Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W3011239636', 'doi': 'https://doi.org/10.1016/j.ejmech.2020.112232', 'title': 'A series of novel aryl-methanone derivatives as inhibitors of FMS-like tyrosine kinase 3 (FLT3) in FLT3-ITD-positive acute myeloid leukemia', 'display_name': 'A series of novel aryl-methanone derivatives as inhibitors of FMS-like tyrosine kinase 3 (FLT3) in FLT3-ITD-positive acute myeloid leukemia', 'publication_year': 2020, 'publication_date': '2020-03-13', 'ids': {'openalex': 'https://openalex.org/W3011239636', 'doi': 'https://doi.org/10.1016/j.ejmech.2020.112232', 'mag': '3011239636', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/32199135'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.ejmech.2020.112232', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210169613', 'display_name': 'European Journal of Medicinal Chemistry', 'issn_l': '0223-5234', 'issn': ['0223-5234', '1768-3254'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5027721352', 'display_name': 'Andreas Sellmer', 'orcid': 'https://orcid.org/0000-0002-4752-2418'}, 'institutions': [{'id': 'https://openalex.org/I60668342', 'display_name': 'University of Regensburg', 'ror': 'https://ror.org/01eezs655', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I60668342']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Andreas Sellmer', 'raw_affiliation_strings': ['Institute of Pharmacy, Faculty of Chemistry and Pharmacy, University of Regensburg, 93040, Regensburg, Germany'], 'affiliations': [{'raw_affiliation_string': 'Institute of Pharmacy, Faculty of Chemistry and Pharmacy, University of Regensburg, 93040, Regensburg, Germany', 'institution_ids': ['https://openalex.org/I60668342']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052112287', 'display_name': 'Bernadette Pilsl', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I60668342', 'display_name': 'University of Regensburg', 'ror': 'https://ror.org/01eezs655', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I60668342']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Bernadette Pilsl', 'raw_affiliation_strings': ['Institute of Pharmacy, Faculty of Chemistry and Pharmacy, University of Regensburg, 93040, Regensburg, Germany'], 'affiliations': [{'raw_affiliation_string': 'Institute of Pharmacy, Faculty of Chemistry and Pharmacy, University of Regensburg, 93040, Regensburg, Germany', 'institution_ids': ['https://openalex.org/I60668342']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072822064', 'display_name': 'Mandy Beyer', 'orcid': 'https://orcid.org/0000-0001-8850-6409'}, 'institutions': [{'id': 'https://openalex.org/I4210094062', 'display_name': 'University Medical Center of the Johannes Gutenberg University Mainz', 'ror': 'https://ror.org/00q1fsf04', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210094062']}, {'id': 'https://openalex.org/I197323543', 'display_name': 'Johannes Gutenberg University Mainz', 'ror': 'https://ror.org/023b0x485', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I197323543']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Mandy Beyer', 'raw_affiliation_strings': ['Department of Toxicology, University Medical Center, Mainz, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Toxicology, University Medical Center, Mainz, Germany', 'institution_ids': ['https://openalex.org/I4210094062', 'https://openalex.org/I197323543']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072230092', 'display_name': 'Herwig Pongratz', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I60668342', 'display_name': 'University of Regensburg', 'ror': 'https://ror.org/01eezs655', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I60668342']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Herwig Pongratz', 'raw_affiliation_strings': ['Institute of Pharmacy, Faculty of Chemistry and Pharmacy, University of Regensburg, 93040, Regensburg, Germany'], 'affiliations': [{'raw_affiliation_string': 'Institute of Pharmacy, Faculty of Chemistry and Pharmacy, University of Regensburg, 93040, Regensburg, Germany', 'institution_ids': ['https://openalex.org/I60668342']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5020805698', 'display_name': 'Lukas Wirth', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I60668342', 'display_name': 'University of Regensburg', 'ror': 'https://ror.org/01eezs655', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I60668342']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Lukas Wirth', 'raw_affiliation_strings': ['Institute of Pharmacy, Faculty of Chemistry and Pharmacy, University of Regensburg, 93040, Regensburg, Germany'], 