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'TNF-α组大鼠用单纯熏香烟法制成COPD': [16], '大鼠动物模型,': [17], '分离其伸趾长肌,': [18], '分别给予不含和含TNF-α(': [19], '10': [20], 'μg/L)': [21], '的孵育液进行离体有氧孵育。利用实时定量': [22], 'PCR': [23], '和Western': [24], 'blot': [25], '技术检测C2': [26], '亚基在转录和蛋白水平的变化。结果': [27], 'COPD': [28, 47, 85], 'TNF-α': [31], '组C2': [32], '亚基mRNA': [33], '表达为对照组的1.': [34], '74': [35], '倍和1.': [36], '95': [37], '倍(': [38], 'P': [39, 49, 69, 81], '均lt;': [40], '0.': [41, 74], '01)': [42, 51, 75], ',': [43, 76], '其中COPD': [44], 'TNF-α组显著高于': [46], '组(': [48], 'lt;0.': [50, 70], '。COPD': [52], 'TNF-α组C2': [55], '亚基蛋白表达也显著高于对照组(': [56], '1.': [57], '04': [58], '±0.': [59, 63, 67], '15': [60], '和1.': [61], '23': [62], '16': [64], '比0.': [65], '71': [66], '12,': [68], '05': [71], '和P': [72], 'lt;': [73], 'COPD组和COPD': [77], 'TNF-α组表达无显著差异': [79], '(': [80], 'gt;0.': [82], '05)': [83], '。结论': [84], '时骨骼肌蛋白降解增加可能是经由TNF-α激活泛素-蛋白酶体途径所致。': [86]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3004019477', 'counts_by_year': [], 'updated_date': '2024-12-14T13:05:39.819099', 'created_date': '2020-02-07'}