Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2993387513', 'doi': 'https://doi.org/10.2217/fon-2019-0624', 'title': 'Why precision medicine should be applied across the continuum of care for metastatic colorectal cancer patients', 'display_name': 'Why precision medicine should be applied across the continuum of care for metastatic colorectal cancer patients', 'publication_year': 2019, 'publication_date': '2019-12-03', 'ids': {'openalex': 'https://openalex.org/W2993387513', 'doi': 'https://doi.org/10.2217/fon-2019-0624', 'mag': '2993387513', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/31793396'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.2217/fon-2019-0624', 'pdf_url': 'https://www.futuremedicine.com/doi/pdf/10.2217/fon-2019-0624', 'source': {'id': 'https://openalex.org/S174572715', 'display_name': 'Future Oncology', 'issn_l': '1479-6694', 'issn': ['1479-6694', '1744-8301'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310321119', 'host_organization_name': 'Future Medicine', 'host_organization_lineage': ['https://openalex.org/P4310321119'], 'host_organization_lineage_names': ['Future Medicine'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'editorial', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.futuremedicine.com/doi/pdf/10.2217/fon-2019-0624', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5007635105', 'display_name': 'Marco Puzzoni', 'orcid': 'https://orcid.org/0000-0001-5880-4309'}, 'institutions': [{'id': 'https://openalex.org/I172446870', 'display_name': 'University of Cagliari', 'ror': 'https://ror.org/003109y17', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I172446870']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Marco Puzzoni', 'raw_affiliation_strings': ['Medical Oncology Unit,University Hospital & University of Cagliari, Cagliari, Italy'], 'affiliations': [{'raw_affiliation_string': 'Medical Oncology Unit,University Hospital & University of Cagliari, Cagliari, Italy', 'institution_ids': ['https://openalex.org/I172446870']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5048129292', 'display_name': 'Pina Ziranu', 'orcid': 'https://orcid.org/0000-0002-5659-7366'}, 'institutions': [{'id': 'https://openalex.org/I172446870', 'display_name': 'University of Cagliari', 'ror': 'https://ror.org/003109y17', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I172446870']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Pina Ziranu', 'raw_affiliation_strings': ['Medical Oncology Unit,University Hospital & University of Cagliari, Cagliari, Italy'], 'affiliations': [{'raw_affiliation_string': 'Medical Oncology Unit,University Hospital & University of Cagliari, Cagliari, Italy', 'institution_ids': ['https://openalex.org/I172446870']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076153494', 'display_name': 'Laura Demurtas', 'orcid': 'https://orcid.org/0000-0002-9749-7628'}, 'institutions': [{'id': 'https://openalex.org/I172446870', 'display_name': 'University of Cagliari', 'ror': 'https://ror.org/003109y17', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I172446870']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Laura Demurtas', 'raw_affiliation_strings': ['Medical Oncology Unit,University Hospital & University of Cagliari, Cagliari, Italy'], 'affiliations': [{'raw_affiliation_string': 'Medical Oncology Unit,University Hospital & University of Cagliari, Cagliari, Italy', 'institution_ids': ['https://openalex.org/I172446870']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076563915', 'display_name': 'Eleonora Lai', 'orcid': 'https://orcid.org/0000-0002-0275-8187'}, 'institutions': [{'id': 'https://openalex.org/I172446870', 'display_name': 'University of Cagliari', 'ror': 'https://ror.org/003109y17', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I172446870']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Eleonora Lai', 'raw_affiliation_strings': ['Medical Oncology Unit,University Hospital & University of Cagliari, Cagliari, Italy'], 'affiliations': [{'raw_affiliation_string': 'Medical Oncology Unit,University Hospital & University of Cagliari, Cagliari, Italy', 'institution_ids': ['https://openalex.org/I172446870']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037658807', 'display_name': 'Stefano Mariani', 'orcid': 'https://orcid.org/0000-0001-8921-8150'}, 'institutions': [{'id': 'https://openalex.org/I172446870', 'display_name': 'University of Cagliari', 'ror': 'https://ror.org/003109y17', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I172446870']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Stefano Mariani', 'raw_affiliation_strings': ['Medical Oncology Unit,University Hospital & University of Cagliari, Cagliari, Italy'], 'affiliations': [{'raw_affiliation_string': 'Medical Oncology Unit,University Hospital & University of Cagliari, Cagliari, Italy', 'institution_ids': ['https://openalex.org/I172446870']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056023187', 'display_name': 'Nicole Liscia', 'orcid': 'https://orcid.org/0000-0002-0799-0209'}, 'institutions': [{'id': 'https://openalex.org/I172446870', 'display_name': 'University of Cagliari', 'ror': 'https://ror.org/003109y17', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I172446870']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Nicole Liscia', 'raw_affiliation_strings': ['Medical Oncology Unit,University Hospital & University of Cagliari, Cagliari, Italy'], 