Golgi-endosome transport mediated by M6PR facilitates release of antisense oligonucleotides from endosomes

Name: Work Video:
Duration: 3 min 30 s
Xue‐hai Liang; Hong Sun; Chih‐Wei Hsu; Joshua G Nichols; Timothy A. Vickers; Cheryl Li De Hoyos; Stanley T. Crooke
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'https://openalex.org/W2550012727', 'https://openalex.org/W2184062277', 'https://openalex.org/W2164466394', 'https://openalex.org/W2081861611', 'https://openalex.org/W2021810154', 'https://openalex.org/W2016203088', 'https://openalex.org/W1986280009', 'https://openalex.org/W1965298225'], 'abstract_inverted_index': {'Release': [0], 'of': [1, 30, 51, 102, 118, 121, 139, 146, 157, 170], 'phosphorothioate': [2], 'antisense': [3], 'oligonucleotides': [4], '(PS-ASOs)': [5], 'from': [6, 58], 'late': [7], 'endosomes': [8, 59], '(LEs)': [9], 'is': [10, 125, 151], 'a': [11, 15, 177], 'rate-limiting': [12], 'step': [13], 'and': [14, 42, 60, 74, 111, 120, 167, 190], 'poorly': [16], 'defined': [17], 'process': [18], 'for': [19, 141], 'productive': [20], 'intracellular': [21], 'ASO': [22], 'drug': [23], 'delivery.': [24], 'Here,': [25], 'we': [26], 'examined': [27], 'the': [28, 90, 128, 137, 185], 'role': [29], 'Golgi-endosome': [31], 'transport,': [32], 'specifically': [33], 'M6PR': [34, 54, 75, 108, 119, 158], 'shuttling': [35], 'mediated': [36, 152], 'by': [37, 127, 153], 'GCC2,': [38], 'in': [39, 48, 64, 80, 164, 168], 'PS-ASO': [40, 56, 62, 72, 95, 162, 193], 'trafficking': [41], 'activity.': [43], 'We': [44], 'found': [45], 'that': [46, 101, 107, 144, 184], 'reduction': [47], 'cellular': [49], 'levels': [50, 159], 'GCC2': [52, 67, 98, 122], 'or': [53, 82], 'impaired': [55], 'release': [57], 'decreased': [61, 161], 'activity': [63, 163], 'human': [65], 'cells.': [66], 'relocated': [68], 'to': [69, 93, 135, 149], 'LEs': [70, 81, 150], 'upon': [71], 'treatment,': [73], 'also': [76, 160], 'co-localized': [77], 'with': [78, 97, 123, 174], 'PS-ASOs': [79, 110], 'on': [83], 'LE': [84, 189], 'membranes.': [85], 'These': [86], 'proteins': [87, 148], 'act': [88], 'through': [89], 'same': [91], 'pathway': [92], 'influence': [94], 'activity,': [96], 'action': [99], 'preceding': [100], 'M6PR.': [103], 'Our': [104], 'data': [105], 'indicate': [106], 'binds': [109], 'facilitates': [112, 192], 'their': [113], 'vesicular': [114], 'escape.': [115], 'The': [116], 'co-localization': [117], 'ASOs': [124, 140], 'influenced': [126], 'PS': [129], 'modifications,': [130], 'which': [131], 'have': [132], 'been': [133], 'shown': [134], 'enhance': [136], 'affinity': [138], 'proteins,': [142], 'suggesting': [143], 'localization': [145], 'these': [147, 181], 'ASO-protein': [154], 'interactions.': [155], 'Reduction': [156], 'mouse': [165], 'cells': [166], 'livers': [169], 'mice': [171], 'treated': [172], 'subcutaneously': [173], 'PS-ASO,': [175], 'indicating': [176], 'conserved': [178], 'mechanism.': [179], 'Together,': [180], 'results': [182], 'demonstrate': [183], 'transport': [186], 'machinery': [187], 'between': [188], 'Golgi': [191], 'release.': [194]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2996540198', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 8}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 12}, {'year': 2020, 'cited_by_count': 5}], 'updated_date': '2024-12-07T19:37:50.965148', 'created_date': '2019-12-26'}
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