Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W3003370246', 'doi': 'https://doi.org/10.1101/2020.01.29.925131', 'title': 'Nucleolar disruption, activation of P53 and premature senescence in POLR3A-mutated Wiedemann-Rautenstrauch Syndrome fibroblasts', 'display_name': 'Nucleolar disruption, activation of P53 and premature senescence in POLR3A-mutated Wiedemann-Rautenstrauch Syndrome fibroblasts', 'publication_year': 2020, 'publication_date': '2020-01-30', 'ids': {'openalex': 'https://openalex.org/W3003370246', 'doi': 'https://doi.org/10.1101/2020.01.29.925131', 'mag': '3003370246'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/2020.01.29.925131', 'pdf_url': 'https://www.biorxiv.org/content/biorxiv/early/2020/01/30/2020.01.29.925131.full.pdf', 'source': {'id': 'https://openalex.org/S4306402567', 'display_name': 'bioRxiv (Cold Spring Harbor Laboratory)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2750212522', 'host_organization_name': 'Cold Spring Harbor Laboratory', 'host_organization_lineage': ['https://openalex.org/I2750212522'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'type': 'preprint', 'type_crossref': 'posted-content', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://www.biorxiv.org/content/biorxiv/early/2020/01/30/2020.01.29.925131.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5070710254', 'display_name': 'Cindy Tatiana Báez-Becerra', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I36243813', 'display_name': 'Universidad Nacional de Colombia', 'ror': 'https://ror.org/059yx9a68', 'country_code': 'CO', 'type': 'education', 'lineage': ['https://openalex.org/I36243813']}], 'countries': ['CO'], 'is_corresponding': False, 'raw_author_name': 'Cindy Tatiana Báez-Becerra', 'raw_affiliation_strings': ['Grupo de Neurociencias y Muerte Celular, Instituto de Genética, Universidad Nacional de Colombia, Bogotá, Colombia'], 'affiliations': [{'raw_affiliation_string': 'Grupo de Neurociencias y Muerte Celular, Instituto de Genética, Universidad Nacional de Colombia, Bogotá, Colombia', 'institution_ids': ['https://openalex.org/I36243813']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012708990', 'display_name': 'Estefania Valencia-Rincón', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I36243813', 'display_name': 'Universidad Nacional de Colombia', 'ror': 'https://ror.org/059yx9a68', 'country_code': 'CO', 'type': 'education', 'lineage': ['https://openalex.org/I36243813']}], 'countries': ['CO'], 'is_corresponding': False, 'raw_author_name': 'Estefania Valencia-Rincón', 'raw_affiliation_strings': ['Grupo de Neurociencias y Muerte Celular, Instituto de Genética, Universidad Nacional de Colombia, Bogotá, Colombia'], 'affiliations': [{'raw_affiliation_string': 'Grupo de Neurociencias y Muerte Celular, Instituto de Genética, Universidad Nacional de Colombia, Bogotá, Colombia', 'institution_ids': ['https://openalex.org/I36243813']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054955225', 'display_name': 'Karen L. Velásquez-Méndez', 'orcid': 'https://orcid.org/0000-0002-9043-3146'}, 'institutions': [{'id': 'https://openalex.org/I36243813', 'display_name': 'Universidad Nacional de Colombia', 'ror': 'https://ror.org/059yx9a68', 'country_code': 'CO', 'type': 'education', 'lineage': ['https://openalex.org/I36243813']}], 'countries': ['CO'], 'is_corresponding': False, 'raw_author_name': 'Karen Velásquez-Méndez', 'raw_affiliation_strings': ['Grupo de Neurociencias y Muerte Celular, Instituto de Genética, Universidad Nacional de Colombia, Bogotá, Colombia'], 'affiliations': [{'raw_affiliation_string': 'Grupo de Neurociencias y Muerte Celular, Instituto de Genética, Universidad Nacional de Colombia, Bogotá, Colombia', 'institution_ids': ['https://openalex.org/I36243813']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5010085897', 'display_name': 'Nelson J. Ramírez-Suárez', 'orcid': 'https://orcid.org/0000-0001-7394-860X'}, 'institutions': [{'id': 'https://openalex.org/I36243813', 'display_name': 'Universidad Nacional de Colombia', 'ror': 'https://ror.org/059yx9a68', 'country_code': 'CO', 'type': 'education', 'lineage': ['https://openalex.org/I36243813']}], 'countries': ['CO'], 'is_corresponding': False, 'raw_author_name': 'Nelson J. Ramírez-Suárez', 'raw_affiliation_strings': ['Grupo