A new anti-HER2 antibody that enhances the anti-tumor efficacy of trastuzumab and pertuzumab with a distinct mechanism of action

Name: Work Video:
Duration: 3 min 30 s
Xuesai Zhang; Jianhe Chen; Zhibing Weng; Qingrou Li; Le Zhao; Ning Yu; Lan Deng; Wei Xu; Yan Yang; Zhenping Zhu; Haomin Huang
{'id': 'https://openalex.org/W3001641205', 'doi': 'https://doi.org/10.1016/j.molimm.2020.01.009', 'title': 'A new anti-HER2 antibody that enhances the anti-tumor efficacy of trastuzumab and pertuzumab with a distinct mechanism of action', 'display_name': 'A new anti-HER2 antibody that enhances the anti-tumor efficacy of trastuzumab and pertuzumab with a distinct mechanism of action', 'publication_year': 2020, 'publication_date': '2020-01-21', 'ids': {'openalex': 'https://openalex.org/W3001641205', 'doi': 'https://doi.org/10.1016/j.molimm.2020.01.009', 'mag': '3001641205', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/31978707'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.molimm.2020.01.009', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S92126311', 'display_name': 'Molecular Immunology', 'issn_l': '0161-5890', 'issn': ['0161-5890', '1872-9142'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://doi.org/10.1016/j.molimm.2020.01.009', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5019425650', 'display_name': 'Xuesai Zhang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210114190', 'display_name': 'Shanghai Zhangjiang Laboratory', 'ror': 'https://ror.org/0208qbg77', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210114190']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xuesai Zhang', 'raw_affiliation_strings': ['3Sbio Inc., 399 Libing Road, Zhangjiang, Pudong, Shanghai, 201203, China'], 'affiliations': [{'raw_affiliation_string': '3Sbio Inc., 399 Libing Road, Zhangjiang, Pudong, Shanghai, 201203, China', 'institution_ids': ['https://openalex.org/I4210114190']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5075468860', 'display_name': 'Jianhe Chen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210114190', 'display_name': 'Shanghai Zhangjiang Laboratory', 'ror': 'https://ror.org/0208qbg77', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210114190']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jianhe Chen', 'raw_affiliation_strings': ['3Sbio Inc., 399 Libing Road, Zhangjiang, Pudong, Shanghai, 201203, China'], 'affiliations': [{'raw_affiliation_string': '3Sbio Inc., 399 Libing Road, Zhangjiang, Pudong, Shanghai, 201203, China', 'institution_ids': ['https://openalex.org/I4210114190']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090632692', 'display_name': 'Zhibing Weng', 'orcid': 'https://orcid.org/0000-0002-8808-2658'}, 'institutions': [{'id': 'https://openalex.org/I4210114190', 'display_name': 'Shanghai Zhangjiang Laboratory', 'ror': 'https://ror.org/0208qbg77', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210114190']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhibing Weng', 'raw_affiliation_strings': ['3Sbio Inc., 399 Libing Road, Zhangjiang, Pudong, Shanghai, 201203, China'], 'affiliations': [{'raw_affiliation_string': '3Sbio Inc., 399 Libing Road, Zhangjiang, Pudong, Shanghai, 201203, China', 'institution_ids': ['https://openalex.org/I4210114190']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055167561', 'display_name': 'Qingrou Li', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210114190', 'display_name': 'Shanghai Zhangjiang Laboratory', 'ror': 'https://ror.org/0208qbg77', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210114190']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Qingrou Li', 'raw_affiliation_strings': ['3Sbio Inc., 399 Libing Road, Zhangjiang, Pudong, Shanghai, 201203, China'], 'affiliations': [{'raw_affiliation_string': '3Sbio Inc., 399 Libing Road, Zhangjiang, Pudong, Shanghai, 201203, China', 'institution_ids': ['https://openalex.org/I4210114190']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5089791620', 'display_name': 