Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W3013300349', 'doi': 'https://doi.org/10.1158/1538-7445.sabcs19-p1-10-30', 'title': 'Abstract P1-10-30: Survival benefit of eribulin for metastatic breast cancer depends on absolute lymphocyte count and neutrophil-lymphocyte ratio in peripheral blood', 'display_name': 'Abstract P1-10-30: Survival benefit of eribulin for metastatic breast cancer depends on absolute lymphocyte count and neutrophil-lymphocyte ratio in peripheral blood', 'publication_year': 2020, 'publication_date': '2020-02-15', 'ids': {'openalex': 'https://openalex.org/W3013300349', 'doi': 'https://doi.org/10.1158/1538-7445.sabcs19-p1-10-30', 'mag': '3013300349'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.sabcs19-p1-10-30', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5084747376', 'display_name': 'Ayako Ueno', 'orcid': 'https://orcid.org/0000-0003-4624-0731'}, 'institutions': [{'id': 'https://openalex.org/I4210104416', 'display_name': 'Hiroshima City Asa Citizens Hospital', 'ror': 'https://ror.org/01hkncq81', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210104416']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Ayako Ueno', 'raw_affiliation_strings': ['Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan'], 'affiliations': [{'raw_affiliation_string': 'Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan', 'institution_ids': ['https://openalex.org/I4210104416']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110811411', 'display_name': 'Shoichiro Ohtani', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210104416', 'display_name': 'Hiroshima City Asa Citizens Hospital', 'ror': 'https://ror.org/01hkncq81', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210104416']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Shoichiro Ohtani', 'raw_affiliation_strings': ['Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan'], 'affiliations': [{'raw_affiliation_string': 'Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan', 'institution_ids': ['https://openalex.org/I4210104416']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101037466', 'display_name': 'Kensuke Kawasaki', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210104416', 'display_name': 'Hiroshima City Asa Citizens Hospital', 'ror': 'https://ror.org/01hkncq81', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210104416']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kensuke Kawasaki', 'raw_affiliation_strings': ['Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan'], 'affiliations': [{'raw_affiliation_string': 'Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan', 'institution_ids': ['https://openalex.org/I4210104416']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065192337', 'display_name': 'Mitsuya Ito', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210104416', 'display_name': 'Hiroshima City Asa Citizens Hospital', 'ror': 'https://ror.org/01hkncq81', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210104416']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Mitsuya Ito', 'raw_affiliation_strings': ['Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan'], 'affiliations': [{'raw_affiliation_string': 'Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan', 'institution_ids': ['https://openalex.org/I4210104416']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068483796', 'display_name': 'Takanori Kin', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210104416', 'display_name': 'Hiroshima City Asa Citizens Hospital', 'ror': 'https://ror.org/01hkncq81', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210104416']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Takanori Kin', 'raw_affiliation_strings': ['Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan'], 'affiliations': [{'raw_affiliation_string': 'Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan', 'institution_ids': ['https://openalex.org/I4210104416']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5064666506', 'display_name': 'Reina Maeda', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210104416', 'display_name': 'Hiroshima City Asa Citizens Hospital', 'ror': 'https://ror.org/01hkncq81', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210104416']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Reina