Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W3005844571', 'doi': 'https://doi.org/10.18632/oncotarget.27466', 'title': 'Identification of biomarkers of immune checkpoint blockade efficacy in recurrent or refractory solid tumor malignancies', 'display_name': 'Identification of biomarkers of immune checkpoint blockade efficacy in recurrent or refractory solid tumor malignancies', 'publication_year': 2020, 'publication_date': '2020-02-11', 'ids': {'openalex': 'https://openalex.org/W3005844571', 'doi': 'https://doi.org/10.18632/oncotarget.27466', 'mag': '3005844571', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/32110280', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/7021232'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.27466', 'pdf_url': 'https://www.oncotarget.com/article/27466/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.oncotarget.com/article/27466/pdf/', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5061517006', 'display_name': 'Richard K. Yang', 'orcid': 'https://orcid.org/0000-0003-0433-8626'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Richard K. Yang', 'raw_affiliation_strings': ['Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038954948', 'display_name': 'Yun Qing', 'orcid': 'https://orcid.org/0009-0002-7320-2992'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yun Qing', 'raw_affiliation_strings': ['Department of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, TX, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, TX, USA', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072687747', 'display_name': 'Fatima Zahra Jelloul', 'orcid': 'https://orcid.org/0000-0002-3791-3204'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Fatima Zahra Jelloul', 'raw_affiliation_strings': ['Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045943632', 'display_name': 'Mark J. Routbort', 'orcid': 'https://orcid.org/0000-0003-4860-261X'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Mark J. Routbort', 'raw_affiliation_strings': ['Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100396007', 'display_name': 'Peng Wang', 'orcid': 'https://orcid.org/0000-0002-2972-7495'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Peng Wang', 'raw_affiliation_strings': ['Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067055882', 'display_name': 'Kenna Shaw', 'orcid': 'https://orcid.org/0000-0002-6873-0793'}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kenna Shaw', 'raw_affiliation_strings': ['Institute for Personalized Cancer Treatment (IPCT), University of Texas MD Anderson Cancer Center, Houston, TX, USA'], 'affiliations': [{'raw_affiliation_string': 'Institute for Personalized Cancer Treatment (IPCT), University of Texas MD Anderson Cancer Center, Houston, TX, USA', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062057879', 'display_name': 'Jiexin Zhang', 'orcid': 'https://orcid.org/0000-0001-9526-6730'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jiexin Zhang', 'raw_affiliation_strings': ['Department of Bioinformatics and Computational Biology, University of Texas MD Anderson Cancer Center, Houston, TX, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Bioinformatics and Computational Biology, University of Texas MD Anderson Cancer Center, Houston, TX, USA', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100383910', 'display_name': 'J. Jack Lee', 'orcid': 'https://orcid.org/0000-0001-5469-9214'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jack Lee', 'raw_affiliation_strings': ['Department of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, TX, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, TX, USA', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000027373', 'display_name': 'L. Jeffrey Medeiros', 'orcid': 'https://orcid.org/0000-0001-6577-8006'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'L. Jeffrey Medeiros', 'raw_affiliation_strings': ['Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006348751', 