'affiliations': [{'raw_affiliation_string': 'Medical Oncology Unit,University Hospital & University of Cagliari, Cagliari, Italy', 'institution_ids': ['https://openalex.org/I172446870']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003278404', 'display_name': 'P Soro', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I172446870', 'display_name': 'University of Cagliari', 'ror': 'https://ror.org/003109y17', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I172446870']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Paolo Soro', 'raw_affiliation_strings': ['Medical Oncology Unit,University Hospital & University of Cagliari, Cagliari, Italy'], 'affiliations': [{'raw_affiliation_string': 'Medical Oncology Unit,University Hospital & University of Cagliari, Cagliari, Italy', 'institution_ids': ['https://openalex.org/I172446870']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003848263', 'display_name': 'Andrea Pretta', 'orcid': 'https://orcid.org/0000-0002-0262-9270'}, 'institutions': [{'id': 'https://openalex.org/I172446870', 'display_name': 'University of Cagliari', 'ror': 'https://ror.org/003109y17', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I172446870']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Andrea Pretta', 'raw_affiliation_strings': ['Medical Oncology Unit,University Hospital & University of Cagliari, Cagliari, Italy'], 'affiliations': [{'raw_affiliation_string': 'Medical Oncology Unit,University Hospital & University of Cagliari, Cagliari, Italy', 'institution_ids': ['https://openalex.org/I172446870']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5028994536', 'display_name': 'Valentino Impera', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I172446870', 'display_name': 'University of Cagliari', 'ror': 'https://ror.org/003109y17', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I172446870']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Valentino Impera', 'raw_affiliation_strings': ['Medical Oncology Unit,University Hospital & University of Cagliari, Cagliari, Italy'], 'affiliations': [{'raw_affiliation_string': 'Medical Oncology Unit,University Hospital & University of Cagliari, Cagliari, Italy', 'institution_ids': ['https://openalex.org/I172446870']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004540717', 'display_name': 'S. Camera', 'orcid': 'https://orcid.org/0000-0001-8203-1684'}, 'institutions': [{'id': 'https://openalex.org/I172446870', 'display_name': 'University of Cagliari', 'ror': 'https://ror.org/003109y17', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I172446870']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Silvia Camera', 'raw_affiliation_strings': ['Medical Oncology Unit,University Hospital & University of Cagliari, Cagliari, Italy'], 'affiliations': [{'raw_affiliation_string': 'Medical Oncology Unit,University Hospital & University of Cagliari, Cagliari, Italy', 'institution_ids': ['https://openalex.org/I172446870']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073332364', 'display_name': 'Francesca Musio', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I172446870', 'display_name': 'University of Cagliari', 'ror': 'https://ror.org/003109y17', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I172446870']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Francesca Musio', 'raw_affiliation_strings': ['Medical Oncology Unit,University Hospital & University of Cagliari, Cagliari, Italy'], 'affiliations': [{'raw_affiliation_string': 'Medical Oncology Unit,University Hospital & University of Cagliari, Cagliari, Italy', 'institution_ids': ['https://openalex.org/I172446870']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033536074', 'display_name': 'Mara Persano', 'orcid': 'https://orcid.org/0000-0003-3600-0232'}, 'institutions': [{'id': 'https://openalex.org/I172446870', 'display_name': 'University of Cagliari', 'ror': 'https://ror.org/003109y17', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I172446870']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Mara Persano', 'raw_affiliation_strings': ['Medical Oncology Unit,University Hospital & University of Cagliari, Cagliari, Italy'], 'affiliations': [{'raw_affiliation_string': 'Medical Oncology Unit,University Hospital & University of Cagliari, Cagliari, Italy', 'institution_ids': ['https://openalex.org/I172446870']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5063263109', 'display_name': 'Clelia Donisi', 'orcid': 'https://orcid.org/0000-0003-4129-3375'}, 'institutions': [{'id': 'https://openalex.org/I172446870', 'display_name': 'University of Cagliari', 'ror': 'https://ror.org/003109y17', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I172446870']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Clelia Donisi', 'raw_affiliation_strings': ['Medical Oncology Unit,University Hospital & University of Cagliari, Cagliari, Italy'], 'affiliations': [{'raw_affiliation_string': 'Medical Oncology Unit,University Hospital & University of Cagliari, Cagliari, Italy', 'institution_ids': ['https://openalex.org/I172446870']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012817229', 'display_name': 'S. Tolu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I172446870', 'display_name': 'University of Cagliari', 'ror': 'https://ror.org/003109y17', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I172446870']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Simona Tolu', 