Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2998888862', 'doi': 'https://doi.org/10.1177/0271678x19899577', 'title': 'Metabolic endotoxemia promotes neuroinflammation after focal cerebral ischemia', 'display_name': 'Metabolic endotoxemia promotes neuroinflammation after focal cerebral ischemia', 'publication_year': 2020, 'publication_date': '2020-01-07', 'ids': {'openalex': 'https://openalex.org/W2998888862', 'doi': 'https://doi.org/10.1177/0271678x19899577', 'mag': '2998888862', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/31910709', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/7820690'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1177/0271678x19899577', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S89339265', 'display_name': 'Journal of Cerebral Blood Flow & Metabolism', 'issn_l': '0271-678X', 'issn': ['0271-678X', '1559-7016'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320017', 'host_organization_name': 'SAGE Publishing', 'host_organization_lineage': ['https://openalex.org/P4310320017'], 'host_organization_lineage_names': ['SAGE Publishing'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://doi.org/10.1177/0271678x19899577', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5101926664', 'display_name': 'Naohide Kurita', 'orcid': 'https://orcid.org/0000-0003-4445-8358'}, 'institutions': [{'id': 'https://openalex.org/I34077901', 'display_name': 'Juntendo University', 'ror': 'https://ror.org/01692sz90', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I34077901']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Naohide Kurita', 'raw_affiliation_strings': ['Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan', 'institution_ids': ['https://openalex.org/I34077901']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5075749348', 'display_name': 'Kazuo Yamashiro', 'orcid': 'https://orcid.org/0000-0002-0948-3657'}, 'institutions': [{'id': 'https://openalex.org/I34077901', 'display_name': 'Juntendo University', 'ror': 'https://ror.org/01692sz90', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I34077901']}], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'Kazuo Yamashiro', 'raw_affiliation_strings': ['Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan', 'institution_ids': ['https://openalex.org/I34077901']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110240946', 'display_name': 'Takuma Kuroki', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I34077901', 'display_name': 'Juntendo University', 'ror': 'https://ror.org/01692sz90', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I34077901']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Takuma Kuroki', 'raw_affiliation_strings': ['Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan', 'institution_ids': ['https://openalex.org/I34077901']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016589120', 'display_name': 'Ryota Tanaka', 'orcid': 'https://orcid.org/0000-0003-3158-1955'}, 'institutions': [{'id': 'https://openalex.org/I146500386', 'display_name': 'Jichi Medical University', 'ror': 'https://ror.org/010hz0g26', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I146500386']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Ryota Tanaka', 'raw_affiliation_strings': ['Division of Neurology, Department of Internal Medicine, Jichi Medical University, Tochigi Japan'], 'affiliations': [{'raw_affiliation_string': 'Division of Neurology, Department of Internal Medicine, Jichi Medical University, Tochigi Japan', 'institution_ids': ['https://openalex.org/I146500386']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041604185', 'display_name': 'Takao Urabe', 'orcid': 'https://orcid.org/0000-0002-3204-0010'}, 'institutions': [{'id': 'https://openalex.org/I4210137488', 'display_name': 'Juntendo University Urayasu Hospital', 'ror': 'https://ror.org/03gxkq182', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210137488']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Takao Urabe', 'raw_affiliation_strings': ['Department of Neurology, Juntendo University Urayasu Hospital, Chiba, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, Juntendo University Urayasu Hospital, Chiba, Japan', 