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[38], 'however,': [39], 'specific': [40], 'autophagic': [41, 108], 'effects': [42, 161], 'on': [43, 162], 'Aβ': [45, 62, 73, 87, 96, 109, 118, 149, 164], 'kinetics': [46, 63], 'only': [47], 'have': [48, 156], 'begun': [49], 'be': [51], 'explored.We': [52], 'develop': [53], 'a': [54], 'mathematical': [55], 'model': [56, 137], 'with': [59], 'respect': [60], 'perform': [65], 'simulations': [66], 'understand': [68], 'quantitative': [70], 'relationship': [71], 'between': [72], 'levels': [74, 103, 165], 'activity.': [77], 'In': [78], 'case': [80], 'of': [81, 95, 104, 128, 141, 144, 173], 'abnormal': [83], 'increase': [84], 'generation,': [88, 119], 'degradation,': [90], 'secretion,': [91], 'clearance': [93], 'rates': [94], 'are': [97], 'significantly': [98], 'changed,': [99], 'leading': [100], 'increased': [102, 117], 'Aβ.': [105], 'When': [106], 'degradation': [110], 'defective': [112], 'addition': [114], 'Aβ-regulation': [121], 'failure': [122], 'accompanied': [124], 'by': [125], 'elevated': [126], 'concentrations': [127], 'autophagosome': [129, 151], 'autolysosome,': [131], 'may': [133], 'further': [134], 'clog': [135], 'neurons.The': [136], 'predicts': [138], 'modulations': [140], 'different': [142], 'steps': [143], 'pathway': [147], '(i.e.,': [148], 'sequestration,': [150], 'maturation,': [152], 'intralysosomal': [154], 'hydrolysis)': [155], 'significant': [157], 'step-specific': [158], 'combined': [160], 'thus': [167], 'suggests': [168], 'therapeutic': [169], 'preventive': [171], 'implications': [172], 'AD.': [176]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3011924010', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 1}], 'updated_date': '2024-09-01T08:19:17.419927', 'created_date': '2020-03-23'}