'raw_affiliation_strings': ['Medical Oncology Unit,University Hospital & University of Cagliari, Cagliari, Italy'], 'affiliations': [{'raw_affiliation_string': 'Medical Oncology Unit,University Hospital & University of Cagliari, Cagliari, Italy', 'institution_ids': ['https://openalex.org/I172446870']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5060227057', 'display_name': 'Francesca Balconi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I172446870', 'display_name': 'University of Cagliari', 'ror': 'https://ror.org/003109y17', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I172446870']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Francesca Balconi', 'raw_affiliation_strings': ['Medical Oncology Unit,University Hospital & University of Cagliari, Cagliari, Italy'], 'affiliations': [{'raw_affiliation_string': 'Medical Oncology Unit,University Hospital & University of Cagliari, Cagliari, Italy', 'institution_ids': ['https://openalex.org/I172446870']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5034035272', 'display_name': 'Mario Scartozzi', 'orcid': 'https://orcid.org/0000-0001-5977-5546'}, 'institutions': [{'id': 'https://openalex.org/I172446870', 'display_name': 'University of Cagliari', 'ror': 'https://ror.org/003109y17', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I172446870']}, {'id': 'https://openalex.org/I188703185', 'display_name': 'GTx (United States)', 'ror': 'https://ror.org/0400j3f74', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I188703185']}], 'countries': ['IT', 'US'], 'is_corresponding': False, 'raw_author_name': 'Mario Scartozzi', 'raw_affiliation_strings': ['Fax: +39 070 5109 3215', 'Medical Oncology Unit,University Hospital & University of Cagliari, Cagliari, Italy'], 'affiliations': [{'raw_affiliation_string': 'Medical Oncology Unit,University Hospital & University of Cagliari, Cagliari, Italy', 'institution_ids': ['https://openalex.org/I172446870']}, {'raw_affiliation_string': 'Fax: +39 070 5109 3215', 'institution_ids': ['https://openalex.org/I188703185']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': None, 'has_fulltext': False, 'cited_by_count': 13, 'citation_normalized_percentile': {'value': 0.882812, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 88, 'max': 89}, 'biblio': {'volume': '16', 'issue': '2', 'first_page': '4337', 'last_page': '4339'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11067', 'display_name': 'Advancements in Colorectal Cancer Research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11067', 'display_name': 'Advancements in Colorectal Cancer Research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11287', 'display_name': 'Genomic Landscape of Cancer and Mutational Signatures', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11369', 'display_name': 'Molecular Characterization of Colorectal Cancer', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/precision-medicine', 'display_name': 'Precision Medicine', 'score': 0.542866}, {'id': 'https://openalex.org/keywords/metastatic-colorectal-cancer', 'display_name': 'Metastatic Colorectal Cancer', 'score': 0.538614}, {'id': 'https://openalex.org/keywords/continuum-of-care', 'display_name': 'Continuum of care', 'score': 0.5285572}], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.89413714}, {'id': 'https://openalex.org/C526805850', 'wikidata': 'https://www.wikidata.org/wiki/Q188874', 'display_name': 'Colorectal cancer', 'level': 3, 'score': 0.730374}, {'id': 'https://openalex.org/C163763905', 'wikidata': 'https://www.wikidata.org/wiki/Q17075943', 'display_name': 'Precision medicine', 'level': 2, 'score': 0.5335138}, {'id': 'https://openalex.org/C3019007097', 'wikidata': 'https://www.wikidata.org/wiki/Q7834462', 'display_name': 'Continuum of care', 'level': 3, 'score': 0.5285572}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.44931948}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.4468372}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.4076171}, {'id': 'https://openalex.org/C160735492', 'wikidata': 'https://www.wikidata.org/wiki/Q31207', 'display_name': 'Health care', 'level': 2, 'score': 0.257363}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.17743948}, {'id': 'https://openalex.org/C162324750', 'wikidata': 'https://www.wikidata.org/wiki/Q8134', 'display_name': 'Economics', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C50522688', 'wikidata': 'https://www.wikidata.org/wiki/Q189833', 'display_name': 'Economic growth', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000971', 'descriptor_name': 'Antineoplastic Combined Chemotherapy Protocols', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D003266', 'descriptor_name': 'Continuity of Patient Care', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D057285', 'descriptor_name': 'Precision Medicine', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D000971', 'descriptor_name': 'Antineoplastic Combined Chemotherapy Protocols', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014408', 'descriptor_name': 'Biomarkers, Tumor', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D014408', 'descriptor_name': 'Biomarkers, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018450', 'descriptor_name': 'Disease Progression', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058990', 'descriptor_name': 'Molecular Targeted Therapy', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}, {'descriptor_ui': 