'display_name': 'Scott Kopetz', 'orcid': 'https://orcid.org/0000-0001-9647-3416'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Scott Kopetz', 'raw_affiliation_strings': ['Department of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067831105', 'display_name': 'Michael T. Tetzlaff', 'orcid': 'https://orcid.org/0000-0001-7899-4138'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Michael T. Tetzlaff', 'raw_affiliation_strings': ['Departments of Anatomical Pathology and Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA'], 'affiliations': [{'raw_affiliation_string': 'Departments of Anatomical Pathology and Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5059484239', 'display_name': 'Russell R. Broaddus', 'orcid': 'https://orcid.org/0000-0002-8692-273X'}, 'institutions': [{'id': 'https://openalex.org/I114027177', 'display_name': 'University of North Carolina at Chapel Hill', 'ror': 'https://ror.org/0130frc33', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I114027177']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Russell R. Broaddus', 'raw_affiliation_strings': ['Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA', 'institution_ids': ['https://openalex.org/I114027177']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5059484239'], 'corresponding_institution_ids': ['https://openalex.org/I114027177'], 'apc_list': None, 'apc_paid': None, 'fwci': 1.332, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 17, 'citation_normalized_percentile': {'value': 0.999965, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 91, 'max': 92}, 'biblio': {'volume': '11', 'issue': '6', 'first_page': '600', 'last_page': '618'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10158', 'display_name': 'Cancer Immunotherapy and Biomarkers', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10158', 'display_name': 'Cancer Immunotherapy and Biomarkers', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10417', 'display_name': 'Lung Cancer Treatments and Mutations', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10231', 'display_name': 'Pancreatic and Hepatic Oncology Research', 'score': 0.9985, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/immune-checkpoint', 'display_name': 'Immune checkpoint', 'score': 0.64126486}, {'id': 'https://openalex.org/keywords/refractory', 'display_name': 'Refractory (planetary science)', 'score': 0.4891787}], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.7820586}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.7384024}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.67555475}, {'id': 'https://openalex.org/C2780851360', 'wikidata': 'https://www.wikidata.org/wiki/Q21686041', 'display_name': 'Immune checkpoint', 'level': 4, 'score': 0.64126486}, {'id': 'https://openalex.org/C2778468042', 'wikidata': 'https://www.wikidata.org/wiki/Q273976', 'display_name': 'Blockade', 'level': 3, 'score': 0.5958906}, {'id': 'https://openalex.org/C142424586', 'wikidata': 'https://www.wikidata.org/wiki/Q7307572', 'display_name': 'Refractory (planetary science)', 'level': 2, 'score': 0.4891787}, {'id': 'https://openalex.org/C2777701055', 'wikidata': 'https://www.wikidata.org/wiki/Q1427096', 'display_name': 'Immunotherapy', 'level': 3, 'score': 0.47433868}, {'id': 'https://openalex.org/C50382708', 'wikidata': 'https://www.wikidata.org/wiki/Q223218', 'display_name': 'Proportional hazards model', 'level': 2, 'score': 0.45673347}, {'id': 'https://openalex.org/C38180746', 'wikidata': 'https://www.wikidata.org/wiki/Q1952580', 'display_name': 'Multivariate analysis', 'level': 2, 'score': 0.4517821}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.4268416}, {'id': 'https://openalex.org/C2781053074', 'wikidata': 'https://www.wikidata.org/wiki/Q21100639', 'display_name': 'PD-L1', 'level': 4, 'score': 0.41600847}, {'id': 'https://openalex.org/C535046627', 'wikidata': 'https://www.wikidata.org/wiki/Q30612', 'display_name': 'Clinical trial', 'level': 2, 'score': 0.41148195}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.0785158}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C87355193', 'wikidata': 'https://www.wikidata.org/wiki/Q411', 'display_name': 'Astrobiology', 'level': 1, 'score': 0.0}], 'mesh': [], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.27466', 'pdf_url': 'https://www.oncotarget.com/article/27466/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc7021232', 'pdf_url': 'https://europepmc.org/articles/pmc7021232?