de Neurociencias y Muerte Celular, Instituto de Genética, Universidad Nacional de Colombia, Bogotá, Colombia'], 'affiliations': [{'raw_affiliation_string': 'Grupo de Neurociencias y Muerte Celular, Instituto de Genética, Universidad Nacional de Colombia, Bogotá, Colombia', 'institution_ids': ['https://openalex.org/I36243813']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5078049576', 'display_name': 'Claudia Guevara', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I36243813', 'display_name': 'Universidad Nacional de Colombia', 'ror': 'https://ror.org/059yx9a68', 'country_code': 'CO', 'type': 'education', 'lineage': ['https://openalex.org/I36243813']}], 'countries': ['CO'], 'is_corresponding': False, 'raw_author_name': 'Claudia Guevara', 'raw_affiliation_strings': ['Grupo de Neurociencias y Muerte Celular, Instituto de Genética, Universidad Nacional de Colombia, Bogotá, Colombia'], 'affiliations': [{'raw_affiliation_string': 'Grupo de Neurociencias y Muerte Celular, Instituto de Genética, Universidad Nacional de Colombia, Bogotá, Colombia', 'institution_ids': ['https://openalex.org/I36243813']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5075252981', 'display_name': 'Adrián G. Sandoval‐Hernández', 'orcid': 'https://orcid.org/0000-0002-0661-6872'}, 'institutions': [{'id': 'https://openalex.org/I36243813', 'display_name': 'Universidad Nacional de Colombia', 'ror': 'https://ror.org/059yx9a68', 'country_code': 'CO', 'type': 'education', 'lineage': ['https://openalex.org/I36243813']}], 'countries': ['CO'], 'is_corresponding': False, 'raw_author_name': 'Adrian Sandoval-Hernandez', 'raw_affiliation_strings': ['Departamento de Química, Faculatd de Ciencias, Universidad Nacional de Colombia, Bogotá, Colombia', 'Grupo de Neurociencias y Muerte Celular, Instituto de Genética, Universidad Nacional de Colombia, Bogotá, Colombia'], 'affiliations': [{'raw_affiliation_string': 'Grupo de Neurociencias y Muerte Celular, Instituto de Genética, Universidad Nacional de Colombia, Bogotá, Colombia', 'institution_ids': ['https://openalex.org/I36243813']}, {'raw_affiliation_string': 'Departamento de Química, Faculatd de Ciencias, Universidad Nacional de Colombia, Bogotá, Colombia', 'institution_ids': ['https://openalex.org/I36243813']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103281518', 'display_name': 'Carlos Bustos', 'orcid': 'https://orcid.org/0000-0002-1783-3063'}, 'institutions': [{'id': 'https://openalex.org/I36243813', 'display_name': 'Universidad Nacional de Colombia', 'ror': 'https://ror.org/059yx9a68', 'country_code': 'CO', 'type': 'education', 'lineage': ['https://openalex.org/I36243813']}], 'countries': ['CO'], 'is_corresponding': False, 'raw_author_name': 'Carlos E. Arboleda-Bustos', 'raw_affiliation_strings': ['Grupo de Neurociencias y Muerte Celular, Instituto de Genética, Universidad Nacional de Colombia, Bogotá, Colombia'], 'affiliations': [{'raw_affiliation_string': 'Grupo de Neurociencias y Muerte Celular, Instituto de Genética, Universidad Nacional de Colombia, Bogotá, Colombia', 'institution_ids': ['https://openalex.org/I36243813']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057247837', 'display_name': 'Leonora Olivos-Cisneros', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I8961855', 'display_name': 'Universidad Nacional Autónoma de México', 'ror': 'https://ror.org/01tmp8f25', 'country_code': 'MX', 'type': 'education', 'lineage': ['https://openalex.org/I8961855']}], 'countries': ['MX'], 'is_corresponding': False, 'raw_author_name': 'Leonora Olivos-Cisneros', 'raw_affiliation_strings': ['Departmento de Biología Celular y Fisiología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, México'], 'affiliations': [{'raw_affiliation_string': 'Departmento de Biología Celular y Fisiología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, México', 'institution_ids': ['https://openalex.org/I8961855']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5021405937', 'display_name': 'Gabriel Gutiérrez–Ospina', 'orcid': 'https://orcid.org/0000-0002-6286-8281'}, 'institutions': [{'id': 'https://openalex.org/I8961855', 'display_name': 'Universidad Nacional Autónoma de México', 'ror': 'https://ror.org/01tmp8f25', 'country_code': 'MX', 'type': 'education', 'lineage': ['https://openalex.org/I8961855']}], 