'D058990', 'descriptor_name': 'Molecular Targeted Therapy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009362', 'descriptor_name': 'Neoplasm Metastasis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D057285', 'descriptor_name': 'Precision Medicine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015996', 'descriptor_name': 'Survival Rate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016896', 'descriptor_name': 'Treatment Outcome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.2217/fon-2019-0624', 'pdf_url': 'https://www.futuremedicine.com/doi/pdf/10.2217/fon-2019-0624', 'source': {'id': 'https://openalex.org/S174572715', 'display_name': 'Future Oncology', 'issn_l': '1479-6694', 'issn': ['1479-6694', '1744-8301'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310321119', 'host_organization_name': 'Future Medicine', 'host_organization_lineage': ['https://openalex.org/P4310321119'], 'host_organization_lineage_names': ['Future Medicine'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/31793396', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.2217/fon-2019-0624', 'pdf_url': 'https://www.futuremedicine.com/doi/pdf/10.2217/fon-2019-0624', 'source': {'id': 'https://openalex.org/S174572715', 'display_name': 'Future Oncology', 'issn_l': '1479-6694', 'issn': ['1479-6694', '1744-8301'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310321119', 'host_organization_name': 'Future Medicine', 'host_organization_lineage': ['https://openalex.org/P4310321119'], 'host_organization_lineage_names': ['Future Medicine'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.55, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 13, 'referenced_works': ['https://openalex.org/W1499456432', 'https://openalex.org/W1503485936', 'https://openalex.org/W1681999520', 'https://openalex.org/W1914351667', 'https://openalex.org/W2113988922', 'https://openalex.org/W2116731538', 'https://openalex.org/W2156834559', 'https://openalex.org/W2760824766', 'https://openalex.org/W2898439571', 'https://openalex.org/W2901178367', 'https://openalex.org/W2907303978', 'https://openalex.org/W2907801580', 'https://openalex.org/W2929970742'], 'related_works': ['https://openalex.org/W4213156115', 'https://openalex.org/W3137876420', 'https://openalex.org/W3039284339', 'https://openalex.org/W3004259476', 'https://openalex.org/W3003904233', 'https://openalex.org/W2473759769', 'https://openalex.org/W2409949902', 'https://openalex.org/W2392730113', 'https://openalex.org/W2055656665', 'https://openalex.org/W2000479004'], 'abstract_inverted_index': {'Future': [0, 2092], 'OncologyVol.': [1], '16,': [2, 1990, 2055], 'No.': [3, 1897, 1923, 1962, 1991, 2018, 2031, 2056], '2': [4, 2057], 'EditorialFree': [5], 'AccessWhy': [6], 'precision': [7, 28, 711, 1206, 2036], 'medicine': [8, 29, 433, 1207, 2037], 'should': [9, 30, 2038], 'be': [10, 31, 402, 611, 641, 1209, 1283, 1335, 2039], 'applied': [11, 32, 1210, 2040], 'across': [12, 33, 1211, 2041], 'the': [13, 34, 312, 315, 322, 332, 347, 352, 365, 368, 379, 387, 396, 417, 420, 424, 497, 527, 549, 565, 573, 598, 602, 614, 623, 654, 657, 669, 678, 710, 714, 723, 726, 740, 743, 753, 778, 793, 810, 816, 964, 985, 992, 1020, 1023, 1172, 1179, 1185, 1227, 1232, 1239, 1251, 1277, 1292, 1320, 1323, 1327, 1378, 1385, 1414, 1421, 1428, 1431, 1507, 1614, 1787, 2042, 2067, 2132, 2139, 2168, 2175, 2182, 2185], 'continuum': [14, 35, 2043], 'of': [15, 36, 82, 94, 106, 118, 130, 142, 154, 166, 178, 190, 202, 214, 226, 238, 250, 278, 367, 382, 390, 419, 427, 439, 492, 496, 568, 616, 625, 631, 659, 680, 697, 725, 745, 780, 795, 808, 886, 994, 1004, 1022, 1026, 1053, 1175, 1182, 1188, 1202, 1213, 1231, 1295, 1322, 1377, 1430, 1448, 1473, 1509, 1579, 1616, 1649, 1816, 1826, 1888, 1918, 1965, 2044, 2131, 2184], 'care': [16, 37, 2045], 'for': [17, 38, 257, 327, 442, 502, 533, 734, 927, 942, 1222, 1313, 1478, 1505, 1731, 2021, 2046, 2066], 'metastatic': [18, 39, 1514, 1556, 1617, 1644, 1673, 1708, 1738, 1784, 1832, 1866, 2047], 'colorectal': [19, 40, 293, 391, 574, 836, 1183, 1450, 1482, 1515, 1557, 1587, 1618, 1645, 1674, 1709, 1739, 1785, 1833, 1867, 2048], 'cancer': [20, 41, 294, 575, 837, 1483, 1516, 1619, 1675, 1740, 1868, 1903, 2049], 'patientsThis': [21], 'article': [22], 'is': [23, 434, 494, 561, 579, 586, 591, 628, 719, 1196, 1331], 'corrected': [24], 'byCorrigendum': [25], 'to': [26, 286, 363, 375, 378, 386, 452, 486, 544, 564, 572, 601, 610, 634, 683, 722, 990, 1006, 1040, 1085, 1094, 1159, 1208, 1269, 1304, 1334, 1552, 1582, 1610, 1678, 1744, 1777, 1780, 2034], "'Why": [27, 2035], "patients'Marco": [42], 'Puzzoni,': [43, 1342, 2096], 'Pina': [44, 86, 1343, 2097], 'Ziranu,': [45, 1344, 2098], 'Laura': [46, 98, 1345, 2099], 'Demurtas,': [47, 1346, 2100], 'Eleonora': [48, 110, 1347, 2101], 'Lai,': [49, 1348, 2102], 'Stefano': [50, 122, 1349, 2103], 'Mariani,': [51, 1350, 2104], 'Nicole': [52, 134, 1351, 2105], 'Liscia,': [53, 1352, 2106], 'Paolo': [54, 146, 1353, 2107], 'Soro,': [55, 1354, 2108], 'Andrea': [56, 158, 1355, 2109], 'Pretta,': [57, 1356, 2110], 'Valentino': [58, 170, 1357, 2111], 'Impera,': [59, 1358, 2112], 'Silvia': [60, 182, 1359, 2113], 'Camera,': [61, 1360, 2114], 'Francesca': [62, 70, 194, 242, 1367, 2121], 'Musio,': [63], 'Mara': [64, 206, 1361, 2115], 'Persano,': [65, 1362, 2116], 'Clelia': [66, 218, 1363, 2117], 'Donisi,': [67, 1364, 2118], 'Simona': [68, 230, 1365, 2119], 'Tolu,': [69, 1366, 2120], 'Balconi': [71, 