001n': [545], '(%)Chemo': [546], '(n=263),TILs29': [547], '(11.0)0.180950': [548], '(19.0)0.3026191': [549], '(72.6)0.234236': [550], '(89.7)0.3321n': [551], '(%)*P': [552], 'values': [553], 'are': [554], '1-sided': [555], '2-sided': [559], 'chemo.The': [561], 'stratification': [562], 'variable,': [563], '(neo)adjuvant': [565], 'therapy': [566], 'diagnosis,': [574], 'used': [576], 'covariate': [579], 'model.TILs': [582], 'square': [584], 'root': [585], 'transformed.BOR,': [586], 'best': [587], 'overall': [588, 597], 'response;': [589], 'chemo,': [590], 'chemotherapy;': [591], 'DCR,': [592], 'control': [594], 'rate;': [595], 'OS,': [596], 'survival;': [598, 603], 'pembro,': [599], 'pembrolizumab;': [600], 'progression-free': [602], 'TILs,': [604], 'tumor-infiltrating': [605, 652], 'lymphocytes.': [606], 'Citation': [607], 'Format:': [608], 'Sherene': [609], 'Loi,': [610], 'Eric': [611], 'Winer,': [612], 'Oleg': [613], 'Lipatov,': [614], 'Seock-Ah': [615], 'Im,': [616], 'Anthony': [617], 'Goncalves,': [618], 'Javier': [619], 'Cortes,': [620], 'Keun': [621], 'S': [622], 'Lee,': [623], 'Peter': [624], 'Schmid,': [625], 'Laura': [626], 'Testa,': [627], 'Isabell': [628], 'Witzel,': [629], 'Shoichiro': [630], 'Ohtani,': [631], 'Nicholas': [632], 'Turner,': [633], 'Stefania': [634], 'Zambelli,': [635], 'Nadia': [636], 'Harbeck,': [637], 'Fabrice': [638], 'Andre,': [639], 'Rebecca': [640], 'Dent,': [641], 'LingKang': [642], 'Huang,': [643], 'Jaime': [644], 'Mejia,': [645], 'Vassiliki': [646], 'Karantza,': [647], 'Roberto': [648], 'Salgado.': [649], 'Relationship': [650], 'lymphocytes': [653], '(TILs)': [654], 'breast': [670], 'cancer': [671], '(mTNBC)': [672], '[abstract].': [673], 'In:': [674], 'Proceedings': [675], '2019': [678, 684], 'San': [679, 687], 'Antonio': [680], 'Breast': [681], 'Cancer': [682, 693], 'Symposium;': [683], 'Dec': [685], '10-14;': [686], 'Antonio,': [688], 'TX.': [689], 'Philadelphia': [690], '(PA):': [691], 'AACR;': [692], 'Res': [694], '2020;80(4': [695], 'Suppl):Abstract': [696], 'nr': [697], 'PD5-03.': [698]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3013777135', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 15}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 19}, {'year': 2020, 'cited_by_count': 7}], 'updated_date': '2024-12-24T17:26:09.884315', 'created_date': '2020-04-03'}