Chronic Adipose Tissue Inflammation Linking Obesity to Insulin Resistance and Type 2 Diabetes

Name: Work Video:
Duration: 3 min 30 s
Federica Zatterale; Michele Longo; Jamal Naderi; Gregory Alexander Raciti; Antonella Desiderio; Claudia Miele; Francesco Bèguinot
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'stress)': [96], 'capable': [97, 174], 'initiating': [99], 'inflammatory': [101, 234], 'response.': [102], 'Immune': [103], 'dysregulation': [104], 'subjects': [110], 'results': [111], 'characterized': [117], 'by': [118], 'increased': [119], 'infiltration': [120], 'activation': [122], 'innate': [124, 134], 'adaptive': [126], 'immune': [127, 135, 190], 'cells.': [128], 'Macrophages': [129], 'most': [132], 'abundant': [133], 'cells': [136, 155, 191], 'infiltrating': [137], 'accumulating': [139], 'into': [140, 165], 'individuals;': [145], 'they': [146], 'constitute': [147], 'up': [148], '40%': [150], 'all': [152], 'obesity.': [157], 'In': [158, 246], 'obesity,': [159, 208, 226], 'macrophages': [162, 168], 'polarized': [164], 'pro-inflammatory': [166, 172], 'M1': [167], 'secrete': [170], 'many': [171, 188], 'cytokines': [173], 'impairing': [176], 'signaling;': [178], 'therefore,': [179], 'promoting': [180], 'progression': [182, 262], 'resistance.': [185, 222], 'Besides': [186], 'macrophages,': [187], 'other': [189], 'dendritic': [193], 'cells,': [194, 196, 199], 'mast': [195], 'neutrophils,': [197], 'B': [198], 'T': [201], 'cells)': [202], 'reside': [203], 'during': [207], 'playing': [209], 'key': [211], 'association': [224], 'inflammation,': [229], 'metabolic': [231, 244], 'diseases': [232], 'makes': [233], 'pathways': [235], 'an': [236], 'appealing': [237], 'target': [238], 'treatment': [241], 'obesity-related': [243], 'complications.': [245], 'this': [247], 'review,': [248], 'we': [249], 'summarize': [250], 'molecular': [252], 'mechanisms': [253], 'responsible': [254], 'toward': [263], 'obesity-associated': [264], 'comorbidities': [265], 'highlight': [267], 'current': [269], 'therapeutic': [270], 'strategies.': [271]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3003265560', 'counts_by_year': [{'year': 2024, 'cited_by_count': 147}, {'year': 2023, 'cited_by_count': 189}, {'year': 2022, 'cited_by_count': 173}, {'year': 2021, 'cited_by_count': 131}, {'year': 2020, 'cited_by_count': 46}, {'year': 2018, 'cited_by_count': 1}], 'updated_date': '2024-12-19T10:37:07.324800', 'created_date': '2020-02-07'}
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