1368, 2122], '&': [72, 80, 92, 104, 116, 128, 140, 152, 164, 176, 188, 200, 212, 224, 236, 248, 254, 276, 1388, 2142], 'Mario': [73, 255, 1370, 2124], 'ScartozziMarco': [74], 'PuzzoniMedical': [75], 'Oncology': [76, 88, 100, 112, 124, 136, 148, 160, 172, 184, 196, 208, 220, 232, 244, 272, 2053], 'Unit,': [77, 89, 101, 113, 125, 137, 149, 161, 173, 185, 197, 209, 221, 233, 245, 273], 'University': [78, 81, 90, 93, 102, 105, 114, 117, 126, 129, 138, 141, 150, 153, 162, 165, 174, 177, 186, 189, 198, 201, 210, 213, 222, 225, 234, 237, 246, 249, 274, 277], 'Hospital': [79, 91, 103, 115, 127, 139, 151, 163, 175, 187, 199, 211, 223, 235, 247, 275], 'Cagliari,': [83, 84, 95, 96, 107, 108, 119, 120, 131, 132, 143, 144, 155, 156, 167, 168, 179, 180, 191, 192, 203, 204, 215, 216, 227, 228, 239, 240, 251, 252, 279, 280], 'Italy,': [85, 97, 109, 121, 133, 145, 157, 169, 181, 193, 205, 217, 229, 241], 'ZiranuMedical': [87], 'DemurtasMedical': [99], 'LaiMedical': [111], 'MarianiMedical': [123], 'LisciaMedical': [135], 'SoroMedical': [147], 'PrettaMedical': [159], 'ImperaMedical': [171], 'CameraMedical': [183], 'MusioMedical': [195], 'PersanoMedical': [207], 'DonisiMedical': [219], 'ToluMedical': [231], 'BalconiMedical': [243], 'Italy': [253], 'Scartozzi*Author': [256], 'correspondence:': [258], 'Tel.:': [259], '+39': [260, 265], '070': [261, 266], '5109': [262, 267], '3217;': [263], 'Fax:': [264], '3215;': [268], 'E-mail': [269], 'Address:': [270], '[email protected]': [271], 'ItalyPublished': [281], 'Online:3': [282], 'Dec': [283], '2019https://doi.org/10.2217/fon-2019-0624AboutSectionsPDF/EPUB': [284], 'ToolsAdd': [285], 'favoritesDownload': [287], 'CitationsTrack': [288], 'CitationsPermissionsReprints': [289], 'ShareShare': [290], 'onFacebookTwitterLinkedInReddit': [291], 'Metastatic': [292, 1883, 1932, 1973, 2007, 2022], '(mCRC)': [295, 1869], 'treatment': [296, 371, 398, 558, 755, 1161, 1258, 1315, 1554, 1782], 'has': [297, 704, 767], 'been': [298, 344], 'improved': [299], 'by': [300], 'several': [301, 773], 'effective': [302], 'therapies,': [303], 'including': [304], 'chemotherapeutic': [305], 'agents': [306], 'combined': [307], 'with': [308, 460, 613, 643, 750, 782, 786, 797, 833, 853, 863, 888, 898, 919, 996, 1057, 1069, 1103, 1113, 1151, 1241, 1261, 1280, 1400, 1405, 1413, 1511, 1518, 1528, 1639, 1702, 1707, 1733, 1741, 1970, 2154, 2159, 2167], 'monoclonal': [309, 1523, 1641], 'antibodies': [310, 1642], 'targeting': [311], 'EGFR': [313, 431, 514, 617, 635, 701, 855, 865, 1007, 1030, 1584, 1611, 1703, 1827], 'or': [314, 1397, 1403, 1410, 1417, 1910, 2151, 2157, 2164, 2171], 'VEGF.': [316], 'The': [317, 489, 595, 694, 1077, 1149, 1441, 1576], 'multikinase': [318], 'inhibitor': [319], 'regorafenib': [320], 'and': [321, 336, 351, 385, 522, 559, 571, 589, 637, 752, 846, 1140, 1162, 1178, 1215, 1369, 1375, 1383, 1445, 1608, 1735, 1747, 1774, 1859, 1978, 2001, 2006, 2123, 2129, 2137], 'fluoropyrimidine': [323], 'trifluridine/tipiracil': [324], 'are': [325, 358, 450, 473, 480, 525, 665, 772, 1302], 'indicated': [326], 'pretreated': [328, 356, 1289], 'patients.': [329, 940, 1148, 1620], 'However,': [330], 'despite': [331], 'efforts': [333], 'in': [334, 346, 355, 373, 437, 445, 483, 504, 556, 581, 663, 688, 709, 756, 762, 784, 801, 806, 839, 937, 963, 971, 998, 1016, 1055, 1123, 1129, 1146, 1259, 1288, 1308, 1316, 1319, 1409, 1420, 1427, 1555, 1586, 1613, 1643, 1672, 1705, 1783, 1820, 1829, 1854, 1865, 1882, 1901, 1904, 1929, 1940, 1951, 1968, 2004, 2086, 2163, 2174, 2181], 'clinical': [335, 505, 540, 1275, 1339, 1446, 1753, 1824, 1905], 'translational': [337], 'research,': [338], 'no': [339, 1394, 2148], 'novel': [340], 'drugs': [341], 'have': [342, 362, 759, 1393, 2147], 'recently': [343], 'included': [345, 538], 'mCRC': [348, 503, 557, 1037], 'therapeutic': [349, 1286], 'scenario': [350], 'results': [353, 655, 744, 805, 1143], 'obtained': [354], 'patients': [357, 459, 757, 785, 832, 859, 897, 955, 974, 999, 1056, 1068, 1125, 1131, 1260, 1290, 1484, 1510, 1706, 1732], 'disappointing.': [359], 'Therefore,': [360], 'we': [361, 449], 'improve': [364], 'management': [366], 'already': [369], 'available': [370], 'options': [372], 'order': [374], 'adapt': [376], 'them': [377], 'dynamic': [380, 566, 592, 736, 1173], 'nature': [381, 567, 1174], 'tumor': [383, 569, 1075, 1176, 1203, 1264, 1856], 'biology': [384, 570, 1177, 1204], 'genetic': [388, 576, 1180], 'heterogeneity': [389, 1181], 'cancer.': [392, 1558, 1834], 'In': [393, 621, 651, 923], 'this': [394, 638, 652, 1270, 1309], 'respect,': [395], 'global': [397], 'strategy': [399, 1279], 'would': [400], 'not': [401, 537, 587, 605, 1000, 1197, 1332], 'obtusely': [403], 'based': [404, 685, 1087], 'only': [405], 'on': [406, 409, 416, 464, 904, 1009, 1073, 1191, 1712, 2063], 'RAS-BRAF': [407, 899, 1189], 'status': [408, 441, 491, 585, 764, 1043, 1080, 1120, 1155, 1190, 1853], 'tissue': [410, 465, 905, 1010, 1192], 'samples': [411, 972, 1102, 1193], 'at': [412, 467, 677, 931, 1083, 1107, 1194], 'diagnosis': [413, 1195], 'but': [414], 'also': [415], 'basis': [418], 'recent': [421, 746, 1032, 1049, 1254], 'findings': [422, 1255], 'regarding': [423, 748, 1238], 'pulsatile': [425, 695, 1024], 'behavior': [426, 696, 1025], 'RAS': [428, 440, 584, 698, 737, 763, 834, 933, 961, 967, 1018, 1027, 1071, 1078, 1096, 1104, 1117, 1224, 1479, 1734, 1817, 1830, 1871], 'clones': [429, 699, 1028, 1819], 'under': [430, 700, 1029], 