Publication Information

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[150], 'HD': [151, 727], 'models,': [152, 666], 'assess': [155, 408, 443], 'whether': [156, 563], 'occurs': [158], 'contributes': [162], 'pathology.': [167], 'tested': [169, 631], 'hypothesis': [171, 633], 'that': [172, 214, 269, 311, 363, 381, 587, 634], 'at': [177, 334, 338, 553, 607], 'least': [178], 'other': [182], 'mice.': [187, 678], 'To': [188, 602], 'characterise': [189, 395], 'its': [193], 'spatio-temporal': [194], 'relationship': [195], 'aggregate': [197], 'formation,': [198], 'onset,': [203], 'crossed': [205, 677], 'mice': [209, 213, 244, 326, 486, 692], 'with': [210, 546, 637, 641], 'YFP-H': [211], 'express': [215], 'yellow': [217], 'fluorescent': [218, 246], 'protein': [219, 646], '(YFP)': [220], 'subset': [223], 'neurons.': [225], 'Neuronal': [226], 'pathways': [227], 'labelled': [228], 'YFP': [230], 'model': [233], 'include': [234], 'reported': [236], 'be': [238, 249, 257, 498], 'affected': [239], 'HD.': [241], 'individual': [245], 'neurons': [247], 'can': [248, 256], 'tracked': [250], 'over': [251], 'long': [252], 'distance': [253], 'traced': [258], 'back': [259], 'their': [261, 654], 'cell': [262, 375], 'bodies.\r\n\r\nUsing': [263], 'powerful': [265], 'imaging': [267], 'method': [268], 'was': [270, 280, 316, 359, 457, 503, 526, 698], 'developed': [271], 'successfully': [273], 'applied': [274], 'Alzheimer’s': [277], 'disease,': [278], 'able': [281], 'place': [283], 'accurately': [286], 'sequence': [289], 'pathological': [291, 462], 'events': [292], 'develop': [294], 'methods': [295], 'quantify': [297], 'it': [298, 583], 'as': [299, 500, 536, 538, 582], 'readout': [300], 'for': [301], 'future': [302, 667], 'studies': [304], 'from': [305, 452, 464], 'our': [306], 'group': [307], 'elsewhere.\r\n\r\nI': [309], 'found': [310, 364, 477, 542, 552, 699], 'morphology': [313], 'strikingly': [317], 'abnormal': [318, 521, 539], 'brain': [321], 'areas': [322], 'homozygous': [325, 580], '(HdhQ140/Q140)': [327], 'where': [328], 'large': [329], 'axonal': [330, 354], 'swellings': [331, 355], 'were': [332, 506, 551], 'detected': [333, 508, 527, 577, 681], '6': [335], 'months': [336, 340, 456, 558], '12': [339, 455, 557], 'age': [342], 'stria': [344], 'terminalis': [345], 'striatum.': [347], 'number': [352], 'increased': [356], 'age-dependently': [357], 'significantly': [360], 'higher': [361], 'than': [362], 'wild-type': [366], 'littermates.': [367], 'However,': [368], 'did': [370], 'detect': [372, 461], 'bodies,': [376], 'dendrites': [377], 'synapses': [379], 'suggesting': [380, 512, 714], 'main': [386], 'feature': [387], 'model.\r\n\r\nTo': [393], 'better': [394], 'KI': [397, 691], 'model,': [398], 'performed': [401], 'battery': [403], 'behavioural': [405, 446], 'tests': [406, 418, 434], 'motor': [409, 422, 431], 'cognitive': [411, 444, 522], 'impairment': [412], 'during': [413], 'progression.': [415], 'used': [417], 'locomotor': [420, 482], 'activity,': [421], 'coordination': [423, 494], 'balance': [425, 492], 'sensorimotor': [427, 513], 'gating': [428], 'measure': [430], 'function': [432], 'spatial': [436], 'working': [437], 'memory': [438], 'anxiety-like': [440], 'behaviour': [441, 525], 'symptoms,': [447, 535], 'respectively.': [448], 'A': [449], 'longitudinal': [450], '1': [453], 'changes': [463, 541], 'stage': [466], 'relate': [468], 'them': [469], 'swelling': [471], 'formation.': [472], 'all': [474], 'tests,': [475], 'strong': [479], 'reduction': [480], 'activity': [483, 620, 688], 'compared': [487, 693], 'controls': [490], 'although': [491], 'seemed': [495], 'impaired': [499], 'rotarod': [501], 'performance': [502], 'unaltered.': [504], 'Alterations': [505], 'prepulse': [510], 'inhibition,': [511], 'defects': [514], 'occur': [515], 'while': [519], 'psychiatric': [524], 'time-frame': [530], 'study.': [533], 'Behavioural': [534], 'well': [537], 'morphological': [540], 'axons,': [544], 'worsened': [545], 'time': [547], 'major': [549], 'impairments': [550], 'latest': [555], 'time-point,': [556], 'age.\r\n\r\nFinally,': [560], 'asked': [562], 'alterations': [564, 609, 682], 'NAD': [567], 'biosynthetic': [568], 'pathway': [569, 589, 626], 'could': [570, 722], 'underline': [571], 'signs': [573], 'has': [584], 'recently': [585], 'emerged': [586], 'regulates': [590], 'survival': [592, 712], 'purpose,': [604], 'looked': [606], 'possible': [608, 716], 'level': [612], 'nucleotides': [614], '(NMN,': [615], 'NAD)': [616], 'key': [622], 'enzymes': [623, 639], '(NMNAT,': [627], 'NAMPT).': [628], 'mHTT': [635, 701, 706], 'interacts': [636], 'NMNAT': [638, 649], 'Wallerian': [643], 'slow': [645], '(WLDs),': [647], 'fusion': [650], 'protein,': [651], 'interferes/impairs': [653], 'normal': [655], 'function.': [656], 'As': [657], 'WLDs': [658, 674, 703], 'delays': [659], 'acute': [663], 'neurodegeneration': [665], 'works': [668], 'beneficial': [671], 'role': [672, 725], 'HD/WldS': [676], 'Despite': [679], 'nucleotide': [684], 'levels': [685], 'enzymatic': [687], 'controls,': [696], 'colocalisation': [697], 'between': [700, 705, 718], 'NMNAT2,': [708], 'important': [710], 'factor,': [713], 'interaction': [717], 'proteins': [720], 'play': [723], 'neurodegeneration.': [728]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3002022713', 'counts_by_year': [], 'updated_date': '2024-12-12T20:10:12.769704', 'created_date': '2020-01-30'}