Publication Information

{'id': 'https://openalex.org/W3004887264', 'doi': 'https://doi.org/10.1371/journal.pntd.0008054', 'title': 'Pathogenesis of local necrosis induced by Naja atra venom: Assessment of the neutralization ability of Taiwanese freeze-dried neurotoxic antivenom in animal models', 'display_name': 'Pathogenesis of local necrosis induced by Naja atra venom: Assessment of the neutralization ability of Taiwanese freeze-dried neurotoxic antivenom in animal models', 'publication_year': 2020, 'publication_date': '2020-02-07', 'ids': {'openalex': 'https://openalex.org/W3004887264', 'doi': 'https://doi.org/10.1371/journal.pntd.0008054', 'mag': '3004887264', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/32032357', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/7032728'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pntd.0008054', 'pdf_url': 'https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.pntd.0008054/2/pntd.0008054.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210220%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210220T143925Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=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', 'source': {'id': 'https://openalex.org/S46544255', 'display_name': 'PLoS neglected tropical diseases', 'issn_l': '1935-2727', 'issn': ['1935-2727', '1935-2735'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.pntd.0008054/2/pntd.0008054.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210220%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210220T143925Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=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', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5008094900', 'display_name': 'Chien-Chun Liu', 'orcid': 'https://orcid.org/0000-0002-2324-7976'}, 'institutions': [{'id': 'https://openalex.org/I173093425', 'display_name': 'Chang Gung University', 'ror': 'https://ror.org/00d80zx46', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I173093425']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Chien-Chun Liu', 'raw_affiliation_strings': ['Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan'], 'affiliations': [{'raw_affiliation_string': 'Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan', 'institution_ids': ['https://openalex.org/I173093425']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5080848126', 'display_name': 'Yu-Shao Chou', 'orcid': 'https://orcid.org/0000-0003-3205-2385'}, 'institutions': [{'id': 'https://openalex.org/I4210098629', 'display_name': 'En Chu Kong Hospital', 'ror': 'https://ror.org/015a6df35', 'country_code': 'TW', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210098629']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Yu-Shao Chou', 'raw_affiliation_strings': ['Department of Emergency Medicine, En Chu Kong Hospital, New Taipei City, Taiwan'], 'affiliations': [{'raw_affiliation_string': 'Department of Emergency Medicine, En Chu Kong Hospital, New Taipei City, Taiwan', 'institution_ids': ['https://openalex.org/I4210098629']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100347522', 'display_name': 'Chun‐Yu Chen', 'orcid': 'https://orcid.org/0000-0001-7199-3271'}, 'institutions': [{'id': 'https://openalex.org/I4210098629', 'display_name': 'En Chu Kong Hospital', 'ror': 'https://ror.org/015a6df35', 'country_code': 'TW', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210098629']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Chun-Yu Chen', 'raw_affiliation_strings': ['Department of Emergency Medicine, En Chu Kong Hospital, New Taipei City, Taiwan'], 'affiliations': [{'raw_affiliation_string': 'Department of Emergency Medicine, En Chu Kong Hospital, New Taipei City, Taiwan', 'institution_ids': ['https://openalex.org/I4210098629']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047518852', 'display_name': 'Kuei-Lin Liu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I148366613', 'display_name': 'National Yang Ming Chiao Tung University', 'ror': 'https://ror.org/00se2k293', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I148366613']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Kuei-Lin