Publication Information

{'id': 'https://openalex.org/W3009604744', 'doi': 'https://doi.org/10.1158/1940-6207.capr-19-0316', 'title': 'Dysplastic Aberrant Crypt Foci: Biomarkers of Early Colorectal Neoplasia and Response to Preventive Intervention', 'display_name': 'Dysplastic Aberrant Crypt Foci: Biomarkers of Early Colorectal Neoplasia and Response to Preventive Intervention', 'publication_year': 2020, 'publication_date': '2020-03-01', 'ids': {'openalex': 'https://openalex.org/W3009604744', 'doi': 'https://doi.org/10.1158/1940-6207.capr-19-0316', 'mag': '3009604744', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/32132117', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/7080315'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/1940-6207.capr-19-0316', 'pdf_url': 'https://cancerpreventionresearch.aacrjournals.org/content/canprevres/13/3/229.full.pdf', 'source': {'id': 'https://openalex.org/S68240649', 'display_name': 'Cancer Prevention Research', 'issn_l': '1940-6215', 'issn': ['1940-6215', '1940-6207'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://cancerpreventionresearch.aacrjournals.org/content/canprevres/13/3/229.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5022569332', 'display_name': 'Margie L. Clapper', 'orcid': 'https://orcid.org/0000-0001-7712-5109'}, 'institutions': [{'id': 'https://openalex.org/I1289437631', 'display_name': 'Fox Chase Cancer Center', 'ror': 'https://ror.org/0567t7073', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1289437631', 'https://openalex.org/I4210122924']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Margie L. Clapper', 'raw_affiliation_strings': ['1Cancer Prevention and Control Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania.'], 'affiliations': [{'raw_affiliation_string': '1Cancer Prevention and Control Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania.', 'institution_ids': ['https://openalex.org/I1289437631']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030196668', 'display_name': 'Wen‐Chi Chang', 'orcid': 'https://orcid.org/0000-0002-0347-1516'}, 'institutions': [{'id': 'https://openalex.org/I1289437631', 'display_name': 'Fox Chase Cancer Center', 'ror': 'https://ror.org/0567t7073', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1289437631', 'https://openalex.org/I4210122924']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Wen-Chi L. Chang', 'raw_affiliation_strings': ['1Cancer Prevention and Control Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania.'], 'affiliations': [{'raw_affiliation_string': '1Cancer Prevention and Control Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania.', 'institution_ids': ['https://openalex.org/I1289437631']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5090126068', 'display_name': 'Harry S. Cooper', 'orcid': 'https://orcid.org/0000-0001-7574-1928'}, 'institutions': [{'id': 'https://openalex.org/I1289437631', 'display_name': 'Fox Chase Cancer Center', 'ror': 'https://ror.org/0567t7073', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1289437631', 'https://openalex.org/I4210122924']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Harry S. Cooper', 'raw_affiliation_strings': ['1Cancer Prevention and Control Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania.', '2Department of Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania.'], 'affiliations': [{'raw_affiliation_string': '2Department of Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania.', 'institution_ids': ['https://openalex.org/I1289437631']}, {'raw_affiliation_string': '1Cancer Prevention and Control Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania.', 'institution_ids': ['https://openalex.org/I1289437631']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5022569332'], 'corresponding_institution_ids': ['https://openalex.org/I1289437631'], 'apc_list': None, 'apc_paid': None, 'fwci': 0.735, 'has_fulltext': False, 'cited_by_count': 35, 'citation_normalized_percentile': {'value': 0.999592, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '13', 'issue': '3', 'first_page': '229', 'last_page': '240'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10552', 'display_name': 'Colorectal Cancer Screening and Detection', 'score': 0.9984, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10552', 'display_name': 'Colorectal Cancer Screening and Detection', 'score': 0.9984, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11369', 'display_name': 'Genetic factors in colorectal cancer', 'score': 0.9979, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11067', 'display_name': 'Colorectal Cancer Treatments and Studies', 'score': 