Publication Information

{'id': 'https://openalex.org/W2998655779', 'doi': 'https://doi.org/10.1172/jci129202', 'title': 'Integrative omics approaches provide biological and clinical insights: examples from mitochondrial diseases', 'display_name': 'Integrative omics approaches provide biological and clinical insights: examples from mitochondrial diseases', 'publication_year': 2020, 'publication_date': '2020-01-01', 'ids': {'openalex': 'https://openalex.org/W2998655779', 'doi': 'https://doi.org/10.1172/jci129202', 'mag': '2998655779', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/31895050', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/6934214'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1172/jci129202', 'pdf_url': 'http://www.jci.org/articles/view/129202/files/pdf', 'source': {'id': 'https://openalex.org/S114430552', 'display_name': 'Journal of Clinical Investigation', 'issn_l': '0021-9738', 'issn': ['0021-9738', '1558-8238'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320279', 'host_organization_name': 'American Society for Clinical Investigation', 'host_organization_lineage': ['https://openalex.org/P4310320279'], 'host_organization_lineage_names': ['American Society for Clinical Investigation'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'http://www.jci.org/articles/view/129202/files/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5052915247', 'display_name': 'Sofia Khan', 'orcid': 'https://orcid.org/0000-0003-4185-8882'}, 'institutions': [{'id': 'https://openalex.org/I183173800', 'display_name': 'Turku Centre for Computer Science', 'ror': 'https://ror.org/00vy7ed73', 'country_code': 'FI', 'type': 'facility', 'lineage': ['https://openalex.org/I130217899', 'https://openalex.org/I155660961', 'https://openalex.org/I183173800']}, {'id': 'https://openalex.org/I155660961', 'display_name': 'University of Turku', 'ror': 'https://ror.org/05vghhr25', 'country_code': 'FI', 'type': 'education', 'lineage': ['https://openalex.org/I155660961']}, {'id': 'https://openalex.org/I130217899', 'display_name': 'Åbo Akademi University', 'ror': 'https://ror.org/029pk6x14', 'country_code': 'FI', 'type': 'education', 'lineage': ['https://openalex.org/I130217899']}], 'countries': ['FI'], 'is_corresponding': False, 'raw_author_name': 'Sofia Khan', 'raw_affiliation_strings': ['Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.'], 'affiliations': [{'raw_affiliation_string': 'Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.', 'institution_ids': ['https://openalex.org/I183173800', 'https://openalex.org/I155660961', 'https://openalex.org/I130217899']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050673996', 'display_name': 'Gulayse Ince-Dunn', 'orcid': 'https://orcid.org/0000-0003-1352-990X'}, 'institutions': [{'id': 'https://openalex.org/I133731052', 'display_name': 'University of Helsinki', 'ror': 'https://ror.org/040af2s02', 'country_code': 'FI', 'type': 'education', 'lineage': ['https://openalex.org/I133731052']}], 'countries': ['FI'], 'is_corresponding': False, 'raw_author_name': 'Gulayse Ince-Dunn', 'raw_affiliation_strings': ['Research Programs Unit, Stem Cells and Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.'], 'affiliations': [{'raw_affiliation_string': 'Research Programs Unit, Stem Cells and Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.', 'institution_ids': ['https://openalex.org/I133731052']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061096092', 'display_name': 'Anu Suomalainen', 'orcid': 'https://orcid.org/0000-0003-4833-5195'}, 'institutions': [{'id': 'https://openalex.org/I133731052', 'display_name': 'University of Helsinki', 'ror': 'https://ror.org/040af2s02', 'country_code': 'FI', 'type': 'education', 'lineage': ['https://openalex.org/I133731052']}, {'id': 