Publication Information

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[184, 1639, 1867], 'symptoms.': [187, 801], 'Liver': [188, 1307, 1775, 1822], 'impairment': [189, 1727], 'been': [191, 230, 1338, 1564, 1805, 1874, 1893], 'reported': [192, 231, 272, 567, 1565], 'up': [194], '60%': [196], 'SARS3Chau': [200], 'TN': [201, 1488], 'Lee': [202, 1489], 'KC': [203, 1490], 'Yao': [204, 1491], 'H': [205, 408, 730, 1074, 1492], 'al.SARS-associated': [207, 1494], 'viral': [208, 1320, 1383, 1477, 1483, 1495, 1518, 1680, 1826, 1940, 1955], 'hepatitis': [209, 1496, 1933], 'caused': [210, 1317, 1497], 'by': [211, 599, 774, 1119, 1318, 1498], 'coronavirus:': [214, 1501], 'cases.Hepatology.': [218, 1505], '2004;': [219, 1506], '39:': [220, 1507], '302-310Crossref': [221, 1508], '(326)': [224, 1511], 'infected': [234, 318, 458, 613, 932, 1158], 'MERS-CoV.4Alsaad': [236], 'KO': [237, 1526], 'Hajeer': [238, 1527], 'AH': [239, 1528], 'Al': [240, 1529], 'Balwi': [241, 1530], 'M': [242, 342, 998, 1531], 'al.Histopathology': [244, 1533], 'coronovirus': [250, 1539], '(MERS-CoV)': [251, 1540], 'infection—clinicopathological': [252, 1541], 'ultrastructural': [254, 1543], 'study.Histopathology.': [255, 1544], '2018;': [256, 1545], '72:': [257, 1546], '516-524Crossref': [258, 1547], '(228)': [261, 1550], 'At': [264], 'least': [265], 'seven': [266, 653, 982], 'relatively': [267, 1480], 'large-scale': [268], 'case': [269, 470, 537, 1170, 1570, 1878], 'studies': [270, 538, 1461, 1879], 'have': [271, 587, 1455, 1803], 'clinical': [274, 348, 1004, 1456, 2070], 'features': [275, 315, 610, 929], 'COVID-19.1Guan': [279], 'Scholar,': [306, 338, 376, 406, 443, 481], '5Huang': [307], 'Wang': [309, 604, 923, 1255, 1691], 'Li': [311, 606, 925], 'X': [312, 344, 410, 483, 607, 732, 926, 1000, 1076, 1186, 1627], 'China.Lancet.': [325, 620, 939], '497-506Summary': [328, 623, 942], '(32861)': [336, 631, 950], '6Chen': [339], 'N': [340, 412, 734, 996, 1078], 'Zhou': [341, 997], 'Dong': [343, 999], 'al.Epidemiological': [346, 1002], '99': [351, 1007], 'pneumonia': [357, 394, 421, 499, 743, 1013, 1058, 1087, 1202, 1421], 'China:': [360, 424, 468, 502, 746, 1016, 1090, 1168, 1205], 'descriptive': [362, 426, 748, 1018, 1092], 'study.Lancet.': [363, 1019], '507-513Summary': [366, 1022], '(14363)': [374, 1030], '7Wang': [377], 'D': [378, 1042, 1349, 1405], 'B': [380, 1044, 1407, 1934], '138': [387, 1051, 1414], 'hospitalised': [388, 1052, 1415], 'coronavirus-infected': [393, 1057, 1420], 'China.JAMA.': [397, 1061, 1424], '7.)DOI:10.1001/jama.2020.1585Crossref': [402, 1066, 1429], '(16201)': [404, 1068, 1431], '8Shi': [407], 'Han': [409, 731, 1075], 'Jiang': [411, 448, 733, 1077, 1148], 'al.Radiological': [414, 736, 1080], 'findings': [415, 452, 737, 1081, 1152, 1259, 1695], 'from': [416, 541, 674, 738, 1082, 1671, 1676], '81': [417, 739, 1083], 'study.Lancet': [427, 507, 749, 1093, 1210], 'Infect': [428, 750, 1094], 'Dis.': [429, 751, 1095], '24.)DOI:10.1016/S1473-3099(20)30086-4Summary': [434, 756, 