Liu', 'raw_affiliation_strings': ['Faculty of Biotechnology and Laboratory Science in Medicine, School of Medical Technology and Engineering, National Yang-Ming University, Taipei, Taiwan'], 'affiliations': [{'raw_affiliation_string': 'Faculty of Biotechnology and Laboratory Science in Medicine, School of Medical Technology and Engineering, National Yang-Ming University, Taipei, Taiwan', 'institution_ids': ['https://openalex.org/I148366613', 'https://openalex.org/I148366613']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050807379', 'display_name': 'Guo‐Jen Huang', 'orcid': 'https://orcid.org/0000-0002-6392-2155'}, 'institutions': [{'id': 'https://openalex.org/I173093425', 'display_name': 'Chang Gung University', 'ror': 'https://ror.org/00d80zx46', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I173093425']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Guo-Jen Huang', 'raw_affiliation_strings': ['Department and Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan'], 'affiliations': [{'raw_affiliation_string': 'Department and Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan', 'institution_ids': ['https://openalex.org/I173093425']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022647839', 'display_name': 'Jau‐Song Yu', 'orcid': 'https://orcid.org/0000-0002-4295-983X'}, 'institutions': [{'id': 'https://openalex.org/I173093425', 'display_name': 'Chang Gung University', 'ror': 'https://ror.org/00d80zx46', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I173093425']}, {'id': 'https://openalex.org/I141243467', 'display_name': 'Chang Gung University of Science and Technology', 'ror': 'https://ror.org/009knm296', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I141243467']}, {'id': 'https://openalex.org/I3020100970', 'display_name': 'Chang Gung Memorial Hospital', 'ror': 'https://ror.org/02verss31', 'country_code': 'TW', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3020100970']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Jau-Song Yu', 'raw_affiliation_strings': ['Department of Cell and Molecular Biology, College of Medicine, Chang Gung University, Taoyuan, Taiwan', 'Liver Research Center, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan', 'Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan', 'Research Center for Food and Cosmetic Safety, Research Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan'], 'affiliations': [{'raw_affiliation_string': 'Department of Cell and Molecular Biology, College of Medicine, Chang Gung University, Taoyuan, Taiwan', 'institution_ids': ['https://openalex.org/I173093425']}, {'raw_affiliation_string': 'Research Center for Food and Cosmetic Safety, Research Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan', 'institution_ids': ['https://openalex.org/I141243467']}, {'raw_affiliation_string': 'Liver Research Center, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan', 'institution_ids': ['https://openalex.org/I3020100970']}, {'raw_affiliation_string': 'Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan', 'institution_ids': ['https://openalex.org/I173093425']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051960294', 'display_name': 'Cho-Ju Wu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I173093425', 'display_name': 'Chang Gung University', 'ror': 'https://ror.org/00d80zx46', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I173093425']}, {'id': 'https://openalex.org/I3020100970', 'display_name': 'Chang Gung Memorial Hospital', 'ror': 'https://ror.org/02verss31', 'country_code': 'TW', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3020100970']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Cho-Ju Wu', 'raw_affiliation_strings': ['Department of Emergency Medicine, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, Taiwan'], 'affiliations': [{'raw_affiliation_string': 'Department of Emergency Medicine, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, Taiwan', 'institution_ids': ['https://openalex.org/I173093425', 'https://openalex.org/I3020100970']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5089212401', 