Title: α-1 Antitrypsin as a potential biomarker in chronic heart failure
Abstract: Background Heart failure is characterized by a tissue damage that progressively leads to mechanical cardiac dysfunction and remodeling. A recent investigation showed that α-1 antitripsin, an antiprotease, able to inhibit metalloproteinases, provides prognostic information about heart failure and mortality postacute myocardial infarction. Therefore, we conducted a study to establish if α-1 antitrypsin (AAT) could be considered a marker of severity of heart failure. Methods A total of 182 heart failure patients (Group 1) were enrolled and AAT values were compared with controls (Group 2). Results In Group 1 a significant increment of AAT levels respect to Group 2 was observed ( P < 0.0001). Moreover, in patients enrolled a progressive elevation of AAT levels across New York Heart Association classes ( P < 0.0001) was found. Patients with α-1 antitripsin levels above median value showed lower hemoglobin concentration, higher circulating levels of C-reactive protein, hs-troponin T and B-type natriuretic peptide prohormone. Group 1 AAT levels resulted highly positively associated to B-type natriuretic peptide prohormone, C-reactive protein levels, while negatively associated to left ventricular ejection fraction%. However, at multivariate logistic analysis, only C-reactive protein was confirmed in a subgroup of postischemic heart failure patients. Conclusion Adding AAT levels to the panel of heart failure biomarkers allow a better stratification of patients with heart failure.
Publication Year: 2020
Publication Date: 2020-03-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 5
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