0.9865, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/aberrant-crypt-foci', 'display_name': 'Aberrant crypt foci', 'score': 0.80506724}, {'id': 'https://openalex.org/keywords/cancer-prevention', 'display_name': 'Cancer Prevention', 'score': 0.60143125}], 'concepts': [{'id': 'https://openalex.org/C2780669762', 'wikidata': 'https://www.wikidata.org/wiki/Q4667164', 'display_name': 'Aberrant crypt foci', 'level': 5, 'score': 0.80506724}, {'id': 'https://openalex.org/C2775894508', 'wikidata': 'https://www.wikidata.org/wiki/Q1128996', 'display_name': 'Dysplasia', 'level': 2, 'score': 0.74699533}, {'id': 'https://openalex.org/C526805850', 'wikidata': 'https://www.wikidata.org/wiki/Q188874', 'display_name': 'Colorectal cancer', 'level': 3, 'score': 0.6339869}, {'id': 'https://openalex.org/C555283112', 'wikidata': 'https://www.wikidata.org/wiki/Q1637543', 'display_name': 'Carcinogenesis', 'level': 3, 'score': 0.61988956}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.61435646}, {'id': 'https://openalex.org/C2780234812', 'wikidata': 'https://www.wikidata.org/wiki/Q1787013', 'display_name': 'Cancer prevention', 'level': 3, 'score': 0.60143125}, {'id': 'https://openalex.org/C2781197716', 'wikidata': 'https://www.wikidata.org/wiki/Q864574', 'display_name': 'Biomarker', 'level': 2, 'score': 0.51512593}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.47110656}, {'id': 'https://openalex.org/C2777428134', 'wikidata': 'https://www.wikidata.org/wiki/Q272741', 'display_name': 'Adenoma', 'level': 2, 'score': 0.46781015}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.40228963}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.35419482}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.3188645}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.21456426}, {'id': 'https://openalex.org/C3018440083', 'wikidata': 'https://www.wikidata.org/wiki/Q11083', 'display_name': 'Colonic disease', 'level': 4, 'score': 0.119512916}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.07750818}], 'mesh': [{'descriptor_ui': 'D058739', 'descriptor_name': 'Aberrant Crypt Foci', 'qualifier_ui': 'Q000628', 'qualifier_name': 'therapy', 'is_major_topic': True}, {'descriptor_ui': 'D000236', 'descriptor_name': 'Adenoma', 'qualifier_ui': 'Q000517', 'qualifier_name': 'prevention & control', 'is_major_topic': True}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': 'Q000517', 'qualifier_name': 'prevention & control', 'is_major_topic': True}, {'descriptor_ui': 'D019587', 'descriptor_name': 'Dietary Supplements', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D058739', 'descriptor_name': 'Aberrant Crypt Foci', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058739', 'descriptor_name': 'Aberrant Crypt Foci', 'qualifier_ui': 'Q000175', 'qualifier_name': 'diagnosis', 'is_major_topic': False}, {'descriptor_ui': 'D058739', 'descriptor_name': 'Aberrant Crypt Foci', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D058739', 'descriptor_name': 'Aberrant Crypt Foci', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D000236', 'descriptor_name': 'Adenoma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000236', 'descriptor_name': 'Adenoma', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D025601', 'descriptor_name': 'Adenomatous Polyposis Coli Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D025601', 'descriptor_name': 'Adenomatous Polyposis Coli Protein', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D001241', 'descriptor_name': 'Aspirin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001241', 'descriptor_name': 'Aspirin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D001241', 'descriptor_name': 'Aspirin', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D000069059', 'descriptor_name': 'Atorvastatin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000069059', 'descriptor_name': 'Atorvastatin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000069059', 'descriptor_name': 'Atorvastatin', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D063646', 'descriptor_name': 'Carcinogenesis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D063646', 'descriptor_name': 'Carcinogenesis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002392', 'descriptor_name': 'Catechin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002392', 'descriptor_name': 'Catechin', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D002392', 'descriptor_name': 'Catechin', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': False}, {'descriptor_ui': 'D002986', 'descriptor_name': 'Clinical Trials as Topic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003106', 'descriptor_name': 