'institution_ids': ['https://openalex.org/I4210137488']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037688368', 'display_name': 'Yuji Ueno', 'orcid': 'https://orcid.org/0000-0002-8617-3695'}, 'institutions': [{'id': 'https://openalex.org/I34077901', 'display_name': 'Juntendo University', 'ror': 'https://ror.org/01692sz90', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I34077901']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yuji Ueno', 'raw_affiliation_strings': ['Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan', 'institution_ids': ['https://openalex.org/I34077901']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019184835', 'display_name': 'Nobukazu Miyamoto', 'orcid': 'https://orcid.org/0000-0003-3037-169X'}, 'institutions': [{'id': 'https://openalex.org/I34077901', 'display_name': 'Juntendo University', 'ror': 'https://ror.org/01692sz90', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I34077901']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Nobukazu Miyamoto', 'raw_affiliation_strings': ['Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan', 'institution_ids': ['https://openalex.org/I34077901']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5064755910', 'display_name': 'Masashi Takanashi', 'orcid': 'https://orcid.org/0000-0002-3100-2370'}, 'institutions': [{'id': 'https://openalex.org/I34077901', 'display_name': 'Juntendo University', 'ror': 'https://ror.org/01692sz90', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I34077901']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Masashi Takanashi', 'raw_affiliation_strings': ['Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan', 'institution_ids': ['https://openalex.org/I34077901']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084716950', 'display_name': 'Hideki Shimura', 'orcid': 'https://orcid.org/0000-0002-2630-0293'}, 'institutions': [{'id': 'https://openalex.org/I4210137488', 'display_name': 'Juntendo University Urayasu Hospital', 'ror': 'https://ror.org/03gxkq182', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210137488']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hideki Shimura', 'raw_affiliation_strings': ['Department of Neurology, Juntendo University Urayasu Hospital, Chiba, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, Juntendo University Urayasu Hospital, Chiba, Japan', 'institution_ids': ['https://openalex.org/I4210137488']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036814115', 'display_name': 'Toshiki Inaba', 'orcid': 'https://orcid.org/0009-0003-4381-4290'}, 'institutions': [{'id': 'https://openalex.org/I4210137488', 'display_name': 'Juntendo University Urayasu Hospital', 'ror': 'https://ror.org/03gxkq182', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210137488']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Toshiki Inaba', 'raw_affiliation_strings': ['Department of Neurology, Juntendo University Urayasu Hospital, Chiba, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, Juntendo University Urayasu Hospital, Chiba, Japan', 'institution_ids': ['https://openalex.org/I4210137488']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109437899', 'display_name': 'Yuichiro Yamashiro', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I34077901', 'display_name': 'Juntendo University', 'ror': 'https://ror.org/01692sz90', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I34077901']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yuichiro Yamashiro', 'raw_affiliation_strings': ['Probiotics Research Laboratory, Juntendo University Graduate School of Medicine, Tokyo, Japan'], 'affiliations': [{'raw_affiliation_string': 'Probiotics Research Laboratory, Juntendo University Graduate School of Medicine, Tokyo, Japan', 'institution_ids': ['https://openalex.org/I34077901']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108443834', 'display_name': 'Koji Nomoto', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I34077901', 'display_name': 'Juntendo University', 'ror': 'https://ror.org/01692sz90', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I34077901']}, {'id': 'https://openalex.org/I127317711', 'display_name': 'Tokyo University of Agriculture', 'ror': 