Abstract: This chapter focuses on drug-metabolizing enzymes and drug transporters of mammals. Xenobiotic chemicals can be hydrophilic or lipophilic. Hydrophilic chemicals are less absorbed and more easily excreted by living system. Lipophilic chemicals, on the other hand, are more easily absorbed and more slowly excreted. Drug-metabolizing enzymes metabolize lipophilic chemicals into more hydrophilic metabolites, and the hydrophilic metabolites are more readily excreted through transporters and therefore detoxified. Metabolism of xenobiotics mostly leads to detoxification. However, it may also lead to bioactivation. In this case the xenobiotic metabolites are more toxic than the parent compound to living organisms.
Publication Year: 2020
Publication Date: 2020-01-01
Language: en
Type: book-chapter
Indexed In: ['crossref']
Access and Citation
Cited By Count: 134
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot