Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2992077194', 'doi': 'https://doi.org/10.1186/s40478-019-0848-6', 'title': 'Secernin-1 is a novel phosphorylated tau binding protein that accumulates in Alzheimer’s disease and not in other tauopathies', 'display_name': 'Secernin-1 is a novel phosphorylated tau binding protein that accumulates in Alzheimer’s disease and not in other tauopathies', 'publication_year': 2019, 'publication_date': '2019-12-01', 'ids': {'openalex': 'https://openalex.org/W2992077194', 'doi': 'https://doi.org/10.1186/s40478-019-0848-6', 'mag': '2992077194', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/31796108', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/6892024'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1186/s40478-019-0848-6', 'pdf_url': 'https://actaneurocomms.biomedcentral.com/track/pdf/10.1186/s40478-019-0848-6', 'source': {'id': 'https://openalex.org/S2764650462', 'display_name': 'Acta Neuropathologica Communications', 'issn_l': '2051-5960', 'issn': ['2051-5960'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://actaneurocomms.biomedcentral.com/track/pdf/10.1186/s40478-019-0848-6', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5014952212', 'display_name': 'Geoffrey Pires', 'orcid': 'https://orcid.org/0000-0002-7050-9844'}, 'institutions': [{'id': 'https://openalex.org/I4210086933', 'display_name': 'NYU Langone Health', 'ror': 'https://ror.org/005dvqh91', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210086933']}, {'id': 'https://openalex.org/I57206974', 'display_name': 'New York University', 'ror': 'https://ror.org/0190ak572', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I57206974']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Geoffrey Pires', 'raw_affiliation_strings': ['NYU - New York University School of Medicine (NYU Medical Center, 550 First Ave New York, NY 10016 - United States)'], 'affiliations': [{'raw_affiliation_string': 'NYU - New York University School of Medicine (NYU Medical Center, 550 First Ave New York, NY 10016 - United States)', 'institution_ids': ['https://openalex.org/I4210086933', 'https://openalex.org/I57206974']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005562750', 'display_name': 'Sacha McElligott', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210086933', 'display_name': 'NYU Langone Health', 'ror': 'https://ror.org/005dvqh91', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210086933']}, {'id': 'https://openalex.org/I57206974', 'display_name': 'New York University', 'ror': 'https://ror.org/0190ak572', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I57206974']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sacha McElligott', 'raw_affiliation_strings': ['NYU - New York University School of Medicine (NYU Medical Center, 550 First Ave New York, NY 10016 - United States)'], 'affiliations': [{'raw_affiliation_string': 'NYU - New York University School of Medicine (NYU Medical Center, 550 First Ave New York, NY 10016 - United States)', 'institution_ids': ['https://openalex.org/I4210086933', 'https://openalex.org/I57206974']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5058400785', 'display_name': 'Shiron Drusinsky', 'orcid': 'https://orcid.org/0000-0003-1184-8835'}, 'institutions': [{'id': 'https://openalex.org/I4210086933', 'display_name': 'NYU Langone Health', 'ror': 'https://ror.org/005dvqh91', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210086933']}, {'id': 'https://openalex.org/I57206974', 'display_name': 'New York University', 'ror': 'https://ror.org/0190ak572', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I57206974']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Shiron Drusinsky', 'raw_affiliation_strings': ['NYU - New York University School of Medicine (NYU Medical Center, 550 First Ave New York, NY 10016 - United States)'], 'affiliations': [{'raw_affiliation_string': 'NYU - New York University School of Medicine (NYU Medical Center, 550 First Ave New York, NY 10016 - United States)', 'institution_ids': ['https://openalex.org/I4210086933', 'https://openalex.org/I57206974']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047141421', 'display_name': 'Glenda M. Halliday', 'orcid': 'https://orcid.org/0000-0003-0422-8398'}, 'institutions': [{'id': 'https://openalex.org/I129604602', 'display_name': 'University of Sydney', 'ror': 'https://ror.org/0384j8v12', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I129604602']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Glenda Halliday', 'raw_affiliation_strings': ['The University of Sydney (New South Wales 2006 - Australia)'], 'affiliations': [{'raw_affiliation_string': 'The University of Sydney (New South Wales 2006 - Australia)', 'institution_ids': ['https://openalex.org/I129604602']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067992372', 'display_name': 'Marie‐Claude Potier', 'orcid': 'https://orcid.org/0000-0003-2462-7150'}, 'institutions': [{'id': 'https://openalex.org/I4210152724', 'display_name': 'Institut du Cerveau', 'ror': 'https://ror.org/050gn5214', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I154526488', 'https://openalex.org/I39804081', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210152724']}, {'id': 'https://openalex.org/I4210121705', 'display_name': 'Pitié-Salpêtrière Hospital', 'ror': 'https://ror.org/02mh9a093', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210097159', 'https://openalex.org/I4210121705']}, {'id': 'https://openalex.org/I39804081', 'display_name': 'Sorbonne Université', 'ror': 'https://ror.org/02en5vm52', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I39804081']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Marie-Claude Potier', 'raw_affiliation_strings': ["CIC-BTi - Centre d'investigation clinique Biothérapie [CHU Pitié-Salpêtrière] (47-83 Boulevard de l'Hôpital 75013 Paris - France)", "ICM - Institut du Cerveau = Paris Brain Institute (47-83 Boulevard de l'Hôpital 75651 Paris Cedex 13 - France)"], 'affiliations': [{'raw_affiliation_string': "ICM - Institut du Cerveau = Paris Brain Institute (47-83 Boulevard de l'Hôpital 75651 Paris Cedex 13 - France)", 'institution_ids': ['https://openalex.org/I4210152724']}, {'raw_affiliation_string': "CIC-BTi - Centre d'investigation clinique Biothérapie [CHU Pitié-Salpêtrière] (47-83 Boulevard de l'Hôpital 75013 Paris - France)", 'institution_ids': ['https://openalex.org/I4210121705', 'https://openalex.org/I39804081']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5060656369', 'display_name': 'Thomas Wısnıewskı', 'orcid': 'https://orcid.org/0000-0002-3379-8966'}, 'institutions': [{'id': 'https://openalex.org/I4210086933', 'display_name': 'NYU Langone Health', 'ror': 'https://ror.org/005dvqh91', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210086933']}, {'id': 'https://openalex.org/I57206974', 'display_name': 'New York University', 'ror': 'https://ror.org/0190ak572', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I57206974']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Thomas Wisniewski', 'raw_affiliation_strings': ['NYU - New York University School of Medicine (NYU Medical Center, 550 First Ave New York, NY 10016 - United States)'], 'affiliations': [{'raw_affiliation_string': 'NYU - New York University School of Medicine (NYU Medical Center, 550 First Ave New York, NY 10016 - United States)', 'institution_ids': ['https://openalex.org/I4210086933', 'https://openalex.org/I57206974']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5063931891', 'display_name': 'Eleanor Drummond', 'orcid': 'https://orcid.org/0000-0002-5466-4609'}, 'institutions': [{'id': 'https://openalex.org/I4210086933', 'display_name': 'NYU Langone Health', 'ror': 'https://ror.org/005dvqh91', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210086933']}, {'id': 'https://openalex.org/I129604602', 'display_name': 'University of Sydney', 'ror': 'https://ror.org/0384j8v12', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I129604602']}, {'id': 'https://openalex.org/I57206974', 'display_name': 'New York University', 'ror': 'https://ror.org/0190ak572', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I57206974']}], 'countries': ['AU', 'US'], 'is_corresponding': False, 'raw_author_name': 'Eleanor Drummond', 'raw_affiliation_strings': ['NYU - New York University School of Medicine (NYU Medical Center, 550 First Ave New York, NY 10016 - United States)', 'The University of Sydney (New South Wales 2006 - Australia)'], 'affiliations': [{'raw_affiliation_string': 'NYU - New York University School of Medicine (NYU Medical Center, 550 First Ave New York, NY 10016 - United States)', 'institution_ids': ['https://openalex.org/I4210086933', 'https://openalex.org/I57206974']}, {'raw_affiliation_string': 'The University of Sydney (New South Wales 2006 - Australia)', 'institution_ids': ['https://openalex.org/I129604602']}]}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 6, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2390, 'currency': 'GBP', 'value_usd': 2931, 'provenance': 'doaj'}, 'apc_paid': {'value': 2390, 'currency': 'GBP', 'value_usd': 2931, 'provenance': 'doaj'}, 'fwci': 1.924, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 24, 'citation_normalized_percentile': {'value': 0.849873, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '7', 'issue': '1', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10086', 'display_name': "Mechanisms of Alzheimer's Disease", 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10086', 'display_name': "Mechanisms of Alzheimer's Disease", 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11219', 'display_name': 'Molecular Mechanisms of Osteoclast Differentiation and Bone Remodeling', 'score': 0.9752, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12030', 'display_name': 'S100 Proteins: Structure, Function, and Pathology', 'score': 0.9709, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/tauopathy', 'display_name': 'Tauopathy', 'score': 0.84978414}, {'id': 'https://openalex.org/keywords/frontotemporal-lobar-degeneration', 'display_name': 'Frontotemporal lobar degeneration', 'score': 0.7469395}, {'id': 'https://openalex.org/keywords/neuropathology', 'display_name': 'Neuropathology', 'score': 0.7204405}, {'id': 'https://openalex.org/keywords/corticobasal-degeneration', 'display_name': 'Corticobasal degeneration', 'score': 0.7162432}, {'id': 'https://openalex.org/keywords/neurofibrillary-tangle', 'display_name': 'Neurofibrillary tangle', 'score': 0.56418383}, {'id': 'https://openalex.org/keywords/tau-protein', 'display_name': 'Tau protein', 'score': 0.55653375}, {'id': 'https://openalex.org/keywords/protein-misfolding', 'display_name': 'Protein Misfolding', 'score': 0.461415}], 'concepts': [{'id': 'https://openalex.org/C2776477761', 'wikidata': 'https://www.wikidata.org/wiki/Q945930', 'display_name': 'Progressive supranuclear palsy', 'level': 3, 'score': 0.8545772}, {'id': 'https://openalex.org/C2777739294', 'wikidata': 'https://www.wikidata.org/wiki/Q2397106', 'display_name': 'Tauopathy', 'level': 4, 'score': 0.84978414}, {'id': 'https://openalex.org/C2776939681', 'wikidata': 'https://www.wikidata.org/wiki/Q18579', 'display_name': 'Frontotemporal lobar degeneration', 'level': 5, 'score': 0.7469395}, {'id': 'https://openalex.org/C2780130745', 'wikidata': 'https://www.wikidata.org/wiki/Q1650750', 'display_name': 'Neuropathology', 'level': 3, 'score': 0.7204405}, {'id': 'https://openalex.org/C2776936178', 'wikidata': 'https://www.wikidata.org/wiki/Q1755684', 'display_name': 'Corticobasal degeneration', 'level': 4, 'score': 0.7162432}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.68038297}, {'id': 'https://openalex.org/C2779721402', 'wikidata': 'https://www.wikidata.org/wiki/Q767442', 'display_name': 'Neurofibrillary tangle', 'level': 5, 'score': 0.56418383}, {'id': 'https://openalex.org/C2778670691', 'wikidata': 'https://www.wikidata.org/wiki/Q419507', 'display_name': 'Tau protein', 'level': 4, 'score': 0.55653375}, {'id': 'https://openalex.org/C204232928', 'wikidata': 'https://www.wikidata.org/wiki/Q899285', 'display_name': 'Immunohistochemistry', 'level': 2, 'score': 0.5486461}, {'id': 'https://openalex.org/C502032728', 'wikidata': 'https://www.wikidata.org/wiki/Q11081', 'display_name': "Alzheimer's disease", 'level': 3, 'score': 0.5046772}, {'id': 'https://openalex.org/C68026918', 'wikidata': 'https://www.wikidata.org/wiki/Q1970256', 'display_name': 'Senile plaques', 'level': 4, 'score': 0.4721508}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.45579988}, {'id': 'https://openalex.org/C2776925932', 'wikidata': 'https://www.wikidata.org/wiki/Q1755122', 'display_name': 'Neurodegeneration', 'level': 3, 'score': 0.4061975}, {'id': 'https://openalex.org/C2779483572', 'wikidata': 'https://www.wikidata.org/wiki/Q83030', 'display_name': 'Dementia', 'level': 3, 'score': 0.40285456}, {'id': 'https://openalex.org/C2778641062', 'wikidata': 'https://www.wikidata.org/wiki/Q18592', 'display_name': 'Frontotemporal dementia', 'level': 4, 'score': 0.39482766}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.29278898}], 'mesh': [{'descriptor_ui': 'D000544', 'descriptor_name': 'Alzheimer Disease', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D024801', 'descriptor_name': 'Tauopathies', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000369', 'descriptor_name': 'Aged, 80 and over', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002540', 'descriptor_name': 'Cerebral Cortex', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009419', 'descriptor_name': 'Nerve Tissue Proteins', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D016875', 'descriptor_name': 'tau Proteins', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}], 'locations_count': 7, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1186/s40478-019-0848-6', 'pdf_url': 'https://actaneurocomms.biomedcentral.com/track/pdf/10.1186/s40478-019-0848-6', 'source': {'id': 'https://openalex.org/S2764650462', 'display_name': 'Acta Neuropathologica Communications', 'issn_l': '2051-5960', 'issn': ['2051-5960'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/8c189191b8a54681aa029f35da706688', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://hal.sorbonne-universite.fr/hal-02472742', 'pdf_url': 'https://hal.sorbonne-universite.fr/hal-02472742/document', 'source': {'id': 'https://openalex.org/S4306402512', 'display_name': 'HAL (Le Centre pour la Communication Scientifique Directe)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1294671590', 'host_organization_name': 'Centre National de la Recherche Scientifique', 'host_organization_lineage': ['https://openalex.org/I1294671590'], 'host_organization_lineage_names': ['Centre National de la Recherche Scientifique'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc6892024', 'pdf_url': 'https://europepmc.org/articles/pmc6892024?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://hal.sorbonne-universite.fr/hal-02472742/file/document.pdf', 'pdf_url': 'https://hal.sorbonne-universite.fr/hal-02472742/file/document.pdf', 'source': {'id': 'https://openalex.org/S4306402512', 'display_name': 'HAL (Le Centre pour la Communication Scientifique Directe)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1294671590', 'host_organization_name': 'Centre National de la Recherche Scientifique', 'host_organization_lineage': ['https://openalex.org/I1294671590'], 'host_organization_lineage_names': ['Centre National de la Recherche Scientifique'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892024', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/31796108', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1186/s40478-019-0848-6', 'pdf_url': 'https://actaneurocomms.biomedcentral.com/track/pdf/10.1186/s40478-019-0848-6', 'source': {'id': 'https://openalex.org/S2764650462', 'display_name': 'Acta Neuropathologica Communications', 'issn_l': '2051-5960', 'issn': ['2051-5960'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.7, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [{'funder': 