Publication Information

{'id': 'https://openalex.org/W3004333995', 'doi': 'https://doi.org/10.14740/wjon1241', 'title': 'Overcoming Proteasome Inhibitor-Refractory Multiple Myeloma With Elotuzumab, Bortezomib, Nelfinavir, and Dexamethasone', 'display_name': 'Overcoming Proteasome Inhibitor-Refractory Multiple Myeloma With Elotuzumab, Bortezomib, Nelfinavir, and Dexamethasone', 'publication_year': 2020, 'publication_date': '2020-01-01', 'ids': {'openalex': 'https://openalex.org/W3004333995', 'doi': 'https://doi.org/10.14740/wjon1241', 'mag': '3004333995', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/32095187', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/7011904'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.14740/wjon1241', 'pdf_url': 'https://www.wjon.org/index.php/wjon/article/download/1241/970', 'source': {'id': 'https://openalex.org/S47071105', 'display_name': 'World Journal of Oncology', 'issn_l': '1920-4531', 'issn': ['1920-4531', '1920-454X'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.wjon.org/index.php/wjon/article/download/1241/970', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5073440728', 'display_name': 'Alexandra Erath', 'orcid': 'https://orcid.org/0000-0002-8440-6643'}, 'institutions': [{'id': 'https://openalex.org/I200719446', 'display_name': 'Vanderbilt University', 'ror': 'https://ror.org/02vm5rt34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I200719446']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Alexandra Erath', 'raw_affiliation_strings': ['Vanderbilt University School of Medicine, Nashville, TN'], 'affiliations': [{'raw_affiliation_string': 'Vanderbilt University School of Medicine, Nashville, TN', 'institution_ids': ['https://openalex.org/I200719446']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040135202', 'display_name': 'Dilan A. Patel', 'orcid': 'https://orcid.org/0000-0003-0765-4990'}, 'institutions': [{'id': 'https://openalex.org/I901861585', 'display_name': 'Vanderbilt University Medical Center', 'ror': 'https://ror.org/05dq2gs74', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210162197', 'https://openalex.org/I901861585']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Dilan A. Patel', 'raw_affiliation_strings': ['Department of Hematology and Bone Marrow Transplant, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematology and Bone Marrow Transplant, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN', 'institution_ids': ['https://openalex.org/I901861585']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052770977', 'display_name': 'Eric A. Hosack', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I200719446', 'display_name': 'Vanderbilt University', 'ror': 'https://ror.org/02vm5rt34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I200719446']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Eric A. Hosack', 'raw_affiliation_strings': ['Vanderbilt University, Nashville, TN'], 'affiliations': [{'raw_affiliation_string': 'Vanderbilt University, Nashville, TN', 'institution_ids': ['https://openalex.org/I200719446']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069388990', 'display_name': 'James E. Patanella', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4390039299', 'display_name': 'Vanderbilt-Ingram Cancer Center', 'ror': 'https://ror.org/02rjj2m04', 'country_code': None, 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210162197', 'https://openalex.org/I4390039299', 'https://openalex.org/I901861585']}, {'id': 'https://openalex.org/I901861585', 'display_name': 'Vanderbilt University Medical Center', 'ror': 'https://ror.org/05dq2gs74', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210162197', 'https://openalex.org/I901861585']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'James E. Patanella', 'raw_affiliation_strings': ['Vanderbilt Ingram Cancer Center, 1301 Medical Center Drive #1710, Nashville, TN 37232'], 'affiliations': [{'raw_affiliation_string': 'Vanderbilt Ingram Cancer Center, 1301 Medical Center Drive #1710, Nashville, TN 37232', 'institution_ids': ['https://openalex.org/I4390039299', 'https://openalex.org/I901861585']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006224043', 'display_name': 'Daniel M. Ibach', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210104194', 'display_name': 'Tennessee Cancer Specialists', 'ror': 'https://ror.org/01krbfc31', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210104194']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Daniel M. Ibach', 'raw_affiliation_strings': ['Tennessee Cancer