'blockade.Precision': [432], 'well': [435], 'established': [436], 'terms': [438, 807], 'first-line': [443, 914, 1745, 1860], 'decision-making': [444], 'mCRC.': [446, 787, 1060], 'To': [447], 'date,': [448], 'able': [451], 'exclude': [453], 'from': [454, 656, 831, 973, 1099, 1245, 1299, 1681], 'anti-EGFR': [455, 487, 534, 545, 684, 691, 751, 754, 783, 1160, 1242, 1257, 1281, 1314, 1640, 1781], 'therapy': [456, 546, 686, 800, 1214], 'putative': [457, 530], 'refractory': [458], 'RAS-mutated': [461, 1036], 'profile': [462, 1098, 1106, 1134, 1265, 1477], 'evaluated': [463, 896, 1066], 'sample': [466, 1229], 'diagnosis;': [468], 'therefore,': [469], 'positive': [470], 'predictive': [471, 500, 509, 531], 'factors': [472, 479, 501], 'lacking.': [474], 'Moreover,': [475, 1048], 'many': [476], 'other': [477, 741, 1252], 'molecular': [478, 1475, 1577], 'probably': [481], 'involved': [482], 'primary': [484, 547, 943, 1074], 'resistance': [485, 551, 600, 633, 1005, 1581, 1609, 1743, 1779], 'therapy.': [488], 'mutational': [490, 1079, 1097], 'BRAF': [493, 1736], 'one': [495], 'most': [498, 528], 'utilized': [499, 1426, 2180], 'practice;': [506], 'nevertheless,': [507], 'its': [508], 'role': [510, 779], 'remains': [511], 'unclear': [512], '[1].Furthermore,': [513], 'gene': [515], 'copy': [516], 'number,': [517], 'PIK3CA': [518], 'mutations,': [519], 'PTEN': [520], 'mutations': [521, 934, 968], 'ERBB2': [523], 'amplification': [524], 'among': [526], 'important': [529, 667], 'determinants': [532], 'therapy,': [535], 'although': [536, 604], 'into': [539, 1274, 1338], 'practice': [541, 1276], '[2–4].In': [542], 'addition': [543], 'resistance,': [548], 'secondary': [550], 'represents': [552, 730, 1218], 'a': [553, 629, 731, 760, 798, 881, 957, 1013, 1219, 1247, 1284, 1406, 1474, 1525, 1749, 1822, 1908, 2160], 'challenging': [554, 1271, 1310], 'issue': [555], 'it': [560, 590], 'closely': [562], 'related': [563], 'heterogeneity.': [577], 'It': [578], 'known,': [580], 'fact,': [582], 'that': [583, 672, 1035], 'fixed': [588], 'over': [593, 713], 'time.': [594], 'mechanism': [596], 'underlying': [597], 'acquired': [599, 632, 705, 1580, 1682, 1742], 'anti-EGFR,': [603], 'yet': [606, 1337], 'fully': [607], 'understood,': [608], 'seems': [609], 'linked': [612], 'emergence': [615], 'downstream': [618], 'pathway': [619], 'mutation.': [620, 1872], 'particular,': [622], 'occurrence': [624], 'KRAS': [626, 673, 1512], 'mutation': [627, 639, 1852], 'mediator': [630], 'blockade': [636, 702, 1585, 1612], 'can': [640], 'detected': [642, 970], 'circulating,': [644], 'cell-free': [645], 'DNA': [646, 1857, 1900], 'analysis': [647], '(liquid': [648], 'biopsy)': [649], '[5].': [650], 'connection,': [653], 'study': [658, 895, 1472], 'Siravegna': [660, 1597], 'et': [661, 789, 825, 877, 982, 1062, 1439, 1469, 1501, 1546, 1574, 1603, 1636, 1668, 1699, 1728, 1769, 1812, 1849], 'al.': [662, 790, 826, 878, 983, 1063, 1440, 1470, 1502, 1547, 1575, 1604, 1637, 1669, 1700, 1729, 1770, 1813, 1850], '2015': [664], 'particularly': [666], '[6]:': [668], 'authors': [670, 1381, 1392, 2135, 2146], 'observed': [671], 'mutant': [674, 1072, 1818, 1831], 'alleles': [675], 'emerging': [676], 'time': [679], 'disease': [681], 'progression': [682, 818, 1084], 'declined': [687], 'blood': [689, 1615], 'during': [690], 'antibody': [692], 'suspension.': [693], '[7]': [703], 'an': [706, 854, 864], 'increasing': [707], 'importance': [708], 'oncology': [712], 'last': [715], 'few': [716], 'years.': [717], 'This': [718], 'partly': [720], 'due': [721], 'diffusion': [724], 'liquid': [727, 925, 1216, 1775], 'biopsy,': [728], 'which': [729, 775], 'useful': [732, 1220], 'tool': [733, 1221], 'monitoring': [735, 1223], 'status.': [738, 1225], 'On': [739, 1250], 'hand,': [742, 1253], 'studies': [747, 774, 1033], 'rechallenge': [749, 781, 871, 887, 995, 1240, 1278, 1671], 'who': [758, 850, 907, 975], 'change': [761], '(neo-RAS': [765, 1044], 'WT)': [766], 'triggered': [768], 'further': [769], 'research': [770], 'development.There': [771], 'specifically': [776], 'assess': [777, 991], 'Santini': [788, 1662], '[8]': [791], 'investigated': [792], 'activity': [794], 'retreatment': [796, 918], 'cetuximab-based': [799, 911], '2012,': [802], 'achieving': [803, 956], 'encouraging': [804], 'outcome:': [809], 'objective': [811], 'response': [812, 946, 959], 'rate': [813, 947], 'was': [814, 821, 872, 948, 1081, 1092, 1121, 1135, 1425, 2179], '53.8%,': [815], 'median': [817, 867], 'free': [819], 'survival': [820, 869], '6.6': [822], 'months.': [823], 'Siena': [824, 981, 1693, 1763], '[9]': [827], 'retrospectively': [828], 'collected': [829], 'data': [830, 1050], 'WT': [835], 'enrolled': [838], 'two': [840], 'randomized': [841], 'controlled': [842], 'trials': [843], '(i.e.,': [844, 892], 'PRIME': [845], 'PEAK)': [847], 'receiving': [848, 1485], 'panitumumab': [849, 997], 'were': [851, 861, 929, 935, 960, 969, 1110, 1144, 1156, 1164], 'rechallenged': [852, 862], 'inhibitor.': [856], 'Globally,': [857], '69/675': [858], '(10%)': [860], 'inhibitor;': [866], 'overall': [868], 'after': [870], '14.2': [873], 'months': [874], '(10.2–17.7).': [875], 'Cremolini': [876, 1721], '[10]': [879], 'designed': [880, 984], 'prospective': [882, 894, 1236], 'Phase': [883, 1234, 1750], 'II': [884, 1235, 1751], 'trial': [885, 987, 1237, 1301], 'cetuximab': [889, 920, 1054, 1746], 'plus': [890, 910, 921, 1862], 'irinotecan': [891, 909], 'CRICKET).This': [893], 'wild': [900, 