'Le Zhao', 'orcid': 'https://orcid.org/0000-0002-1213-1126'}, 'institutions': [{'id': 'https://openalex.org/I4210114190', 'display_name': 'Shanghai Zhangjiang Laboratory', 'ror': 'https://ror.org/0208qbg77', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210114190']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Le Zhao', 'raw_affiliation_strings': ['3Sbio Inc., 399 Libing Road, Zhangjiang, Pudong, Shanghai, 201203, China'], 'affiliations': [{'raw_affiliation_string': '3Sbio Inc., 399 Libing Road, Zhangjiang, Pudong, Shanghai, 201203, China', 'institution_ids': ['https://openalex.org/I4210114190']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101733019', 'display_name': 'Ning Yu', 'orcid': 'https://orcid.org/0000-0003-2812-9300'}, 'institutions': [{'id': 'https://openalex.org/I4210114190', 'display_name': 'Shanghai Zhangjiang Laboratory', 'ror': 'https://ror.org/0208qbg77', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210114190']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ning Yu', 'raw_affiliation_strings': ['3Sbio Inc., 399 Libing Road, Zhangjiang, Pudong, Shanghai, 201203, China'], 'affiliations': [{'raw_affiliation_string': '3Sbio Inc., 399 Libing Road, Zhangjiang, Pudong, Shanghai, 201203, China', 'institution_ids': ['https://openalex.org/I4210114190']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046892926', 'display_name': 'Lan Deng', 'orcid': 'https://orcid.org/0000-0003-0643-7652'}, 'institutions': [{'id': 'https://openalex.org/I4210114190', 'display_name': 'Shanghai Zhangjiang Laboratory', 'ror': 'https://ror.org/0208qbg77', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210114190']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Lan Deng', 'raw_affiliation_strings': ['3Sbio Inc., 399 Libing Road, Zhangjiang, Pudong, Shanghai, 201203, China'], 'affiliations': [{'raw_affiliation_string': '3Sbio Inc., 399 Libing Road, Zhangjiang, Pudong, Shanghai, 201203, China', 'institution_ids': ['https://openalex.org/I4210114190']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032994590', 'display_name': 'Wei Xu', 'orcid': 'https://orcid.org/0000-0003-3013-7182'}, 'institutions': [{'id': 'https://openalex.org/I4210114190', 'display_name': 'Shanghai Zhangjiang Laboratory', 'ror': 'https://ror.org/0208qbg77', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210114190']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Wei Xu', 'raw_affiliation_strings': ['3Sbio Inc., 399 Libing Road, Zhangjiang, Pudong, Shanghai, 201203, China'], 'affiliations': [{'raw_affiliation_string': '3Sbio Inc., 399 Libing Road, Zhangjiang, Pudong, Shanghai, 201203, China', 'institution_ids': ['https://openalex.org/I4210114190']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101909728', 'display_name': 'Yan Yang', 'orcid': 'https://orcid.org/0000-0002-9739-1807'}, 'institutions': [{'id': 'https://openalex.org/I4210114190', 'display_name': 'Shanghai Zhangjiang Laboratory', 'ror': 'https://ror.org/0208qbg77', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210114190']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yan Yang', 'raw_affiliation_strings': ['3Sbio Inc., 399 Libing Road, Zhangjiang, Pudong, Shanghai, 201203, China'], 'affiliations': [{'raw_affiliation_string': '3Sbio Inc., 399 Libing Road, Zhangjiang, Pudong, Shanghai, 201203, China', 'institution_ids': ['https://openalex.org/I4210114190']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102120005', 'display_name': 'Zhenping Zhu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210114190', 'display_name': 'Shanghai Zhangjiang Laboratory', 'ror': 'https://ror.org/0208qbg77', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210114190']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Zhenping Zhu', 'raw_affiliation_strings': ['3Sbio Inc., 399 Libing Road, Zhangjiang, Pudong, Shanghai, 201203, China'], 'affiliations': [{'raw_affiliation_string': '3Sbio Inc., 399 Libing Road, Zhangjiang, Pudong, Shanghai, 201203, China', 