'https://openalex.org/F4320337337', 'funder_display_name': 'National Institute on Aging', 'award_id': 'AG008051'}, {'funder': 'https://openalex.org/F4320337337', 'funder_display_name': 'National Institute on Aging', 'award_id': 'AG058267'}], 'datasets': [], 'versions': [], 'referenced_works_count': 81, 'referenced_works': ['https://openalex.org/W104689190', 'https://openalex.org/W1465395011', 'https://openalex.org/W1540680906', 'https://openalex.org/W1586465707', 'https://openalex.org/W1600934558', 'https://openalex.org/W1611407165', 'https://openalex.org/W1797343225', 'https://openalex.org/W1964049915', 'https://openalex.org/W1967464880', 'https://openalex.org/W1969472602', 'https://openalex.org/W1971032265', 'https://openalex.org/W1975040221', 'https://openalex.org/W1985738617', 'https://openalex.org/W1991023630', 'https://openalex.org/W1992918771', 'https://openalex.org/W1995426930', 'https://openalex.org/W1997426613', 'https://openalex.org/W2012034410', 'https://openalex.org/W2018838463', 'https://openalex.org/W2026077861', 'https://openalex.org/W2027659335', 'https://openalex.org/W2032221178', 'https://openalex.org/W2036755018', 'https://openalex.org/W2048299052', 'https://openalex.org/W2051218719', 'https://openalex.org/W2054632638', 'https://openalex.org/W2057682957', 'https://openalex.org/W2058581619', 'https://openalex.org/W2059797637', 'https://openalex.org/W2061438201', 'https://openalex.org/W2070817114', 'https://openalex.org/W2077422298', 'https://openalex.org/W2084002557', 'https://openalex.org/W2085382634', 'https://openalex.org/W2100756758', 'https://openalex.org/W2103829129', 'https://openalex.org/W2105611633', 'https://openalex.org/W2109655755', 'https://openalex.org/W2125172225', 'https://openalex.org/W2126264983', 'https://openalex.org/W2128228199', 'https://openalex.org/W2133548029', 'https://openalex.org/W2156093068', 'https://openalex.org/W2167898988', 'https://openalex.org/W2195527239', 'https://openalex.org/W2255215236', 'https://openalex.org/W2263488737', 'https://openalex.org/W2293901317', 'https://openalex.org/W2413556564', 'https://openalex.org/W2482317947', 'https://openalex.org/W2530330371', 'https://openalex.org/W2563754444', 'https://openalex.org/W2593979775', 'https://openalex.org/W2605036205', 'https://openalex.org/W2698130214', 'https://openalex.org/W2727625182', 'https://openalex.org/W2727929522', 'https://openalex.org/W2747995740', 'https://openalex.org/W2769171126', 'https://openalex.org/W2787375839', 'https://openalex.org/W2790500393', 'https://openalex.org/W2790704031', 'https://openalex.org/W2791403874', 'https://openalex.org/W2791805346', 'https://openalex.org/W2793034296', 'https://openalex.org/W2796637563', 'https://openalex.org/W2803767896', 'https://openalex.org/W2891796239', 'https://openalex.org/W2895694428', 'https://openalex.org/W2902279935', 'https://openalex.org/W2912165492', 'https://openalex.org/W2914706199', 'https://openalex.org/W2942678593', 'https://openalex.org/W2950571742', 'https://openalex.org/W2969293681', 'https://openalex.org/W2980481080', 'https://openalex.org/W2980897543', 'https://openalex.org/W3005583156', 'https://openalex.org/W3093903285', 'https://openalex.org/W4235875658', 'https://openalex.org/W4248567869'], 'related_works': ['https://openalex.org/W80903083', 'https://openalex.org/W3122749474', 'https://openalex.org/W3004337821', 'https://openalex.org/W2977575374', 'https://openalex.org/W2166670430', 'https://openalex.org/W2133939491', 'https://openalex.org/W2070463563', 'https://openalex.org/W2017294495', 'https://openalex.org/W1988690519', 'https://openalex.org/W1979994131'], 'abstract_inverted_index': {'Abstract': [0], 'We': [1], 'recently': [2], 'identified': [3], 'Secernin-1': [4], '(SCRN1)': [5], 'as': [6, 117, 307, 315], 'a': [7, 65, 87, 93, 205, 308, 316], 'novel': [8, 309], 'amyloid': [9], 'plaque': [10], 'associated': [11, 293], 'protein': [12, 207], 'using': [13], 'localized': [14], 