'https://openalex.org/I2800394112', 'display_name': 'Helsinki University Hospital', 'ror': 'https://ror.org/02e8hzf44', 'country_code': 'FI', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800394112', 'https://openalex.org/I4210166427']}], 'countries': ['FI'], 'is_corresponding': True, 'raw_author_name': 'Anu Suomalainen', 'raw_affiliation_strings': ['Helsinki University Hospital, HUSlab, Helsinki, Finland.', 'Neuroscience Center, HiLife, University of Helsinki, Helsinki, Finland.', 'Research Programs Unit, Stem Cells and Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.'], 'affiliations': [{'raw_affiliation_string': 'Research Programs Unit, Stem Cells and Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.', 'institution_ids': ['https://openalex.org/I133731052']}, {'raw_affiliation_string': 'Helsinki University Hospital, HUSlab, Helsinki, Finland.', 'institution_ids': ['https://openalex.org/I2800394112']}, {'raw_affiliation_string': 'Neuroscience Center, HiLife, University of Helsinki, Helsinki, Finland.', 'institution_ids': ['https://openalex.org/I133731052']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5062339398', 'display_name': 'Laura L. Elo', 'orcid': 'https://orcid.org/0000-0001-5648-4532'}, 'institutions': [{'id': 'https://openalex.org/I183173800', 'display_name': 'Turku Centre for Computer Science', 'ror': 'https://ror.org/00vy7ed73', 'country_code': 'FI', 'type': 'facility', 'lineage': ['https://openalex.org/I130217899', 'https://openalex.org/I155660961', 'https://openalex.org/I183173800']}, {'id': 'https://openalex.org/I155660961', 'display_name': 'University of Turku', 'ror': 'https://ror.org/05vghhr25', 'country_code': 'FI', 'type': 'education', 'lineage': ['https://openalex.org/I155660961']}, {'id': 'https://openalex.org/I130217899', 'display_name': 'Åbo Akademi University', 'ror': 'https://ror.org/029pk6x14', 'country_code': 'FI', 'type': 'education', 'lineage': ['https://openalex.org/I130217899']}], 'countries': ['FI'], 'is_corresponding': False, 'raw_author_name': 'Laura L. Elo', 'raw_affiliation_strings': ['Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.'], 'affiliations': [{'raw_affiliation_string': 'Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.', 'institution_ids': ['https://openalex.org/I183173800', 'https://openalex.org/I155660961', 'https://openalex.org/I130217899']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 5, 'corresponding_author_ids': ['https://openalex.org/A5061096092'], 'corresponding_institution_ids': ['https://openalex.org/I133731052', 'https://openalex.org/I2800394112'], 'apc_list': {'value': 5200, 'currency': 'USD', 'value_usd': 5200, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.914, 'has_fulltext': False, 'cited_by_count': 47, 'citation_normalized_percentile': {'value': 0.999775, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '130', 'issue': '1', 'first_page': '20', 'last_page': '28'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10301', 'display_name': 'Mitochondrial Function and Pathology', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10301', 'display_name': 'Mitochondrial Function and Pathology', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12763', 'display_name': 'ATP Synthase and ATPases Research', 'score': 0.9984, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11027', 'display_name': 'Metabolism and Genetic Disorders', 'score': 0.9974, 'subfield': {'id': 'https://openalex.org/subfields/1308', 'display_name': 'Clinical Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/omics', 'display_name': 'Omics', 'score': 0.79218006}, {'id': 'https://openalex.org/keywords/metabolome', 'display_name': 'Metabolome', 'score': 0.7435279}, {'id': 'https://openalex.org/keywords/mitochondrial-disease', 'display_name': 