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[413], 'Learn': [414], 'more.Copy': [415], 'URL': [416], 'Share': [417], 'linkShare': [419], 'onFacebookTwitterLinkedInRedditWechat': [420], 'To': [421], 'Editor:': [423], 'Over': [424], 'past': [426], 'five': [427, 1403, 1447], 'decades,': [428], '361': [429, 1987], '(12%)': [430], '3023patients': [432], 'neoplasms': [435, 1979], '(MPN),': [436], 'seen': [437], 'at': [438, 749, 1000], 'were': [442, 632, 665, 787, 810, 838, 860, 870, 908, 1395, 1425, 1676], 'age': [443, 748, 1586, 1653, 1989], '40': [444, 813, 1077, 1990], 'years': [445, 611, 757, 1589, 1785, 1991], 'or': [446, 640, 743, 1570, 1633, 1673, 1733, 1768, 1931, 1992], 'younger;': [447], 'specific': [448], 'diagnosis': [449, 627, 754, 1684], 'approximately': [451], 'half': [452, 704], 'these': [454], 'patients': [455, 869, 1988, 2041, 2064], 'was': [456, 628, 684, 755, 1480, 1543, 1561, 1686, 1757], 'essential': [457, 996, 2043, 2066, 2091, 2120, 2157], 'thrombocythemia': [458, 997, 2067, 2121, 2158], '(ET).1': [459], 'True': [460], 'incidence': [461], 'pregnancy': [463, 486, 553, 659, 712, 751, 904, 981, 990, 1002, 1126, 1132, 1138, 1144, 1181, 1245, 1415, 1451, 1457, 1465, 1474, 1540, 1548, 1560, 1698, 1717, 1756, 1774, 1804, 1826, 1874, 2038, 2061, 2088], 'MPN': [465, 600, 626, 1817], 'is': [466, 473, 480, 498, 514, 1444], 'difficult': [467], 'ascertain': [469], 'since': [470], 'most': [471, 488], 'data': [472], 'derived': [474], 'from': [475, 518, 678, 1818, 1886, 2125], 'retrospective': [476], 'series.': [477], 'However,': [478], 'it': [479], 'known': [481, 833], 'that': [482, 1446, 1538, 1685], 'among': [483], 'MPNs,': [485], 'occurs': [487], 'frequently': [489], 'ET,': [491, 613], 'followed': [492], 'polycythemia': [494, 2160], 'vera': [495], '(PV)': [496], 'but': [497], 'extremely': [499], 'rare': [500], 'context': [503], 'primary': [505], 'myelofibrosis': [506], '(PMF).2': [507], 'In': [508, 1809], 'ET': [509, 735, 753, 906, 1004, 1009, 1184, 1527, 1625], 'live': [511, 635, 1396, 1484, 1710, 1738, 1836, 1852], 'birth': [512, 1235, 1303, 1439, 1485, 1837, 1853], 'rate': [513], 'highly': [515, 1544], 'variable': [516], 'ranging': [517], '50%': [519], '75%': [521], 'primarily': [522], 'due': [523], 'first': [525, 750, 865, 903, 923, 1001, 1006, 1131, 1143, 1456, 1539, 1697, 1773, 1871], 'trimester': [526, 638, 1197, 1201, 1264, 1268, 1399, 1429, 1434], 'fetal': [527, 531, 556, 576, 745, 918, 958, 1416, 1426, 1452, 1534, 1541, 1566, 1621, 1705, 1734, 1866, 1898], 'loss.': [528, 746, 1417], 'Predictors': [529, 2086], 'loss': [532, 919, 1400, 1466, 1535, 1542, 1549, 1567, 1622, 1867, 1899], 'including': [533, 555], 'role': [535], 'JAK2V617F': [538, 839, 1057, 1348], 'mutation': [539, 1602, 1607], 'remain': [540], 'debatable.2-5': [541], 'The': [542, 1891, 1961], 'current': [543, 1943], 'study': [544, 1892, 2096], 'aims': [545], 'to:': [546], '(a)': [547], 'provide': [548], 'an': [549, 1695, 1771], 'accurate': [550], 'description': [551], 'maternal': [558, 1585], 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'leukocyte': [763, 1660], 'count': [764, 775, 