'https://ror.org/05crbcr45', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I127317711']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Koji Nomoto', 'raw_affiliation_strings': ['Department of Molecular Microbiology, Tokyo University of Agriculture, Tokyo, Japan', 'Probiotics Research Laboratory, Juntendo University Graduate School of Medicine, Tokyo, Japan'], 'affiliations': [{'raw_affiliation_string': 'Probiotics Research Laboratory, Juntendo University Graduate School of Medicine, Tokyo, Japan', 'institution_ids': ['https://openalex.org/I34077901']}, {'raw_affiliation_string': 'Department of Molecular Microbiology, Tokyo University of Agriculture, Tokyo, Japan', 'institution_ids': ['https://openalex.org/I127317711']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005177820', 'display_name': 'Satoshi Matsumoto', 'orcid': 'https://orcid.org/0000-0003-4836-7170'}, 'institutions': [{'id': 'https://openalex.org/I34077901', 'display_name': 'Juntendo University', 'ror': 'https://ror.org/01692sz90', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I34077901']}, {'id': 'https://openalex.org/I4210153337', 'display_name': 'Yakult Central Institute', 'ror': 'https://ror.org/04gcc2383', 'country_code': 'JP', 'type': 'facility', 'lineage': ['https://openalex.org/I4210153337']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Satoshi Matsumoto', 'raw_affiliation_strings': ['Probiotics Research Laboratory, Juntendo University Graduate School of Medicine, Tokyo, Japan', 'Yakult Central Institute, Tokyo, Japan'], 'affiliations': [{'raw_affiliation_string': 'Probiotics Research Laboratory, Juntendo University Graduate School of Medicine, Tokyo, Japan', 'institution_ids': ['https://openalex.org/I34077901']}, {'raw_affiliation_string': 'Yakult Central Institute, Tokyo, Japan', 'institution_ids': ['https://openalex.org/I4210153337']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101432788', 'display_name': 'Takuya Takahashi', 'orcid': 'https://orcid.org/0000-0001-9998-2611'}, 'institutions': [{'id': 'https://openalex.org/I34077901', 'display_name': 'Juntendo University', 'ror': 'https://ror.org/01692sz90', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I34077901']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Takuya Takahashi', 'raw_affiliation_strings': ['Probiotics Research Laboratory, Juntendo University Graduate School of Medicine, Tokyo, Japan', 'Yakult Honsha European Research Center for Microbiology ESV, Gent, Belgium'], 'affiliations': [{'raw_affiliation_string': 'Probiotics Research Laboratory, Juntendo University Graduate School of Medicine, Tokyo, Japan', 'institution_ids': ['https://openalex.org/I34077901']}, {'raw_affiliation_string': 'Yakult Honsha European Research Center for Microbiology ESV, Gent, Belgium', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026642736', 'display_name': 'Hirokazu Tsuji', 'orcid': 'https://orcid.org/0000-0003-2856-6447'}, 'institutions': [{'id': 'https://openalex.org/I34077901', 'display_name': 'Juntendo University', 'ror': 'https://ror.org/01692sz90', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I34077901']}, {'id': 'https://openalex.org/I4210153337', 'display_name': 'Yakult Central Institute', 'ror': 'https://ror.org/04gcc2383', 'country_code': 'JP', 'type': 'facility', 'lineage': ['https://openalex.org/I4210153337']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hirokazu Tsuji', 'raw_affiliation_strings': ['Probiotics Research Laboratory, Juntendo University Graduate School of Medicine, Tokyo, Japan', 'Yakult Central Institute, Tokyo, Japan'], 'affiliations': [{'raw_affiliation_string': 'Probiotics Research Laboratory, Juntendo University Graduate School of Medicine, Tokyo, Japan', 'institution_ids': ['https://openalex.org/I34077901']}, {'raw_affiliation_string': 'Yakult Central Institute, Tokyo, Japan', 'institution_ids': ['https://openalex.org/I4210153337']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061247668', 'display_name': 'Takashi Asahara', 'orcid': 'https://orcid.org/0000-0001-5126-0636'}, 'institutions': [{'id': 'https://openalex.org/I34077901', 'display_name': 'Juntendo University', 'ror': 'https://ror.org/01692sz90', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I34077901']}, {'id': 