Specialists, Knoxville, TN'], 'affiliations': [{'raw_affiliation_string': 'Tennessee Cancer Specialists, Knoxville, TN', 'institution_ids': ['https://openalex.org/I4210104194']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5048457597', 'display_name': 'Adetola A. Kassim', 'orcid': 'https://orcid.org/0000-0002-0484-5903'}, 'institutions': [{'id': 'https://openalex.org/I901861585', 'display_name': 'Vanderbilt University Medical Center', 'ror': 'https://ror.org/05dq2gs74', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210162197', 'https://openalex.org/I901861585']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Adetola A. Kassim', 'raw_affiliation_strings': ['Department of Hematology and Bone Marrow Transplant, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematology and Bone Marrow Transplant, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN', 'institution_ids': ['https://openalex.org/I901861585']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.142, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 1, 'citation_normalized_percentile': {'value': 0.446243, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 60, 'max': 69}, 'biblio': {'volume': '11', 'issue': '1', 'first_page': '33', 'last_page': '36'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10649', 'display_name': 'Multiple Myeloma Research and Treatments', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10649', 'display_name': 'Multiple Myeloma Research and Treatments', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12534', 'display_name': 'Protein Degradation and Inhibitors', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11041', 'display_name': 'Ubiquitin and proteasome pathways', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/nelfinavir', 'display_name': 'Nelfinavir', 'score': 0.76715183}, {'id': 'https://openalex.org/keywords/refractory', 'display_name': 'Refractory (planetary science)', 'score': 0.54918706}], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.93365145}, {'id': 'https://openalex.org/C2777478702', 'wikidata': 'https://www.wikidata.org/wiki/Q419319', 'display_name': 'Bortezomib', 'level': 3, 'score': 0.898618}, {'id': 'https://openalex.org/C2781160516', 'wikidata': 'https://www.wikidata.org/wiki/Q423366', 'display_name': 'Nelfinavir', 'level': 5, 'score': 0.76715183}, {'id': 'https://openalex.org/C2778367456', 'wikidata': 'https://www.wikidata.org/wiki/Q7251235', 'display_name': 'Proteasome inhibitor', 'level': 3, 'score': 0.7360822}, {'id': 'https://openalex.org/C2776364478', 'wikidata': 'https://www.wikidata.org/wiki/Q467635', 'display_name': 'Multiple myeloma', 'level': 2, 'score': 0.7219408}, {'id': 'https://openalex.org/C2780401358', 'wikidata': 'https://www.wikidata.org/wiki/Q422252', 'display_name': 'Dexamethasone', 'level': 2, 'score': 0.69870764}, {'id': 'https://openalex.org/C2776063141', 'wikidata': 'https://www.wikidata.org/wiki/Q425681', 'display_name': 'Lenalidomide', 'level': 3, 'score': 0.55629104}, {'id': 'https://openalex.org/C142424586', 'wikidata': 'https://www.wikidata.org/wiki/Q7307572', 'display_name': 'Refractory (planetary science)', 'level': 2, 'score': 0.54918706}, {'id': 'https://openalex.org/C27740335', 'wikidata': 'https://www.wikidata.org/wiki/Q14878333', 'display_name': 'Proteasome', 'level': 2, 'score': 0.547491}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.50700045}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.48247936}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.4104844}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.4004922}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.15428388}, {'id': 'https://openalex.org/C121332964', 'wikidata': 'https://www.wikidata.org/wiki/Q413', 'display_name': 'Physics', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C87355193', 'wikidata': 'https://www.wikidata.org/wiki/Q411', 'display_name': 'Astrobiology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C3013748606', 'wikidata': 'https://www.wikidata.org/wiki/Q15787', 'display_name': 'Human immunodeficiency virus (HIV)', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C2993143319', 'wikidata': 'https://www.wikidata.org/wiki/Q583050', 'display_name': 'Antiretroviral therapy', 'level': 4, 'score': 0.0}, {'id': 'https://openalex.org/C142462285', 'wikidata': 'https://www.wikidata.org/wiki/Q2528140', 'display_name': 'Viral load', 'level': 3, 'score': 0.0}], 'mesh': [], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.14740/wjon1241', 'pdf_url': 'https://www.wjon.org/index.php/wjon/article/download/1241/970', 'source': {'id': 'https://openalex.org/S47071105', 'display_name': 'World Journal of Oncology', 'issn_l': '1920-4531', 'issn': ['1920-4531', '1920-454X'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc7011904', 'pdf_url': 'https://europepmc.org/articles/pmc7011904?