Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W3002931386', 'doi': 'https://doi.org/10.23937/2469-5750/1510075', 'title': 'A New Way to Inhibit IL-17 in Psoriasis: Real-Life Use of Brodalumab Goes Beyond Clinical Trials Expectations', 'display_name': 'A New Way to Inhibit IL-17 in Psoriasis: Real-Life Use of Brodalumab Goes Beyond Clinical Trials Expectations', 'publication_year': 2019, 'publication_date': '2019-12-30', 'ids': {'openalex': 'https://openalex.org/W3002931386', 'doi': 'https://doi.org/10.23937/2469-5750/1510075', 'mag': '3002931386'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.23937/2469-5750/1510075', 'pdf_url': 'https://www.clinmedjournals.org/articles/ijdrt/journal-of-dermatology-research-and-therapy-ijdrt-5-075.pdf?jid=ijdrt', 'source': {'id': 'https://openalex.org/S4210172428', 'display_name': 'Journal of Dermatology Research and Therapy', 'issn_l': '2469-5750', 'issn': ['2469-5750'], 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.clinmedjournals.org/articles/ijdrt/journal-of-dermatology-research-and-therapy-ijdrt-5-075.pdf?jid=ijdrt', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5058842585', 'display_name': 'Mario Valenti', 'orcid': 'https://orcid.org/0000-0001-9140-9263'}, 'institutions': [{'id': 'https://openalex.org/I1339471597', 'display_name': 'Humanitas University', 'ror': 'https://ror.org/020dggs04', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I1339471597']}, {'id': 'https://openalex.org/I4210153126', 'display_name': 'Istituti di Ricovero e Cura a Carattere Scientifico', 'ror': 'https://ror.org/04tfzc498', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Valenti Mario', 'raw_affiliation_strings': ['Department of Biomedical Sciences, Humanitas University, Italy', 'Department of Dermatology, Humanitas Clinical and Research Center, IRCCS, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Dermatology, Humanitas Clinical and Research Center, IRCCS, Italy', 'institution_ids': ['https://openalex.org/I1339471597', 'https://openalex.org/I4210153126']}, {'raw_affiliation_string': 'Department of Biomedical Sciences, Humanitas University, Italy', 'institution_ids': ['https://openalex.org/I1339471597']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019346097', 'display_name': 'Paola Facheris', 'orcid': 'https://orcid.org/0000-0002-5171-9854'}, 'institutions': [{'id': 'https://openalex.org/I1339471597', 'display_name': 'Humanitas University', 'ror': 'https://ror.org/020dggs04', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I1339471597']}, {'id': 'https://openalex.org/I4210153126', 'display_name': 'Istituti di Ricovero e Cura a Carattere Scientifico', 'ror': 'https://ror.org/04tfzc498', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Facheris Paola', 'raw_affiliation_strings': ['Department of Biomedical Sciences, Humanitas University, Italy', 'Department of Dermatology, Humanitas Clinical and Research Center, IRCCS, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Dermatology, Humanitas Clinical and Research Center, IRCCS, Italy', 'institution_ids': ['https://openalex.org/I1339471597', 'https://openalex.org/I4210153126']}, {'raw_affiliation_string': 'Department of Biomedical Sciences, Humanitas University, Italy', 'institution_ids': ['https://openalex.org/I1339471597']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007545259', 'display_name': 'Giulia Pavia', 'orcid': 'https://orcid.org/0000-0001-5600-288X'}, 'institutions': [{'id': 'https://openalex.org/I1339471597', 'display_name': 'Humanitas University', 'ror': 'https://ror.org/020dggs04', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I1339471597']}, {'id': 'https://openalex.org/I4210153126', 'display_name': 'Istituti di Ricovero e Cura a Carattere Scientifico', 'ror': 'https://ror.org/04tfzc498', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Pavia Giulia', 'raw_affiliation_strings': ['Department of Biomedical Sciences, Humanitas University, Italy', 'Department of Dermatology, Humanitas Clinical and Research Center, IRCCS, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Dermatology, Humanitas Clinical and Research Center, IRCCS, Italy', 'institution_ids': ['https://openalex.org/I1339471597', 'https://openalex.org/I4210153126']}, {'raw_affiliation_string': 'Department of Biomedical Sciences, Humanitas University, Italy', 'institution_ids': ['https://openalex.org/I1339471597']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5082265951', 'display_name': 'Alessandra Narcisi', 'orcid': 'https://orcid.org/0000-0002-1938-8581'}, 'institutions': [{'id': 'https://openalex.org/I1339471597', 'display_name': 'Humanitas University', 'ror': 'https://ror.org/020dggs04', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I1339471597']}, {'id': 'https://openalex.org/I4210153126', 'display_name': 'Istituti di Ricovero e Cura a Carattere Scientifico', 'ror': 'https://ror.org/04tfzc498', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Narcisi Alessandra', 'raw_affiliation_strings': ['Department of Dermatology, Humanitas Clinical and Research Center, IRCCS, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Dermatology, Humanitas Clinical and Research Center, IRCCS, Italy', 'institution_ids': ['https://openalex.org/I1339471597', 'https://openalex.org/I4210153126']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031018757', 'display_name': 'Borroni Riccardo', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1339471597', 'display_name': 'Humanitas University', 'ror': 'https://ror.org/020dggs04', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I1339471597']}, {'id': 'https://openalex.org/I4210153126', 'display_name': 'Istituti di Ricovero e Cura a Carattere Scientifico', 'ror': 'https://ror.org/04tfzc498', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Borroni Riccardo', 'raw_affiliation_strings': ['Department of Biomedical Sciences, Humanitas University, Italy', 'Department of Dermatology, Humanitas Clinical and Research Center, IRCCS, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Dermatology, Humanitas Clinical and Research Center, IRCCS, Italy', 'institution_ids': ['https://openalex.org/I1339471597', 'https://openalex.org/I4210153126']}, {'raw_affiliation_string': 'Department of Biomedical Sciences, Humanitas University, Italy', 'institution_ids': ['https://openalex.org/I1339471597']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5103887750', 'display_name': 'Costanzo Antonio', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1339471597', 'display_name': 'Humanitas University', 'ror': 'https://ror.org/020dggs04', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I1339471597']}, {'id': 'https://openalex.org/I4210153126', 'display_name': 'Istituti di Ricovero e Cura a Carattere Scientifico', 'ror': 'https://ror.org/04tfzc498', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Costanzo Antonio', 'raw_affiliation_strings': ['Department of Biomedical Sciences, Humanitas University, Italy', 'Department of Dermatology, Humanitas Clinical and Research Center, IRCCS, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Dermatology, Humanitas Clinical and Research Center, IRCCS, Italy', 'institution_ids': ['https://openalex.org/I1339471597', 'https://openalex.org/I4210153126']}, {'raw_affiliation_string': 'Department of Biomedical Sciences, Humanitas University, Italy', 'institution_ids': ['https://openalex.org/I1339471597']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.212, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 2, 'citation_normalized_percentile': {'value': 0.554996, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 70, 'max': 75}, 'biblio': {'volume': '5', 'issue': '2', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10469', 'display_name': 'Reciprocal Development of TH17 and Treg Cells', 'score': 0.9975, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10469', 'display_name': 'Reciprocal Development of TH17 and Treg Cells', 'score': 0.9975, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11725', 'display_name': 'Genetic Basis of Primary Immunodeficiency Disorders', 'score': 0.9296, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11503', 'display_name': 'Role of STAT3 in Cancer Inflammation and Immunity', 'score': 0.9114, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/ixekizumab', 'display_name': 'Ixekizumab', 'score': 0.9902755}, {'id': 'https://openalex.org/keywords/il-17', 'display_name': 'IL-17', 'score': 0.476941}], 'concepts': [{'id': 'https://openalex.org/C2779745271', 'wikidata': 'https://www.wikidata.org/wiki/Q13574436', 'display_name': 'Ixekizumab', 'level': 5, 'score': 0.9902755}, {'id': 'https://openalex.org/C2779786854', 'wikidata': 'https://www.wikidata.org/wiki/Q7444755', 'display_name': 'Secukinumab', 'level': 