1027, 1035, 1661, 1667, 2151], '×': [767, 771, 778, 782, 1663, 1669, 1792, 1796], '109/L': [768, 779, 1670, 1793, 1797], '3.9-19.8': [770], '109/L)': [772], 'platelet': [774, 1666, 1788], '849': [777], '(range;': [780], '252-1998': [781], '109/L).': [783], 'Seven': [784], '(13%)': [786], 'active': [788], 'smokers,': [789], 'diabetes': [791], 'mellitus,': [792, 1111], 'hypertension': [793, 1112], 'hyperlipidemia': [795], 'woman': [798, 884], 'each.': [799, 968], 'International': [800], 'Prognostic': [801, 1315], 'Score': [802, 1316], 'Thrombosis': [804, 1116, 1123, 1129, 1212, 1280, 1318], 'Essential': [806, 1320], 'Thrombocythemia': [807], '(IPSET-thrombosis)': [808], 'categories': [809], 'computable': [811], 'women;': [814, 1651], 'low': [815, 896, 1352], '20),': [818], 'intermediate': [819, 1327], '14),': [822], 'high': [824, 1333], 'risk': [825, 1080, 1084, 1088, 1106, 1323, 1343, 2059, 2146], '6).': [828], 'Among': [829], '34': [830, 911, 1053, 1188], 'mutational': [835, 2035], 'status,': [836], '45%': [837], 'mutated': [840, 846, 1800], '18),': [843], '30%': [844], 'CALR': [845, 1065, 1606, 1799, 1929], '12)': [849], 'remainder': [852, 916], 'triple': [853], 'negative.': [854], 'group': [856], '33(60%)': [858], 'aspirin': [862, 1557, 1572, 1760, 1864, 1912], 'therapy': [863, 873, 1169, 1358, 1635], 'during': [864, 1559], 'pregnancy,': [866, 1390], 'additionally': [867], '13': [868, 1127, 1210], 'receiving': [871], 'cytoreductive': [872, 1164, 1634], '(interferon': [874], '8),': [877], 'anagrelide': [878], '3),': [881, 940], 'each': [885, 1805], 'hydroxyurea': [887], 'radioactive': [889], 'phosphorus).': [890, 1367], 'Five': [891], 'received': [893], 'anticoagulation': [894, 1629], 'molecular': [897, 1353], 'weight': [898, 1354], 'heparin.': [899, 1355], 'Live': [900, 1185, 1251], 'births': [901, 967], 'noted': [909], '(62%)': [913], 'experiencing': [917], 'predominantly': [920], 'trimester.': [924], '24%': [928], 'post-partum': [931, 1745], '5),': [935], 'venous': [936, 1681], 'thromboembolism': [937], 'preeclampsia': [941], '3)': [944], 'abruption': [947, 1151, 1222, 1290], '2).': [950], 'On': [951, 1553], 'other': [953, 1555], 'hand': [954], 'only': [955], '(7%)': [957], 'arose;': [960], 'two': [961, 1713, 1725], 'intrauterine': [962], 'growth': [963, 1380], 'retardation': [964], 'pre-term': [966], 'We': [969], 'recommend': [970], 'referring': [971], 'Table': [973, 985], '1': [974, 1272], 'details': [976], 'clinical': [978], 'parameters': [979], '1.': [986], 'Clinical': [987, 1091], 'characteristics': [988], '(ET)': [998], 'Variables': [999], 'All': [1005, 1244], 'N': [1010], 'Age': [1013], 'years,': [1015, 1655], '(range)': [1017, 1023, 1031, 1039], '(20-36)': [1019], 'Hemoglobin': [1020], '(g/dL),': [1021], '12.7': [1024], '(9-16.6)': [1025], 'Leukocyte': [1026], '(×': [1028, 1036], '109/L),': [1029, 1037], '8.4': [1032], '(3.9-19.8)': [1033], 'Platelet': [1034], '840': [1040], '(252-1998)': [1041], 'Driver': [1042], '(N': [1044, 1050, 1074, 1093, 1119, 1155], 'evaluable': [1045, 1051, 1075, 1094, 1120, 1156], '40[%]': [1047], 'JAK2)': [1049], '[%]': [1054], 