Title: Clinical Trial in a Patient with Reduced Osmotic Resistency of Platelets
Abstract: 5 from 8 children of a family presented with severe bleeding symptoms, which repeatedly required blood transfusions. In all members of the family the following tests were normal: Plasmatic coagulation factors, several platelet function tests (spontaneous and ADP-aggregation, clotretraction, spreading) and capillary resistency. All children with bleeding tendency had a prolonged bleeding time (over 15 min) and a reduced osmotic resistency of platelets, in addition the hemorrhagometry (method of Sutor et al.) showed a prolonged bleeding time with increased bleeding intensity from a standardized small skin wound, which remained at the same high level until the test was interrupted after 60 minutes. In one child, who had bled profoundly from the nose for hours, we gave freshly prepared cryoprecipitate. Before administration of the cryoprecipitate, hemorrhagometry showed a constant high blood flow for 30 minutes. 8 minutes after cryoprecipitate had been given the bleeding intensity decreased, after 5½ more minutes hemostasis was complete. At the same time bleeding from the nose stopped. Bleeding time now was within normal limits (5 min). The corrective effect of cryoprecipitate could repeatedly be demonstrated, its duration, however, was rather short: 6 hours after the transfusion the bleeding time became abnormal again.
Publication Year: 1975
Publication Date: 1975-01-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 1
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