1041, 1045, 1118, 1480], 'type': [901, 1042, 1119, 1154, 1481], 'status,': [902], 'verified': [903], 'sample,': [906], 'received': [908], 'regimen': [912], 'as': [913, 1980], 'treatment.': [915], 'They': [916], 'underwent': [917], 'irinotecan.': [922], 'addition,': [924], 'biopsies': [926], 'ctDNA': [928, 1017], 'performed': [930, 1372, 2126], 'baseline.': [932], 'found': [936, 1122, 1145], '48%': [938], '(12/25)': [939], 'As': [941, 1312], 'end': [944], 'point,': [945], '21%;': [949], '95%': [950], 'CI:': [951], '10%–40%.': [952], 'Notably,': [953], 'all': [954], 'partial': [958, 978], 'wild-type': [962, 1513, 1737], 'ctDNA.': [965], 'No': [966], 'achieved': [976], 'confirmed': [977], 'response.': [979], 'Similarly,': [980], 'CHRONOS': [986, 1300, 1788], '(NCT03227926)': [988], '[11]': [989], 'efficacy': [993], 'harboring': [1001, 1870], 'any': [1002, 1401, 2155], 'drivers': [1003], 'inhibitors': [1008, 1704, 1828], 'samples,': [1011], 'experiencing': [1012], '>50%': [1014], 'drop': [1015], 'levels.Beyond': [1019], 'concept': [1021], 'blockade,': [1031], 'suggested': [1034], 'may': [1038], 'convert': [1039], 'type)': [1046], '[12,13].': [1047], 'showed': [1051], 'benefit': [1052], 'neo-RAS': [1058, 1262, 1317], 'wt': [1059, 1105, 1263], 'Raimondi': [1061, 1806], '[12]': [1064], 'prospectively': [1065], '11': [1067], 'mCRC-defined': [1070], 'biopsy.': [1076], 'assessed': [1082], 'anti-VEGF': [1086], 'treatments.': [1088], 'A': [1089, 1199, 1635, 1768, 1955], 'real-time': [1090, 1108, 1138], 'PCR': [1091, 1109, 1139], 'used': [1093], 'screen': [1095], 'plasma.': [1100], 'Plasma': [1101], 'subsequently': [1111], 'analyzed': [1112], 'next-generation': [1114, 1141], 'sequencing': [1115, 1142], '(NGS).': [1116], 'four': [1124], '(4/11,': [1126], '36%)': [1127], 'whereas,': [1128], 'six': [1130], '(6/11),': [1132], 'RAS-mutant': [1133], 'confirmed.': [1136], 'Discordant': [1137], '1/11': [1147], 'population': [1150], 'de': [1152], 'novoRAS': [1153], 'considered': [1157], 'eligible': [1158], 'they': [1163], 'treated': [1165, 1517], 'accordingly,': [1166], 'obtaining': [1167], 'promising': [1168], 'results.In': [1169], 'conclusion,': [1170], 'given': [1171], 'cancer,': [1184], 'simple': [1186], 'evaluation': [1187], 'sufficient.': [1198], 'growing': [1200], 'understanding': [1201], 'enables': [1205], 'lines': [1212], 'biopsy': [1217, 1776], 'Nevertheless,': [1226], 'reduced': [1228], 'size': [1230], 'mentioned': [1233], 'prevents': [1243], 'us': [1244, 2062], 'deriving': [1246], 'definitive': [1248], 'conclusion.': [1249], 'about': [1256], 'lend': [1266], 'strong': [1267, 1324], 'support': [1268], 'approach.': [1272], 'Turning': [1273], 'could': [1282], 'viable': [1285], 'option': [1287], 'meeting': [1291], 'inclusion': [1293], 'criteria': [1294], 'CRICKET': [1296], 'trial.': [1297, 1754, 1789], 'Results': [1298], 'expected': [1303], 'give': [1305], 'new': [1306], 'insight': [1307], 'issue.': [1311], 'wt,': [1318], 'face': [1321], 'biological': [1325], 'rationale,': [1326], 'actual': [1328], 'scientific': [1329], 'evidence': [1330], 'enough': [1333], 'translated': [1336], 'practice.Author': [1340], 'contributionsMarco': [1341, 2095], 'Scartozzi': [1371, 1433, 2125], 'conception,': [1373, 2127], 'writing': [1374, 1423, 2128, 2177], 'revision': [1376, 2130], 'manuscript.': [1379, 2133], 'All': [1380, 2134], 'read': [1382, 2136], 'approved': [1384, 2138], 'final': [1386, 2140], 'manuscript.Financial': [1387, 2141], 'competing': [1389, 2143], 'interests': [1390, 2144], 'disclosureThe': [1391, 2145], 'relevant': [1395, 2149], 'affiliations': [1396, 2150], 'financial': [1398, 1407, 1411, 2152, 2161, 2165], 'involvement': [1399, 2153], 'organization': [1402, 2156], 'entity': [1404, 2158], 'interest': [1408, 2162], 'conflict': [1412, 2166], 'subject': [1415, 2169], 'matter': [1416, 2170], 'materials': [1418, 2172], 'discussed': [1419, 2173], 'manuscript.No': [1422, 2176], 'assistance': [1424, 2178], 'production': [1429, 2183], 'manuscript.References1.': [1432], 'M,': [1434], 'Giampieri': [1435, 1463], 'R,': [1436, 1464, 1571], 'Aprile': [1437], 'G': [1438], 'distinctive': [1442], 'molecular,': [1443], 'pathological': [1444], 'characteristics': [1447], 'BRAF-mutant': [1449], 'tumors.': [1451], 'Expert': [1452], 'Rev.': [1453, 1654], 'Mol.': [1454, 1794], 'Diagn.': [1455], '15(8),': [1456], '979–987': [1457], '(2015).Crossref,': [1458, 1625], 'Medline,': [1459, 1536, 1563, 1593, 1626, 1658, 1689, 1760], 'CAS,': [1460, 1537, 1564, 1594, 1627, 1659, 1690, 1840], 'Google': [1461, 1493, 1538, 1565, 1595, 1628, 1660, 1691, 1719, 1761, 1804, 1841], 'Scholar2.': [1462], 'Mandolesi': [1465], 'A,': [1466, 1541, 1543, 1766], 'Abouelkhair': [1467], 'KM': [1468], 'Prospective': [1471], 'selection': [1476], 'irinotecan-cetuximab.': [1486], 'J.': [1487, 1531], 'Transl.': [1488], 'Med.': [1489, 1622], '13(140),': [1490], '1': [1491], '(2015).Medline,': [1492], 'Scholar3.': [1494], 'Yang': [1495], 'ZY,': [1496], 'Wu': [1497, 1572], 'XY,': [1498], 'Huang': [1499], 'YF': [1500], 'Promising': [1503], 'biomarkers': [1504], 'predicting': [1506], 'outcomes': [1508], 'anti-epidermal': [1519], 'growth': [1520], 'factor': [1521], 'receptor': [1522], 'antibodies:': [1524], 'systematic': [1526, 1647], 'review': [1527, 1648], 'meta-analysis.': [1529], 'Int.': [1530], 'Cancer': [1532, 1652, 1796, 1934, 1975, 2010], '133(8),': [1533], '1914–1925': [1534], '(2013).Crossref,': [1535], 'Scholar4.': [1539], 