'countries': ['MX'], 'is_corresponding': False, 'raw_author_name': 'Gabriela Gutiérrez-Ospina', 'raw_affiliation_strings': ['Departmento de Biología Celular y Fisiología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, México'], 'affiliations': [{'raw_affiliation_string': 'Departmento de Biología Celular y Fisiología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, México', 'institution_ids': ['https://openalex.org/I8961855']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5039401399', 'display_name': 'Humberto Arboleda', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I36243813', 'display_name': 'Universidad Nacional de Colombia', 'ror': 'https://ror.org/059yx9a68', 'country_code': 'CO', 'type': 'education', 'lineage': ['https://openalex.org/I36243813']}], 'countries': ['CO'], 'is_corresponding': False, 'raw_author_name': 'Humberto Arboleda', 'raw_affiliation_strings': ['Departamento de Pediatría, Facultad de Medicina, Universidad Nacional de Colombia Bogotá, Colombia', 'Grupo de Neurociencias y Muerte Celular, Instituto de Genética, Universidad Nacional de Colombia, Bogotá, Colombia'], 'affiliations': [{'raw_affiliation_string': 'Departamento de Pediatría, Facultad de Medicina, Universidad Nacional de Colombia Bogotá, Colombia', 'institution_ids': ['https://openalex.org/I36243813']}, {'raw_affiliation_string': 'Grupo de Neurociencias y Muerte Celular, Instituto de Genética, Universidad Nacional de Colombia, Bogotá, Colombia', 'institution_ids': ['https://openalex.org/I36243813']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5001275163', 'display_name': 'Gonzálo Arboleda', 'orcid': 'https://orcid.org/0000-0003-1781-939X'}, 'institutions': [{'id': 'https://openalex.org/I36243813', 'display_name': 'Universidad Nacional de Colombia', 'ror': 'https://ror.org/059yx9a68', 'country_code': 'CO', 'type': 'education', 'lineage': ['https://openalex.org/I36243813']}], 'countries': ['CO'], 'is_corresponding': True, 'raw_author_name': 'Gonzalo Arboleda', 'raw_affiliation_strings': ['Departamento de Patología, Faculatd de Medicina, Universidad Nacional de Colombia, Bogotá, Colombia', 'Grupo de Neurociencias y Muerte Celular, Instituto de Genética, Universidad Nacional de Colombia, Bogotá, Colombia'], 'affiliations': [{'raw_affiliation_string': 'Departamento de Patología, Faculatd de Medicina, Universidad Nacional de Colombia, Bogotá, Colombia', 'institution_ids': ['https://openalex.org/I36243813']}, {'raw_affiliation_string': 'Grupo de Neurociencias y Muerte Celular, Instituto de Genética, Universidad Nacional de Colombia, Bogotá, Colombia', 'institution_ids': ['https://openalex.org/I36243813']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5001275163'], 'corresponding_institution_ids': ['https://openalex.org/I36243813'], 'apc_list': None, 'apc_paid': None, 'fwci': None, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 2, 'citation_normalized_percentile': {'value': 0.764431, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 69, 'max': 73}, 'biblio': {'volume': None, 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10604', 'display_name': 'RNA Research and Splicing', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10604', 'display_name': 'RNA Research and Splicing', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11841', 'display_name': 'Nuclear Structure and Function', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12610', 'display_name': 'RNA regulation and disease', 'score': 0.9977, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/rna-polymerase-iii', 'display_name': 'RNA polymerase III', 'score': 0.6787902}, {'id': 'https://openalex.org/keywords/progeria', 'display_name': 'Progeria', 'score': 0.6503384}, {'id': 'https://openalex.org/keywords/transcription', 'display_name': 'Transcription', 'score': 0.45586705}, {'id': 'https://openalex.org/keywords/senescence', 'display_name': 'Senescence', 'score': 0.44175628}], 'concepts': [{'id': 'https://openalex.org/C70916841', 'wikidata': 'https://www.wikidata.org/wiki/Q3501658', 'display_name': 'RNA polymerase III', 'level': 5, 'score': 0.6787902}, {'id': 'https://openalex.org/C2778465436', 'wikidata': 'https://www.wikidata.org/wiki/Q213098', 'display_name': 'Progeria', 'level': 3, 'score': 0.6503384}, {'id': 'https://openalex.org/C183873130', 