'affiliations': [{'raw_affiliation_string': 'Institute of Pharmacy, Faculty of Chemistry and Pharmacy, University of Regensburg, 93040, Regensburg, Germany', 'institution_ids': ['https://openalex.org/I60668342']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076810446', 'display_name': 'Sigurd Elz', 'orcid': 'https://orcid.org/0000-0002-2766-0098'}, 'institutions': [{'id': 'https://openalex.org/I60668342', 'display_name': 'University of Regensburg', 'ror': 'https://ror.org/01eezs655', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I60668342']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Sigurd Elz', 'raw_affiliation_strings': ['Institute of Pharmacy, Faculty of Chemistry and Pharmacy, University of Regensburg, 93040, Regensburg, Germany'], 'affiliations': [{'raw_affiliation_string': 'Institute of Pharmacy, Faculty of Chemistry and Pharmacy, University of Regensburg, 93040, Regensburg, Germany', 'institution_ids': ['https://openalex.org/I60668342']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103565483', 'display_name': 'Stefan Dove', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I60668342', 'display_name': 'University of Regensburg', 'ror': 'https://ror.org/01eezs655', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I60668342']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Stefan Dove', 'raw_affiliation_strings': ['Institute of Pharmacy, Faculty of Chemistry and Pharmacy, University of Regensburg, 93040, Regensburg, Germany'], 'affiliations': [{'raw_affiliation_string': 'Institute of Pharmacy, Faculty of Chemistry and Pharmacy, University of Regensburg, 93040, Regensburg, Germany', 'institution_ids': ['https://openalex.org/I60668342']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045918252', 'display_name': 'Sven J. Henninger', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210094062', 'display_name': 'University Medical Center of the Johannes Gutenberg University Mainz', 'ror': 'https://ror.org/00q1fsf04', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210094062']}, {'id': 'https://openalex.org/I197323543', 'display_name': 'Johannes Gutenberg University Mainz', 'ror': 'https://ror.org/023b0x485', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I197323543']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Sven Julian Henninger', 'raw_affiliation_strings': ['Department of Toxicology, University Medical Center, Mainz, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Toxicology, University Medical Center, Mainz, Germany', 'institution_ids': ['https://openalex.org/I4210094062', 'https://openalex.org/I197323543']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012020159', 'display_name': 'Karsten Spiekermann', 'orcid': 'https://orcid.org/0000-0002-5139-4957'}, 'institutions': [{'id': 'https://openalex.org/I8204097', 'display_name': 'Ludwig-Maximilians-Universität München', 'ror': 'https://ror.org/05591te55', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I8204097']}, {'id': 'https://openalex.org/I3018771216', 'display_name': 'LMU Klinikum', 'ror': 'https://ror.org/02jet3w32', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3018771216', 'https://openalex.org/I8204097']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Karsten Spiekermann', 'raw_affiliation_strings': ['Department of Medicine III, University Hospital, LMU Munich, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine III, University Hospital, LMU Munich, Germany', 'institution_ids': ['https://openalex.org/I8204097', 'https://openalex.org/I3018771216']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108833584', 'display_name': 'Harald Polzer', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I3018771216', 'display_name': 'LMU Klinikum', 'ror': 'https://ror.org/02jet3w32', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3018771216', 'https://openalex.org/I8204097']}, {'id': 'https://openalex.org/I8204097', 'display_name': 'Ludwig-Maximilians-Universität München', 'ror': 'https://ror.org/05591te55', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I8204097']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Harald Polzer', 'raw_affiliation_strings': ['Department of Medicine III, University Hospital, LMU Munich, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine III, University Hospital, LMU Munich, Germany', 'institution_ids': ['https://openalex.org/I3018771216', 'https://openalex.org/I8204097']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032974629', 'display_name': 'Susan Klaeger', 'orcid': 'https://orcid.org/0000-0002-0074-5163'}, 'institutions': [{'id': 'https://openalex.org/I62916508', 