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011904', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/32095187', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.14740/wjon1241', 'pdf_url': 'https://www.wjon.org/index.php/wjon/article/download/1241/970', 'source': {'id': 'https://openalex.org/S47071105', 'display_name': 'World Journal of Oncology', 'issn_l': '1920-4531', 'issn': ['1920-4531', '1920-454X'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.85, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 12, 'referenced_works': ['https://openalex.org/W1982415141', 'https://openalex.org/W2026076762', 'https://openalex.org/W2039180923', 'https://openalex.org/W2041469831', 'https://openalex.org/W2121595165', 'https://openalex.org/W2132485651', 'https://openalex.org/W2153716391', 'https://openalex.org/W2205355516', 'https://openalex.org/W2258542938', 'https://openalex.org/W2566193100', 'https://openalex.org/W2620424585', 'https://openalex.org/W2751037830'], 'related_works': ['https://openalex.org/W4300495055', 'https://openalex.org/W4281831295', 'https://openalex.org/W3032840474', 'https://openalex.org/W3032571198', 'https://openalex.org/W3029266790', 'https://openalex.org/W2321752808', 'https://openalex.org/W2066699439', 'https://openalex.org/W2053506257', 'https://openalex.org/W1996748901', 'https://openalex.org/W1973074169'], 'abstract_inverted_index': {'Multiple': [0], 'myeloma': [1, 48, 197], 'is': [2], 'a': [3, 9, 38, 43, 105, 115, 133], 'common': [4], 'plasma': [5, 177], 'cell': [6, 63], 'malignancy': [7], 'with': [8, 54, 72, 202, 207], 'median': [10], 'overall': [11], 'survival': [12], 'of': [13, 24, 37, 46, 86, 108, 136, 183], 'fewer': [14], 'than': [15], '10': [16], 'years.': [17], 'Proteasome': [18], 'inhibitors': [19, 204], 'comprise': [20], 'an': [21], 'important': [22], 'part': [23], 'the': [25, 35, 84, 97, 121, 145, 155], 'treatment': [26, 53, 107, 122, 172], 'regimen': [27], 'for': [28], 'this': [29, 75, 189], 'disease.': [30], 'The': [31, 65, 130], 'present': [32], 'study': [33, 191], 'reports': [34], 'case': [36, 190], '57-year-old': [39], 'man': [40], 'who': [41], 'experienced': [42], 'second': [44, 81], 'relapse': [45, 67, 92], 'multiple': [47, 196], '6': [49], 'years': [50], 'after': [51, 170], 'initial': [52], 'bortezomib,': [55, 138], 'lenalidomide,': [56, 110], 'dexamethasone': [57], '(VRD)': [58], 'followed': [59], 'by': [60, 179], 'autologous': [61], 'hematopoietic': [62], 'transplant.': [64], 'first': [66], 'had': [68], 'been': [69], 'successfully': [70, 200], 'treated': [71], 'VRD,': [73], 'but': [74], 'approach': [76], 'failed': [77], 'to': [78, 88, 126, 151, 162], 'control': [79], 'his': [80], 'relapse.': [82], 'Given': [83], 'lack': [85], 'response': [87], 'VRD': [89], 'therapy': [90], 'and': [91, 103, 111, 114, 140, 154, 181], 'while': [93], 'on': [94], 'bortezomib': [95], 'maintenance,': [96], 'patient': [98, 131], 'was': [99, 123, 149], 'deemed': [100], 'proteasome': [101, 194, 203], 'inhibitor-refractory': [102, 195], 'received': [104, 132], 'new': [106], 'elotuzumab,': [109, 137], 'dexamethasone.': [112, 141], 'Four': [113], 'half': [116], 'cycles': [117, 173], 'were': [118], 'completed': [119], 'before': [120], 'stopped': [124], 'due': [125], 'grade': [127], '4': [128], 'cytopenias.': [129], 'novel': [134], 'combination': [135], 'nelfinavir,': [139], 'After': [142], 'six': [143], 'cycles,': [144], 'serum': [146], 'M-protein': [147], 'level': [148], 'improved': [150], '0.6': [152], 'g/dL': [153], 'kappa': [156], 'light': [157], 'chains': [158], 'dropped': [159], 'from': [160], '3.49': [161], '1.04': [163], 'mg/dL.': [164], 'A': [165], 'bone': [166], 'marrow': [167], 'biopsy': [168], 'conducted': [169], 'five': [171], 'demonstrated': [174], '<': [175], '1%': [176], 'cells': [178], 'immunohistochemistry': [180], 'achievement': [182], 'minimal': [184], 'residual': [185], 'disease': [186], 'status.': [187], 'Overall,': [188], 'suggests': [192], 'that': [193], 'may': [198], 'be': [199], 're-treated': [201], 'when': [205], 'co-administered': [206], 'nelfinavir.': [208]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3004333995', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}], 'updated_date': '2024-12-24T21:54:25.707844', 'created_date': '2020-02-07'}