Abstract GS1-07: Effects of capecitabine as part of neo-/adjuvant chemotherapy. A meta-analysis of individual patient data from 12 randomized trials including 15,457 patients

Name: Work Video:
Duration: 3 min 30 s
Marion van Mackelenbergh; Fenja Seither; Volker Möbus; Joyce O'Shaugnessy; Miguel Martín; Heikki Joenssuu; Michael Untch; Ulrike Nitz; J. Miralles; Masakazu Toi; Harry D. Bear; Hymann Muss; Toralf Reimer; Valentina Nekljudova; Sibylle Loibl
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[107], 'yielded': [108], 'trials:': [111], 'GeparTrio,': [112], 'GeparQuattro,': [113], 'GAIN,': [114], 'ICE,': [115], 'ICE': [116], 'II,': [117], 'FinXX,': [118], 'Alliance/CALGB': [119], '49907,': [120], 'Roche': [121], '/': [122], 'US': [123], 'Oncology': [124], '01062,': [125], 'NSABP-B40,': [126], 'ABCSG-24,': [127], 'CREATE-X,': [128], 'GEICAM': [129, 131], '2003/10,': [130], '2003/11_CIBOMA': [132], '2004/01.': [133], 'Data': [134], 'available': [136], 'for': [137, 238, 453], 'all': [138, 335], 'these': [139, 252], '15,457': [142, 247, 429, 517], 'included': [145, 336], 'this': [147, 426], 'based': [151], 'meta-analysis.': [152], 'The': [153], 'primary': [154], 'objective': [155], 'was': [156, 189, 249, 275, 303, 362, 375, 447], 'examine': [158, 171], 'effect': [160, 365], 'on': [163, 173, 366], '(DFS).': [166], 'Secondary': [167], 'objectives': [168], 'effects': [172, 216], 'distant': [174], 'DFS': [175, 347, 367, 402, 424, 446], '(DDFS),': [176], 'overall': [177], '(OS),': [179], 'pathological': [180], 'complete': [181], '(for': [183], 'studies)': [185], 'whether': [187], 'there': [188], 'interaction': [191], 'occurrence': [193], 'capecitabine-specific': [195], 'toxicity': [196], '(mucositis,': [197], 'diarrhea,': [198], 'hand-foot': [199], 'syndrome)': [200], 'treatment': [202, 261, 323, 351, 393, 445], 'effect.': [203], 'Bi-': [204], 'multivariable': [206], 'frailty-based': [207], 'Cox': [208, 331], 'proportional': [209], 'hazards': [210], 'models': [211], 'log-normal': [213], 'distributed': [214], 'random': [215], 'study': [218], 'hazard': [223], 'ratios': [224], '95%': [226, 356, 383, 405], 'CI': [227, 357, 384, 406], 'between': [228], 'groups': [230], 'without': [236, 352], 'DFS,': [239], 'DDFS': [240], 'OS.': [242], 'Results:': [243], 'Individual': [244], 'from': [246, 435, 512], 'collected.': [250], 'Of': [251], '7,980': [253], 'received': [254, 321], 'during': [256], 'course': [258], 'their': [260], '7,477': [263], 'control': [269], 'arms.': [270], 'Median': [271], 'age': [272], 'diagnosis': [274], '54': [276], 'years': [277], 'both': [279], 'groups.': [280], 'Most': [281], 'diagnosed': [284, 315], 'stage': [286], '2': [287], 'tumors': [288], '(55.9%)': [289], 'majority': [292], 'presented': [293, 415, 459], 'nodal': [295], 'involvement': [296], '(74.0%).': [297], 'Estrogen': [298], 'progesterone': [300], 'receptor': [301], 'positivity': [302], 'observed': [304], '66.0%': [306], '56.9%,': [308], 'respectively,': [309], '15.1%': [311], 'HER2-positive.': [317], '2,816': [318], '(18.2%)': [320], '12,641': [325], '(81.8%)': [326], 'chemotherapy': [329], 'regimen.': [330], 'regression': [332], 'analyses': [333, 450], 'revealed': [338], 'addition': [341, 390, 442], 'alter': [346, 423], 'significantly': [348], 'compared': [349], '(HR': [354, 381, 403], '0.952;': [355], '0.895-1.012;': [358], 'p-value': [359], '0.115).': [360], 'There': [361], 'also': [363], 'if': [368], 'selected': [371], 'which': [373], 'given': [376], 'instead': [377], 'another': [379], 'drug': [380], '1.035;': [382], '0.945-1.134;': [385], 'p=0.455).': [386], 'However,': [387], 'systemic': [392, 444], 'lead': [394], 'a': [396], 'small': [397], 'but': [398, 440], 'significant': [399], '0.888;': [404], '0.817-0.965;': [407], 'p=0.005).': [408], 'Results': [409], 'concerning': [410], 'other': [411], 'endpoints': [412], 'will': [413, 457], 'be': [414, 458], 'meeting.': [418, 462], 'Conclusion:': [419], 'Capecitabine': [420], '12': [436, 513], 'prospective': [437], 'improved.': [448], 'Subgroup': [449], 'are': [451], 'needed': [452], 'final': [454], 'interpretation': [455], 'Citation': [463], 'Format:': [464], 'Marion': [465], 'van': [466], 'Mackelenbergh,': [467], 'Fenja': [468], 'Seither,': [469], 'Volker': [470], 'Möbus,': [471], 'Joyce': [472], "O'Shaugnessy,": [473], 'Miguel': [474], 'Martin,': [475], 'Heikki': [476], 'Joenssuu,': [477], 'Michael': [478], 'Untch,': [479], 'Ulrike': [480], 'Nitz,': [481], 'Juan': [482], 'J': [483], 'Miralles,': [484], 'Masakazu': [485], 'Toi,': [486], 'Harry': [487], 'D': [488], 'Bear,': [489], 'Hymann': [490], 'Muss,': [491], 'Toralf': [492], 'Reimer,': [493], 'Valentina': [494], 'Nekljudova,': [495], 'Sibylle': [496], 'Loibl.': [497], 'Effects': [498], 'part': [502], 'neo-/adjuvant': [504], 'chemotherapy.': [505], 'A': [506], '[abstract].': [519], 'In:': [520], 'Proceedings': [521], '2019': [524, 530], 'San': [525, 533], 'Antonio': [526], 'Breast': [527], 'Cancer': [528, 539], 'Symposium;': [529], 'Dec': [531], '10-14;': [532], 'Antonio,': [534], 'TX.': [535], 'Philadelphia': [536], '(PA):': [537], 'AACR;': [538], 'Res': [540], '2020;80(4': [541], 'Suppl):Abstract': [542], 'nr': [543], 'GS1-07.': [544]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3009694998', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 7}, {'year': 2020, 'cited_by_count': 9}], 'updated_date': '2025-01-06T16:53:03.187181', 'created_date': '2020-03-13'}
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