Title: Effects of Yuhyangjeongtong-san on Fracture Healing in Rats
Abstract:Objectives The purpose of this study is to determine the effect of Yuhyangjeongtong-san on the recovery of tibial fractures in rats. Methods In this study, osteocalcin and Calcitonin, CTX-2, TGF-β an...Objectives The purpose of this study is to determine the effect of Yuhyangjeongtong-san on the recovery of tibial fractures in rats. Methods In this study, osteocalcin and Calcitonin, CTX-2, TGF-β and BMP-2, which are used as indicators of bone formation, were analyzed after hematologic fractures using experimental rats. In addition, the fracture union process was confirmed using X-rays. Results Osteocalcin, Calcitonin and BMP-2 showed a significant increase compared with the control at 4 weeks. CTX-2 and TGF-β showed a significant increase compared with the control at 3 weeks. On X-ray, YJS treated group, as the experiment progressed, the boundary line became blurred, the bone outline was clearly visible, and the fracture recover was progressing. Conclusion The findings suggest that YJS can play a significant role in the repair of fractures. Therefore YJS is likely to be used to treat fractures. Keywords: Yuhyangjeongtong-san, Fracture, Rat, Tibia, Korean medicineRead More