Publication Information

{'id': 'https://openalex.org/W2996088318', 'doi': 'https://doi.org/10.3760/cma.j.issn.1001-9391.2018.10.001', 'title': '[The effects of resveratrol on mitochondrial biogenesis dysfunction induced by fluoride in human neuroblastoma SH-SY5Y cells].', 'display_name': '[The effects of resveratrol on mitochondrial biogenesis dysfunction induced by fluoride in human neuroblastoma SH-SY5Y cells].', 'publication_year': 2018, 'publication_date': '2018-10-20', 'ids': {'openalex': 'https://openalex.org/W2996088318', 'doi': 'https://doi.org/10.3760/cma.j.issn.1001-9391.2018.10.001', 'mag': '2996088318', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/30541189'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/30541189', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 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'is_corresponding': False, 'raw_author_name': 'Z Y Tian', 'raw_affiliation_strings': ['Department of Occupational and Environmental Health, School of Public Health, MOE Key Lab of Environment and Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Occupational and Environmental Health, School of Public Health, MOE Key Lab of Environment and Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China', 'institution_ids': ['https://openalex.org/I47720641']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013488675', 'display_name': 'Jingyi Chen', 'orcid': 'https://orcid.org/0009-0008-9002-6322'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'J W Chen', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112493493', 'display_name': 'Gaoliang Zhou', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'G Y Zhou', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5080679098', 'display_name': 'P Li', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'P Li', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026941913', 'display_name': 'Qian Zhao', 'orcid': 'https://orcid.org/0000-0002-7058-0739'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Q Zhao', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041541617', 'display_name': 'Changqing Luo', 'orcid': 'https://orcid.org/0000-0002-6776-7519'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'C Luo', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056202139', 'display_name': 'S Zhang', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'S Zhang', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5040929213', 'display_name': 'A G Wang', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'A G Wang', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 4, 'citation_normalized_percentile': {'value': 0.461561, 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'display_name': 'Genetics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D005459', 'descriptor_name': 'Fluorides', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': True}, {'descriptor_ui': 'D028361', 'descriptor_name': 'Mitochondrial Diseases', 'qualifier_ui': 'Q000517', 'qualifier_name': 'prevention & control', 'is_major_topic': True}, {'descriptor_ui': 'D001678', 'descriptor_name': 'Organelle Biogenesis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000077185', 'descriptor_name': 'Resveratrol', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004272', 'descriptor_name': 'DNA, Mitochondrial', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004272', 'descriptor_name': 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'D000077185', 'descriptor_name': 'Resveratrol', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016896', 'descriptor_name': 'Treatment Outcome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/30541189', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W650810029', 'https://openalex.org/W2996088318', 'https://openalex.org/W2957538743', 'https://openalex.org/W2595165076', 'https://openalex.org/W2554255666', 'https://openalex.org/W2120071225', 'https://openalex.org/W2048860529', 'https://openalex.org/W2042796333', 'https://openalex.org/W2039045409', 'https://openalex.org/W1966191258'], 'abstract_inverted_index': {'Objective:': [0], 'To': [1], 