4, 'score': 0.96704936}, {'id': 'https://openalex.org/C2780564577', 'wikidata': 'https://www.wikidata.org/wiki/Q179945', 'display_name': 'Psoriasis', 'level': 2, 'score': 0.6882874}, {'id': 'https://openalex.org/C542903549', 'wikidata': 'https://www.wikidata.org/wiki/Q422248', 'display_name': 'Monoclonal antibody', 'level': 3, 'score': 0.6758868}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.66535515}, {'id': 'https://openalex.org/C47348012', 'wikidata': 'https://www.wikidata.org/wiki/Q99486570', 'display_name': 'Interleukin 17', 'level': 3, 'score': 0.6468718}, {'id': 'https://openalex.org/C163864487', 'wikidata': 'https://www.wikidata.org/wiki/Q6901461', 'display_name': 'Monoclonal', 'level': 4, 'score': 0.4994552}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.44517595}, {'id': 'https://openalex.org/C3020604521', 'wikidata': 'https://www.wikidata.org/wiki/Q179945', 'display_name': 'Plaque psoriasis', 'level': 3, 'score': 0.4365247}, {'id': 'https://openalex.org/C535046627', 'wikidata': 'https://www.wikidata.org/wiki/Q30612', 'display_name': 'Clinical trial', 'level': 2, 'score': 0.42287886}, {'id': 'https://openalex.org/C16005928', 'wikidata': 'https://www.wikidata.org/wiki/Q171171', 'display_name': 'Dermatology', 'level': 1, 'score': 0.345733}, {'id': 'https://openalex.org/C159654299', 'wikidata': 'https://www.wikidata.org/wiki/Q79460', 'display_name': 'Antibody', 'level': 2, 'score': 0.2422109}, {'id': 'https://openalex.org/C2778690821', 'wikidata': 'https://www.wikidata.org/wiki/Q212354', 'display_name': 'Cytokine', 'level': 2, 'score': 0.21900684}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.17939755}, {'id': 'https://openalex.org/C2776260265', 'wikidata': 'https://www.wikidata.org/wiki/Q511097', 'display_name': 'Psoriatic arthritis', 'level': 3, 'score': 0.105570436}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.23937/2469-5750/1510075', 'pdf_url': 'https://www.clinmedjournals.org/articles/ijdrt/journal-of-dermatology-research-and-therapy-ijdrt-5-075.pdf?jid=ijdrt', 'source': {'id': 'https://openalex.org/S4210172428', 'display_name': 'Journal of Dermatology Research and Therapy', 'issn_l': '2469-5750', 'issn': ['2469-5750'], 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.23937/2469-5750/1510075', 'pdf_url': 'https://www.clinmedjournals.org/articles/ijdrt/journal-of-dermatology-research-and-therapy-ijdrt-5-075.pdf?jid=ijdrt', 'source': {'id': 'https://openalex.org/S4210172428', 'display_name': 'Journal of Dermatology Research and Therapy', 'issn_l': '2469-5750', 'issn': ['2469-5750'], 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Zero hunger', 'id': 'https://metadata.un.org/sdg/2', 'score': 0.73}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 8, 'referenced_works': ['https://openalex.org/W2068089617', 'https://openalex.org/W2079598877', 'https://openalex.org/W2168384861', 'https://openalex.org/W2276035339', 'https://openalex.org/W2326643498', 'https://openalex.org/W2622966691', 'https://openalex.org/W2763793357', 'https://openalex.org/W2792373301'], 'related_works': ['https://openalex.org/W4387016096', 'https://openalex.org/W4248644124', 'https://openalex.org/W4224863577', 'https://openalex.org/W3154471392', 'https://openalex.org/W3081361112', 'https://openalex.org/W2906051248', 'https://openalex.org/W2562601801', 'https://openalex.org/W230361150', 'https://openalex.org/W2116633865', 'https://openalex.org/W2079598877'], 'abstract_inverted_index': {'Specific': [0], 'IL-17': [1], 'inhibitors': [2], 'are': [3], 'represented': [4], 'by': [5, 41], 'Secukinumab': [6], 'and': [7, 11], 'Ixekizumab,': [8], 'fully': [9, 22], 'human': [10, 23], 'humanized': [12], '(respectively)': [13], 'monoclonal': [14, 28], 'antibodies': [15], 'against': [16], 'IL-17A,': [17], 'while': [18], 'Brodalumab': [19], 'is': [20], 'a': [21, 32], 'anti-interleukin-17': [24], 'receptor': [25], 'A': [26], '(IL-17RA)': [27], 'antibody.': [29], 'We': [30], 'present': [31], 'single': [33], 'center': [34], 'case': [35], 'series': [36], 'of': [37], '6': [38], 'patients': [39], 'affected': [40], 'moderate': [42], 'to': [43], 'severe': [44], 'psoriasis': [45], 'treated': [46], 'with': [47], 'brodalumab.': [48]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3002931386', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}], 'updated_date': '2024-09-12T00:40:27.040405', 'created_date': '2020-01-30'}