'wikidata': 'https://www.wikidata.org/wiki/Q30869', 'display_name': 'Nucleolus', 'level': 3, 'score': 0.6221888}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5547946}, {'id': 'https://openalex.org/C143065580', 'wikidata': 'https://www.wikidata.org/wiki/Q3285695', 'display_name': 'Mutant', 'level': 3, 'score': 0.48813543}, {'id': 'https://openalex.org/C179926584', 'wikidata': 'https://www.wikidata.org/wiki/Q207714', 'display_name': 'Transcription (linguistics)', 'level': 2, 'score': 0.45586705}, {'id': 'https://openalex.org/C522857546', 'wikidata': 'https://www.wikidata.org/wiki/Q2070979', 'display_name': 'Senescence', 'level': 2, 'score': 0.44175628}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.4158377}, {'id': 'https://openalex.org/C67705224', 'wikidata': 'https://www.wikidata.org/wiki/Q11053', 'display_name': 'RNA', 'level': 3, 'score': 0.3927828}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.35990795}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.30733794}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.22376463}, {'id': 'https://openalex.org/C2776449523', 'wikidata': 'https://www.wikidata.org/wiki/Q272631', 'display_name': 'RNA polymerase', 'level': 4, 'score': 0.17005381}, {'id': 'https://openalex.org/C190062978', 'wikidata': 'https://www.wikidata.org/wiki/Q79899', 'display_name': 'Cytoplasm', 'level': 2, 'score': 0.08154845}, {'id': 'https://openalex.org/C41895202', 'wikidata': 'https://www.wikidata.org/wiki/Q8162', 'display_name': 'Linguistics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C138885662', 'wikidata': 'https://www.wikidata.org/wiki/Q5891', 'display_name': 'Philosophy', 'level': 0, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/2020.01.29.925131', 'pdf_url': 'https://www.biorxiv.org/content/biorxiv/early/2020/01/30/2020.01.29.925131.full.pdf', 'source': {'id': 'https://openalex.org/S4306402567', 'display_name': 'bioRxiv (Cold Spring Harbor Laboratory)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2750212522', 'host_organization_name': 'Cold Spring Harbor Laboratory', 'host_organization_lineage': ['https://openalex.org/I2750212522'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/2020.01.29.925131', 'pdf_url': 'https://www.biorxiv.org/content/biorxiv/early/2020/01/30/2020.01.29.925131.full.pdf', 'source': {'id': 'https://openalex.org/S4306402567', 'display_name': 'bioRxiv (Cold Spring Harbor Laboratory)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2750212522', 'host_organization_name': 'Cold Spring Harbor Laboratory', 'host_organization_lineage': ['https://openalex.org/I2750212522'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 88, 'referenced_works': ['https://openalex.org/W1510449384', 'https://openalex.org/W1511334651', 'https://openalex.org/W1606581221', 'https://openalex.org/W1771113533', 'https://openalex.org/W1890766043', 'https://openalex.org/W1892158199', 'https://openalex.org/W1963578989', 'https://openalex.org/W1964551999', 'https://openalex.org/W1967676658', 'https://openalex.org/W1970338621', 'https://openalex.org/W1974449792', 'https://openalex.org/W1974862758', 'https://openalex.org/W1974947918', 'https://openalex.org/W1978518304', 'https://openalex.org/W1984185924', 'https://openalex.org/W1985837612', 'https://openalex.org/W1996245886', 'https://openalex.org/W1999200731', 'https://openalex.org/W1999440327', 'https://openalex.org/W1999962568', 'https://openalex.org/W2007114922', 'https://openalex.org/W2007477365', 'https://openalex.org/W2020337099', 'https://openalex.org/W2021302591', 'https://openalex.org/W2021429966', 'https://openalex.org/W2024317507', 'https://openalex.org/W2024412804', 'https://openalex.org/W2029040415', 'https://openalex.org/W2041884820', 'https://openalex.org/W2046960746', 'https://openalex.org/W2048951894', 'https://openalex.org/W2059999514', 'https://openalex.org/W2062056287', 'https://openalex.org/W2064451594', 'https://openalex.org/W2065575443', 'https://openalex.org/W2072810104', 'https://openalex.org/W2079013447', 'https://openalex.org/W2081576851', 'https://openalex.org/W2084929037', 'https://openalex.org/W2088983871', 'https://openalex.org/W2096739788', 'https://openalex.org/W2097005988', 'https://openalex.org/W2104088469', 'https://openalex.org/W2104908670', 'https://openalex.org/W2120902817', 