'JAK2,CALR,MPL)': [1056], 'Mutated': [1058], '18': [1059], '(45)': [1060], 'Wild': [1061], 'type': [1062], '22': [1063, 1393], '(55)': [1064], '12': [1066, 1170, 1662], '(35)': [1067, 1086, 1199], 'Triple': [1068], 'negative': [1069], '4': [1070, 1139, 1229, 1281, 1287, 1647, 1940], '(12)': [1071], 'IPSET': [1072, 1616], '[%])': [1078, 1097], 'Low': [1079, 1322], '20': [1081], '(50)': [1082], 'Intermediate': [1083], '14': [1085], 'High': [1087], '(15)': [1090, 1104], 'features': [1092, 1531], '53': [1096], 'Splenomegaly': [1098], '(17)': [1100, 1179], 'Microvascular': [1101], 'symptoms': [1102], '8': [1103], 'Cardiovascular': [1105], 'factors': [1107, 1339, 1582], '10': [1108, 1420], '(19)': [1109], '(diabetes': [1110], 'tobacco': [1113], 'use,': [1114], 'hyperlipidemia)': [1115], '&': [1117], '50[%])': [1122], '(26)': [1128], '3': [1133, 1148, 1213, 1219, 1269, 1300], '(6)': [1134, 1149], 'Hemorrhage': [1135, 1141, 1215, 1283], '(8)': [1140], '(10)': [1146], 'Preeclampsia': [1147, 1218, 1286], 'Placental': [1150, 1221, 1289], '2': [1152, 1202, 1223, 1232, 1236, 1291, 1304], '(4)': [1153, 1203, 1224, 1282, 1288], 'Treatments': [1154], '53[%])': [1158], 'Aspirin': [1159, 1162], 'alone': [1160], '33(62)': [1161], '+': [1163], 'therapya': [1165], '(9)': [1167, 1175, 1217, 1243], 'Cytoreductive': [1168, 1357], '(23)': [1171], 'Anticoagulation': [1172], '(LMWH)': [1173], 'No': [1176], 'treatment': [1177], 'outcome': [1182, 2039, 2089], 'n(%)': [1187], '(62)': [1189], 'n': [1192, 1208, 1227, 1240, 1253, 1259, 1276, 1295, 1308], '(%)': [1193, 1209, 1228, 1241, 1254, 1260, 1277, 1296, 1309], '(38)': [1195], '19': [1198], 'Second': [1200, 1267], 'Stillbirth': [1204, 1271], '0': [1205], 'complicationsb,': [1207, 1275], '(24)': [1211], '(5)': [1214, 1220, 1298], 'complicationsc,': [1226], '(7)': [1230, 1285, 1311], 'IUGR': [1231, 1299], '(3.5)': [1233, 1237], 'Preterm': [1234, 1302], 'Cesarean': [1238, 1306, 1702, 1741], 'section,': [1239, 1307], 'ET(N': [1248], '95)': [1250], '64': [1255], '(67)': [1256], '31': [1261], '(33)': [1262], '27': [1265, 1405], '(28)': [1266], '(3)': [1270, 1301], '(1)': [1273], '17': [1278], '(18)': [1279], '7': [1284, 1310], '(2)': [1292, 1305], 'complicationc,': [1294], 'Note:': [1312], 'IPSET-thrombosis': [1313], '-International': [1314], 'Thrombocythemia:': [1321], 'score': [1324, 1329, 1335], '0-1;': [1326], 'risk,': [1328, 1334], '2;': [1331], '≥': [1336], '3.': [1337], 'Risk': [1338], 'included:': [1340], 'age,': [1341], 'cardiovascular': [1342], 'factors,': [1344, 2147], 'previous': [1345], 'thrombosis,': [1346], 'mutation.': [1349, 2072], 'Abbreviation:': [1350], 'LMWH,': [1351], 'Hydroxyurea,': [1360], 'Interferon': [1361], 'alpha,': [1362], 'Anagrelide': [1363], 'P32': [1365], '(radioactive': [1366], 'b': [1368], 'complications-': [1370, 1378], '(Thrombosis,': [1371], 'hemorrhage,': [1372], 'preeclampsia,': [1373], 'abruption).': [1375], 'c': [1376], '(IUGR-intrauterine': [1379], 'retardation,': [1381], 'preterm': [1382], 'birth).': [1383], 'Twenty': [1384], 'seven': [1385], 'underwent': [1387], 'second': [1389, 1406, 1433, 1464, 1547, 1873], '(81%)': [1394], 