1100], '(2575)': [441, 763, 1107], '9Xu': [444], 'X-W': [445, 1145], 'Wu': [446, 1146], 'X-X': [447, 1147], 'X-G': [449, 1149], 'group': [455, 1155], '(SARS-Cov-2)': [464, 1164], 'outside': [465, 1165], 'retrospective': [469, 1169], 'series.BMJ.': [471, 1171], '19.)DOI:10.1136/bmj.m606Crossref': [476, 1176], '(1449)': [479, 1179], '10Yang': [482], 'Yu': [484, 1187], 'Xu': [486, 1189], 'course': [490, 1193], 'outcomes': [492, 1195], 'critically': [494, 1197, 1773], 'ill': [495, 1198], 'single-centered,': [504, 1207], 'retrospective,': [505, 1208], 'observational': [506, 1209], 'Respir': [508, 1211, 1268, 1704], '24.)DOI:10.1016/S2213-2600(20)30079-5Summary': [514, 1217], '(6966)': [521, 1224], 'this': [525, 1844], 'Comment,': [526], 'we': [527, 1572], 'assess': [528], 'how': [529, 1847], 'liver': [531, 562, 591, 690, 803, 818, 821, 833, 837, 963, 1037, 1234, 1250, 1323, 1473, 1524, 1640, 1663, 1669, 1726, 1759, 1765, 1797, 1800, 1814, 1830, 1834, 1850, 1853, 1870, 1887, 1951, 2025, 2028, 2062, 2097, 2114], 'is': [532, 805, 1354, 1623, 1721, 1728, 1782, 1982, 2084], 'affected': [533], 'using': [534], 'available': [536], 'data': [540, 553, 1242], 'Fifth': [543], 'Medical': [544], 'Center': [545], 'PLS': [547], 'General': [548], 'Hospital,': [549], 'Beijing,': [550], 'These': [552], 'indicate': [554], 'that': [555, 1574, 1595, 1619, 1653, 1679, 1724], '2–11%': [556], 'had': [561, 688, 768, 786, 958, 1113, 1127], 'comorbidities': [563, 2124], '14–53%': [565], 'abnormal': [568, 689, 836, 869, 872, 962, 1233, 1904], 'levels': [569, 692, 874, 898, 1599, 1906], 'alanine': [571, 1287, 1302], 'aminotransferase': [572, 575, 691], 'aspartate': [574, 1284, 1299], '(AST)': [576], 'during': [577, 1586, 1610], 'progression': [579], '(table).': [580], 'Patients': [581], 'seem': [585], 'higher': [588], 'rates': [589], 'dysfunction.': [592], 'study': [595, 1614], 'Lancet': [598], 'Huang': [600], 'colleagues,5Huang': [602], 'elevation': [634], 'AST': [636, 791, 876, 967, 1132], 'was': [637, 969, 1479, 1576], 'observed': [638, 878, 902, 970, 1601, 1684, 1739], 'eight': [640, 972], '(62%)': [641, 973], '13': [643, 975], 'intensive': [647, 2077], 'care': [648, 662, 990, 1290, 1305], 'unit': [649], '(ICU)': [650], 'compared': [651, 980], '(25%)': [654, 983], '28': [656], 'who': [658, 767, 986, 1112, 1674, 1771], 'did': [659, 694, 794, 987, 1135], 'not': [660, 988, 1486, 1521, 1563, 1616, 1683, 1873, 1892], 'require': [661, 989], 'ICU.': [665], 'Moreover,': [666, 2020], 'large': [669, 1737], 'cohort': [670], 'including': [671, 1824, 2053], '1099': [672], '552': [675], 'hospitals': [676], '31': [678], 'provinces': [679], 'or': [680, 1761, 1938, 2005, 2027, 2079], 'provincial': [681], 'municipalities,': [682], 'more': [683, 806, 2032, 2076], 'than': [693, 793, 811, 1134], 'non-severe': [695, 886, 909], 'disease.1Guan': [698], 'Furthermore,': [726], 'another': [728], 'study,8Shi': [729], 'diagnosis': [770, 1115], 'CT': [775, 1120], 'scan': [776, 1121], 'while': [777, 1122], 'subclinical': [780, 