'https://openalex.org/W2127708563', 'https://openalex.org/W2143185290', 'https://openalex.org/W2160621707', 'https://openalex.org/W2167558439', 'https://openalex.org/W2176755515', 'https://openalex.org/W2177129405', 'https://openalex.org/W2330237189', 'https://openalex.org/W2335986416', 'https://openalex.org/W2342847104', 'https://openalex.org/W2514670387', 'https://openalex.org/W2535085122', 'https://openalex.org/W2560684820', 'https://openalex.org/W2591404506', 'https://openalex.org/W2608468149', 'https://openalex.org/W2612084086', 'https://openalex.org/W2727858063', 'https://openalex.org/W2730315793', 'https://openalex.org/W2733653638', 'https://openalex.org/W2737074918', 'https://openalex.org/W2737693232', 'https://openalex.org/W2742756490', 'https://openalex.org/W2749445972', 'https://openalex.org/W2768919265', 'https://openalex.org/W2769923893', 'https://openalex.org/W2784064453', 'https://openalex.org/W2792023503', 'https://openalex.org/W2803484355', 'https://openalex.org/W2809546154', 'https://openalex.org/W2851949430', 'https://openalex.org/W2896613866', 'https://openalex.org/W2896763522', 'https://openalex.org/W2901192951', 'https://openalex.org/W2901811678', 'https://openalex.org/W2902984431', 'https://openalex.org/W2912395132', 'https://openalex.org/W2913509582', 'https://openalex.org/W2922555409', 'https://openalex.org/W2923924598', 'https://openalex.org/W2936816157', 'https://openalex.org/W2942472270', 'https://openalex.org/W2957149875', 'https://openalex.org/W4252902870', 'https://openalex.org/W955991595'], 'related_works': ['https://openalex.org/W3102520865', 'https://openalex.org/W3044133821', 'https://openalex.org/W2972234736', 'https://openalex.org/W2462973229', 'https://openalex.org/W2126517368', 'https://openalex.org/W2069500184', 'https://openalex.org/W2025269594', 'https://openalex.org/W1997722811', 'https://openalex.org/W1987788866', 'https://openalex.org/W1602096670'], 'abstract_inverted_index': {'ABSTRACT': [0], 'Recently,': [1], 'mutations': [2], 'in': [3, 29, 74, 79, 100, 125], 'the': [4, 15, 18, 30, 80, 126, 148], 'RNA': [5], 'polymerase': [6], 'III': [7], 'subunit': [8], '3A': [9], '(POLR3A)': [10], 'have': [11, 26], 'been': [12], 'described': [13], 'as': [14], 'cause': [16], 'of': [17, 32, 34, 52, 56, 82, 91, 114, 128, 147], 'neonatal': [19], 'progeria': [20], 'or': [21], 'Wiedemann-Rautenstrauch': [22], 'syndrome': [23], '(WRS).': [24], 'POLR3A': [25, 64, 75, 83], 'important': [27], 'roles': [28], 'regulation': [31], 'transcription': [33], 'small': [35], 'RNAs,': [36], 'including': [37], 'tRNA,': [38], '5S': [39], 'rRNA': [40], 'and': [41, 49, 68, 85, 87, 112, 121, 130, 152, 154, 162], 'U6': [42], 'snRNA.': [43], 'We': [44], 'aim': [45], 'to': [46, 108, 137, 144, 158], 'describe': [47], 'cellular': [48], 'molecular': [50], 'features': [51], 'WRS': [53, 61], 'fibroblasts.': [54], 'Cultures': [55], 'primary': [57], 'fibroblasts': [58], 'from': [59], 'one': [60, 69], 'patient': [62], '[monoallelic': [63], 'variant': [65], 'c.3772_3773delCT': [66], '(p.Leu1258Glyfs*12)]': [67], 'control': [70], 'were': [71, 106, 135], 'grown.': [72], 'Mutation': [73], 'causes': [76], 'a': [77, 88, 116, 122], 'decreased': [78], 'expression': [81, 127], 'mRNA': [84], 'protein': [86], 'sharp': [89], 'increased': [90, 99, 124], 'mutant': [92], 'protein.': [93], 'In': [94], 'addition,': [95], 'there': [96], 'was': [97], 'an': [98, 109], 'its': [101], 'nuclear': [102, 119], 'localization.': [103], 'These': [104], 'changes': [105, 134], 'associated': [107, 136], 'increase': [110], 'number': [111], 'area': [113], 'nucleoli,': [115], 'significantly': [117], 'larger': [118], 'area,': [120], 'high': [123], 'pP53': [129], 'pH2AX.': [131], 'All': [132], 'these': [133], 'premature': [138], 'senescence.': [139], 'The': [140], 'present': [141], 'observations': [142], 'add': [143], 'our': [145], 'understanding': [146], 'differences': [149], 'between': [150], 'HGPS': [151], 'WRS,': [153], 'opens': [155], 'new': [156], 'alternatives': [157], 'study': [159], 'cell': [160], 'senesce': [161], 'human': [163], 'aging.': [164]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3003370246', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}], 'updated_date': '2025-01-11T17:32:17.130476', 'created_date': '2020-02-07'}