Publication Information

{'id': 'https://openalex.org/W3013353529', 'doi': 'https://doi.org/10.1158/2326-6074.tumimm19-a62', 'title': 'Abstract A62: Inhibition of tumor growth by novel CART redirected against cells expressing high levels of fibroblast activation protein', 'display_name': 'Abstract A62: Inhibition of tumor growth by novel CART redirected against cells expressing high levels of fibroblast activation protein', 'publication_year': 2020, 'publication_date': '2020-03-01', 'ids': {'openalex': 'https://openalex.org/W3013353529', 'doi': 'https://doi.org/10.1158/2326-6074.tumimm19-a62', 'mag': '3013353529'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/2326-6074.tumimm19-a62', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2765010658', 'display_name': 'Cancer Immunology Research', 'issn_l': '2326-6066', 'issn': ['2326-6066', '2326-6074'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5029769755', 'display_name': 'Estela Noguera-Ortega', 'orcid': 'https://orcid.org/0000-0001-6507-0673'}, 'institutions': [{'id': 'https://openalex.org/I79576946', 'display_name': 'University of Pennsylvania', 'ror': 'https://ror.org/00b30xv10', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I79576946']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Estela Noguera-Ortega', 'raw_affiliation_strings': ['University of Pennsylvania, Philadelphia, PA.'], 'affiliations': [{'raw_affiliation_string': 'University of Pennsylvania, Philadelphia, PA.', 'institution_ids': ['https://openalex.org/I79576946']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109891238', 'display_name': 'Leslie Todd', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I79576946', 'display_name': 'University of Pennsylvania', 'ror': 'https://ror.org/00b30xv10', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I79576946']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Leslie Todd', 'raw_affiliation_strings': ['University of Pennsylvania, Philadelphia, PA.'], 'affiliations': [{'raw_affiliation_string': 'University of Pennsylvania, Philadelphia, PA.', 'institution_ids': ['https://openalex.org/I79576946']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016493527', 'display_name': 'James Monslow', 'orcid': 'https://orcid.org/0000-0002-6775-489X'}, 'institutions': [{'id': 'https://openalex.org/I79576946', 'display_name': 'University of Pennsylvania', 'ror': 'https://ror.org/00b30xv10', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I79576946']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'James Monslow', 'raw_affiliation_strings': ['University of Pennsylvania, Philadelphia, PA.'], 'affiliations': [{'raw_affiliation_string': 'University of Pennsylvania, Philadelphia, PA.', 'institution_ids': ['https://openalex.org/I79576946']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5063310226', 'display_name': 'Jing Sun', 'orcid': 'https://orcid.org/0000-0002-6644-4320'}, 'institutions': [{'id': 'https://openalex.org/I79576946', 'display_name': 'University of Pennsylvania', 'ror': 'https://ror.org/00b30xv10', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I79576946']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jing Sun', 'raw_affiliation_strings': ['University of Pennsylvania, Philadelphia, PA.'], 'affiliations': [{'raw_affiliation_string': 'University of Pennsylvania, Philadelphia, PA.', 'institution_ids': ['https://openalex.org/I79576946']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005953721', 'display_name': 'Steven Μ. Albelda', 'orcid': 'https://orcid.org/0000-0002-6598-3752'}, 'institutions': [{'id': 'https://openalex.org/I79576946', 'display_name': 'University of Pennsylvania', 'ror': 'https://ror.org/00b30xv10', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I79576946']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Steven M. Albelda', 'raw_affiliation_strings': ['University of Pennsylvania, Philadelphia, PA.'], 'affiliations': [{'raw_affiliation_string': 'University of Pennsylvania, Philadelphia, PA.', 'institution_ids': ['https://openalex.org/I79576946']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5004098027', 'display_name': 'Ellen Puré', 'orcid': 'https://orcid.org/0000-0003-2107-3711'}, 'institutions': [{'id': 'https://openalex.org/I79576946', 'display_name': 'University of Pennsylvania', 'ror': 