'Sartore-Bianchi': [1540, 1767], 'Amatu': [1542, 1634], 'Porcu': [1544], 'L': [1545], 'HER2': [1548], 'positivity': [1549], 'predicts': [1550], 'unresponsiveness': [1551], 'EGFR-targeted': [1553], 'Oncologist': [1559], '24(10),': [1560], '1395–1402': [1561], '(2019).Crossref,': [1562, 1657, 1759, 1839], 'Scholar5.': [1566], 'Diaz': [1567], 'LA': [1568], 'Jr,': [1569], 'Williams': [1570], 'J': [1573], 'evolution': [1578, 1607, 1773], 'targeted': [1583], 'cancers.': [1588], 'Nature': [1589], '486(7404),': [1590], '537–540': [1591], '(2012).Crossref,': [1592, 1688], 'Scholar6.': [1596], 'G,': [1598, 1631], 'Mussolin': [1599], 'B,': [1600, 1665], 'Buscarino': [1601], 'M': [1602], 'Monitoring': [1605], 'clonal': [1606, 1772], 'Nat.': [1621], '21(7),': [1623], '795–801': [1624], 'Scholar7.': [1629], 'Mauri': [1630], 'Pizzutilo': [1632], 'EG,': [1633], 'Retreatment': [1638], 'cancer:': [1646, 1710, 1786], 'different': [1650], 'strategies.': [1651], 'Treat.': [1653], '73,': [1655], '41–53': [1656], 'Scholar8.': [1661], 'D,': [1663, 1724], 'Vincenzi': [1664], 'Addeo': [1666], 'R': [1667], 'Cetuximab': [1670, 1926, 1979], 'patients:': [1676], 'how': [1677], 'come': [1679], 'away': [1680], 'resistance?': [1683], 'Ann.': [1684, 1714, 1873], 'Oncol.': [1685, 1715, 1756, 1874], '23,': [1686], '2313–2318': [1687], 'Scholar9.': [1692], 'S,': [1694, 1764], 'George': [1695], 'P,': [1696], 'Gerald': [1697], 'P': [1698], 'Rechallenge': [1701, 1730, 1927], 'effect': [1711], 'out-comes.': [1713], '28,': [1716], '113': [1717], '(2017).Crossref,': [1718], 'Scholar10.': [1720], 'C,': [1722, 1807, 1809], 'Rossini': [1723], 'E': [1725, 1727], "Dell'Aquila": [1726], 'irinotecan:': [1748], 'single-arm': [1752], 'JAMA': [1755], '5(3),': [1757], '343–350': [1758], 'Scholar11.': [1762], 'Bardelli': [1765], 'Exploiting': [1771], 'overcome': [1778], 'Abstracts:': [1790], 'AACR-NCI-EORTC': [1791], 'International': [1792], 'Conference.': [1793], 'Targets': [1795], 'Ther.': [1797], '17(Suppl.': [1798], '1),': [1799], 'Abstract': [1800], 'A089;': [1801], '26–30': [1802], '(2017).Medline,': [1803], 'Scholar12.': [1805], 'Nicolazzo': [1808], 'Belardinilli': [1810], 'F': [1811], 'Transient': [1814], 'disappearance': [1815], 'plasma:': [1821], 'counterintuitive': [1823], 'use': [1825], 'Cancers': [1835], '(Basel)': [1836], '11(1),': [1837], '42': [1838], 'Scholar13.': [1842], 'Sunakawa': [1843], 'Y,': [1844], 'Usher': [1845], 'J,': [1846], 'Satake': [1847], 'H': [1848], 'Gene': [1851], 'circulating': [1855], '(ctDNA)': [1858], 'FOLFOXIRI': [1861], 'bevacizumab': [1863], '(bev)': [1864], '29(Suppl.': [1875], '8),': [1876], 'viii150–viii204': [1877], '(2018).Google': [1878], 'ScholarFiguresReferencesRelatedDetailsCited': [1879], 'ByNew': [1880], 'Horizons': [1881], 'Colorectal': [1884, 1933, 1958, 1974, 2023], 'Cancer:': [1885], 'Prognostic': [1886], 'Role': [1887, 1964], 'CD44': [1889], 'Expression14': [1890], 'February': [1891], '2023': [1892], '|': [1893, 1915, 1938, 1986, 2014, 2027], 'Cancers,': [1894, 2028], 'Vol.': [1895, 1921, 1942, 1960, 1989, 2016, 2029, 2054], '15,': [1896], '4Circulating': [1898], 'tumour': [1899], 'gastrointestinal': [1902], 'practice:': [1906], 'Just': [1907], 'dream': [1909], 'maybe': [1911], 'not?24': [1912], 'December': [1913, 2083], '2022': [1914, 1937], 'World': [1916], 'Journal': [1917], 'Clinical': [1919], 'Oncology,': [1920, 1941, 1988], '13,': [1922], '12Liquid': [1924], 'Biopsy-Driven': [1925], 'Strategy': [1928], 'Molecularly': [1930], 'Selected': [1931], 'Patients21': [1935], 'April': [1936], 'Frontiers': [1939], '12Long': [1943], 'Term': [1944], 'Survival': [1945], 'With': [1946], 'Regorafenib:': [1947], 'REALITY': [1948], '(Real': [1949], 'Life': [1950], 'Italy)': [1952], 'Trial': [1953], '-': [1954], 'GISCAD': [1956], 'StudyClinical': [1957], 'Cancer,': [1959], '20,': [1961], '4The': [1963, 1992], 'p53': [1966], 'Expression': [1967], 'Patients': [1969], 'RAS/BRAF': [1971], 'Wild-Type': [1972], 'Receiving': [1976], 'Irinotecan': [1977], 'Later': [1981], 'Line': [1982], 'Treatment10': [1983], 'May': [1984, 2025], '2021': [1985], 'Targeted': [1987], 'Curcumin': [1993], 'Analogue,': [1994], 'MS13': [1995], '(1,5-Bis(4-hydroxy-3-': [1996], 'methoxyphenyl)-1,4-pentadiene-3-one),': [1997], 'Inhibits': [1998], 'Cell': [1999], 'Proliferation': [2000], 'Induces': [2002], 'Apoptosis': [2003], 'Primary': [2005], 'Human': [2008], 'Colon': [2009], 'Cells20': [2011], 'August': [2012], '2020': [2013, 2026, 2089], 'Molecules,': [2015], '25,': [2017], '17Molecular-Biology-Driven': [2019], 'Treatment': [2020], 'Cancer13': [2024], '12,': [2030], '5Related': [2032], 'articlesCorrigendum': [2033], "patients'5": [2050], 'Feb': [2051], '2020Future': [2052], 'eToC': [2058], 'Sign': [2059], 'up': [2060], 'Follow': [2061], 'social': [2064], 'media': [2065], 'latest': [2068], 'updates': [2069], 'Metrics': [2070], 'History': [2071], 'Received': [2072], '7': [2073], 'October': [2074], '2019': [2075, 2079, 2084, 2091], 'Accepted': [2076], '19': [2077], 'November': [2078], 'Published': [2080, 2085], 'online': [2081], '3': [2082], 'print': [2087], 'January': [2088], 'Information©': [2090], 'Medicine': [2093], 'LtdAuthor': [2094], 'manuscript.PDF': [2186], 'download': [2187]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2993387513', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 2}], 'updated_date': '2024-09-13T22:35:56.467398', 'created_date': '2019-12-13'}