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021232', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/32110280', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.27466', 'pdf_url': 'https://www.oncotarget.com/article/27466/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.76, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 45, 'referenced_works': ['https://openalex.org/W1940241680', 'https://openalex.org/W1988009043', 'https://openalex.org/W2018652183', 'https://openalex.org/W2049553585', 'https://openalex.org/W2062497242', 'https://openalex.org/W2104347254', 'https://openalex.org/W2111404268', 'https://openalex.org/W2145550995', 'https://openalex.org/W2152061559', 'https://openalex.org/W2166662937', 'https://openalex.org/W2171480930', 'https://openalex.org/W2191233876', 'https://openalex.org/W2201379305', 'https://openalex.org/W2330820318', 'https://openalex.org/W2339890238', 'https://openalex.org/W2506663245', 'https://openalex.org/W2526607882', 'https://openalex.org/W2560367415', 'https://openalex.org/W2561459036', 'https://openalex.org/W2572174216', 'https://openalex.org/W2606495925', 'https://openalex.org/W2622499649', 'https://openalex.org/W2673558759', 'https://openalex.org/W2740497784', 'https://openalex.org/W2747774814', 'https://openalex.org/W2767010895', 'https://openalex.org/W2779221466', 'https://openalex.org/W2790164909', 'https://openalex.org/W2791483720', 'https://openalex.org/W2797675588', 'https://openalex.org/W2797855256', 'https://openalex.org/W2804812017', 'https://openalex.org/W2889242099', 'https://openalex.org/W2891795654', 'https://openalex.org/W2892387054', 'https://openalex.org/W2895123463', 'https://openalex.org/W2909679049', 'https://openalex.org/W2911188335', 'https://openalex.org/W2921349646', 'https://openalex.org/W2921564361', 'https://openalex.org/W2946272661', 'https://openalex.org/W2950628134', 'https://openalex.org/W2970410478', 'https://openalex.org/W2981171248', 'https://openalex.org/W3061157080'], 'related_works': ['https://openalex.org/W4393219064', 'https://openalex.org/W4361271945', 'https://openalex.org/W4200507838', 'https://openalex.org/W3204147903', 'https://openalex.org/W3197188017', 'https://openalex.org/W2921651111', 'https://openalex.org/W2794408630', 'https://openalex.org/W2263980547', 'https://openalex.org/W2153718647', 'https://openalex.org/W2085972006'], 'abstract_inverted_index': {'//': [0], 'Richard': [1], 'K.': [2], 'Yang': [3], '1': [4, 13, 18, 22, 39, 54], ',': [5, 9, 14, 19, 23, 27, 31, 35, 40, 44], 'Yun': [6], 'Qing': [7], '2': [8, 34, 68], 'Fatima': [10], 'Zahra': [11], 'Jelloul': [12], 'Mark': [15], 'J.': [16], 'Routbort': [17], 'Peng': [20], 'Wang': [21], 'Kenna': [24], 'Shaw': [25], '3': [26, 82], 'Jiexin': [28], 'Zhang': [29], '4': [30, 99], 'Jack': [32], 'Lee': [33], 'L.': [36], 'Jeffrey': [37], 'Medeiros': [38], 'Scott': [41], 'Kopetz': [42], '5': [43, 116], 'Michael': [45], 'T.': [46], 'Tetzlaff': [47], '6': [48, 132], 'and': [49, 103, 137, 155, 252, 294, 296, 314, 350, 391, 395], 'Russell': [50, 171], 'R.': [51, 172], 'Broaddus': [52], '7': [53, 151], 'Department': [55, 69, 100, 117, 152], 'of': [56, 59, 70, 73, 90, 101, 107, 118, 123, 134, 142, 153, 159, 212, 232, 238, 289, 360, 389], 'Hematopathology,': [57], 'University': [58, 72, 89, 106, 122, 141, 158], 'Texas': [60, 74, 91, 108, 124, 143], 'MD': [61, 75, 92, 109, 125, 144], 'Anderson': [62, 76, 93, 110, 126, 145], 'Cancer': [63, 77, 86, 94, 