'https://openalex.org/I4210153337', 'display_name': 'Yakult Central Institute', 'ror': 'https://ror.org/04gcc2383', 'country_code': 'JP', 'type': 'facility', 'lineage': ['https://openalex.org/I4210153337']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Takashi Asahara', 'raw_affiliation_strings': ['Probiotics Research Laboratory, Juntendo University Graduate School of Medicine, Tokyo, Japan', 'Yakult Central Institute, Tokyo, Japan'], 'affiliations': [{'raw_affiliation_string': 'Probiotics Research Laboratory, Juntendo University Graduate School of Medicine, Tokyo, Japan', 'institution_ids': ['https://openalex.org/I34077901']}, {'raw_affiliation_string': 'Yakult Central Institute, Tokyo, Japan', 'institution_ids': ['https://openalex.org/I4210153337']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5014705038', 'display_name': 'Nobutaka Hattori', 'orcid': 'https://orcid.org/0000-0002-2034-2556'}, 'institutions': [{'id': 'https://openalex.org/I34077901', 'display_name': 'Juntendo University', 'ror': 'https://ror.org/01692sz90', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I34077901']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Nobutaka Hattori', 'raw_affiliation_strings': ['Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan', 'institution_ids': ['https://openalex.org/I34077901']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 5, 'corresponding_author_ids': ['https://openalex.org/A5075749348'], 'corresponding_institution_ids': ['https://openalex.org/I34077901'], 'apc_list': None, 'apc_paid': None, 'fwci': 5.654, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 79, 'citation_normalized_percentile': {'value': 0.999808, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '40', 'issue': '12', 'first_page': '2505', 'last_page': '2520'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11266', 'display_name': 'Neuroinflammation and Neurodegeneration Mechanisms', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2808', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11266', 'display_name': 'Neuroinflammation and Neurodegeneration Mechanisms', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2808', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10066', 'display_name': 'Gut microbiota and health', 'score': 0.9984, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11872', 'display_name': 'Barrier Structure and Function Studies', 'score': 0.9927, 'subfield': {'id': 'https://openalex.org/subfields/2808', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/intestinal-permeability', 'display_name': 'Intestinal Permeability', 'score': 0.4534235}, {'id': 'https://openalex.org/keywords/stroke', 'display_name': 'Stroke', 'score': 0.43629038}], 'concepts': [{'id': 'https://openalex.org/C87753298', 'wikidata': 'https://www.wikidata.org/wiki/Q17157137', 'display_name': 'Neuroinflammation', 'level': 3, 'score': 0.8102201}, {'id': 'https://openalex.org/C2778754761', 'wikidata': 'https://www.wikidata.org/wiki/Q421804', 'display_name': 'Lipopolysaccharide', 'level': 2, 'score': 0.71985275}, {'id': 'https://openalex.org/C2776070231', 'wikidata': 'https://www.wikidata.org/wiki/Q14914098', 'display_name': 'TLR4', 'level': 3, 'score': 0.7196586}, {'id': 'https://openalex.org/C539455810', 'wikidata': 'https://www.wikidata.org/wiki/Q739734', 'display_name': 'Gut flora', 'level': 2, 'score': 0.5897205}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.5792054}, {'id': 'https://openalex.org/C2776914184', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammation', 'level': 2, 'score': 0.5148972}, {'id': 'https://openalex.org/C541997718', 'wikidata': 'https://www.wikidata.org/wiki/Q188151', 'display_name': 'Ischemia', 'level': 2, 'score': 0.5124936}, {'id': 'https://openalex.org/C136449434', 'wikidata': 'https://www.wikidata.org/wiki/Q428253', 'display_name': 'Innate immune system', 'level': 3, 'score': 0.46589172}, {'id': 'https://openalex.org/C2781071285', 'wikidata': 'https://www.wikidata.org/wiki/Q17141320', 'display_name': 'Intestinal permeability', 'level': 2, 'score': 0.4534235}, {'id': 'https://openalex.org/C2780645631', 'wikidata': 'https://www.wikidata.org/wiki/Q671554', 