'https://ror.org/00b30xv10', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I79576946']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ellen Pure', 'raw_affiliation_strings': ['University of Pennsylvania, Philadelphia, PA.'], 'affiliations': [{'raw_affiliation_string': 'University of Pennsylvania, Philadelphia, PA.', 'institution_ids': ['https://openalex.org/I79576946']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 1, 'citation_normalized_percentile': {'value': 0.442707, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 60, 'max': 69}, 'biblio': {'volume': '8', 'issue': '3_Supplement', 'first_page': 'A62', 'last_page': 'A62'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12505', 'display_name': 'Peptidase Inhibition and Analysis', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12505', 'display_name': 'Peptidase Inhibition and Analysis', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11041', 'display_name': 'Ubiquitin and proteasome pathways', 'score': 0.9956, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12226', 'display_name': 'Neuroblastoma Research and Treatments', 'score': 0.9922, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cancer-associated-fibroblasts', 'display_name': 'Cancer-Associated Fibroblasts', 'score': 0.6279354}], 'concepts': [{'id': 'https://openalex.org/C111798993', 'wikidata': 'https://www.wikidata.org/wiki/Q21117471', 'display_name': 'Fibroblast activation protein, alpha', 'level': 3, 'score': 0.86383176}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.6519396}, {'id': 'https://openalex.org/C2909706936', 'wikidata': 'https://www.wikidata.org/wiki/Q42417562', 'display_name': 'Cancer-Associated Fibroblasts', 'level': 4, 'score': 0.6279354}, {'id': 'https://openalex.org/C3875195', 'wikidata': 'https://www.wikidata.org/wiki/Q5099363', 'display_name': 'Chimeric antigen receptor', 'level': 4, 'score': 0.56065625}, {'id': 'https://openalex.org/C52124034', 'wikidata': 'https://www.wikidata.org/wiki/Q557179', 'display_name': 'Stroma', 'level': 3, 'score': 0.5233656}, {'id': 'https://openalex.org/C2776107976', 'wikidata': 'https://www.wikidata.org/wiki/Q1786433', 'display_name': 'Tumor microenvironment', 'level': 3, 'score': 0.5158431}, {'id': 'https://openalex.org/C2777701055', 'wikidata': 'https://www.wikidata.org/wiki/Q1427096', 'display_name': 'Immunotherapy', 'level': 3, 'score': 0.45215225}, {'id': 'https://openalex.org/C159654299', 'wikidata': 'https://www.wikidata.org/wiki/Q79460', 'display_name': 'Antibody', 'level': 2, 'score': 0.42646575}, {'id': 'https://openalex.org/C542903549', 'wikidata': 'https://www.wikidata.org/wiki/Q422248', 'display_name': 'Monoclonal antibody', 'level': 3, 'score': 0.41986609}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.35928532}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.35782278}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.32287493}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.3099696}, {'id': 'https://openalex.org/C3020616263', 'wikidata': 'https://www.wikidata.org/wiki/Q1216998', 'display_name': 'Tumor cells', 'level': 2, 'score': 0.17572516}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.14263165}, {'id': 'https://openalex.org/C204232928', 'wikidata': 'https://www.wikidata.org/wiki/Q899285', 'display_name': 'Immunohistochemistry', 'level': 2, 'score': 0.14174482}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.1064387}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/2326-6074.tumimm19-a62', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2765010658', 'display_name': 'Cancer Immunology Research', 'issn_l': '2326-6066', 'issn': ['2326-6066', '2326-6074'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.72}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4312823718', 'https://openalex.org/W4225370449', 'https://openalex.org/W4207043495', 'https://openalex.org/W4200547365', 'https://openalex.org/W3193347267', 'https://openalex.org/W2944211926', 'https://openalex.org/W2780274283', 'https://openalex.org/W2362034133', 'https://openalex.org/W2256616461', 'https://openalex.org/W2158770220'], 'abstract_inverted_index': {'Abstract': [0], 'Cancer-associated': [1], 'fibroblasts': [2], '(CAFs)': [3], 'support': [4, 81], 'tumor': [5, 69, 82, 248, 294], 'growth': [6, 70, 243, 295], 'and': [7, 37, 86, 88, 93, 192, 199, 202, 320], 'metastasis': [8], 'of': [9, 35, 97, 114, 127, 143, 226, 244, 293, 305, 312], 'virtually': [10], 