Maeda', 'raw_affiliation_strings': ['Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan'], 'affiliations': [{'raw_affiliation_string': 'Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan', 'institution_ids': ['https://openalex.org/I4210104416']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 60}, 'biblio': {'volume': '80', 'issue': '4_Supplement', 'first_page': 'P1', 'last_page': '30'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10158', 'display_name': 'Cancer Immunotherapy and Biomarkers', 'score': 0.9869, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10158', 'display_name': 'Cancer Immunotherapy and Biomarkers', 'score': 0.9869, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12992', 'display_name': 'Metastasis and carcinoma case studies', 'score': 0.978, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11355', 'display_name': 'Inflammatory Biomarkers in Disease Prognosis', 'score': 0.9642, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/eribulin', 'display_name': 'Eribulin', 'score': 0.95483375}], 'concepts': [{'id': 'https://openalex.org/C2776387010', 'wikidata': 'https://www.wikidata.org/wiki/Q408717', 'display_name': 'Eribulin', 'level': 5, 'score': 0.95483375}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.84508693}, {'id': 'https://openalex.org/C2775930923', 'wikidata': 'https://www.wikidata.org/wiki/Q12859063', 'display_name': 'Metastatic breast cancer', 'level': 4, 'score': 0.68324405}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.6822829}, {'id': 'https://openalex.org/C530470458', 'wikidata': 'https://www.wikidata.org/wiki/Q128581', 'display_name': 'Breast cancer', 'level': 3, 'score': 0.6606902}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.644057}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.49194643}, {'id': 'https://openalex.org/C72563966', 'wikidata': 'https://www.wikidata.org/wiki/Q1303415', 'display_name': 'Cohort', 'level': 2, 'score': 0.43161833}, {'id': 'https://openalex.org/C2778963024', 'wikidata': 'https://www.wikidata.org/wiki/Q17132454', 'display_name': 'Neutrophil to lymphocyte ratio', 'level': 3, 'score': 0.41659892}, {'id': 'https://openalex.org/C2777761686', 'wikidata': 'https://www.wikidata.org/wiki/Q715347', 'display_name': 'Lymphocyte', 'level': 2, 'score': 0.3685242}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.32677308}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.sabcs19-p1-10-30', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.85}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3160156778', 'https://openalex.org/W3153808353', 'https://openalex.org/W2884577979', 'https://openalex.org/W2796001254', 'https://openalex.org/W2767183100', 'https://openalex.org/W2613871272', 'https://openalex.org/W2613657120', 'https://openalex.org/W2416167623', 'https://openalex.org/W2314283413', 'https://openalex.org/W2196426442'], 'abstract_inverted_index': {'Abstract': [0], 'Background': [1], 'and': [2, 37, 71, 104, 120, 127, 143, 150, 164, 195, 204, 209, 241, 285, 322, 337, 359, 417], 'Aims:': [3], 'Eribulin': [4], 'is': [5], 'a': [6], 'cytotoxic': [7], 'anti-cancer': [8], 'agent': [9], 'targeting': [10], 'microtubule': [11], 'dynamics,': [12], 'which': [13], 'improves': [14], 'the': [15, 62, 65, 112, 135, 226, 233, 272, 364, 385, 427], 'prognosis': [16], 'of': [17, 43, 57, 68, 85, 137, 219, 236, 348, 351, 366, 388, 406, 426], 'patients': [18, 75, 87, 198, 211, 247, 270, 275, 375], 'with': [19, 41, 139, 146, 156, 295, 312, 376], 'metastatic': [20, 79, 92, 222, 369, 409], 'breast': [21, 46, 80, 93, 178, 370, 410], 'cancer.': [22, 81], 'Preclinical': [23], 'studies': [24], 'have': [25], 'shown': [26], 'that': [27], 'eribulin': [28, 77, 90, 140, 367, 407], 'enhances': [29], 'anti-tumor': [30], 'immunity': [31], 'by': [32, 177], 'inhibiting': [33], 'regulatory': [34], 'T': [35], 'cells': [36], 'M2': [38], 'macrophages.': [39], 'Along': [40], 'advances': [42], 'immunotherapy': [44], 'for': [45, 78, 91, 162, 201, 221, 239, 243, 368, 408], 'cancer,': [47], 'there': [48], 'has': [49], 'been': [50], 'growing': [51], 'interest': [52], 'in': [53, 74, 131, 172, 268, 333, 362, 420], 'such': [54, 354], 'immunologic': [55], 'effects': [56], 'eribulin.': [58, 389], 'Here': [59], 'we': [60], 'investigated': [61], 'association': [63, 145], 'between': [64, 101, 335], 'immunological': [66], 'status': [67, 252, 280, 350, 379], 'peripheral': [69, 132, 352, 421], 'blood': [70, 133, 422], 'survival': [72, 148, 152, 338], 'outcomes': [73, 339], 'receiving': [76], 'Methods:': [82], 'Medical': [83], 'records': [84], '125': [86], 'who': [88], 'received': [89, 214], 'cancer': [94, 179, 371, 411], 'at': [95, 134], 'Hiroshima': [96, 98], 'City': [97], 'Citizens': [99], 'Hospital': [100], 'July': [102], '2011': [103], 'April': [105], '2019': [106, 428, 434], 'were': [107, 141, 154, 166, 181, 199, 260, 309, 340], 'retrospectively': [108], 'reviewed.': [109], 'We': [110, 224], 'collected': [111], 'data': [113], 'on': [114, 169, 413], 'patients’': [115], 'baseline': [116], 'characteristics,': [117], 'laboratory': [118], 'tests': [119], 'clinical': [121], 'courses.': [122], 'Absolute': [123], 'lymphocyte': [124, 415], 'count': [125, 416], '(ALC)': [126], 'neutrophil-lymphocyte': [128, 418], 'ratio': [129, 419], '(NLR)': [130], 'start': [136], 'treatment': [138], 'calculated,': [142], 'their': [144, 170], 'progression-free': [147], '(PFS)': [149], 'overall': [151], '(OS)': [153], 'analyzed': [155], 'log-rank': [157], 'test.': [158], 'The': [159, 185, 345], 'cutoff': [160, 234], 'values': [161, 235], 'ALC': [163, 240, 254, 282, 289, 356], 'NLR': [165, 266, 286, 307, 360], 'determined': [167], 'based': [168], 'distribution': [171], 'this': [173], 'cohort.': [174], 'Subgroup': [175], 'analyses': [176], 'subtypes': [180], 'also': [182], 'conducted.': [183], 'Results:': [184], 'mean': [186], 'age': [187], 'was': [188, 292, 372], '57': [189], 'years': [190], '(range,': [191], '28-88).': [192], 'Eighty': [193], '(64%)': [194], '14': [196], '(11.2%)': [197], 'positive': [200], 'hormone': [202], 'receptors': [203], 'HER2': [205], 'overexpression.': [206], 'One': [207], 'hundred': [208], 'ten': [210], '(88%)': [212], 'had': [213, 249, 277], 'one': [215], 'or': [216], 'more': [217], 'lines': [218], 'chemotherapy': [220], 'disease.': [223], 'divided': [225], 'entire': [227], 'cohort': [228], 'into': [229], 'three': [230], 'groups,': [231], 'using': [232], '1500': [237], '/µL': [238, 284, 291, 358], '5': [242], 'NLR.': [244], 'Accordingly,': [245], '30': [246], '(24%)': [248], 'favorable': [250, 377], 'immune': [251, 258, 279, 349, 378], '(i.e.,': [253, 265, 281], '≥1500': [255, 290, 357], '/µL),': [256], 'whereas': [257], 'systems': [259], 'considered': [261], 'to': [262, 383], 'be': [263, 381], 'suppressed': [264], '≥5)': [267], '19': [269], '(15.2%);': [271], 'rest': [273], '76': [274], '(60.8%)': [276], 'neutral': [278], '<1500': [283], '<5).': [287], 'Overall,': [288], 'significantly': [293, 310], 'associated': [294, 311], 'better': [296], 'PFS': [297, 314], '(hazard': [298, 315, 324], 'ratio,': [299, 316, 325], '0.55;': [300], '95%': [301, 318, 327], 'CI,': [302, 319, 328], '0.35-0.88;': [303], 'p=.013).': [304], 'In': [305], 'contrast,': [306], '≥5': [308], 'worse': [313], '1.92;': [317], '1.11-3.32;': [320], 'p=.019)': [321], 'OS': [323], '4.26;': [326], '2.29-7.91;': [329], 'p<.001).': [330], 'These': [331], 'trends': [332], 'relationship': [334], 'ALC/NLR': [336], 'consistent': [341], 'across': [342], 'subgroups.': [343], 'Conclusions:': [344], 'potential': [346], 'role': [347], 'blood,': [353], 'as': [355], '≥5,': [361], 'predicting': [363], 'efficacy': [365], 'suggested.': [373], 'Selecting': [374], 'will': [380], 'important': [382], 'make': [384], 'best': [386], 'use': [387], 'Citation': [390], 'Format:': [391], 'Ayako': [392], 'Ueno,': [393], 'Shoichiro': [394], 'Ohtani,': [395], 'Kensuke': [396], 'Kawasaki,': [397], 'Mitsuya': [398], 'Ito,': [399], 'Takanori': [400], 'Kin,': [401], 'Reina': [402], 'Maeda.': [403], 'Survival': [404], 'benefit': [405], 'depends': [412], 'absolute': [414], '[abstract].': [423], 'In:': [424], 'Proceedings': [425], 'San': [429, 437], 'Antonio': [430], 'Breast': [431], 'Cancer': [432, 443], 'Symposium;': [433], 'Dec': [435], '10-14;': [436], 'Antonio,': [438], 'TX.': [439], 'Philadelphia': [440], '(PA):': [441], 'AACR;': [442], 'Res': [444], '2020;80(4': [445], 'Suppl):Abstract': [446], 'nr': [447], 'P1-10-30.': [448]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3013300349', 'counts_by_year': [], 'updated_date': '2024-12-27T00:17:41.362711', 'created_date': '2020-04-03'}