'births.': [1397], '(19%);': [1408], 'whom': [1411], 'antecedent': [1414], 'Six': [1418], '(60%)': [1421], 'third': [1423, 1450], 'losses': [1427, 1453], '(first': [1428], '4),': [1432], '1),': [1437], 'still': [1438], '1)).': [1442], 'It': [1443], 'noteworthy': [1445], 'six': [1449], 'coincided': [1454], '(P': [1458, 1467, 1498, 1519, 1550, 1578, 1590, 1594, 1598, 1603, 1608, 1613, 1618, 1626, 1636], '.58),': [1460], '.34).': [1469, 1500], 'An': [1470], 'encouraging': [1471], 'trend': [1472, 1504, 1907], 'preceding': [1478], 'observed': [1481], 'increasing': [1483], 'rates': [1486, 1568, 1838, 1854], '76%': [1488], 'opposed': [1492], '63%': [1494], 'As': [1501], 'expected,': [1502], 'aligned': [1505], 'significant': [1508], 'reduction': [1509], 'both': [1511], 'maternal/fetal': [1512], '(5%': [1516], 'vs': [1517, 1575, 1850], '34%)': [1518], '.007).': [1521], 'Subsequently,': [1522], 'interrogated': [1524], 'disease': [1530], 'predictive': [1532, 1545], 'learnt': [1537], '.004).': [1552], 'hand,': [1556], 'use': [1558, 1913, 1933], 'preventive': [1563], 'measure': [1564], 'without': [1571, 1730, 1765], '27%': [1574], '60%': [1576], 'respectively': [1577], '.02).': [1580], 'Other': [1581], 'such': [1583], '>': [1587], '30': [1588], '.8),': [1592], 'leukocytosis': [1593], '.85),': [1596], 'thrombocytosis': [1597], '.41),': [1600], 'JAK2': [1601, 2070], '.62),': [1605], '.28),': [1610], '.3),': [1615], '.63),': [1620], '.53),': [1628], 'use,P': [1630], '.88),': [1632], '.72)': [1638], 'did': [1639], 'not': [1640], 'outcomes.': [1642], 'With': [1643], 'regards': [1644], 'PV,': [1646], '36': [1649], '(11%)': [1650], '29.7': [1654], 'hemoglobin': [1657], '17.4': [1658], 'g/dL,': [1659], '109/L,': [1664], '703': [1668], 'studied.': [1677], 'Patient': [1678, 1712, 1728, 1763], 'managed': [1687], 'aspirin,': [1689, 1720, 1750], 'enoxaparin': [1690, 1751], 'hydroxyurea.': [1692], 'She': [1693], 'uncomplicated': [1696, 1758], 'save': [1699], 'emergent': [1701], 'section': [1703, 1742], 'distress': [1706], 'resulting': [1707], 'birth.': [1711], 'successful': [1716, 1803], 'while': [1718, 1806], 'despite': [1721], 'spontaneous': [1726], 'miscarriages.': [1727], 'three,': [1729], 'delivered': [1736], 'fetus': [1739], 'complicated': [1743], 'pulmonary': [1746], 'embolism,': [1747], 'treated': [1748], 'phlebotomies.': [1753], 'Her': [1754], 'subsequent': [1755], 'enoxaparin.': [1762], 'uneventful': [1772], 'aspirin.': [1776, 1808], 'Two': [1777], 'PMF': [1780], '28': [1784], 'elevated': [1787], 'counts': [1789], '1205': [1791], '784': [1795], 'respectively,': [1798], 'summary,': [1810], 'largest': [1812], 'analysis': [1813], 'single': [1820, 2094], 'institution': [1821, 2095], 'highlights': [1822], 'substantial': [1823], 'progress': [1824], 'improving': [1833], 'being': [1839], 'consistent': [1840], 'multi-center': [1843], 'Italian': [1844, 2127], 'cohort': [1845, 2016], '122': [1847, 2117], '(76%': [1849], '75.4%': [1851], 'respectively).3,': [1855], 'Salient': [1857], 'findings': [1858], 'include': [1859], 'protective': [1861], 'effect': [1862], 'concordance': [1869], 'losses,': [1875], 