'Colon', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003106', 'descriptor_name': 'Colon', 'qualifier_ui': 'Q000000981', 'qualifier_name': 'diagnostic imaging', 'is_major_topic': False}, {'descriptor_ui': 'D003106', 'descriptor_name': 'Colon', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D003106', 'descriptor_name': 'Colon', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D003113', 'descriptor_name': 'Colonoscopy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D004195', 'descriptor_name': 'Disease Models, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007413', 'descriptor_name': 'Intestinal Mucosa', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007413', 'descriptor_name': 'Intestinal Mucosa', 'qualifier_ui': 'Q000000981', 'qualifier_name': 'diagnostic imaging', 'is_major_topic': False}, {'descriptor_ui': 'D007413', 'descriptor_name': 'Intestinal Mucosa', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D007413', 'descriptor_name': 'Intestinal Mucosa', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D000077276', 'descriptor_name': 'Lycopene', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077276', 'descriptor_name': 'Lycopene', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016896', 'descriptor_name': 'Treatment Outcome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/1940-6207.capr-19-0316', 'pdf_url': 'https://cancerpreventionresearch.aacrjournals.org/content/canprevres/13/3/229.full.pdf', 'source': {'id': 'https://openalex.org/S68240649', 'display_name': 'Cancer Prevention Research', 'issn_l': '1940-6215', 'issn': ['1940-6215', '1940-6207'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080315', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/32132117', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/1940-6207.capr-19-0316', 'pdf_url': 'https://cancerpreventionresearch.aacrjournals.org/content/canprevres/13/3/229.full.pdf', 'source': {'id': 'https://openalex.org/S68240649', 'display_name': 'Cancer Prevention Research', 'issn_l': '1940-6215', 'issn': ['1940-6215', '1940-6207'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.82, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 106, 'referenced_works': ['https://openalex.org/W1490402378', 'https://openalex.org/W1501597866', 'https://openalex.org/W1529373525', 'https://openalex.org/W1628660054', 'https://openalex.org/W1663072708', 'https://openalex.org/W1776885212', 'https://openalex.org/W1798670389', 'https://openalex.org/W1939207334', 'https://openalex.org/W1964290751', 'https://openalex.org/W1975076018', 'https://openalex.org/W1975373973', 'https://openalex.org/W1977989492', 'https://openalex.org/W1984283228', 'https://openalex.org/W1990489545', 'https://openalex.org/W1990691513', 'https://openalex.org/W1993058852', 'https://openalex.org/W1994656623', 'https://openalex.org/W1996588062', 'https://openalex.org/W1998136639', 'https://openalex.org/W1998761065', 'https://openalex.org/W2000879000', 'https://openalex.org/W2003206908', 'https://openalex.org/W2004098247', 'https://openalex.org/W2005873003', 'https://openalex.org/W2006460889', 'https://openalex.org/W2008557163', 'https://openalex.org/W2011100584', 'https://openalex.org/W2018973796', 'https://openalex.org/W2019076663', 'https://openalex.org/W2023993468', 'https://openalex.org/W2027860750', 'https://openalex.org/W2027911316', 'https://openalex.org/W2028804965', 'https://openalex.org/W2041580439', 'https://openalex.org/W2046499340', 'https://openalex.org/W2047330711', 'https://openalex.org/W2052555886', 'https://openalex.org/W2053117633', 'https://openalex.org/W2053672068', 'https://openalex.org/W2058703787', 'https://openalex.org/W2059198233', 'https://openalex.org/W2059969113', 'https://openalex.org/W2067089521', 'https://openalex.org/W2067332299', 'https://openalex.org/W2068712629', 'https://openalex.org/W2074787458', 'https://openalex.org/W2084633619', 'https://openalex.org/W2088987931', 'https://openalex.org/W2097903769', 'https://openalex.org/W2099263399', 'https://openalex.org/W2099468308', 'https://openalex.org/W2100124291', 'https://openalex.org/W2100283599', 'https://openalex.org/W2101685363', 'https://openalex.org/W2103253489', 'https://openalex.org/W2103679353', 'https://openalex.org/W2105452647', 'https://openalex.org/W2110085049', 'https://openalex.org/W2114237338', 'https://openalex.org/W2114621779', 'https://openalex.org/W2117918767', 'https://openalex.org/W2119139450', 'https://openalex.org/W2120045074', 'https://openalex.org/W2121251645', 'https://openalex.org/W2124806794', 'https://openalex.org/W2128271627', 'https://openalex.org/W2132154571', 'https://openalex.org/W2132864244', 