Title: THE FEATURES OF THE HORMONAL HOMESOSTASIS OF PREGNANT GROUPS OF THE RISK OF DEVELOPMENT OF THE LATE MATURATION OF THE CERVIX BASED ON THE INTERGENETIC INTERVAL
Abstract: The importance of the problem of prolonged pregnancy is due to a significant number of complications in childbirth, a high rate of surgical methods of delivery, which can further lead to a violation of the reproductive function of women, as well as high perinatal mortality.The purpose of the study. Determination of the peculiarities of hormonal homeostasis in women with late maturation of the cervix depending on the intergenetic interval.Materials and research methods. 156 women at risk of delayed cervical maturation after 41 weeks of pregnancy were examined. Women are divided into groups as follows: 1 group - first births (26 women); Group 2 - IGI was up to 3 years old (13 women); Group 3 - IGI from 3 to 5 years (57 women); Group 4 - IGI from 5 to 10 years (34 women); Group 5 - IGI for over 10 years (26 women).Results. The concentration of estradiol at 39–40 weeks of pregnancy in the bloodstream of 1 group reached the maximum value and stored (69.1 ± 1.1) nmol / L. Concentration of progesterone in blood at all times in women with physiological terminology of the canopy of the floor (769.9 ± 22.1) nmol / l, coefficient P / E2 - 10.7 ± 0.7. Women of the first and second groups had a timely maturation of the birth canal, which showed the prevalence of estrogenic effects on the vaginal epithelium and reduced inhibition of progesterone on target organs and tissues. There was an increase in the concentration of cortisol in the blood of pregnant women of group 5. At the same time, prolactin secretion was significantly decreased in pregnant women in groups 4 and 5 relative to those of women in group 1.Conclusions. In pregnant women with delayed maturation of the cervix, a decrease in the concentration of cortisol and a tendency to decrease prolactin. There is also a disruption of the function of the fetoplacental complex, represented by absolute and relative hypoestrogenia in the presence of serum progesterone concentration unchanged relative to the norm. In women with late maturation of the cervix, hyperandrogenism was not detected.