'display_name': 'Stroke (engine)', 'level': 2, 'score': 0.43629038}, {'id': 'https://openalex.org/C2778384902', 'wikidata': 'https://www.wikidata.org/wiki/Q183134', 'display_name': 'Sepsis', 'level': 2, 'score': 0.4342345}, {'id': 'https://openalex.org/C25498285', 'wikidata': 'https://www.wikidata.org/wiki/Q1981368', 'display_name': 'Neuroprotection', 'level': 2, 'score': 0.4309606}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.3952297}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.39191586}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.371302}, {'id': 'https://openalex.org/C78519656', 'wikidata': 'https://www.wikidata.org/wiki/Q101333', 'display_name': 'Mechanical engineering', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C127413603', 'wikidata': 'https://www.wikidata.org/wiki/Q11023', 'display_name': 'Engineering', 'level': 0, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D002545', 'descriptor_name': 'Brain Ischemia', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D019446', 'descriptor_name': 'Endotoxemia', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D008070', 'descriptor_name': 'Lipopolysaccharides', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D020078', 'descriptor_name': 'Neurogenic Inflammation', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000284', 'descriptor_name': 'Administration, Oral', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000900', 'descriptor_name': 'Anti-Bacterial Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000900', 'descriptor_name': 'Anti-Bacterial Agents', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D000900', 'descriptor_name': 'Anti-Bacterial Agents', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D002545', 'descriptor_name': 'Brain Ischemia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002545', 'descriptor_name': 'Brain Ischemia', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D016022', 'descriptor_name': 'Case-Control Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D003924', 'descriptor_name': 'Diabetes Mellitus, Type 2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003924', 'descriptor_name': 'Diabetes Mellitus, Type 2', 'qualifier_ui': 'Q000150', 'qualifier_name': 'complications', 'is_major_topic': False}, {'descriptor_ui': 'D019446', 'descriptor_name': 'Endotoxemia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019446', 'descriptor_name': 'Endotoxemia', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D019446', 'descriptor_name': 'Endotoxemia', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D000069196', 'descriptor_name': 'Gastrointestinal Microbiome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000069196', 'descriptor_name': 'Gastrointestinal Microbiome', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D000069196', 'descriptor_name': 'Gastrointestinal Microbiome', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D006090', 'descriptor_name': 'Gram-Negative Bacteria', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006090', 'descriptor_name': 'Gram-Negative Bacteria', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D007113', 'descriptor_name': 'Immunity, Innate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007113', 'descriptor_name': 'Immunity, Innate', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D020244', 'descriptor_name': 'Infarction, Middle Cerebral Artery', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020244', 'descriptor_name': 'Infarction, Middle Cerebral Artery', 'qualifier_ui': 'Q000150', 'qualifier_name': 'complications', 'is_major_topic': False}, {'descriptor_ui': 'D020244', 'descriptor_name': 'Infarction, Middle Cerebral Artery', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D020244', 'descriptor_name': 'Infarction, Middle Cerebral Artery', 'qualifier_ui': 'Q000662', 'qualifier_name': 'veterinary', 'is_major_topic': False}, {'descriptor_ui': 'D008070', 'descriptor_name': 'Lipopolysaccharides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008070', 'descriptor_name': 'Lipopolysaccharides', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D008070', 'descriptor_name': 'Lipopolysaccharides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D023421', 