1125], 'phase': [781, 1126], '(ie,': [782], 'before': [783], 'symptom': [784], 'onset)': [785], 'significantly': [787, 1128], 'lower': [788, 1129], 'incidence': [789, 960, 1130, 2047], 'abnormality': [792, 1133], 'diagnosed': [796, 1137], 'after': [797, 1138, 1642, 1957], 'onset': [799, 1140], 'Therefore,': [802], 'injury': [804, 1760, 1854, 1952, 2115], 'prevalent': [807], 'mild': [813, 1778], 'COVID-19.TableComorbidity': [816], 'dysfunction': [822], 'infectionPatients': [827, 830], 'pre-existing': [832, 1869, 2092], 'conditionsPatients': [834], 'functionNotesGuan': [838], 'al1Guan': [840], 'Scholar109923': [867], '(2·3%)AST': [868], '(22·2%),': [870], 'ALT': [871, 900], '(21·3%)Elevated': [873], 'were': [877, 901, 1485, 1520, 1600, 1682], '112': [880], '(18·2%)': [881], '615': [883], '56': [889, 1582, 1606], '(39·4%)': [890], '142': [892], 'disease.': [896], 'Elevated': [897], '120': [904], '(19·8%)': [905], '38': [912], '(28·1%)': [913], '135': [915], 'disease.Huang': [919], 'al5Huang': [921], 'Scholar411': [952], '(2·0%)15': [953], '(31·0%)Patients': [954], 'increased': [959], 'function.': [964, 1664], 'Elevation': [965], 'level': [968], 'ICU': [979], '25': [984], 'ICU.Chen': [993], 'al6Chen': [995], 'Scholar99NA43': [1032], '(43·0%)One': [1033], 'patient': [1034, 1673], 'function': [1038, 1235], 'damage.Wang': [1039], 'al7Wang': [1041], 'Scholar1384': [1070], '(2·9%)NA..Shi': [1071], 'al8Shi': [1073], 'Scholar817': [1109], '(8·6%)43': [1110], '(53·1%)Patients': [1111], 'symptoms.Xu': [1142], 'al9Xu': [1144], 'Scholar627': [1181], '(11·0%)10': [1182], '(16·1%)..Yang': [1183], 'al10Yang': [1185], 'Scholar52NA15': [1226], '(29·0%)No': [1227], 'difference': [1228], 'for': [1229, 1559, 2086], 'incidences': [1231], 'between': [1236, 1885], 'survivors': [1237], '(30%)': [1238], 'non-survivors': [1240], '(28%).Our': [1241], '(unpublished)562': [1243], '(3·6%)16': [1244], '(28·6%)One': [1245], 'fatal': [1246], 'case,': [1247], 'evaluated': [1249], 'injury.13Xu': [1251], 'Z': [1252, 1688], 'Shi': [1253, 1689], 'L': [1254, 1629, 1690], 'al.Pathological': [1258, 1694], 'associated': [1262, 1698, 1923], 'distress': [1266, 1702], 'syndrome.Lancet': [1267, 1703], '18.)DOI:10.1016/S2213-2600(20)30076-XSummary': [1274, 1710], '(6346)': [1281, 1717], 'ScholarAST=': [1283], 'aminotransferase.': [1285, 1288, 1300, 1303], 'ALT=': [1286, 1301], 'ICU=intensive': [1289, 1304], 'unit.': [1291, 1306, 1812], 'Open': [1292], 'table': [1293], 'new': [1296], 'tab': [1297], 'AST=': [1298], 'infections': [1313], 'might': [1314, 1655, 1734, 1755, 1918, 2030], 'directly': [1316, 1656], 'cells.': [1324], 'Approximately': [1325], '2–10%': [1326], 'present': [1331], 'diarrhoea,': [1333], 'RNA': [1336], 'detected': [1339], 'stool': [1341], 'blood': [1343], 'samples.11Yeo': [1344], 'Kaushal': [1346], 'S': [1347], 'Yeo': [1348], 'Enteric': [1350], 'involvement': [1351], 'coronaviruses:': [1353], 'faecal–oral': [1355], 'transmission': [1356], 'possible?.Lancet': [1359], 'Gastroenterol': [1360], 