'Mitochondrial disease', 'score': 0.63141453}], 'concepts': [{'id': 'https://openalex.org/C157585117', 'wikidata': 'https://www.wikidata.org/wiki/Q158666', 'display_name': 'Omics', 'level': 2, 'score': 0.79218006}, {'id': 'https://openalex.org/C21565614', 'wikidata': 'https://www.wikidata.org/wiki/Q12149006', 'display_name': 'Metabolomics', 'level': 2, 'score': 0.74849576}, {'id': 'https://openalex.org/C135870905', 'wikidata': 'https://www.wikidata.org/wiki/Q903667', 'display_name': 'Metabolome', 'level': 3, 'score': 0.7435279}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.6617205}, {'id': 'https://openalex.org/C46111723', 'wikidata': 'https://www.wikidata.org/wiki/Q471857', 'display_name': 'Proteomics', 'level': 3, 'score': 0.6389807}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.6380857}, {'id': 'https://openalex.org/C2777614518', 'wikidata': 'https://www.wikidata.org/wiki/Q935710', 'display_name': 'Mitochondrial disease', 'level': 4, 'score': 0.63141453}, {'id': 'https://openalex.org/C189206191', 'wikidata': 'https://www.wikidata.org/wiki/Q222046', 'display_name': 'Genomics', 'level': 4, 'score': 0.60419667}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.5824084}, {'id': 'https://openalex.org/C152662350', 'wikidata': 'https://www.wikidata.org/wiki/Q815297', 'display_name': 'Systems biology', 'level': 2, 'score': 0.5018861}, {'id': 'https://openalex.org/C60644358', 'wikidata': 'https://www.wikidata.org/wiki/Q128570', 'display_name': 'Bioinformatics', 'level': 1, 'score': 0.47594738}, {'id': 'https://openalex.org/C162317418', 'wikidata': 'https://www.wikidata.org/wiki/Q252857', 'display_name': 'Transcriptome', 'level': 4, 'score': 0.47283468}, {'id': 'https://openalex.org/C28859421', 'wikidata': 'https://www.wikidata.org/wiki/Q39572', 'display_name': 'Mitochondrion', 'level': 2, 'score': 0.45181942}, {'id': 'https://openalex.org/C24586158', 'wikidata': 'https://www.wikidata.org/wiki/Q27075', 'display_name': 'Mitochondrial DNA', 'level': 3, 'score': 0.43197283}, {'id': 'https://openalex.org/C141231307', 'wikidata': 'https://www.wikidata.org/wiki/Q7020', 'display_name': 'Genome', 'level': 3, 'score': 0.34440362}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.2568382}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.24535632}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.16685048}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.16344193}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.06764856}], 'mesh': [{'descriptor_ui': 'D055432', 'descriptor_name': 'Metabolomics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D028361', 'descriptor_name': 'Mitochondrial Diseases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004195', 'descriptor_name': 'Disease Models, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D028361', 'descriptor_name': 'Mitochondrial Diseases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D028361', 'descriptor_name': 'Mitochondrial Diseases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009928', 'descriptor_name': 'Organ Specificity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D040641', 'descriptor_name': 'Quantitative Trait Loci', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1172/jci129202', 'pdf_url': 'http://www.jci.org/articles/view/129202/files/pdf', 'source': {'id': 'https://openalex.org/S114430552', 'display_name': 'Journal of Clinical Investigation', 'issn_l': '0021-9738', 'issn': ['0021-9738', '1558-8238'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320279', 'host_organization_name': 'American Society for Clinical Investigation', 'host_organization_lineage': ['https://openalex.org/P4310320279'], 'host_organization_lineage_names': ['American Society for Clinical Investigation'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc6934214', 'pdf_url': 'https://europepmc.org/articles/pmc6934214?