Title: PENURUNAN KADAR KOLESTEROL TIKUS PUTIH (Rattus norvegicus)PADA PEMBERIAN SERBUK KONJAK (Amorphophallus konjac)TERSTANDARDISASI GLUKOMANAN
Abstract:Konjac glucomannan is obtained from the tuber of Amorphophallus
konjac plant from genus Amorphophallus. Glucomannan is a water-solube
polysaccharide consisting of D-glucose and D-mannose that linked...Konjac glucomannan is obtained from the tuber of Amorphophallus
konjac plant from genus Amorphophallus. Glucomannan is a water-solube
polysaccharide consisting of D-glucose and D-mannose that linked by β-1,4
glycosidic bonds. Glucomannan in konjac tuber can reduce cholesterol level
by forming gel and delay gastric emptying process, thus result inhibited
absorption of fat and carbohydrates. The decrease in absorption of fat and
carbohydrates is expected to reduce cholesterol levels in the blood. This
study aims to determine the hypolipidemic effect of konjac powder
(Amorphophallus konjac) that had been standarized with its glucomannan
level. Glucomannan level obtained in konjac powder were 61.24 ± 0.61%
(w/w). This study consisted of 5 treatment groups, each group consist of six
male white rats (Rattus norvegicus) aged 2-2,5 months, weight of 100-300
grams. Those rats has induced with mixture of high-cholesterol diet
contained lard and duch egg yolk and PTU 0,005%. Treatment groups
consisted of negatif control group (CMC Na-0,3%), positive control group
(simvastatin 0,455mg/kg white rat), and konjac powder dosage group I, II,
and III (with glucomannan dose of 59,5 ; 115,5; 175 mg/kg white rat,
respectively). The treatment was given everyday for 27 days. Measurement
of cholesterol levels performed in day-5,7,10,13, 20, and 27. Meanwhile
measurement of rats body weight was done everyday in order to calculate
konjac powder dosage that must be given. The data obtained was analyzed
with One Way ANOVA with significant value of p<0,05 and p<0,01. The
result showed that konjac powder dosage group III (175mg/kg white rat) is
the best dose to reducing cholesterol levels.Read More
Publication Year: 2019
Publication Date: 2019-01-01
Language: en
Type: dissertation
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