'Hepatol.': [1361], '19.)DOI:10.1016/S2468-1253(20)30048-0Summary': [1366], '(623)': [1374], 'This': [1377], 'evidence': [1378, 1948], 'implicates': [1379], 'possibility': [1381], 'exposure': [1384], 'liver.': [1387], 'Both': [1388], 'bind': [1392, 1657], 'angiotensin-converting': [1395], 'enzyme': [1396], '(ACE2)': [1398], 'receptor': [1399, 1621, 1990], 'enter': [1401], 'target': [1403], 'cell,7Wang': [1404], 'where': [1434], 'virus': [1436, 1471], 'replicates': [1437], 'subsequently': [1439], 'infects': [1440], 'other': [1441, 2104], 'cells': [1442], 'upper': [1445, 2058], 'tract': [1447], 'lung': [1449], 'tissue;': [1450], 'then': [1452], 'begin': [1453], 'symptoms': [1457], 'manifestations.': [1459], 'Pathological': [1460], 'SARS': [1465], 'presence': [1468], 'tissue,': [1474], 'although': [1475], 'titre': [1478], 'low': [1481], 'because': [1482, 2037], 'inclusions': [1484, 1681], 'observed.3Chau': [1487], 'MERS,': [1517], 'particles': [1519], 'detectable': [1522], 'tissue.4Alsaad': [1525], 'Gamma-glutamyl': [1553], 'transferase': [1554], '(GGT),': [1555], 'diagnostic': [1557], 'biomarker': [1558], 'cholangiocyte': [1560], 'injury,': [1561], 'existing': [1568, 1886, 2122], 'studies;': [1571], 'found': [1573, 1594], 'it': [1575], 'elevated': [1577, 1596], '30': [1579], '(54%)': [1580], 'hospitalisation': [1587], 'our': [1589, 1811], 'centre': [1590], '(unpublished).': [1591], 'We': [1592, 2131], 'alkaline': [1597, 2011], 'phosphatase': [1598, 2012], 'one': [1603], '(1·8%)': [1604], 'hospitalisation.': [1611], 'A': [1612], 'preliminary': [1613], '(albeit': [1615], 'peer-reviewed)': [1617], 'suggested': [1618], 'ACE2': [1620, 1634, 1989], 'expression': [1622, 1635, 1986], 'enriched': [1624], 'cholangiocytes,12Chai': [1626], 'al.Specific': [1633], 'cholangiocytes': [1637, 1660], 'may': [1638], 'infection.bioRxiv.': [1644], '4.)': [1649], '(preprint).https://doi.org/10.1101/2020.02.03.931766Google': [1650], 'indicating': [1652], 'ACE2-positive': [1659], 'dysregulate': [1662], 'Nevertheless,': [1665], 'pathological': [1666], 'analysis': [1667], 'tissue': [1670], 'died': [1675], 'showed': [1678], 'liver.13Xu': [1687], 'It': [1720], 'possible': [1723], 'drug': [1731], 'hepatotoxicity,': [1732], 'which': [1733], 'explain': [1735], 'variation': [1738], 'across': [1740], 'different': [1742, 1848], 'cohorts.': [1743], 'addition,': [1745], 'immune-mediated': [1746], 'inflammation,': [1747], 'such': [1748, 1808, 2094], 'cytokine': [1750, 1905, 1908], 'storm': [1751], 'pneumonia-associated': [1753], 'hypoxia,': [1754], 'contribute': [1757], 'even': [1762], 'develop': [1763], 'into': [1764], 'failure': [1766], 'ill.': [1774], 'often': [1783], 'transient': [1784], 'return': [1787], 'normal': [1789], 'without': [1790], 'any': [1791], 'special': [1792], 'treatment.': [1793], 'However,': [1794, 1864], 'when': [1795], 'occurs,': [1799], 'protective': [1801], 'drugs': [1802], 'usually': [1804], 'given': [1806], 'Chronic': [1813], 'represents': [1816], 'major': [1818], 