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934214', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/31895050', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1172/jci129202', 'pdf_url': 'http://www.jci.org/articles/view/129202/files/pdf', 'source': {'id': 'https://openalex.org/S114430552', 'display_name': 'Journal of Clinical Investigation', 'issn_l': '0021-9738', 'issn': ['0021-9738', '1558-8238'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320279', 'host_organization_name': 'American Society for Clinical Investigation', 'host_organization_lineage': ['https://openalex.org/P4310320279'], 'host_organization_lineage_names': ['American Society for Clinical Investigation'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.43}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 107, 'referenced_works': ['https://openalex.org/W1480100581', 'https://openalex.org/W1521947818', 'https://openalex.org/W1538574688', 'https://openalex.org/W1576093526', 'https://openalex.org/W1932780354', 'https://openalex.org/W1935434993', 'https://openalex.org/W1964010911', 'https://openalex.org/W1964572291', 'https://openalex.org/W1972140717', 'https://openalex.org/W1973894442', 'https://openalex.org/W1989299822', 'https://openalex.org/W1997501197', 'https://openalex.org/W2000367221', 'https://openalex.org/W2007056893', 'https://openalex.org/W2044897807', 'https://openalex.org/W2045528132', 'https://openalex.org/W2048633779', 'https://openalex.org/W2060705109', 'https://openalex.org/W2065070435', 'https://openalex.org/W2069630982', 'https://openalex.org/W2075614768', 'https://openalex.org/W2098356981', 'https://openalex.org/W2118426638', 'https://openalex.org/W2119475811', 'https://openalex.org/W2121647203', 'https://openalex.org/W2130230447', 'https://openalex.org/W2130410032', 'https://openalex.org/W2131415852', 'https://openalex.org/W2132438126', 'https://openalex.org/W2132485204', 'https://openalex.org/W2137386173', 'https://openalex.org/W2138707492', 'https://openalex.org/W2139036189', 'https://openalex.org/W2144944663', 'https://openalex.org/W2145265944', 'https://openalex.org/W2146512944', 'https://openalex.org/W2148044817', 'https://openalex.org/W2155158051', 'https://openalex.org/W2155680682', 'https://openalex.org/W2157010532', 'https://openalex.org/W2180760460', 'https://openalex.org/W2258318060', 'https://openalex.org/W2277318350', 'https://openalex.org/W2278488296', 'https://openalex.org/W2287154159', 'https://openalex.org/W2395626624', 'https://openalex.org/W2398956125', 'https://openalex.org/W2415103133', 'https://openalex.org/W2418056440', 'https://openalex.org/W2439976878', 'https://openalex.org/W2474529975', 'https://openalex.org/W2497248775', 'https://openalex.org/W2518810695', 'https://openalex.org/W2521096491', 'https://openalex.org/W2521327281', 'https://openalex.org/W2540762799', 'https://openalex.org/W2559588208', 'https://openalex.org/W2560849088', 'https://openalex.org/W2561035469', 'https://openalex.org/W2587946751', 'https://openalex.org/W2590397144', 'https://openalex.org/W2611138580', 'https://openalex.org/W2611243475', 'https://openalex.org/W2617446144', 'https://openalex.org/W2618870156', 'https://openalex.org/W2624701078', 'https://openalex.org/W2740717097', 'https://openalex.org/W2740838806', 'https://openalex.org/W2742984768', 'https://openalex.org/W2750245257', 'https://openalex.org/W2753167114', 'https://openalex.org/W2753910921', 'https://openalex.org/W2761275051', 'https://openalex.org/W2767683865', 'https://openalex.org/W2769550393', 'https://openalex.org/W2769589482', 'https://openalex.org/W277256728', 'https://openalex.org/W2781939187', 'https://openalex.org/W2783788528', 'https://openalex.org/W2784764983', 