111, 127, 146], 'Center,': [64, 78, 95, 112, 128, 147], 'Houston,': [65, 79, 96, 113, 129, 148], 'TX,': [66, 80, 97, 114, 130, 149], 'USA': [67, 81, 98, 115, 131, 150, 168], 'Biostatistics,': [71], 'Institute': [83], 'for': [84, 215], 'Personalized': [85], 'Treatment': [87], '(IPCT),': [88], 'Bioinformatics': [102], 'Computational': [104], 'Biology,': [105], 'Gastrointestinal': [119], 'Medical': [120], 'Oncology,': [121], 'Departments': [133], 'Anatomical': [135], 'Pathology': [136, 154], 'Translational': [138], 'Molecular': [139], 'Pathology,': [140], 'Laboratory': [156], 'Medicine,': [157], 'North': [160], 'Carolina': [161], 'at': [162], 'Chapel': [163, 165], 'Hill,': [164, 166], 'NC,': [167], 'Correspondence': [169], 'to:': [170], 'Broaddus,': [173], 'email:': [174], '[email protected]': [175], 'Keywords:': [176], 'biomarkers;': [177], 'immunotherapy;': [178], 'mutations;': [179], 'TMB;': [180], 'histology': [181, 394], 'Received:': [182], 'October': [183], '21,': [184], '2019    ': [185], 'Accepted:': [186], 'January': [187], '13,': [188], '2020    ': [189], 'Published:': [190], 'February': [191], '11,': [192], '2020': [193], 'ABSTRACT': [194], 'Patients': [195], 'with': [196, 235, 261, 273, 304, 309, 317, 329, 372, 385], 'advanced': [197, 239, 373], 'solid': [198, 240, 374], 'malignancies': [199], 'recurrent': [200], 'or': [201], 'resistant': [202], 'to': [203, 249, 279, 383], 'standard': [204], 'therapy': [205, 256], 'have': [206], 'limited': [207], 'treatment': [208, 260, 270, 355], 'options.': [209], 'The': [210], 'role': [211], 'molecular': [213], 'biomarkers': [214], 'predicting': [216], 'immune': [217], 'checkpoint': [218], 'blockade': [219], '(ICB)': [220], 'efficacy': [221], 'are': [222, 368], 'not': [223], 'well': [224], 'characterized': [225], 'in': [226, 243, 320, 370], 'these': [227, 333], 'patients.': [228, 323], 'Tumor': [229, 324], 'mutational': [230], 'profiles': [231], '490': [233], 'patients': [234, 334, 371, 384], 'a': [236, 244], 'variety': [237], 'tumors': [241], 'enrolled': [242], 'prospective': [245], 'protocol': [246], 'were': [247], 'analyzed': [248], 'identify': [250], 'prognostic': [251], 'predictive': [253], 'biomarkers.': [254], 'ICB': [255, 269, 312, 321, 354], 'was': [257, 271, 327, 356], 'defined': [258], 'as': [259], 'any': [262], 'CTLA-4,': [263], 'PD-1,': [264], 'and/or': [265], 'PD-L1': [266], 'monoclonal': [267], 'antibody.': [268], 'associated': [272, 303, 308, 328], 'significantly': [274], 'improved': [275, 315, 361], 'overall': [276, 362], 'survival': [277, 302, 307], 'compared': [278], 'non-ICB': [280], 'therapy.': [281], 'Multivariate': [282], 'regression': [283], 'analysis': [284, 343], 'including': [285, 344], 'the': [286, 377, 386], 'two': [287], 'variables': [288], 'tumor': [290, 393], 'mutation': [291, 326], 'burden': [292], '(TMB)': [293], 'ICB,': [295, 305], 'their': [297], 'interaction': [298], 'term,': [299], 'showed': [300], 'favorable': [301], 'unfavorable': [306], 'TMB': [310, 319, 351, 390], 'without': [311], 'treatment,': [313], 'outcome': [316], 'increasing': [318], 'treated': [322], 'TP53': [325], 'worse': [330], 'survival,': [331], 'but': [332, 376], 'still': [335], 'benefitted': [336], 'from': [337], 'ICB.': [338], 'A': [339], 'more': [340], 'comprehensive': [341], 'multivariate': [342], 'cancer': [345], 'type,': [346], 'specific': [347, 392], 'gene': [348], 'mutations,': [349], 'revealed': [352], 'that': [353], 'an': [357], 'independent': [358], 'predictor': [359], 'survival.': [363], 'Therefore,': [364], 'ICB-based': [365], 'therapeutic': [366], 'trials': [367], 'beneficial': [369], 'malignancies,': [375], 'most': [378], 'benefit': [379], 'may': [380], 'be': [381], 'restricted': [382], 'right': [387], 'combination': [388], 'genotype.': [396]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3005844571', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 3}], 'updated_date': '2024-12-12T20:51:30.733644', 'created_date': '2020-02-24'}