'display_name': 'Geng-Wang Liaw', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210115437', 'display_name': 'Tao Yuan General Hospital', 'ror': 'https://ror.org/0367d2222', 'country_code': 'TW', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210115437', 'https://openalex.org/I4210121532']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Geng-Wang Liaw', 'raw_affiliation_strings': ['Department of Emergency Medicine, Yeezen General Hospital, Taoyuan, Taiwan'], 'affiliations': [{'raw_affiliation_string': 'Department of Emergency Medicine, Yeezen General Hospital, Taoyuan, Taiwan', 'institution_ids': ['https://openalex.org/I4210115437']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005496850', 'display_name': 'C.H. Hsieh', 'orcid': 'https://orcid.org/0000-0003-4961-8779'}, 'institutions': [{'id': 'https://openalex.org/I47519274', 'display_name': 'Taipei Medical University', 'ror': 'https://ror.org/05031qk94', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I47519274']}, {'id': 'https://openalex.org/I4210098629', 'display_name': 'En Chu Kong Hospital', 'ror': 'https://ror.org/015a6df35', 'country_code': 'TW', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210098629']}], 'countries': ['TW'], 'is_corresponding': True, 'raw_author_name': 'Cheng-Hsien Hsieh', 'raw_affiliation_strings': ['Department of Emergency Medicine, En Chu Kong Hospital, New Taipei City, Taiwan', 'Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan'], 'affiliations': [{'raw_affiliation_string': 'Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan', 'institution_ids': ['https://openalex.org/I47519274']}, {'raw_affiliation_string': 'Department of Emergency Medicine, En Chu Kong Hospital, New Taipei City, Taiwan', 'institution_ids': ['https://openalex.org/I4210098629']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5101848187', 'display_name': 'Chun-Kuei Chen', 'orcid': 'https://orcid.org/0000-0002-8367-4320'}, 'institutions': [{'id': 'https://openalex.org/I173093425', 'display_name': 'Chang Gung University', 'ror': 'https://ror.org/00d80zx46', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I173093425']}, {'id': 'https://openalex.org/I3020100970', 'display_name': 'Chang Gung Memorial Hospital', 'ror': 'https://ror.org/02verss31', 'country_code': 'TW', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3020100970']}], 'countries': ['TW'], 'is_corresponding': True, 'raw_author_name': 'Chun-Kuei Chen', 'raw_affiliation_strings': ['Department of Emergency Medicine, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, Taiwan'], 'affiliations': [{'raw_affiliation_string': 'Department of Emergency Medicine, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, Taiwan', 'institution_ids': ['https://openalex.org/I173093425', 'https://openalex.org/I3020100970']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 7, 'corresponding_author_ids': ['https://openalex.org/A5005496850', 'https://openalex.org/A5101848187'], 'corresponding_institution_ids': ['https://openalex.org/I47519274', 'https://openalex.org/I4210098629', 'https://openalex.org/I173093425', 'https://openalex.org/I3020100970'], 'apc_list': {'value': 2495, 'currency': 'USD', 'value_usd': 2495, 'provenance': 'doaj'}, 'apc_paid': {'value': 2495, 'currency': 'USD', 'value_usd': 2495, 'provenance': 'doaj'}, 'fwci': 5.621, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 44, 'citation_normalized_percentile': {'value': 0.99995, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '14', 'issue': '2', 'first_page': 'e0008054', 'last_page': 'e0008054'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11353', 'display_name': 'Snake Venom Evolution and Toxinology', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11353', 'display_name': 'Snake Venom Evolution and Toxinology', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11780', 'display_name': 'Rabies Virus Transmission and Control', 'score': 0.9876, 'subfield': {'id': 'https://openalex.org/subfields/2406', 'display_name': 'Virology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12142', 'display_name': 'Evolution and Diversity of Cnidarians and Jellyfish