'been': [1878], 'partially': [1879], 'endorsed': [1880], 'recent': [1883], 'contemporary': [1884], 'series': [1885, 1944], 'Harvard': [1887], '130': [1889], 'pregnancies.': [1890, 2099], 'showed': [1893], 'adverse': [1894], '(OR': [1900, 1914], '8.82,': [1901], 'P': [1902, 1916], '.023)': [1904], 'toward': [1908], 'improved': [1909], '0.33,': [1915], '.12).7': [1918], 'Our': [1919], 'discrepant': [1920], 'observations': [1921], 'regarding': [1922], 'lack': [1924], 'JAK2,': [1928], 'mutations,': [1930], 'interferon': [1932], 'warrant': [1936], 'further': [1937], 'collaborative': [1938], 'investigations.3,': [1939], 'Lastly,': [1941], 'serves': [1945], 'valuable': [1948], 'resource': [1949], 'reproductive': [1951], 'counseling': [1952], 'young': [1954], 'MPN.': [1957], 'CONFLICT': [1958], 'OF': [1959], 'INTEREST': [1960], 'authors': [1962], 'declare': [1963], 'no': [1964], 'potential': [1965], 'conflict': [1966], 'interest.': [1968], 'REFERENCES': [1969], '1Szuber': [1970], 'N,': [1971, 2079], 'Vallapureddy': [1972], 'RR,': [1973], 'Penna': [1974], 'D,': [1975], 'et': [1976, 2007, 2031, 2056, 2113, 2142], 'al.': [1977, 2008, 2032, 2057, 2114, 2143], 'Myeloproliferative': [1978], 'young:': [1982], 'experience': [1985], 'younger.': [1993], 'Am': [1994, 2129], 'J': [1995, 2019, 2101, 2130], 'Hematol.': [1996, 2131], '2018;': [1997], '93:': [1998], '1474-': [1999], '1484.': [2000], '2Alimam': [2001], 'S,': [2002, 2004, 2083], 'Bewley': [2003], 'Chappell': [2005], 'LC,': [2006], 'UK': [2014], 'prospective': [2015], 'study.': [2017], 'Br': [2018], 'Haematol.': [2020, 2102], '2016;': [2021], '175:': [2022], '31-': [2023], '36.': [2024], '3Rumi': [2025], 'E,': [2026, 2055], 'Bertozzi': [2027], 'I,': [2028], 'Casetti': [2029], 'IC,': [2030], 'Impact': [2033], 'status': [2036], 'thrombocytemia.': [2044], 'Haematologica.': [2045], '2015;': [2046], '100:': [2047], 'e443-': [2048], 'e445.': [2049], '4Passamonti': [2050], 'F,': [2051], 'Randi': [2052], 'ML,': [2053], 'Rumi': [2054], 'Increased': [2058], 'carrying': [2068], '(617V>F)': [2071], 'Blood.': [2073, 2162], '2007;': [2074], '110:': [2075], '485-': [2076], '489.': [2077], '5Gangat': [2078], 'Wolanskyj': [2080], 'AP,': [2081], 'Schwager': [2082], 'A.': [2085], 'thrombocythemia:': [2092], '63': [2098], 'Eur': [2100], '2009;': [2103, 2132], '82:': [2104], '350-': [2105], '353.': [2106], '6Melillo': [2107], 'L,': [2108], 'Tieghi': [2109], 'A,': [2110, 2112], 'Candoni': [2111], 'Outcome': [2115], 'patients:': [2122], 'registry.': [2128], '84:': [2133], '636-': [2134], '640.': [2135], '7How': [2136], 'C,': [2137], 'Leiva': [2138], 'O,': [2139], 'Bogue': [2140], 'T,': [2141], 'outcomes,': [2145], 'gestational': [2149], 'cell': [2150], 'pregnant': [2154], 'vera.': [2161], '2019;': [2163], '134:4172.': [2164], 'Citing': [2165], 'Literature': [2166], 'Volume95,': [2167], 'Issue5May': [2168], '2020Pages': [2169], 'ReferencesRelatedInformation': [2171]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3004861616', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 2}], 'updated_date': '2024-12-24T07:30:49.868888', 'created_date': '2020-02-14'}