'institution_ids': ['https://openalex.org/I4210114190']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5103056570', 'display_name': 'Haomin Huang', 'orcid': 'https://orcid.org/0000-0002-6671-2233'}, 'institutions': [{'id': 'https://openalex.org/I4210114190', 'display_name': 'Shanghai Zhangjiang Laboratory', 'ror': 'https://ror.org/0208qbg77', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210114190']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Haomin Huang', 'raw_affiliation_strings': ['3Sbio Inc., 399 Libing Road, Zhangjiang, Pudong, Shanghai, 201203, China'], 'affiliations': [{'raw_affiliation_string': '3Sbio Inc., 399 Libing Road, Zhangjiang, Pudong, Shanghai, 201203, China', 'institution_ids': ['https://openalex.org/I4210114190']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5102120005', 'https://openalex.org/A5103056570'], 'corresponding_institution_ids': ['https://openalex.org/I4210114190', 'https://openalex.org/I4210114190'], 'apc_list': {'value': 2970, 'currency': 'USD', 'value_usd': 2970, 'provenance': 'doaj'}, 'apc_paid': {'value': 2970, 'currency': 'USD', 'value_usd': 2970, 'provenance': 'doaj'}, 'fwci': 3.14, 'has_fulltext': False, 'cited_by_count': 39, 'citation_normalized_percentile': {'value': 0.999965, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '119', 'issue': None, 'first_page': '48', 'last_page': '58'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10755', 'display_name': 'HER2/EGFR in Cancer Research', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10755', 'display_name': 'HER2/EGFR in Cancer Research', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11016', 'display_name': 'Monoclonal and Polyclonal Antibodies Research', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12505', 'display_name': 'Peptidase Inhibition and Analysis', 'score': 0.9927, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/pertuzumab', 'display_name': 'Pertuzumab', 'score': 0.9901982}, {'id': 'https://openalex.org/keywords/humanized-antibody', 'display_name': 'Humanized antibody', 'score': 0.48156074}, {'id': 'https://openalex.org/keywords/growth-inhibition', 'display_name': 'Growth inhibition', 'score': 0.45773625}], 'concepts': [{'id': 'https://openalex.org/C2781164504', 'wikidata': 'https://www.wikidata.org/wiki/Q1998021', 'display_name': 'Pertuzumab', 'level': 5, 'score': 0.9901982}, {'id': 'https://openalex.org/C2779786085', 'wikidata': 'https://www.wikidata.org/wiki/Q412616', 'display_name': 'Trastuzumab', 'level': 4, 'score': 0.97317266}, {'id': 'https://openalex.org/C542903549', 'wikidata': 'https://www.wikidata.org/wiki/Q422248', 'display_name': 'Monoclonal antibody', 'level': 3, 'score': 0.68096375}, {'id': 'https://openalex.org/C159654299', 'wikidata': 'https://www.wikidata.org/wiki/Q79460', 'display_name': 'Antibody', 'level': 2, 'score': 0.5260929}, {'id': 'https://openalex.org/C2781190966', 'wikidata': 'https://www.wikidata.org/wiki/Q420436', 'display_name': 'Docetaxel', 'level': 3, 'score': 0.5114264}, {'id': 'https://openalex.org/C2777092746', 'wikidata': 'https://www.wikidata.org/wiki/Q5939625', 'display_name': 'Humanized antibody', 'level': 4, 'score': 0.48156074}, {'id': 'https://openalex.org/C2779707156', 'wikidata': 'https://www.wikidata.org/wiki/Q5611758', 'display_name': 'Growth inhibition', 'level': 3, 'score': 0.45773625}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.41638824}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.40248248}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.393056}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.3907174}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.33646518}, {'id': 'https://openalex.org/C530470458', 'wikidata': 'https://www.wikidata.org/wiki/Q128581', 'display_name': 'Breast cancer', 'level': 3, 'score': 0.31041753}, {'id': 'https://openalex.org/C62112901', 'wikidata': 'https://www.wikidata.org/wiki/Q189159', 'display_name': 'Cell growth', 'level': 2, 'score': 