Blooms', 'score': 0.9533, 'subfield': {'id': 'https://openalex.org/subfields/1911', 'display_name': 'Paleontology'}, 'field': {'id': 'https://openalex.org/fields/19', 'display_name': 'Earth and Planetary Sciences'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cobra', 'display_name': 'Cobra', 'score': 0.82383716}, {'id': 'https://openalex.org/keywords/naja', 'display_name': 'Naja', 'score': 0.7276454}, {'id': 'https://openalex.org/keywords/antivenom', 'display_name': 'Antivenom', 'score': 0.432389}, {'id': 'https://openalex.org/keywords/viper-venoms', 'display_name': 'Viper Venoms', 'score': 0.42629433}], 'concepts': [{'id': 'https://openalex.org/C145600735', 'wikidata': 'https://www.wikidata.org/wiki/Q3055418', 'display_name': 'Envenomation', 'level': 3, 'score': 0.94658846}, {'id': 'https://openalex.org/C117287731', 'wikidata': 'https://www.wikidata.org/wiki/Q424427', 'display_name': 'Antivenom', 'level': 3, 'score': 0.92160994}, {'id': 'https://openalex.org/C2779448229', 'wikidata': 'https://www.wikidata.org/wiki/Q3386847', 'display_name': 'Venom', 'level': 2, 'score': 0.9118731}, {'id': 'https://openalex.org/C2779547071', 'wikidata': 'https://www.wikidata.org/wiki/Q608565', 'display_name': 'Cobra', 'level': 2, 'score': 0.82383716}, {'id': 'https://openalex.org/C2778256186', 'wikidata': 'https://www.wikidata.org/wiki/Q220475', 'display_name': 'Naja', 'level': 3, 'score': 0.7276454}, {'id': 'https://openalex.org/C503630168', 'wikidata': 'https://www.wikidata.org/wiki/Q178069', 'display_name': 'Necrosis', 'level': 2, 'score': 0.65799785}, {'id': 'https://openalex.org/C2776725428', 'wikidata': 'https://www.wikidata.org/wiki/Q424200', 'display_name': 'Snake venom', 'level': 3, 'score': 0.5369506}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.51577187}, {'id': 'https://openalex.org/C29730261', 'wikidata': 'https://www.wikidata.org/wiki/Q274160', 'display_name': 'Toxicity', 'level': 2, 'score': 0.48540935}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.4588713}, {'id': 'https://openalex.org/C2910624479', 'wikidata': 'https://www.wikidata.org/wiki/Q163656', 'display_name': 'Viper Venoms', 'level': 4, 'score': 0.42629433}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.39394408}, {'id': 'https://openalex.org/C33070731', 'wikidata': 'https://www.wikidata.org/wiki/Q7218', 'display_name': 'Toxicology', 'level': 1, 'score': 0.35489997}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.3338164}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.20083657}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.08981934}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.072035104}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C199360897', 'wikidata': 'https://www.wikidata.org/wiki/Q9143', 'display_name': 'Programming language', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000997', 'descriptor_name': 'Antivenins', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D004546', 'descriptor_name': 'Elapid Venoms', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': True}, {'descriptor_ui': 'D000073176', 'descriptor_name': 'Naja naja', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D009336', 'descriptor_name': 'Necrosis', 'qualifier_ui': 'Q000139', 'qualifier_name': 'chemically induced', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000997', 'descriptor_name': 'Antivenins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003603', 'descriptor_name': 'Cytotoxins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D003603', 'descriptor_name': 'Cytotoxins', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': False}, {'descriptor_ui': 'D003603', 'descriptor_name': 'Cytotoxins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004546', 'descriptor_name': 'Elapid Venoms', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D004546', 'descriptor_name': 'Elapid Venoms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008813', 'descriptor_name': 'Mice, Inbred ICR', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009336', 'descriptor_name': 'Necrosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013624', 'descriptor_name': 'Taiwan', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pntd.0008054', 'pdf_url': 'https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.pntd.0008054/2/pntd.0008054.