'https://openalex.org/W2785995348', 'https://openalex.org/W2786394271', 'https://openalex.org/W2789128799', 'https://openalex.org/W2790549059', 'https://openalex.org/W2803664483', 'https://openalex.org/W2885145724', 'https://openalex.org/W2885291112', 'https://openalex.org/W2889921316', 'https://openalex.org/W2891014905', 'https://openalex.org/W2891967723', 'https://openalex.org/W2896108989', 'https://openalex.org/W2897589467', 'https://openalex.org/W2899070097', 'https://openalex.org/W2899231248', 'https://openalex.org/W2899265341', 'https://openalex.org/W2911395238', 'https://openalex.org/W2914852051', 'https://openalex.org/W2919632356', 'https://openalex.org/W2945506324', 'https://openalex.org/W2949726389', 'https://openalex.org/W2952015518', 'https://openalex.org/W2955364443', 'https://openalex.org/W2972994498', 'https://openalex.org/W2977605477', 'https://openalex.org/W4210476933', 'https://openalex.org/W4211085285', 'https://openalex.org/W4294326454'], 'related_works': ['https://openalex.org/W4295779760', 'https://openalex.org/W423371831', 'https://openalex.org/W3101161779', 'https://openalex.org/W2916376502', 'https://openalex.org/W2777729175', 'https://openalex.org/W2260452057', 'https://openalex.org/W2093500216', 'https://openalex.org/W2053588008', 'https://openalex.org/W1996644818', 'https://openalex.org/W1965468642'], 'abstract_inverted_index': {'High-throughput': [0], 'technologies': [1], 'for': [2, 27, 108, 144], 'genomics,': [3], 'transcriptomics,': [4], 'proteomics,': [5], 'and': [6, 8, 88, 104, 133, 142], 'metabolomics,': [7], 'integrative': [9], 'analysis': [10], 'of': [11, 61, 102, 141], 'these': [12], 'data,': [13], 'enable': [14], 'new,': [15], 'systems-level': [16], 'insights': [17], 'into': [18], 'disease': [19, 33], 'pathogenesis.': [20], 'Mitochondrial': [21], 'diseases': [22, 45], 'are': [23, 124], 'an': [24], 'excellent': [25], 'target': [26], 'hypothesis-generating': [28], 'omics': [29, 96, 131], 'approaches,': [30], 'as': [31, 112], 'the': [32, 40, 49, 52, 55, 62, 67, 95, 136], 'group': [34], 'is': [35, 46, 59], 'mechanistically': [36], 'exceptionally': [37], 'complex.': [38], 'Although': [39], 'genetic': [41], 'background': [42], 'in': [43, 47], 'mitochondrial': [44, 53, 63, 109, 145], 'either': [48, 74], 'nuclear': [50], 'or': [51, 76], 'genome,': [54], 'typical': [56], 'downstream': [57], 'effect': [58], 'dysfunction': [60], 'respiratory': [64], 'chain.': [65], 'However,': [66, 115], 'clinical': [68], 'manifestations': [69], 'show': [70], 'unprecedented': [71], 'variability,': [72], 'including': [73], 'systemic': [75], 'tissue-specific': [77], 'effects': [78], 'across': [79], 'multiple': [80], 'organ': [81], 'systems,': [82], 'with': [83, 135], 'mild': [84], 'to': [85, 138], 'severe': [86], 'symptoms,': [87], 'occurring': [89], 'at': [90], 'any': [91], 'age.': [92], 'So': [93], 'far,': [94], 'approaches': [97, 123, 132], 'have': [98], 'provided': [99], 'mechanistic': [100], 'understanding': [101], 'tissue-specificity': [103], 'potential': [105, 137], 'treatment': [106], 'options': [107], 'diseases,': [110], 'such': [111], 'metabolome': [113], 'remodeling.': [114], 'no': [116], 'curative': [117], 'treatments': [118], 'exist,': [119], 'suggesting': [120], 'that': [121], 'novel': [122], 'needed.': [125], 'In': [126], 'this': [127], 'Review,': [128], 'we': [129], 'discuss': [130], 'discoveries': [134], 'elucidate': [139], 'mechanisms': [140], 'therapies': [143], 'diseases.': [146]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2998655779', 'counts_by_year': [{'year': 2024, 'cited_by_count': 12}, {'year': 2023, 'cited_by_count': 15}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 9}, {'year': 2020, 'cited_by_count': 8}], 'updated_date': '2025-01-01T22:48:48.727242', 'created_date': '2020-01-10'}