0.29834944}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.17951956}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.14549473}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.11735928}], 'mesh': [{'descriptor_ui': 'D061067', 'descriptor_name': 'Antibodies, Monoclonal, Humanized', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D000074322', 'descriptor_name': 'Antineoplastic Agents, Immunological', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D018719', 'descriptor_name': 'Receptor, ErbB-2', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D000068878', 'descriptor_name': 'Trastuzumab', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D061067', 'descriptor_name': 'Antibodies, Monoclonal, Humanized', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D061067', 'descriptor_name': 'Antibodies, Monoclonal, Humanized', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D061067', 'descriptor_name': 'Antibodies, Monoclonal, Humanized', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D000074322', 'descriptor_name': 'Antineoplastic Agents, Immunological', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D000074322', 'descriptor_name': 'Antineoplastic Agents, Immunological', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000971', 'descriptor_name': 'Antineoplastic Combined Chemotherapy Protocols', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018604', 'descriptor_name': 'Epitope Mapping', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008807', 'descriptor_name': 'Mice, Inbred BALB C', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D048052', 'descriptor_name': 'Mitogen-Activated Protein Kinase 3', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D048052', 'descriptor_name': 'Mitogen-Activated Protein Kinase 3', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051058', 'descriptor_name': 'Oncogene Protein v-akt', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D051058', 'descriptor_name': 'Oncogene Protein v-akt', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000072417', 'descriptor_name': 'Protein Domains', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018719', 'descriptor_name': 'Receptor, ErbB-2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000068878', 'descriptor_name': 'Trastuzumab', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000068878', 'descriptor_name': 'Trastuzumab', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D023041', 'descriptor_name': 'Xenograft Model Antitumor Assays', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.molimm.2020.01.009', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S92126311', 'display_name': 'Molecular Immunology', 'issn_l': '0161-5890', 'issn': ['0161-5890', '1872-9142'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/31978707', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.molimm.2020.01.009', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S92126311', 'display_name': 'Molecular Immunology', 'issn_l': '0161-5890', 'issn': ['0161-5890', '1872-9142'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.87}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 52, 'referenced_works': ['https://openalex.org/W1003261060', 'https://openalex.org/W1644299043', 'https://openalex.org/W1878277203', 'https://openalex.org/W1893360284', 'https://openalex.org/W1968863785', 'https://openalex.org/W1971267920', 'https://openalex.org/W1988104771', 'https://openalex.org/W1988936433', 'https://openalex.org/W2004490932', 'https://openalex.org/W2007435673', 'https://openalex.org/W2011212885', 'https://openalex.org/W2014457594', 'https://openalex.org/W2019182965', 'https://openalex.org/W2027542837', 'https://openalex.org/W2030310433', 'https://openalex.org/W2034801324', 'https://openalex.org/W2039609199', 'https://openalex.org/W2044355123', 'https://openalex.org/W2059411043', 'https://openalex.org/W2062256468', 'https://openalex.org/W2072159023', 'https://openalex.org/W2073385822', 'https://openalex.org/W2078454159', 'https://openalex.org/W2079252551', 'https://openalex.org/W2090855460', 