'explore': [2], 'the': [3, 9, 51, 61, 113, 145, 212, 274], 'role': [4], 'of': [5, 12, 32, 64, 70, 96, 122, 150, 174, 217, 244], 'mitochondrial': [6, 65, 85, 115, 123, 137, 238, 276], 'biogenesis': [7, 66, 277], 'and': [8, 84, 99, 119, 129, 147, 153, 171, 178, 214, 220, 241, 248], 'neuroprotective': [10], 'mechanism': [11], 'resveratrol': [13, 46, 52], 'in': [14, 20, 50, 90, 107, 140, 162, 201, 222, 250, 263, 279], 'fluoride': [15, 34], 'neurotoxicity.': [16], 'Methods:': [17], 'SH-SY5Y': [18, 91, 108, 141, 163, 202, 280], 'cells': [19, 164, 203], 'exponential': [21], 'phase': [22], 'were': [23, 101, 155, 180, 192, 229, 257], 'treated': [24], 'with': [25, 40, 185, 207], 'different': [26], 'concentrations': [27], '(20,': [28], '40,': [29], '60': [30, 41, 158, 197, 208, 264], 'mg/L)': [31], 'sodium': [33], '(NaF)': [35], 'for': [36], '24': [37], 'h.': [38], 'Co-treatment': [39], 'mg/L': [42, 159, 198, 209, 226, 254, 265, 287, 289, 291, 294, 300, 304, 306, 309], 'NaF,': [43], '20': [44, 223, 251], 'μmol/L': [45, 224, 252], '(RSV)': [47], 'was': [48, 57, 133], 'administrated': [49], 'intervene': [53], 'trial.': [54], 'Western': [55], 'blotting': [56], 'used': [58, 134], 'to': [59, 135], 'determine': [60, 136], 'expression': [62, 121, 173], 'levels': [63, 95, 149, 216, 243], 'key': [67], 'regulating': [68], 'factor': [69, 81, 87], 'peroxisome': [71], 'proliferator-activated': [72], 'receptor': [73], 'gamma': [74], 'coactivator': [75], '1α': [76], '(PGC-1α)': [77], ',': [78], 'nuclear': [79], 'respiratory': [80, 124], '1': [82], '(NRF1)': [83], 'transcription': [86], 'A': [88], '(TFAM)': [89], 'cells.': [92, 142], 'The': [93, 167, 234], 'mRNA': [94, 120, 148, 172, 215, 242], 'PGC-1α,': [97, 151, 218], 'NRF1': [98, 152, 219], 'TFAM': [100, 154, 221], 'determined': [102], 'by': [103], 'Quantitative': [104], 'Real-time': [105], 'PCR': [106], 'cells,': [109], 'as': [110, 112], 'well': [111], 'relative': [114, 168, 235], 'DNA': [116], '(mtDNA)': [117], 'contents': [118, 170], 'chain': [125], 'complexes': [126, 175, 245], 'subunit': [127, 176, 246], 'CO1': [128, 177, 247], 'ATP8.': [130], 'Flow': [131], 'cytometry': [132], 'membrane': [138, 190, 239], 'potential': [139, 191, 240], 'Results:': [143], 'Both': [144], 'protein': [146, 213], 'decresed': [156], 'after': [157, 196], 'NaF': [160, 199, 210, 227, 255, 266], 'treatment': [161, 200], '(P<0.05)': [165, 187, 204, 232, 268], '.': [166, 188, 205, 233, 269], 'mtDNA': [169, 236], 'ATP8': [179, 249], 'also': [181, 193, 258], 'significantly': [182, 194, 230, 259], 'decreased': [183, 195], 'compared': [184], 'control': [186], 'Mitochondrial': [189], 'Compared': [206], 'group,': [211], 'RSV+60': [225, 253], 'group': [228, 256, 267], 'increased': [231], 'contents,': [237], 'higher': [260], 'than': [261], 'that': [262], 'Conclusion:': [270], 'Resveratrol': [271], 'may': [272], 'alleviate': [273], 'fluoride-induced': [275], 'dysfunction': [278], 'cells.目的：': [281], '探讨线粒体生物发生在氟神经毒性中的作用，以及白藜芦醇干预氟神经毒性的作用机制。': [282], '方法：': [283], '不同浓度氟化钠（NaF）处理对数生长期人神经母细胞瘤SH-SY5Y细胞24': [284], 'h，并用20': [285], 'μmol/L白藜芦醇对60': [286], 'NaF组进行干预。NaF剂量染毒实验分组：对照组，20、40、60': [288], 'NaF组；白藜芦醇干预NaF染毒实验分组：对照组，60': [290], 'NaF组，20': [292, 295], 'μmol/L白藜芦醇+60': [293, 308], 'μmol/L白藜芦醇组。采用蛋白质免疫印迹（Western': [296], 'blotting）法检测线粒体生物发生关键调控因子过氧化物酶体增殖物激活受体辅激活因子1α（PGC-1α）、核呼吸因子1（NRF1）及线粒体转录因子A（TFAM）的蛋白表达水平；采用实时荧光定量PCR技术检测线粒体生物发生关键调控因子及其下游呼吸链复合物亚基细胞色素C氧化酶亚基1（CO1）和ATP合成酶亚基（ATP8）的mRNA表达水平与线粒体DNA（mtDNA）相对含量；采用流式细胞术检测线粒体膜电位。': [297], '结果：': [298], '与对照组比较，60': [299], 'NaF组SH-SY5Y细胞线粒体生物发生关键调控因子PGC-1α、NRF1、TFAM': [301], 'mRNA与蛋白表达水平、线粒体呼吸链复合物亚基CO1和ATP8': [302], 'mRNA表达水平以及mtDNA相对含量均明显降低，差异均有统计学意义（P<0.05）；60': [303], 'NaF组线粒体膜电位与对照组比较也明显降低（P<0.05）。经白藜芦醇干预后，与60': [305], 'NaF组比较，20': [307], 'NaF组SH-SY5Y细胞的线粒体生物发生关键调控因子PGC-1α、NRF1、TFAM蛋白与mRNA表达水平均明显增加，线粒体呼吸链复合物亚基CO1和ATP8的mRNA表达水平、mtDNA相对含量和线粒体膜电位均明显增加，差异均有统计学意义（P<0.05）。': [310], '结论：': [311], '白藜芦醇干预可缓解氟导致的SH-SY5Y细胞线粒体生物发生障碍。.': [312]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2996088318', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 1}], 'updated_date': '2024-12-15T10:35:34.829008', 'created_date': '2019-12-26'}