'burden': [1820], 'globally.': [1821], 'diseases': [1823], 'chronic': [1825, 1932], 'hepatitis,': [1827, 1972], 'non-alcoholic': [1828], 'fatty': [1829], 'disease,': [1831, 2098], 'alcohol-related': [1833], 'affect': [1836], 'approximately': [1837], '300': [1838], 'million': [1839], 'people': [1840], 'Given': [1843, 1984], 'high': [1845], 'burden,': [1846], 'underlying': [1849], 'conditions': [1851, 1871, 2093], 'influence': [1852], 'needs': [1859, 2016], 'meticulously': [1862], 'evaluated.': [1863], 'exact': [1866], 'outlined': [1875], 'interaction': [1884], 'studied.': [1894], 'Immune': [1895], 'dysfunction—including': [1896], 'lymphopenia,': [1897], 'decreases': [1898], 'CD4+': [1900], 'T-cell': [1901], 'levels,': [1902], '(including': [1907], 'storm)—is': [1909], 'common': [1911], 'feature': [1912], 'critical': [1921], 'factor': [1922], 'severity': [1926], 'mortality.': [1928], 'For': [1929], 'immunotolerant': [1936], 'phases': [1937], 'suppression': [1941], 'under': [1942], 'long-term': [1943], 'treatment': [1944, 2126], 'nucleos(t)ide': [1946], 'analogues,': [1947], 'persistent': [1950], 'active': [1954], 'replication': [1956], 'co-infection': [1958], 'need': [1961, 2064], 'further': [1964], 'investigated.': [1965], 'autoimmune': [1971], 'effects': [1974], 'administration': [1976], 'glucocorticoids': [1978], 'on': [1979, 2110, 2125], 'prognosis': [1981], 'unclear.': [1983], 'cholangiocytes,': [1992], 'whether': [1993], 'aggravates': [1997], 'cholestasis': [1998], 'primary': [2002], 'biliary': [2003], 'cholangitis,': [2004], 'leads': [2006], 'increase': [2009], 'GGT,': [2014], 'monitored.': [2019], 'cirrhosis': [2026], 'cancer': [2029], 'susceptible': [2033], 'their': [2039, 2073], 'systemic': [2040], 'immunocompromised': [2041, 2074], 'status.': [2042], 'severity,': [2044], 'mortality,': [2045], 'complications': [2049], 'patients,': [2052], 'secondary': [2054], 'infection,': [2055], 'hepatic': [2056], 'encephalopathy,': [2057], 'gastrointestinal': [2059], 'bleeding,': [2060], 'failure,': [2063], 'examined': [2067], 'large-cohort': [2069], 'studies.': [2071], 'Considering': [2072], 'status,': [2075], 'surveillance': [2078], 'individually': [2080], 'tailored': [2081], 'therapeutic': [2082], 'approaches': [2083], 'needed': [2085], 'advanced': [2096], 'especially': [2099], 'older': [2101], 'comorbidities.': [2105], 'Further': [2106], 'research': [2107], 'should': [2108], 'focus': [2109], 'causes': [2112], 'effect': [2120], 'liver-related': [2123], 'outcome': [2128], 'COVID-19.': [2130], 'declare': [2132], 'no': [2133], 'competing': [2134], 'interests.': [2135], 'Download': [2136], '.pdf': [2137], '(.56': [2138], 'MB)': [2139], 'Help': [2140], 'pdf': [2142], 'files': [2143], 'Chinese': [2144], 'translation': [2145], 'full': [2148], 'text': [2149]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3010637630', 'counts_by_year': [{'year': 2024, 'cited_by_count': 73}, {'year': 2023, 'cited_by_count': 206}, {'year': 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