'https://openalex.org/W2105516763', 'https://openalex.org/W2105529073', 'https://openalex.org/W2115759102', 'https://openalex.org/W2121216406', 'https://openalex.org/W2122983196', 'https://openalex.org/W2138899227', 'https://openalex.org/W2139126824', 'https://openalex.org/W2139135964', 'https://openalex.org/W2139444209', 'https://openalex.org/W2154568434', 'https://openalex.org/W2158077354', 'https://openalex.org/W2159459001', 'https://openalex.org/W2165003903', 'https://openalex.org/W2170016411', 'https://openalex.org/W2170961135', 'https://openalex.org/W2199225218', 'https://openalex.org/W2213952892', 'https://openalex.org/W2222638000', 'https://openalex.org/W2276972865', 'https://openalex.org/W2330366426', 'https://openalex.org/W2475165174', 'https://openalex.org/W2614676433', 'https://openalex.org/W2799579330', 'https://openalex.org/W2800628662', 'https://openalex.org/W2980571246', 'https://openalex.org/W4239989216', 'https://openalex.org/W51995314'], 'related_works': ['https://openalex.org/W4361939549', 'https://openalex.org/W3139229505', 'https://openalex.org/W3001641205', 'https://openalex.org/W2921099093', 'https://openalex.org/W2901986589', 'https://openalex.org/W2891579961', 'https://openalex.org/W2769397950', 'https://openalex.org/W2330582602', 'https://openalex.org/W2265171146', 'https://openalex.org/W2120631765'], 'abstract_inverted_index': {'The': [0], 'majority': [1], 'of': [2, 28, 54, 81, 101, 120, 134, 144, 156, 167, 178], 'patients': [3], 'with': [4, 11, 48, 67, 93, 117], 'metastatic': [5], 'breast': [6], 'cancer': [7, 57, 108], 'who': [8], 'are': [9], 'treated': [10], 'the': [12, 21, 29, 72, 78, 141, 154, 164, 176], 'anti-HER2': [13, 36], 'monoclonal': [14, 38], 'antibody,': [15, 39], 'trastuzumab,': [16], 'generally': [17], 'develop': [18], 'resistance': [19], 'to': [20, 43, 71, 77, 111], 'drug': [22], 'within': [23], 'a': [24, 34, 61, 172], 'year': [25], 'after': [26], 'initiation': [27], 'treatment.': [30], 'Here': [31], 'we': [32], 'describe': [33], 'new': [35, 173], 'humanized': [37], '19H6-Hu,': [40, 123, 157], 'which': [41, 84], 'binds': [42, 70], 'HER2': [44, 82, 104, 168], 'extracellular': [45], 'domain': [46, 73, 79], '(ECD)': [47], 'high': [49], 'affinity': [50], 'and': [51, 88, 128, 159, 170], 'inhibits': [52], 'proliferation': [53], 'multiple': [55], 'HER2-overexpressing': [56], 'cell': [58], 'lines': [59], 'as': [60, 151, 153], 'single': [62], 'agent': [63], 'or': [64, 114], 'in': [65, 75, 91, 106, 115], 'combination': [66, 92, 116, 155], 'trastuzumab.': [68], '19H6-Hu': [69, 90], 'III': [74], 'proximity': [76], 'IV': [80], 'ECD,': [83], 'differs': [85], 'from': [86], 'trastuzumab': [87, 94, 112, 126], 'pertuzumab.': [89, 118], 'was': [95], 'more': [96], 'effective': [97], 'at': [98], 'blocking': [99], 'phosphorylation': [100], 'ERK1/2,': [102], 'AKT(S473)and': [103], '(Y1248)': [105], 'HER2-positive': [107], 'cells': [109], 'compared': [110], 'alone': [113], 'Combination': [119], 'three': [121], 'antibodies,': [122], 'inetetamab': [124, 146, 158], '(a': [125], 'analog)': [127], 'pertuzumab': [129], 'exhibited': [130], 'much': [131], 'stronger': [132], 'inhibition': [133], 'large': [135], 'NCI-N87': [136], 'tumor': [137], 'xenografts': [138], '(>400mm3)': [139], 'than': [140], 'current': [142], 'standard': [143], 'care,': [145], '(trastuzumab)': [147], 'plus': [148], 'Docetaxel': [149], '(DTX),': [150], 'well': [152], 'DTX.': [160], 'Our': [161], 'results': [162], 'highlight': [163], 'functional': [165], 'variability': [166], 'domains': [169], 'provide': [171], 'insight': [174], 'into': [175], 'design': [177], 'HER2-targeting': [179], 'agents.': [180]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3001641205', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 11}, {'year': 2022, 'cited_by_count': 9}, {'year': 2021, 'cited_by_count': 8}, {'year': 2020, 'cited_by_count': 5}], 'updated_date': '2024-12-09T21:36:53.050218', 'created_date': '2020-01-30'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