'all': [11], 'solid': [12], 'tumors,': [13], 'making': [14], 'them': [15], 'a': [16, 149, 175, 178, 182], 'potential': [17], '“universal': [18], 'therapeutic': [19], 'target.”': [20], 'However,': [21], 'there': [22], 'are': [23, 32], 'challenges': [24], 'to': [25, 50, 75, 132, 136, 147], 'designing': [26], 'CAF': [27], 'targeted': [28], 'therapies.': [29], 'First,': [30], 'CAFs': [31, 47, 254], 'heterogeneous,': [33], 'consisting': [34], 'tumor-promoting': [36, 46, 62], 'tumor-restraining': [38], 'populations.': [39], 'Second,': [40], 'molecular': [41], 'targets': [42, 156], 'expressed': [43], 'strictly': [44], 'by': [45, 251, 296], 'have': [48], 'yet': [49], 'be': [51, 130, 266], 'defined.': [52], 'Nonetheless,': [53], 'Fibroblast': [54], 'Activation': [55], 'Protein': [56], '(FAP)': [57], 'is': [58], 'selectively': [59, 155], 'overexpressed': [60], 'on': [61, 181, 259, 317], 'CAFs.': [63], 'Moreover,': [64, 237], 'deleting': [65], 'FAP+': [66, 120, 252], 'cells': [67, 116, 121, 158, 166, 212, 222, 240, 301], 'inhibits': [68], 'in': [71, 77, 89, 102, 106, 169, 255, 270], 'preclinical': [72, 107], 'models': [73, 108], 'due': [74, 135], 'reductions': [76], 'stroma-dependent': [78], 'signals': [79], 'that': [80, 111, 122, 154, 160, 188, 208], 'cell': [83], 'survival,': [84], 'growth,': [85], 'progression': [87], 'stroma-derived': [90], 'immunosuppressive': [91], 'factors': [92], 'can': [94], 'enhance': [95], 'efficacy': [96], 'other': [98], 'therapies': [99], 'when': [100], 'given': [101], 'combination.': [103], 'Prior': [104], 'studies': [105], 'suggest,': [109], 'however,': [110], 'selective': [112], 'elimination': [113], 'FAPhigh': [115, 157], 'while': [117], 'sparing': [118], 'normal': [119], 'typically': [123], 'express': [124], 'lower': [125], 'levels': [126, 225, 304], 'FAP': [128, 230], 'may': [129], 'necessary': [131], 'avoid': [133], 'toxicity': [134], 'on-target,': [137], 'off-tumor': [138], 'effects.': [139], 'Thus,': [140], 'the': [141, 195, 200, 242, 313], 'aim': [142], 'this': [144, 215, 262], 'study': [145], 'was': [146], 'generate': [148], 'FAP-chimeric': [150], 'antigen': [151], 'receptor': [152], '(CAR)': [153], 'but': [159, 231], 'exhibits': [161], 'minimal': [162], 'activity': [163], 'against': [164, 221, 300], 'FAPlow': [165, 233], 'for': [167, 268, 273], 'use': [168, 269], 'future': [170], 'clinical': [171, 271], 'trials.': [172], 'We': [173, 206], 'generated': [174, 187], 'FAP-CAR': [176, 217, 264], 'containing': [177], 'scFv': [179], 'based': [180], 'monoclonal': [183], 'antibody': [184], '(mAb)': [185], 'we': [186], 'reacts': [189], 'with': [190, 214], 'human': [191, 210, 227, 245, 274], 'mouse': [193, 229], 'FAP,': [194], 'CD8': [196], 'transmembrane': [197], 'region,': [198], 'CD3z': [201], '41BB': [203], 'cytoplasmic': [204], 'domains.': [205], 'show': [207], 'primary': [209], 'T': [211], 'transduced': [213], 'novel': [216, 263, 297], 'exhibit': [218], 'strong': [219], 'reactivity': [220], 'expressing': [223, 302], 'high': [224, 303], 'or': [228, 234], 'not': [232], 'FAP-negative': [235, 246], 'cells.': [236], 'these': [238, 260], 'FAP-CART': [239], 'inhibited': [241], 'A549': [247], 'xenografts': [249], 'infiltrated': [250], 'murine': [253], 'NSG': [256], 'mice.': [257], 'Based': [258], 'characteristics,': [261], 'will': [265], 'developed': [267], 'trials': [272], 'cancer': [275], 'patients.': [276], 'Citation': [277], 'Format:': [278], 'Estela': [279], 'Noguera-Ortega,': [280], 'Leslie': [281], 'Todd,': [282], 'James': [283], 'Monslow,': [284], 'Jing': [285], 'Sun,': [286], 'Steven': [287], 'M.': [288], 'Albelda,': [289], 'Ellen': [290], 'Pure.': [291], 'Inhibition': [292], 'CART': [298], 'redirected': [299], 'fibroblast': [306], 'activation': [307], 'protein': [308], '[abstract].': [309], 'In:': [310], 'Proceedings': [311], 'AACR': [314], 'Special': [315], 'Conference': [316], 'Tumor': [318], 'Immunology': [319], 'Immunotherapy;': [321], '2019': [322], 'Nov': [323], '17-20;': [324], 'Boston,': [325], 'MA.': [326], 'Philadelphia': [327], '(PA):': [328], 'AACR;': [329], 'Cancer': [330], 'Immunol': [331], 'Res': [332], '2020;8(3': [333], 'Suppl):Abstract': [334], 'nr': [335], 'A62.': [336]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3013353529', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}], 'updated_date': '2025-01-03T10:52:06.608275', 'created_date': '2020-04-03'}