'proteomics.': [15], 'Immunohistochemistry': [16, 74, 200], 'studies': [17], 'confirmed': [18, 226], 'that': [19, 202, 208, 227, 274, 289], 'SCRN1': [20, 46, 69, 79, 126, 203, 224, 228, 259, 275, 290, 304], 'was': [21, 75, 128, 204], 'present': [22], 'in': [23, 50, 71, 86, 131, 211, 231, 233, 252, 267, 280, 297], 'plaque-associated': [24, 214], 'dystrophic': [25, 215], 'neurites': [26, 216], 'and': [27, 31, 47, 54, 140, 166, 192, 213, 243, 256, 300, 312], 'also': [28, 129], 'revealed': [29, 273], 'distinct': [30], 'abundant': [32], 'co-localization': [33], 'with': [34, 92, 134, 148, 160, 254, 263, 277, 294], 'neurofibrillary': [35], 'tangles': [36], '(NFTs).': [37], 'Little': [38], 'is': [39, 291], 'known': [40], 'about': [41], 'the': [42, 82, 218], 'physiological': [43], 'function': [44], 'of': [45, 68, 84, 89, 95, 144, 156, 220, 223, 246], 'its': [48], 'role': [49], 'Alzheimer’s': [51], 'disease': [52, 194], '(AD)': [53], 'other': [55, 167, 323], 'neurodegenerative': [56, 72], 'diseases': [57], 'has': [58, 305], 'not': [59, 261], 'been': [60], 'studied.': [61], 'Therefore,': [62], 'we': [63], 'performed': [64], 'comprehensive': [66], 'study': [67], 'distribution': [70], 'diseases.': [73], 'used': [76], 'to': [77, 235, 319], 'map': [78], 'accumulation': [80, 127], 'throughout': [81, 217], 'progression': [83, 219], 'AD': [85, 149, 255, 282, 321], 'cohort': [88], '58': [90], 'patients': [91], 'range': [94], 'NFT': [96], 'pathology': [97, 296], '(Abundant': [98], 'NFT,': [99, 104, 109], 'n': [100, 105, 110, 151, 176, 197], '=': [101, 106, 111, 152, 177, 183, 190, 198], '21;': [102], 'Moderate': [103], '22;': [107], 'Low/No': [108], '15),': [112], 'who': [113], 'were': [114, 250], 'clinically': [115], 'diagnosed': [116], 'having': [118], 'AD,': [119, 298], 'mild': [120], 'cognitive': [121], 'impairment': [122], 'or': [123, 270], 'normal': [124], 'cognition.': [125], 'examined': [130], 'two': [132], 'cases': [133, 143], 'both': [135, 241], 'Frontotemporal': [136], 'Lobar': [137], 'Degeneration': [138, 180], '(FTLD)-Tau': [139], 'AD-related': [141], 'neuropathology,': [142], 'Down': [145], 'Syndrome': [146], '(DS)': [147], '(': [150], '5),': [153], 'one': [154], 'case': [155], 'hereditary': [157], 'cerebral': [158], 'hemorrhage': [159], 'amyloidosis': [161], '–': [162], 'Dutch': [163], 'type': [164], '(HCHWA-D)': [165], 'non-AD': [168], 'tauopathies': [169], 'including:': [170], 'primary': [171], 'age-related': [172], 'tauopathy': [173], '(PART,': [174], '[': [175, 196], '5]),': [178, 184], 'Corticobasal': [179], '(CBD,': [181], '[n': [182, 189], 'Progressive': [185], 'Supranuclear': [186], 'Palsy': [187], '(PSP,': [188], '5])': [191], 'Pick’s': [193], '(PiD,': [195], '4]).': [199], 'showed': [201], 'neuronal': [206], 'abundantly': [209], 'accumulated': [210, 230], 'NFTs': [212, 232], 'AD.': [221, 247], 'Quantification': [222], 'immunohistochemistry': [225], 'preferentially': [229], 'comparison': [234], 'surrounding': [236], 'non-tangle': [237], 'containing': [238], 'neurons': [239], 'at': [240], 'early': [242], 'late': [244], 'stages': [245], 'Similar': [248], 'results': [249, 287], 'observed': [251], 'DS': [253, 299], 'PART.': [257, 301], 'However,': [258], 'did': [260], 'co-localize': [262], 'phosphorylated': [264, 278], 'tau': [265, 279, 295], 'inclusions': [266], 'CBD,': [268], 'PSP': [269], 'PiD.': [271], 'Co-immunoprecipitation': [272], 'interacted': [276], 'human': [281], 'brain': [283], 'tissue.': [284], 'Together,': [285], 'these': [286], 'suggest': [288], 'uniquely': [292], 'As': [302], 'such,': [303], 'potential': [306], 'therapeutic': [310], 'target': [311], 'could': [313], 'serve': [314], 'useful': [317], 'biomarker': [318], 'distinguish': [320], 'from': [322], 'tauopathies.': [324]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2992077194', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 7}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 1}], 'updated_date': '2024-09-17T20:54:00.915985', 'created_date': '2019-12-13'}