'display_name': 'Technical University of Munich', 'ror': 'https://ror.org/02kkvpp62', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I62916508']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Susan Klaeger', 'raw_affiliation_strings': ['Technische Universität München, Wissenschaftszentrum Weihenstephan für Ernährung, Landnutzung und Umwelt, Germany'], 'affiliations': [{'raw_affiliation_string': 'Technische Universität München, Wissenschaftszentrum Weihenstephan für Ernährung, Landnutzung und Umwelt, Germany', 'institution_ids': ['https://openalex.org/I62916508']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5058082024', 'display_name': 'Bernhard Küster', 'orcid': 'https://orcid.org/0000-0002-9094-1677'}, 'institutions': [{'id': 'https://openalex.org/I62916508', 'display_name': 'Technical University of Munich', 'ror': 'https://ror.org/02kkvpp62', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I62916508']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Bernhard Kuster', 'raw_affiliation_strings': ['Technische Universität München, Wissenschaftszentrum Weihenstephan für Ernährung, Landnutzung und Umwelt, Germany'], 'affiliations': [{'raw_affiliation_string': 'Technische Universität München, Wissenschaftszentrum Weihenstephan für Ernährung, Landnutzung und Umwelt, Germany', 'institution_ids': ['https://openalex.org/I62916508']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5104608314', 'display_name': 'Frank D. Böhmer', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210134900', 'display_name': 'Jena University Hospital', 'ror': 'https://ror.org/035rzkx15', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210134900']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Frank D. Böhmer', 'raw_affiliation_strings': ['Universitätsklinikum Jena - Bachstrasse 18 - D-07743 Jena, Germany'], 'affiliations': [{'raw_affiliation_string': 'Universitätsklinikum Jena - Bachstrasse 18 - D-07743 Jena, Germany', 'institution_ids': ['https://openalex.org/I4210134900']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062304427', 'display_name': 'Heinz‐Herbert Fiebig', 'orcid': 'https://orcid.org/0000-0001-6222-7321'}, 'institutions': [], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Heinz-Herbert Fiebig', 'raw_affiliation_strings': ['4HF Biotec GmbH, Am Flughafen 14, 79108, Freiburg, Germany'], 'affiliations': [{'raw_affiliation_string': '4HF Biotec GmbH, Am Flughafen 14, 79108, Freiburg, Germany', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049942833', 'display_name': 'Oliver H. Krämer', 'orcid': 'https://orcid.org/0000-0003-3973-045X'}, 'institutions': [{'id': 'https://openalex.org/I4210094062', 'display_name': 'University Medical Center of the Johannes Gutenberg University Mainz', 'ror': 'https://ror.org/00q1fsf04', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210094062']}, {'id': 'https://openalex.org/I197323543', 'display_name': 'Johannes Gutenberg University Mainz', 'ror': 'https://ror.org/023b0x485', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I197323543']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Oliver H. Krämer', 'raw_affiliation_strings': ['Department of Toxicology, University Medical Center, Mainz, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Toxicology, University Medical Center, Mainz, Germany', 'institution_ids': ['https://openalex.org/I4210094062', 'https://openalex.org/I197323543']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5065454758', 'display_name': 'Siavosh Mahboobi', 'orcid': 'https://orcid.org/0000-0002-3781-9656'}, 'institutions': [{'id': 'https://openalex.org/I60668342', 'display_name': 'University of Regensburg', 'ror': 'https://ror.org/01eezs655', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I60668342']}], 'countries': ['DE'], 'is_corresponding': True, 'raw_author_name': 'Siavosh Mahboobi', 'raw_affiliation_strings': ['Institute of Pharmacy, Faculty of Chemistry and Pharmacy, University of Regensburg, 93040, Regensburg, Germany'], 'affiliations': [{'raw_affiliation_string': 'Institute of Pharmacy, Faculty of Chemistry and Pharmacy, University of Regensburg, 93040, Regensburg, Germany', 'institution_ids': ['https://openalex.org/I60668342']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 7, 'corresponding_author_ids': ['https://openalex.org/A5065454758'], 'corresponding_institution_ids': ['https://openalex.org/I60668342'], 'apc_list': {'value': 4710, 'currency': 'USD', 'value_usd': 4710, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.137, 'has_fulltext': False, 'cited_by_count': 12, 'citation_normalized_percentile': {'value': 