'https://openalex.org/W2135348745', 'https://openalex.org/W2135770108', 'https://openalex.org/W2137449024', 'https://openalex.org/W2137953719', 'https://openalex.org/W2139234336', 'https://openalex.org/W2139592489', 'https://openalex.org/W2139695381', 'https://openalex.org/W2140541583', 'https://openalex.org/W2143942532', 'https://openalex.org/W2148012410', 'https://openalex.org/W2148083325', 'https://openalex.org/W2151855631', 'https://openalex.org/W2155978263', 'https://openalex.org/W2157101480', 'https://openalex.org/W2166353893', 'https://openalex.org/W2166393423', 'https://openalex.org/W2168273902', 'https://openalex.org/W2170740631', 'https://openalex.org/W2171956877', 'https://openalex.org/W2275474088', 'https://openalex.org/W2288971050', 'https://openalex.org/W2313041256', 'https://openalex.org/W2316560853', 'https://openalex.org/W2477093104', 'https://openalex.org/W2509391596', 'https://openalex.org/W2523112479', 'https://openalex.org/W2525822238', 'https://openalex.org/W2736907085', 'https://openalex.org/W2767628584', 'https://openalex.org/W2771584793', 'https://openalex.org/W2791701273', 'https://openalex.org/W2804968745', 'https://openalex.org/W2807134999', 'https://openalex.org/W2887490780', 'https://openalex.org/W2909490434', 'https://openalex.org/W2912448641', 'https://openalex.org/W2971596758', 'https://openalex.org/W2973782057'], 'related_works': ['https://openalex.org/W3148401380', 'https://openalex.org/W2474941067', 'https://openalex.org/W2414565901', 'https://openalex.org/W2414385779', 'https://openalex.org/W2413710987', 'https://openalex.org/W2398321288', 'https://openalex.org/W2385186823', 'https://openalex.org/W2193582402', 'https://openalex.org/W2031813156', 'https://openalex.org/W1999318729'], 'abstract_inverted_index': {'Abstract': [0], 'The': [1], 'discovery': [2], 'of': [3, 18, 61, 87, 121, 156, 164, 184], 'aberrant': [4], 'crypt': [5], 'foci': [6], '(ACF)': [7], 'more': [8], 'than': [9], 'three': [10], 'decades': [11], 'ago': [12], 'not': [13, 44], 'only': [14], 'enhanced': [15], 'our': [16], 'understanding': [17], 'how': [19], 'colorectal': [20, 38, 165], 'tumors': [21], 'form,': [22], 'but': [23], 'provided': [24], 'new': [25, 102], 'opportunities': [26], 'to': [27, 31, 48, 53, 138, 152, 169], 'detect': [28], 'lesions': [29, 56], 'prior': [30], 'adenoma': [32], 'development': [33], 'and': [34, 63, 68, 85, 94, 101, 108, 144, 167], 'intervene': [35], 'in': [36, 81, 90, 112, 134, 174], 'the': [37, 59, 83, 135, 154, 160], 'carcinogenesis': [39, 136], 'process': [40, 137], 'even': [41, 132], 'earlier.': [42], 'Because': [43], 'all': [45, 172], 'ACF': [46, 74, 89, 126, 158], 'progress': [47, 77], 'neoplasia,': [49], 'it': [50], 'is': [51], 'important': [52], 'stratify': [54], 'these': [55], 'based': [57], 'on': [58], 'presence': [60], 'dysplasia': [62], 'establish': [64], 'early': [65], 'detection': [66], 'methods': [67, 97], 'interventions': [69], 'that': [70, 104, 123], 'specifically': [71], 'target': [72, 124], 'dysplastic': [73, 88, 125, 157], '(microadenomas).': [75], 'Significant': [76], 'has': [78], 'been': [79, 99], 'made': [80], 'characterizing': [82], 'morphology': [84], 'genetics': [86], 'both': [91], 'preclinical': [92, 143], 'models': [93], 'humans.': [95], 'Image-based': [96], 'have': [98], 'established': [100], 'techniques': [103], 'utilize': [105], 'bioactivatable': [106], 'probes': [107], 'capture': [109], 'histologic': [110], 'abnormalities': [111], 'vivo': [113], 'are': [114], 'emerging': [115], 'for': [116, 130], 'lesion': [117], 'detection.': [118], 'Successful': [119], 'identification': [120], 'agents': [122], 'holds': [127], 'great': [128], 'promise': [129], 'intervening': [131], 'earlier': [133], 'maximize': [139], 'tumor': [140], 'inhibition.': [141], 'Future': [142], 'clinical': [145], 'prevention': [146], 'studies': [147], 'should': [148], 'give': [149], 'significant': [150], 'attention': [151], 'assessing': [153], 'utility': [155], 'as': [159], 'earliest': [161], 'identifiable': [162], 'biomarker': [163], 'neoplasia': [166], 'response': [168], 'therapy.': [170], 'See': [171], 'articles': [173], 'this': [175], 'Special': [176], 'Collection': [177], 'Honoring': [178], 'Paul': [179], 'F.': [180], 'Engstrom,': [181], 'MD,': [182], 'Champion': [183], 'Cancer': [185], 'Prevention': [186]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3009604744', 'counts_by_year': [{'year': 2024, 'cited_by_count': 11}, {'year': 2023, 'cited_by_count': 8}, {'year': 2022, 'cited_by_count': 7}, {'year': 2021, 'cited_by_count': 7}, {'year': 2020, 'cited_by_count': 2}], 'updated_date': '2024-12-30T08:21:11.980817', 'created_date': '2020-03-13'}