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210220%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210220T143925Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=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', 'source': {'id': 'https://openalex.org/S46544255', 'display_name': 'PLoS neglected tropical diseases', 'issn_l': '1935-2727', 'issn': ['1935-2727', '1935-2735'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/49125d4ef0ab4221b3c5cec3e9cc3cfc', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc7032728', 'pdf_url': 'https://europepmc.org/articles/pmc7032728?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032728', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/32032357', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pntd.0008054', 'pdf_url': 'https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.pntd.0008054/2/pntd.0008054.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210220%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210220T143925Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=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', 'source': {'id': 'https://openalex.org/S46544255', 'display_name': 'PLoS neglected tropical diseases', 'issn_l': '1935-2727', 'issn': ['1935-2727', '1935-2735'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.83, 'display_name': 'Good health and well-being'}], 'grants': [{'funder': 'https://openalex.org/F4320311687', 'funder_display_name': 'Ministry of Education', 'award_id': 'The Featured Areas Research Center Program within the framework of the Higher Education Sprout Project'}, {'funder': 'https://openalex.org/F4320313619', 'funder_display_name': 'Chang Gung Memorial Hospital', 'award_id': 'CMRPG3J1231'}], 'datasets': [], 'versions': [], 'referenced_works_count': 66, 'referenced_works': ['https://openalex.org/W1017783917', 'https://openalex.org/W1046308452', 'https://openalex.org/W140898829', 'https://openalex.org/W1538245086', 'https://openalex.org/W1600416640', 'https://openalex.org/W1807395722', 'https://openalex.org/W1888357425', 'https://openalex.org/W1964776669', 'https://openalex.org/W1965466373', 'https://openalex.org/W1968219289', 'https://openalex.org/W1973640952', 'https://openalex.org/W1976745046', 'https://openalex.org/W1979740497', 'https://openalex.org/W1983204053', 'https://openalex.org/W1987130760', 'https://openalex.org/W1990228949', 'https://openalex.org/W1991060344', 'https://openalex.org/W1992840908', 'https://openalex.org/W1994285164', 'https://openalex.org/W2013622729', 'https://openalex.org/W2017237521', 'https://openalex.org/W2021640998', 'https://openalex.org/W2027878533', 'https://openalex.org/W2031026207', 'https://openalex.org/W2043338537', 'https://openalex.org/W2044533949', 'https://openalex.org/W2045134781', 'https://openalex.org/W2055158765', 'https://openalex.org/W2061651481', 'https://openalex.org/W2062537454', 'https://openalex.org/W2066337733', 'https://openalex.org/W2070654370', 'https://openalex.org/W2080523723', 'https://openalex.org/W2082723832', 'https://openalex.org/W2096642770', 'https://openalex.org/W2116310119', 'https://openalex.org/W2117250036', 'https://openalex.org/W2129916378', 'https://openalex.org/W2135696719', 'https://openalex.org/W2163754385', 'https://openalex.org/W2169475430', 'https://openalex.org/W2179227226', 'https://openalex.org/W2409713086', 'https://openalex.org/W2414480511', 'https://openalex.org/W2417578947', 'https://openalex.org/W2434176832', 'https://openalex.org/W2511415280', 'https://openalex.org/W2582068659', 'https://openalex.org/W2613564777', 'https://openalex.org/W2620531876', 'https://openalex.org/W2746991280', 'https://openalex.org/W2750983690', 'https://openalex.org/W2772298728', 'https://openalex.org/W2789977408', 'https://openalex.org/W2883399150', 'https://openalex.org/W2884065583', 'https://openalex.org/W2885727107', 'https://openalex.org/W2891026587', 'https://openalex.org/W2891511525', 'https://openalex.org/W2892876673', 