0.719058, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 88, 'max': 89}, 'biblio': {'volume': '193', 'issue': None, 'first_page': '112232', 'last_page': '112232'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10309', 'display_name': 'Acute Myeloid Leukemia Research', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10309', 'display_name': 'Acute Myeloid Leukemia Research', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11215', 'display_name': 'Chronic Myeloid Leukemia Treatments', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11736', 'display_name': 'Histone Deacetylase Inhibitors Research', 'score': 0.9984, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cd135', 'display_name': 'CD135', 'score': 0.50959444}], 'concepts': [{'id': 'https://openalex.org/C2778729363', 'wikidata': 'https://www.wikidata.org/wiki/Q11688946', 'display_name': 'Myeloid leukemia', 'level': 2, 'score': 0.8105685}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.72775257}, {'id': 'https://openalex.org/C2910954276', 'wikidata': 'https://www.wikidata.org/wiki/Q14912399', 'display_name': 'Fms-Like Tyrosine Kinase 3', 'level': 4, 'score': 0.7025711}, {'id': 'https://openalex.org/C42362537', 'wikidata': 'https://www.wikidata.org/wiki/Q87099740', 'display_name': 'Tyrosine kinase', 'level': 3, 'score': 0.6762901}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.5536672}, {'id': 'https://openalex.org/C109159458', 'wikidata': 'https://www.wikidata.org/wiki/Q919283', 'display_name': 'Haematopoiesis', 'level': 3, 'score': 0.53852844}, {'id': 'https://openalex.org/C41650920', 'wikidata': 'https://www.wikidata.org/wiki/Q14912399', 'display_name': 'CD135', 'level': 4, 'score': 0.50959444}, {'id': 'https://openalex.org/C101544691', 'wikidata': 'https://www.wikidata.org/wiki/Q420511', 'display_name': 'Receptor tyrosine kinase', 'level': 3, 'score': 0.5056126}, {'id': 'https://openalex.org/C2778461978', 'wikidata': 'https://www.wikidata.org/wiki/Q29496', 'display_name': 'Leukemia', 'level': 2, 'score': 0.47258294}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.45171526}, {'id': 'https://openalex.org/C2779282312', 'wikidata': 'https://www.wikidata.org/wiki/Q1956561', 'display_name': 'Myeloid', 'level': 2, 'score': 0.44680962}, {'id': 'https://openalex.org/C184235292', 'wikidata': 'https://www.wikidata.org/wiki/Q421851', 'display_name': 'Kinase', 'level': 2, 'score': 0.43861705}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.26405153}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.22010955}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.18197846}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.16821226}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.13045189}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.115748316}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.09238869}, {'id': 'https://openalex.org/C28328180', 'wikidata': 'https://www.wikidata.org/wiki/Q48196', 'display_name': 'Stem cell', 'level': 2, 'score': 0.072027}, {'id': 'https://openalex.org/C501734568', 'wikidata': 'https://www.wikidata.org/wiki/Q42918', 'display_name': 'Mutation', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D007211', 'descriptor_name': 'Indoles', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D047428', 'descriptor_name': 'Protein Kinase Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D051941', 'descriptor_name': 'fms-Like Tyrosine Kinase 3', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000138', 'qualifier_name': 'chemical synthesis', 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004354', 'descriptor_name': 'Drug Screening Assays, Antitumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007211', 'descriptor_name': 'Indoles', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D007211', 'descriptor_name': 'Indoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007211', 'descriptor_name': 'Indoles', 'qualifier_ui': 'Q000138', 'qualifier_name': 'chemical synthesis', 'is_major_topic': False}, {'descriptor_ui': 'D015470', 'descriptor_name': 'Leukemia, Myeloid, Acute', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015470', 'descriptor_name': 'Leukemia, Myeloid, Acute', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D015470', 'descriptor_name': 'Leukemia, Myeloid, Acute', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015470', 'descriptor_name': 'Leukemia, Myeloid, Acute', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D008958', 'descriptor_name': 'Models, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015394', 'descriptor_name': 'Molecular Structure', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047428', 