'descriptor_name': 'Models, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020078', 'descriptor_name': 'Neurogenic Inflammation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020078', 'descriptor_name': 'Neurogenic Inflammation', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D020078', 'descriptor_name': 'Neurogenic Inflammation', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D011112', 'descriptor_name': 'Polymyxin B', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011112', 'descriptor_name': 'Polymyxin B', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D011112', 'descriptor_name': 'Polymyxin B', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D020521', 'descriptor_name': 'Stroke', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020521', 'descriptor_name': 'Stroke', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015996', 'descriptor_name': 'Survival Rate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051197', 'descriptor_name': 'Toll-Like Receptor 4', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051197', 'descriptor_name': 'Toll-Like Receptor 4', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D051197', 'descriptor_name': 'Toll-Like Receptor 4', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1177/0271678x19899577', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S89339265', 'display_name': 'Journal of Cerebral Blood Flow & Metabolism', 'issn_l': '0271-678X', 'issn': ['0271-678X', '1559-7016'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320017', 'host_organization_name': 'SAGE Publishing', 'host_organization_lineage': ['https://openalex.org/P4310320017'], 'host_organization_lineage_names': ['SAGE Publishing'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7820690', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://library.med.juntendo.ac.jp/infolib/user_contents/MDK2171-zenbunps.pdf', 'pdf_url': 'https://library.med.juntendo.ac.jp/infolib/user_contents/MDK2171-zenbunps.pdf', 'source': {'id': 'https://openalex.org/S4306402466', 'display_name': '順天堂大学学術情報リポジトリ (Juntendo University)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I34077901', 'host_organization_name': 'Juntendo University', 'host_organization_lineage': ['https://openalex.org/I34077901'], 'host_organization_lineage_names': ['Juntendo University'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/31910709', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1177/0271678x19899577', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S89339265', 'display_name': 'Journal of Cerebral Blood Flow & Metabolism', 'issn_l': '0271-678X', 'issn': ['0271-678X', '1559-7016'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320017', 'host_organization_name': 'SAGE Publishing', 'host_organization_lineage': ['https://openalex.org/P4310320017'], 'host_organization_lineage_names': ['SAGE Publishing'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.82, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 54, 'referenced_works': ['https://openalex.org/W1535151445', 'https://openalex.org/W1647551795', 'https://openalex.org/W1668720646', 'https://openalex.org/W1965049141', 'https://openalex.org/W1969092907', 'https://openalex.org/W1972179333', 'https://openalex.org/W1974411214', 'https://openalex.org/W2000980663', 'https://openalex.org/W2004872316', 'https://openalex.org/W2009759079', 'https://openalex.org/W2010449070', 'https://openalex.org/W2029883168', 'https://openalex.org/W2031062821', 'https://openalex.org/W2044842166', 'https://openalex.org/W2045098547', 'https://openalex.org/W2047218153', 'https://openalex.org/W2050989633', 'https://openalex.org/W2052179757', 'https://openalex.org/W2058623137', 'https://openalex.org/W2062993799', 'https://openalex.org/W2067267561', 'https://openalex.org/W2067297478', 'https://openalex.org/W2078378773', 'https://openalex.org/W2088299611', 'https://openalex.org/W2093099046', 'https://openalex.org/W2099087271', 'https://openalex.org/W2109342780', 'https://openalex.org/W2109491705', 'https://openalex.org/W2109708024', 'https://openalex.org/W2115763995', 'https://openalex.org/W2123355863', 'https://openalex.org/W2128132289', 