'https://openalex.org/W2895496182', 'https://openalex.org/W2899848977', 'https://openalex.org/W3037495005', 'https://openalex.org/W3152322903', 'https://openalex.org/W4211091111', 'https://openalex.org/W4234322560'], 'related_works': ['https://openalex.org/W4388802840', 'https://openalex.org/W4281783961', 'https://openalex.org/W4251611408', 'https://openalex.org/W3187388234', 'https://openalex.org/W2905488398', 'https://openalex.org/W2325868957', 'https://openalex.org/W2202972404', 'https://openalex.org/W2111544031', 'https://openalex.org/W2093393382', 'https://openalex.org/W1959355421'], 'abstract_inverted_index': {'Naja': [0], 'atra': [1, 94, 112, 166, 211, 249], 'envenomation': [2, 39], 'is': [3, 19, 79, 83], 'one': [4], 'of': [5, 26, 37, 48, 54, 69, 74, 110, 145, 163, 180, 198, 208, 234, 244, 247], 'the': [6, 24, 35, 67, 71, 87, 107, 118, 142, 193, 231, 245], 'most': [7], 'significant': [8], 'clinical': [9, 232, 263], 'snakebite': [10, 264], 'concerns': [11], 'in': [12, 61, 100, 157, 161, 225, 266], 'Taiwan.': [13, 267], 'Taiwanese': [14], 'freeze-dried': [15], 'neurotoxic': [16], 'antivenom': [17, 259], '(FNAV)': [18], 'currently': [20], 'used': [21, 129], 'clinically': [22], 'for': [23, 140, 214, 221, 256], 'treatment': [25], 'cobra': [27, 38, 64, 126, 181, 235], 'snakebite,': [28], 'and': [29, 128, 133, 200, 216, 251, 261], 'has': [30, 96], 'been': [31, 98], 'shown': [32], 'to': [33, 40, 85, 136, 171, 187], 'limit': [34], 'mortality': [36], 'less': [41], 'than': [42, 46], '1%.': [43], 'However,': [44], 'more': [45, 241], 'half': [47], 'victims': [49], '(60%)': [50], 'require': [51], 'surgery': [52], 'because': [53], 'local': [55, 88, 223], 'tissue': [56], 'necrosis,': [57], 'a': [58, 175, 206, 218, 240, 254], 'major': [59, 108], 'problem': [60], 'patients': [62], 'with': [63], 'envenomation.': [65], 'Although': [66], 'importance': [68], 'evaluating': [70], 'neutralizing': [72], 'effect': [73], 'FNAV': [75, 82, 146, 168, 215], 'on': [76], 'this': [77], 'pathology': [78], 'recognized,': [80], 'whether': [81], 'able': [84, 170], 'prevent': [86, 188], 'necrosis': [89, 195, 224], 'extension': [90], 'induced': [91], 'by': [92], 'N.': [93, 111, 165, 210, 248], 'venom': [95, 113, 127, 132, 148, 201, 212], 'not': [97], 'investigated': [99], 'detail.': [101], 'Cytotoxins': [102], '(CTXs)': [103], 'are': [104], 'considered': [105], 'as': [106, 253], 'components': [109], 'that': [114, 228], 'cause': [115], 'necrosis.': [116], 'In': [117], 'current': [119, 258], 'study,': [120], 'we': [121, 204], 'isolated': [122], 'CTXs': [123, 135, 160, 199], 'from': [124, 174], 'whole': [125, 131, 164, 209], 'both': [130], 'purified': [134], 'develop': [137], 'animal': [138], 'models': [139, 227], 'assessing': [141], 'neutralization': [143], 'potential': [144], 'against': [147], 'necrotizing': [149], 'activity.': [150], 'Local': [151], 'necrotic': [152], 'lesions': [153], 'were': [154], 'successfully': [155, 229], 'produced': [156], 'mice': [158, 173], 'using': [159, 192], 'place': [162], 'venom.': [167], 'was': [169, 185], 'rescue': [172], 'subcutaneously': [176], 'injected': [177], 'lethal': [178], 'dose': [179, 196, 207], 'venom;': [182], 'however,': [183], 'it': [184], 'unable': [186], 'CTX-induced': [189], 'dermo-necrosis.': [190], 'Furthermore,': [191], 'minimal': [194], '(MND)': [197], 'proteome': [202], 'data,': [203], 'found': [205], 'suitable': [213], 'developed': [217], 'workable': [219], 'protocol': [220], 'inducing': [222], 'rodent': [226], 'imitated': [230], 'circumstance': [233], 'envenoming.': [236], 'This': [237], 'information': [238], 'provides': [239], 'comprehensive': [242], 'understanding': [243], 'pathophysiology': [246], 'envenomation,': [250], 'serves': [252], 'guide': [255], 'improving': [257], 'strategies': [260], 'advancing': [262], 'management': [265]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3004887264', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 14}, {'year': 2022, 'cited_by_count': 14}, {'year': 2021, 'cited_by_count': 8}, {'year': 2020, 'cited_by_count': 2}], 'updated_date': '2024-09-24T17:58:43.967312', 'created_date': '2020-02-14'}