'descriptor_name': 'Protein Kinase Inhibitors', 'qualifier_ui': 'Q000138', 'qualifier_name': 'chemical synthesis', 'is_major_topic': False}, {'descriptor_ui': 'D047428', 'descriptor_name': 'Protein Kinase Inhibitors', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D047428', 'descriptor_name': 'Protein Kinase Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013329', 'descriptor_name': 'Structure-Activity Relationship', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014407', 'descriptor_name': 'Tumor Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051941', 'descriptor_name': 'fms-Like Tyrosine Kinase 3', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051941', 'descriptor_name': 'fms-Like Tyrosine Kinase 3', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.ejmech.2020.112232', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210169613', 'display_name': 'European Journal of Medicinal Chemistry', 'issn_l': '0223-5234', 'issn': ['0223-5234', '1768-3254'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/32199135', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.74, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [{'funder': 'https://openalex.org/F4320320879', 'funder_display_name': 'Deutsche Forschungsgemeinschaft', 'award_id': 'MA 2183/3-1'}, {'funder': 'https://openalex.org/F4320320879', 'funder_display_name': 'Deutsche Forschungsgemeinschaft', 'award_id': 'KR 2291/8-1'}], 'datasets': [], 'versions': [], 'referenced_works_count': 71, 'referenced_works': ['https://openalex.org/W1122804115', 'https://openalex.org/W1551802166', 'https://openalex.org/W1592701464', 'https://openalex.org/W1937648101', 'https://openalex.org/W194185434', 'https://openalex.org/W1971056717', 'https://openalex.org/W1971716764', 'https://openalex.org/W1974674483', 'https://openalex.org/W1984209370', 'https://openalex.org/W1984712646', 'https://openalex.org/W1988016984', 'https://openalex.org/W1988614680', 'https://openalex.org/W1988742984', 'https://openalex.org/W1990030298', 'https://openalex.org/W1990793563', 'https://openalex.org/W1991199289', 'https://openalex.org/W1996307710', 'https://openalex.org/W2008940139', 'https://openalex.org/W2011853681', 'https://openalex.org/W2021663709', 'https://openalex.org/W2029056941', 'https://openalex.org/W2032235066', 'https://openalex.org/W2033842890', 'https://openalex.org/W2041027929', 'https://openalex.org/W2044308376', 'https://openalex.org/W2044942890', 'https://openalex.org/W2047119584', 'https://openalex.org/W2049507332', 'https://openalex.org/W2050768356', 'https://openalex.org/W2051158417', 'https://openalex.org/W2051630780', 'https://openalex.org/W2055582346', 'https://openalex.org/W2056465113', 'https://openalex.org/W2060988261', 'https://openalex.org/W2064479993', 'https://openalex.org/W2065290971', 'https://openalex.org/W2068825953', 'https://openalex.org/W2069618778', 'https://openalex.org/W2080109272', 'https://openalex.org/W2081885253', 'https://openalex.org/W2082117339', 'https://openalex.org/W2092204388', 'https://openalex.org/W2094008870', 'https://openalex.org/W2095403182', 'https://openalex.org/W2102185636', 'https://openalex.org/W2103201873', 'https://openalex.org/W2116669532', 'https://openalex.org/W2122199548', 'https://openalex.org/W2125877707', 'https://openalex.org/W2126075231', 'https://openalex.org/W2130864403', 'https://openalex.org/W2131720847', 'https://openalex.org/W2151222524', 'https://openalex.org/W2151258061', 'https://openalex.org/W2152262856', 'https://openalex.org/W2154742235', 'https://openalex.org/W2161239029', 'https://openalex.org/W2165392081', 'https://openalex.org/W2168604775', 'https://openalex.org/W2213042592', 'https://openalex.org/W2326389383', 'https://openalex.org/W2538202169', 'https://openalex.org/W2755246428', 'https://openalex.org/W2767130235', 'https://openalex.org/W2769885694', 'https://openalex.org/W2794448835', 'https://openalex.org/W2908990432', 'https://openalex.org/W2912080691', 'https://openalex.org/W2914431119', 'https://openalex.org/W2930705189', 'https://openalex.org/W2978070817'], 'related_works': ['https://openalex.org/W3126888141', 'https://openalex.org/W284991352', 'https://openalex.org/W2414493062', 'https://openalex.org/W2395541711', 'https://openalex.org/W2321063763', 'https://openalex.org/W2150814991', 'https://openalex.org/W2068770638', 'https://openalex.org/W2053516170', 'https://openalex.org/W2029323837', 'https://openalex.org/W2027911638'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3011239636', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 4}], 'updated_date': '2025-01-05T03:55:58.416198', 'created_date': '2020-03-23'}