'https://openalex.org/W2129917444', 'https://openalex.org/W2143366420', 'https://openalex.org/W2150679087', 'https://openalex.org/W2152625605', 'https://openalex.org/W2153406190', 'https://openalex.org/W2178133650', 'https://openalex.org/W2280077905', 'https://openalex.org/W2299815162', 'https://openalex.org/W2313441994', 'https://openalex.org/W2330162035', 'https://openalex.org/W2332044667', 'https://openalex.org/W2346477682', 'https://openalex.org/W2460079419', 'https://openalex.org/W2527885929', 'https://openalex.org/W2545292312', 'https://openalex.org/W2553323458', 'https://openalex.org/W2587564932', 'https://openalex.org/W2593444269', 'https://openalex.org/W2771809241', 'https://openalex.org/W2782649551', 'https://openalex.org/W2783536380', 'https://openalex.org/W2964070886'], 'related_works': ['https://openalex.org/W4390463473', 'https://openalex.org/W4353055846', 'https://openalex.org/W3214990960', 'https://openalex.org/W3192422131', 'https://openalex.org/W3186649735', 'https://openalex.org/W3044278198', 'https://openalex.org/W3006607105', 'https://openalex.org/W2965996877', 'https://openalex.org/W2929186841', 'https://openalex.org/W1987143582'], 'abstract_inverted_index': {'Lipopolysaccharide': [0], '(LPS)': [1], 'is': [2, 32], 'a': [3, 14, 54, 79, 152, 193], 'major': [4], 'component': [5], 'of': [6, 10, 47, 65, 82, 126, 151, 175], 'the': [7, 19, 51, 63, 133, 156, 181], 'outer': [8], 'membrane': [9], 'Gram-negative': [11], 'bacteria': [12], 'and': [13, 39, 88, 109, 122, 129, 143, 159, 163, 178], 'potent': [15], 'inflammatory': [16, 130], 'stimulus': [17], 'for': [18], 'innate': [20], 'immune': [21], 'response': [22], 'via': [23], 'toll-like': [24], 'receptor': [25], '(TLR)': [26], '4': [27], 'activation.': [28], 'Type': [29], '2': [30, 84], 'diabetes': [31, 85], 'associated': [33, 172], 'with': [34, 71, 173], 'changes': [35], 'in': [36, 78, 132, 166, 180], 'gut': [37, 103, 157], 'microbiota': [38, 158], 'impaired': [40], 'intestinal': [41, 107], 'barrier': [42], 'functions,': [43], 'leading': [44], 'to': [45, 57, 95, 198], 'translocation': [46], 'microbiota-derived': [48], 'LPS': [49, 112, 176], 'into': [50], 'circulatory': [52], 'system,': [53], 'condition': [55], 'referred': [56], 'as': [58, 136, 138], 'metabolic': [59, 66, 161, 189], 'endotoxemia.': [60], 'We': [61], 'investigated': [62], 'effects': [64, 170], 'endotoxemia': [67, 162, 190], 'after': [68, 147], 'experimental': [69], 'stroke': [70, 164, 200], 'transient': [72], 'middle': [73], 'cerebral': [74], 'artery': [75], 'occlusion': [76], '(MCAO)': [77], 'murine': [80], 'model': [81], 'type': [83], '(': [86, 92], 'db/db)': [87], 'phenotypically': [89], 'normal': [90], 'littermates': [91], 'db/+).': [93], 'Compared': [94], 'db/+': [96], 'mice,': [97], 'db/db': [98, 116, 167], 'mice': [99, 117], 'exhibited': [100], 'an': [101], 'altered': [102], 'microbial': [104], 'composition,': [105], 'increased': [106, 119], 'permeability,': [108], 'higher': [110, 123], 'plasma': [111], 'levels.': [113], 'In': [114], 'addition,': [115], 'presented': [118], 'infarct': [120], 'volumes': [121], 'expression': [124], 'levels': [125, 177], 'LPS,': [127], 'TLR4,': [128], 'cytokines': [131], 'ischemic': [134, 182], 'brain,': [135], 'well': [137], 'more': [139], 'severe': [140], 'neurological': [141], 'impairments': [142], 'reduced': [144], 'survival': [145], 'rates': [146], 'MCAO.': [148], 'Oral': [149], 'administration': [150], 'non-absorbable': [153], 'antibiotic': [154], 'modulated': [155], 'improved': [160], 'outcomes': [165], 'mice;': [168], 'these': [169], 'were': [171], 'reduction': [174], 'neuroinflammation': [179], 'brain.': [183], 'These': [184], 'data': [185], 'suggest': [186], 'that': [187], 'targeting': [188], 'may': [191], 'be': [192], 'novel': [194], 'potential': [195], 'therapeutic': [196], 'strategy': [197], 'improve': [199], 'outcomes.': [201]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2998888862', 'counts_by_year': [{'year': 2024, 'cited_by_count': 23}, {'year': 2023, 'cited_by_count': 24}, {'year': 2022, 'cited_by_count': 19}, {'year': 2021, 'cited_by_count': 10}, {'year': 2020, 'cited_by_count': 3}], 'updated_date': '2025-01-06T23:53:20.402702', 'created_date': '2020-01-23'}